About our lab

The Mandel lab applies a diverse set of approaches to questions related to the mechanisms of gene regulation in the healthy and diseased brain. At one end of a spectrum, we use animal models to study the developing and adult mouse brain, as well as to model the severe neurological disorder, Rett Syndrome, to better understand its molecular basis and how we might reverse symptoms. We also use human cell lines and brain tissue to study aging and its relationship to cognitive decline. At the extreme other end of the spectrum, we use high resolution imaging and single cell chromatin and transcriptomic analyses to unravel fundamental principles of gene regulation that extend across all organisms. This wide berth—from molecule to organism—allows us to capture the excitement of biology at more than one level and keeps our research at the forefront of the field.

We're recruiting postdoctoral fellows

The Mandel Lab has openings for postdocs interested in using molecular analyses to understand nervous system adaptations during aging and underlying neurological disease.

  • A postdoctoral position is available for understanding the role of transcriptional and chromatin changes in brain during human aging.
  • A postdoctoral position is available for exploring new molecular editing approaches toward repair of the neurological disease, Rett Syndrome.

Interested applicants should send a CV and list of references to Gail Mandel at mandelg@ohsu.edu. Prior molecular experience is preferred.

Mandel Lab 2019

Members of the Mandel Lab in the LBRB Courtyard at OHSU

Members of the Mandel Lab gather for a group photo in the LBRB Courtyard.
(Left to Right) Jessica Yeates, Gabe Haw, Michael Spinner, Mike Jacobson, Michael Linhoff, Gail Mandel, John Sinnamon, Jenna Fisk, James McGann, Abinaya Ravisankar and Aliyih Bristol.

Join our lab

Postdoctoral Fellow
If you are interested in working on our projects as a postdoctoral fellow, please send your CV and names of three references to Gail Mandel via email.

Graduate Student Program
Graduate students can enter the Mandel lab via the Neuroscience Graduate Program or the Graduate Program in Biomedical Sciences.

Summer Research Opportunities
Occasional and open only to highly motivated students, usually in their senior year of undergraduate studies. If you are interested, contact Gail Mandel via email.

The MeCP2 Consortium

For over ten years, Gail Mandel has collaborated with fellow Rett Syndrome researchers Michael Greenberg at Harvard Medical School and Adrian Bird at University of Edinburgh, Scotland, to reshape scientific understanding of MeCP2 protein function as part of the MeCP2 Consortium. Even though the three labs are 6,000 miles apart, the researchers are united in the belief that understanding the normal role of MeCP2 is crucial to the successful development of therapies to treat Rett Syndrome and that by working collaboratively, they can accomplish that task much faster than working alone.

Read the “Power of Three” at Rett Syndrome Research Trust