Publications

Recent publications

A model for link pruning to establish correctly polarized and oriented tip links in hair bundles
Tompkins N, Spinelli KJ, Choi D, Barr-Gillespie PG. (2017) Biophys. J. 113, 1868–1881 | doi: 10.1016/j.bpj.2017.08.029 | PMCID: PMC5647544

ELMOD1 stimulates ARF6-GTP hydrolysis to stabilize apical structures in developing vestibular hair cells
Krey JF, Dumont RA, Wilmarth PA, David LL, Johnson KR, Barr-Gillespie PG. (2018) J. Neurosci. 38, 843–857 | doi: 10.1523/JNEUROSCI.2658-17.2017 | PMCID: PMC5783965

TRPV6, TRPM6 and TRPM7 do not contribute to hair-cell mechanotransduction
Morgan CP, Zhao H, LeMasurier M, Xiong W, Pan B, Kazmierczak P, Avenarius MR, Bateschell M, Larisch R, Ricci AJ, Müller U, Barr-Gillespie PG. (2018) Front. Cell. Neurosci. 12: 41 | doi: 10.3389/fncel.2018.00041 | PMCID: PMC5826258

Transcriptional dynamics of hair-bundle morphogenesis revealed with CellTrails
Ellwanger DC, Scheibinger M, Dumont RA, Barr-Gillespie PG, Heller S. (2018) Cell Reports 23, 2901–2914 | doi: 10.1016/j.celrep.2018.05.002 | PMCID: PMC6089258

Mass spectrometry quantitation of proteins from small pools of developing auditory and vestibular cells
Krey JF, Scheffer DI, Choi D, Reddy A, David LL, Corey DP, Barr-Gillespie PG. (2018) Sci. Data 5:180128 | doi: 10.1038/sdata.2018.128 | PMCID: PMC6049031

Honing in on TMC as the hair cell's transduction channel
Barr-Gillespie PG. (2018) Neuron 99, 628–629 | doi: 10.1016/j.neuron.2018.08.013 | PMID:30138584

Single-cell proteomics reveals changes in expression during hair-cell development
Zhu Y, Scheibinger M, Ellwanger DC, Krey JF, Choi D, Kelly RT, Heller S, Barr-Gillespie PG. (2019) Elife 8, e50777 | doi: 10.7554/eLife.50777 | PMCID: PMC6855842

Mechanotransduction-dependent control of stereocilia dimensions and row identity in inner hair cells
Krey JF, Chatterjee P, Dumont RA, O'Sullivan M, Choi D, Bird JE, Barr-Gillespie PG. (2020) Curr. Biol. 30, 442-454 | doi: 10.1016/j.cub.2019.11.076 | PMCID: PMC7002276

A cryo-tomography-based volumetric model of the actin core of mouse vestibular hair cell stereocilia lacking plastin 1
Song J, Patterson R, Metlagel Z, Krey JF, Hao S, Wang L, Ng B, Sazzed S, Kovacs J, Wriggers W, He J, Barr-Gillespie PG*, Auer M*. (2020) J. Struct. Biol. 210(1):107461 | doi: 10.1016/j.jsb.2020.107461 | PMCID: PMC7067663 *Co-corresponding senior authors

Loss of Baiap2l2 destabilizes the transducing stereocilia of cochlear hair cells and leads to deafness
Carlton AJ, Halford J, Underhill A, Jeng JY, Avenarius MR, Gilbert ML, Ceriani F, Ebisine K, Brown SDM, Bowl MR, Barr-Gillespie PG*, Marcotti W* (2021) J. Physiol. 599, 1173-1198. | doi: 10.1113/JP280670 | PMCID: PMC7898316 *Co-corresponding senior authors

Most significant publications

High-purity isolation of bullfrog hair bundles and subcellular and topological localization of constituent proteins
Gillespie PG, Hudspeth AJ. (1991) J. Cell Biol. 112, 625–640.

Regeneration of broken tip links and restoration of mechanical transduction in hair cells
Zhao Y, Yamoah EN, Gillespie PG. (1996) Proc. Natl. Acad. Sci. USA 93, 15469–15474.

High-resolution structure of hair-cell tip links
Kachar B, Parakkal M, Kurc M, Zhao Y, Gillespie PG. (2000) Proc. Natl. Acad. Sci. USA 97, 13336–13341.

Plasma membrane Ca2+-ATPase isoform 2a is the PMCA of hair bundles
Dumont RA, Lins U, Filoteo AG, Penniston JT, Kachar B, Gillespie PG. (2001) J. Neurosci. 21, 5066–5078.

A chemical-genetic strategy demonstrates myosin-1c participates in adaptation by hair cells
Holt JR, Gillespie SK, Provance DW, Shah K, Shokat KM, Corey DP, Mercer JA, Gillespie PG. (2002) Cell 108, 371–381.

Cadherin 23 is a component of the tip link in hair cell stereocilia
Siemens J, Lillo C, Dumont RA, Reynolds A, Williams DS, Gillespie PG, Müller U. (2004) Nature 428, 950–955.

Hair cells require phosphatidylinositol 4,5-bisphosphate for mechanical transduction and adaptation
Hirono M, Denis CS, Richardson GP, Gillespie PG. (2004) Neuron 44, 309–320.

Fast adaptation in vestibular hair cells requires myosin-1c activity
Stauffer EA, Scarborough JD, Hirono M, Miller ED, Shah K, Mercer JA, Holt JR, Gillespie PG. (2005) Neuron 47, 541–553.

Molecular architecture of the chick vestibular hair bundle
Shin JB, Krey JF, Hassan A, Metlagel Z, Tauscher AN, Pagana JM, Sherman NE, Jeffery ED, Spinelli KJ, Zhao H, Wilmarth PA, Choi D, David LL, Auer M, Barr-Gillespie PG. (2013) Nature Neurosci. 16, 365–374.

PDZD7-MYO7A complex identified in enriched stereocilia membranes
Morgan CP, Krey JF, Grati M, Zhao B, Fallen S, Kannan-Sundhari A, Liu XZ, Choi D, Müller U, Barr-Gillespie PG. (2016) eLife 5, e18312.