About

OPERM
Left to Right: Keri Brown, Emily Mishler, Dr. Ov Slayden, Dr. Jeffrey Jensen, Dr. Carrie Hanna, and Dr. Shan Yao

Jeffrey T. Jensen, M.D., M.P.H.; Principal Investigator and Center Director. Dr. Jensen is a Leon Speroff Endowed Professor and Vice Chair for Research in the Department of OB/GYN, OHSU and a Professor for Division of Reproductive and Developmental Sciences, ONPRC. Dr. Jensen brings considerable clinical expertise in contraception and family planning, including that from serving as P.I. (2004-present) of the OHSU site within the NICHD Contraceptive Clinical Trials Network.  Dr. Jensen has been involved in translational research in contraception at ONPRC since the mid-1990s, and is currently co-PI of the NICHD-funded U54 Contraceptive Development Research Center at ONPRC.  Dr. Jensen has received funding from the BMGF for studies of polidocanol foam as a method of nonsurgical permanent contraception.  As OPERM Center Director, Dr. Jensen is the primary point of contact between the Center, the BMGF Program Officer, the OPERM SAB, outside investigators, and the media.  

Ov D. Slayden, Ph.D.; Co-Principal Investigator and Scientific Director. Dr. Slayden is an Associate Professor in the Division of Reproductive and Developmental Sciences, ONPRC.  He is an international expert in reproductive tract biology.  In addition to his NICHD-funded research, he has developed multiple contracts with pharmaceutical companies evaluating the effects of novel chemical entities on the reproductive tract.  Drs. Jensen and Slayden have been close collaborators on Project 3 of the U54 CDRC, and also on Gates-funded studies of polidocanol foam for permanent contraception.   The OPERM Center leadership combines Dr. Slayden's basic/nonhuman primate expertise with Dr. Jensen's applied/human clinical expertise to facilitate translational research on novel methods for permanent contraception in women.  As OPERM Scientific Director, Dr. Slayden will assist external investigators with research plans and animal models.  Dr. Slayden will also provide day-to-day oversight of the OPERM Nonhuman Primate Core. 

Carrie Hanna, Ph. D.; Scientific Support Manager: Dr. Hanna is a Research Assistant Professor and the Director of the Assisted Reproduction Technology Core lab at the ONPRC. She has worked with Dr. Jensen developing non-hormonal contraceptive alternatives for women since 2012, and has been a key contributor to the polidocanol foam research team. Dr. Hanna is experienced in using animal models for studying reproductive physiology and oversees all facets of the projects underway in the OPPEM center at any particular time. She works closely with investigative P.I.s in the design and implementation of funded research, monitors the day-to-day activities related to projects that are underway in the center, and communicates with ONPRC Division of Comparative Medicine Staff to ensure adequate animal availability and housing. In addition, Dr. Hanna provides supervision of the OPERM Histology and Animal Resource Cores.

Shan Yao, MD.; Cell Biology/Histology Research Associate. Shan works  with project P.I.s to ensure successful collection and processing of biological specimens. Area of expertise include specimen processing (preparation of frozen and paraffin embedded specimens, laser capture, RNA/DNA/protein isolation), histology, immunohistochemistry, and microscopy (standard light and confocal methods). She directly communicates with individual project P.I.s and their staff routinely to ensure successful completion of the research objectives and to aid in teaching relevant techniques to trainees. She also works closely with DCM Pathology staff to verify/confirm findings based on histological and morphological endpoints. A member of the Jensen Lab since 2009, Dr. Yao performed all of the histology and cell biology experiments for the nonsurgical permanent contraception project investigating polidocanol foam.  Her expertise is available as a resource for OPERM-funded investigators.

Emily Mishler, MS.; Senior Animal Resource Research Assistant. Emily has a master degree in Animal Science from Oregon State University and experience using animal models for research. She has been a member of the Slayden lab since 2012.  In this role, Mrs. Mishler provides nonhuman primate expertise critical for performing daily activities that are needed for the completion of center research projects. She communicates directly with the Scientific Support Manager regarding activities related to the individual projects, as well as with DCM staff that are involved in the day-to-day care of the research animals. Specific tasks critical for successful completion of center research projects include, but are not limited to, performing blood draws, processing samples for steroid/protein hormone analyses through the ONPRC Endocrine Technologies Support Core, drug administration, monitoring menses, preparing and assisting with imaging studies, scheduling surgical procedure or animal necropsies, and coordinating sample procurement through individual center investigators and their laboratory staff.  Together with other OPERM staff, she provides 365 day per year coverage of animal protocols including daily assessment of cycle characteristics from baboons.

Tanner Grenz, BS.; Animal Resource Research Assistant. Tanner joined the OPERM team in 2017 after graduating from Oregon State University with a bachelor degree in biology. He provides critical support for animal experiments and has direct responsibility for managing the OPERM guinea pig core. He assists Ms. Mishler with essential activities for nonhuman primate experiments.  Tanner has experience with  performing blood draws, processing samples for steroid/protein hormone analyses through the ONPRC Endocrine Technologies Support Core, drug administration, monitoring menses, preparing and assisting with imaging studies, scheduling surgical procedure or animal necropsies, and coordinating sample procurement. In the laboratory, Tanner performs experiments using advanced molecular biology and cell culture techniques. Together with other OPERM staff, he provides 365 day per year coverage of animal protocols.

Keri Brown, BS.; OPERM Center Administrator. Keri has a Bachelors of Science degree from Eastern Oregon University in Health Education, and has been apart of the Jensen/Slayden teams since 2013. She provides administrative support for the co-PIs and the scientific support personnel. Ms. Brown also organizes and assists with the preparation of project reports/manuscripts, IACUC applications, and manages center accounts, budgets and expenses. She maintains the Center Web Site, and is the point of contact between project PIs and OPERM staff. She is also the point of contact for information about OPERM funding opportunities.