Lab publications

1. In-depth virological and immunological characterization of HIV-1 cure after CCR5Δ32/Δ32 allogeneic hematopoietic stem cell transplantation.
Jensen BO, Knops E, Cords L, Lübke N, Salgado M, Busman-Sahay K, Estes JD, Huyveneers LEP, Perdomo-Celis F, Wittner M, Gálvez C, Mummert C, Passaes C, Eberhard JM, Münk C, Hauber I, Hauber J, Heger E, De Clercq J, Vandekerckhove L, Bergmann S, Dunay GA, Klein F, Häussinger D, Fischer JC, Nachtkamp K, Timm J, Kaiser R, Harrer T, Luedde T, Nijhuis M, Sáez-Cirión A, Schulze Zur Wiesch J, Wensing AMJ, Martinez-Picado J, Kobbe G.
Nat Med. 2023 Mar;29(3):583-587. doi: 10.1038/s41591-023-02213-x. Epub 2023 Feb 20.
PMID: 36807684 Free PMC article.

2. Allogeneic immunity clears latent virus following allogeneic stem cell transplantation in SIV-infected ART-suppressed macaques.
Wu HL, Busman-Sahay K, Weber WC, Waytashek CM, Boyle CD, Bateman KB, Reed JS, Hwang JM, Shriver-Munsch C, Swanson T, Northrup M, Armantrout K, Price H, Robertson-LeVay M, Uttke S, Kumar MR, Fray EJ, Taylor-Brill S, Bondoc S, Agnor R, Junell SL, Legasse AW, Moats C, Bochart RM, Sciurba J, Bimber BN, Sullivan MN, Dozier B, MacAllister RP, Hobbs TR, Martin LD, Panoskaltsis-Mortari A, Colgin LMA, Siliciano RF, Siliciano JD, Estes JD, Smedley JV, Axthelm MK, Meyers G, Maziarz RT, Burwitz BJ, Stanton JJ, Sacha JB.
Immunity. 2023 Jul 11;56(7):1649-1663.e5. doi: 10.1016/j.immuni.2023.04.019. Epub 2023 May 25.
PMID: 37236188

3. Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques.
Viox EG, Hoang TN, Upadhyay AA, Nchioua R, Hirschenberger M, Strongin Z, Tharp GK, Pino M, Nguyen K, Harper JL, Gagne M, Marciano S, Boddapati AK, Pellegrini KL, Pradhan A, Tisoncik-Go J, Whitmore LS, Karunakaran KA, Roy M, Kirejczyk S, Curran EH, Wallace C, Wood JS, Connor-Stroud F, Voigt EA, Monaco CM, Gordon DE, Kasturi SP, Levit RD, Gale M Jr, Vanderford TH, Silvestri G, Busman-Sahay K, Estes JD, Vaccari M, Douek DC, Sparrer KMJ, Johnson RP, Kirchhoff F, Schreiber G, Bosinger SE, Paiardini M.
Sci Immunol. 2023 Jul 28;8(85):eadg0033. doi: 10.1126/sciimmunol.adg0033. Epub 2023 Jul 28.
PMID: 37506197

4. Combined protein and nucleic acid imaging reveals virus-dependent B cell and macrophage immunosuppression of tissue microenvironments.
Jiang S, Chan CN, Rovira-Clavé X, Chen H, Bai Y, Zhu B, McCaffrey E, Greenwald NF, Liu C, Barlow GL, Weirather JL, Oliveria JP, Nakayama T, Lee IT, Matter MS, Carlisle AE, Philips D, Vazquez G, Mukherjee N, Busman-Sahay K, Nekorchuk M, Terry M, Younger S, Bosse M, Demeter J, Rodig SJ, Tzankov A, Goltsev Y, McIlwain DR, Angelo M, Estes JD, Nolan GP.
Immunity. 2022 Jun 14;55(6):1118-1134.e8. doi: 10.1016/j.immuni.2022.03.020. Epub 2022 Apr 20.
PMID: 35447093 Free PMC article.

