Orderable EAP code:

LAB00375

Billable EAP Codes:

80003083 x 1

CPT Codes:

80195 x 1

Lab Section:

Core Lab

Turnaround Time:

Routine: 1 day

Test Schedule:

7 days a week.

Units:

ng/mL

Specimen Requirements:

3 mL blood in a LAVENDER top tube (EDTA); redraw if specimen clotted.

Specimens are stable for up to 24 hours at room temperature and 7 days refrigerated at 2 to 8 °C. For longer storage, specimens may be frozen at -20 °C or colder for up to 3 months. 

Pediatric Specimen Requirements:

0.5 mL blood in a LAVENDER top tube (EDTA); redraw if specimen clotted. 

Specimens are stable for up to 24 hours at room temperature and 7 days refrigerated at 2 to 8 °C. For longer storage, specimens may be frozen at -20 °C or colder for up to 3 months. 

Reference Range:

4 to 12 ng/mL

Comments:

Test performed by immunoassay using Siemens Dimension EXL 200.

Kidney transplant (in combination with Cyclosporine): 4 to 12 ng/mL
Toxic value: greater than 25 ng/mL

Interpretive Data: A range of 12 to 20 ng/mL has been suggested for liver transplant. Samples for analysis of Sirolimus should be collected 30 minutes to 1 hour prior to the next dose so that the measured concentration of drug represents trough levels. The optimal therapeutic range for a given patient may differ from this suggested range based on the indication for therapy, treatment phase (initiation or maintenance), use in combination with other drugs, time of specimen collection relative to prior dose and/or type of transplanted organ.

 

Synonyms:

Rapamune
Rapamycin
Sirolimus Quantitation
SIRO