Sleep Management and Recovery after Traumatic Brain Injury in Kids (SMART-kids): Evidence for targeting sleep to improve outcome

Aim 1: Evaluate the association between sleep disturbances and cognitive outcomes after pediatric brain injury

In the first part of the study, we are using questionnaires and actigraphy devices to measure sleep at baseline, 1 month, and 6 months after hospital discharge. We are using questionnaires to measure cognitive function as the primary outcome and evaluating how problems with sleep affect cognitive outcomes and recovery over time. 

This phase of the study is actively recruiting, and you can contact the study team for information. 

Cydni Williams, MD, MCR: willicyd@ohsu.edu, (503) 494-5522

Andrea Rano, BS: rano@ohsu.edu 

Aim 2: Evaluate a melatonin and behavioral intervention to determine if sleep can be modified through early intervention

In this study, we will randomize children with traumatic brain injury to receive melatonin and a sleep focused educational intervention versus placebo and standard care while still in the hospital. We will evaluate sleep outcomes in both groups to see if our intervention is effective at preventing sleep problems. If we can modify sleep, this may give us a target in future studies to see if this intervention can also improve other outcomes after brain injury. 

Both of these projects are funded by the National Heart Lung and Blood Institute