5. Interleukin-10 contributes to reservoir establishment and persistence in SIV-infected macaques treated with antiretroviral therapy.
Harper J, Ribeiro SP, Chan CN, Aid M, Deleage C, Micci L, Pino M, Cervasi B, Raghunathan G, Rimmer E, Ayanoglu G, Wu G, Shenvi N, Barnard RJ, Del Prete GQ, Busman-Sahay K, Silvestri G, Kulpa DA, Bosinger SE, Easley KA, Howell BJ, Gorman D, Hazuda DJ, Estes JD, Sekaly RP, Paiardini M.
J Clin Invest. 2022 Apr 15;132(8):e155251. doi: 10.1172/JCI155251.
PMID: 35230978 Free PMC article.

6. Spontaneous HIV expression during suppressive ART is associated with the magnitude and function of HIV-specific CD4+ and CD8+ T cells.
Dubé M, Tastet O, Dufour C, Sannier G, Brassard N, Delgado GG, Pagliuzza A, Richard C, Nayrac M, Routy JP, Prat A, Estes JD, Fromentin R, Chomont N, Kaufmann DE.
Cell Host Microbe. 2023 Sep 13;31(9):1507-1522.e5. doi: 10.1016/j.chom.2023.08.006.
PMID: 37708853

7. Lymph-Node-Based CD3+ CD20+ Cells Emerge from Membrane Exchange between T Follicular Helper Cells and B Cells and Increase Their Frequency following Simian Immunodeficiency Virus Infection.
Samer S, Chowdhury A, Wiche Salinas TR, Estrada PMDR, Reuter M, Tharp G, Bosinger S, Cervasi B, Auger J, Gill K, Ablanedo-Terrazas Y, Reyes-Teran G, Estes JD, Betts MR, Silvestri G, Paiardini M.
J Virol. 2023 Jun 29;97(6):e0176022. doi: 10.1128/jvi.01760-22. Epub 2023 May 23.
PMID: 37223960 Free PMC article.

8. Nonhuman primate models of human viral infections.
Estes JD, Wong SW, Brenchley JM.
Nat Rev Immunol. 2018 Jun;18(6):390-404. doi: 10.1038/s41577-018-0005-7.
PMID: 29556017 Free PMC article. Review.

9. Recommendations for measuring HIV reservoir size in cure-directed clinical trials.
Abdel-Mohsen M, Richman D, Siliciano RF, Nussenzweig MC, Howell BJ, Martinez-Picado J, Chomont N, Bar KJ, Yu XG, Lichterfeld M, Alcami J, Hazuda D, Bushman F, Siliciano JD, Betts MR, Spivak AM, Planelles V, Hahn BH, Smith DM, Ho YC, Buzon MJ, Gaebler C, Paiardini M, Li Q, Estes JD, Hope TJ, Kostman J, Mounzer K, Caskey M, Fox L, Frank I, Riley JL, Tebas P, Montaner LJ; BEAT-HIV Delaney Collaboratory to Cure HIV-1 infection.
Nat Med. 2020 Sep;26(9):1339-1350. doi: 10.1038/s41591-020-1022-1. Epub 2020 Sep 7.
PMID: 32895573 Free PMC article. Review.

10.Eliminating HIV reservoirs for a cure: the issue is in the tissue.
Busman-Sahay K, Starke CE, Nekorchuk MD, Estes JD.
Curr Opin HIV AIDS. 2021 Jul 1;16(4):200-208. doi: 10.1097/COH.0000000000000688.
PMID: 34039843 Free PMC article. Review.

11. Non-Human Primate Models of HIV Brain Infection and Cognitive Disorders.
Byrnes SJ, Angelovich TA, Busman-Sahay K, Cochrane CR, Roche M, Estes JD, Churchill MJ.
Viruses. 2022 Sep 9;14(9):1997. doi: 10.3390/v14091997.
PMID: 36146803 Free PMC article. Review.

12. The role of oxidative stress in HIV-associated neurocognitive disorders.
Buckley S, Byrnes S, Cochrane C, Roche M, Estes JD, Selemidis S, Angelovich TA, Churchill MJ.
Brain Behav Immun Health. 2021 Feb 28;13:100235. doi: 10.1016/j.bbih.2021.100235. eCollection 2021 May.
PMID: 34589750 Free PMC article. Review.

13. Visualizing the Immune System: Providing Key Insights into HIV/SIV Infections.
Estes JD, LeGrand R, Petrovas C.
Front Immunol. 2018 Mar 2;9:423. doi: 10.3389/fimmu.2018.00423. eCollection 2018.
PMID: 29552017 Free PMC article. Review.