Publications
Recent publications
Belyantseva IA, Liu C, Dragich AK, Miyoshi T, Inagaki S, Imtiaz A, Tona R, Zuluaga-Osorio KS, Hadi S, Wilson E, Morozko E, Olszewski R, Yousaf R, Sokolova Y, Riordan GP, Aston SA, Rehman AU, Fenollar Ferrer C, Wisniewski J, Gu S, Nayak G, Goodyear RJ, Li J, Krey JF, Wafa T, Faridi R, Adadey SM, Drummond M, Perrin B, Winkler DC, Starost MF, Cheng H, Fitzgerald T, Richardson GP, Dong L, Barr-Gillespie PG, Hoa M, Frolenkov GI, Friedman TB, Zhao B. (2025) J Cell Biol. 2025 Aug 4;224(8):e202408026. | doi: 10.1083/jcb.202408026. | Epub 2025 Jun 5. | PMID: 40471101
Myosin-dependent short actin filaments contribute to peripheral widening in developing stereocilia.
Liao X, Tung CY, Krey JF, Behnammanesh G, Cirilo JA Jr, Colpan M, Yengo CM, Barr-Gillespie PG, Bird JE, Perrin BJ. (2024) Res Sq [Preprint]. 2024 Dec 5:rs.3.rs-5448262. | doi: 10.21203/rs.3.rs-5448262/v1. | PMID: 39678325 Free PMC article
Spontaneous allelic variant in deafness-blindness gene Ush1g resulting in an expanded phenotype.
Vartanian V, Krey JF, Chatterjee P, Curtis A, Six M, Rice SPM, Jones SM, Sampath H, Allen CN, Ryals RC, Lloyd RS, Barr-Gillespie PG. (2023) Genes Brain Behav. 2023 Jun 16:e12849 | doi: 10.1111/gbb.12849 | PMID: 37328946
GIPC3 couples to MYO6 and PDZ domain proteins, and shapes the hair cell apical region
Chatterjee P, Morgan CP, Krey JF, Benson C, Goldsmith J, Bateschell M, Ricci AJ, Barr-Gillespie PG. (2023) J Cell Sci. 136(10):jcs261100 | doi: 10.1242/jcs.261100 | PMID: 37096733
Control of stereocilia length during development of hair bundles
Krey JF, Chatterjee P, Halford J, Cunningham CL, Perrin BJ, Barr-Gillespie PG. (2023) PLoS Biol. 21(4):e3001964 | doi: 10.1371/journal.pbio.3001964 | PMID: 37011103
ANKRD24 organizes TRIOBP to reinforce stereocilia insertion points
Krey JF, Liu C, Belyantseva IA, Bateschell M, Dumont RA, Goldsmith J, Chatterjee P, Morrill RS, Fedorov LM, Foster S, Kim J, Nuttall AL, Jones SM, Choi D, Friedman TB, Ricci AJ, Zhao B, Barr-Gillespie PG. (2022) J Cell Biol. 221(4):e202109134 | doi: 10.1083/jcb.202109134 | PMID: 35175278
Ca2+ entry through mechanotransduction channels localizes BAIAP2L2 to stereocilia tips
Halford J, Bateschell M, Barr-Gillespie PG. (2022) Mol Biol Cell. 33(4):br6 | doi: 10.1091/mbc.E21-10-0491 | PMID: 35044843
Cy3-ATP labeling of unfixed, permeabilized mouse hair cells
Pacentine IV, Barr-Gillespie PG. (2021) Sci Rep. 11(1):23855 | doi: 10.1038/s41598-021-03365-x | PMID: 34903829
A comparative analysis of genetic hearing loss phenotypes in European/American and Japanese populations
Walls WD, Moteki H, Thomas TR, Nishio SY, Yoshimura H, Iwasa Y, Frees KL, Nishimura CJ, Azaiez H, Booth KT, Marini RJ, Kolbe DL, Weaver AM, Schaefer AM, Wang K, Braun TA, Usami SI, Barr-Gillespie PG, Richardson GP, Smith RJ, Casavant TL. (2020) Hum Genet. 139(10):1315-1323 | doi: 10.1007/s00439-020-02174-y | PMID: 32382995
Stereocilia Rootlets: Actin-Based Structures That Are Essential for Structural Stability of the Hair Bundle
Pacentine I, Chatterjee P, Barr-Gillespie PG. (2020) Int J Mol Sci. 21(1):324 | doi: 10.3390/ijms21010324 | PMID: 31947734
Electron cryo-tomography of vestibular hair-cell stereocilia
Metlagel Z, Krey JF, Song J, Swift MF, Tivol WJ, Dumont RA, Thai J, Chang A, Seifikar H, Volkmann N, Hanein D, Barr-Gillespie PG, Auer M. (2019) J Struct Biol. 206(2):149-155 | doi: 10.1016/j.jsb.2019.02.006 | PMID: 30822456
Molecular Composition of Vestibular Hair Bundles
Krey JF, Barr-Gillespie PG. (2019) Cold Spring Harb Perspect Med. 9(1):a033209 | doi: 10.1101/cshperspect.a033209 | PMID: 29844221
Most significant publications
High-purity isolation of bullfrog hair bundles and subcellular and topological localization of constituent proteins
Gillespie PG, Hudspeth AJ. (1991) J. Cell Biol. 112, 625–640.
Regeneration of broken tip links and restoration of mechanical transduction in hair cells
Zhao Y, Yamoah EN, Gillespie PG. (1996) Proc. Natl. Acad. Sci. USA 93, 15469–15474.
High-resolution structure of hair-cell tip links
Kachar B, Parakkal M, Kurc M, Zhao Y, Gillespie PG. (2000) Proc. Natl. Acad. Sci. USA 97, 13336–13341.
Plasma membrane Ca2+-ATPase isoform 2a is the PMCA of hair bundles
Dumont RA, Lins U, Filoteo AG, Penniston JT, Kachar B, Gillespie PG. (2001) J. Neurosci. 21, 5066–5078.
A chemical-genetic strategy demonstrates myosin-1c participates in adaptation by hair cells
Holt JR, Gillespie SK, Provance DW, Shah K, Shokat KM, Corey DP, Mercer JA, Gillespie PG. (2002) Cell 108, 371–381.
Cadherin 23 is a component of the tip link in hair cell stereocilia
Siemens J, Lillo C, Dumont RA, Reynolds A, Williams DS, Gillespie PG, Müller U. (2004) Nature 428, 950–955.
Hair cells require phosphatidylinositol 4,5-bisphosphate for mechanical transduction and adaptation
Hirono M, Denis CS, Richardson GP, Gillespie PG. (2004) Neuron 44, 309–320.
Fast adaptation in vestibular hair cells requires myosin-1c activity
Stauffer EA, Scarborough JD, Hirono M, Miller ED, Shah K, Mercer JA, Holt JR, Gillespie PG. (2005) Neuron 47, 541–553.
Molecular architecture of the chick vestibular hair bundle
Shin JB, Krey JF, Hassan A, Metlagel Z, Tauscher AN, Pagana JM, Sherman NE, Jeffery ED, Spinelli KJ, Zhao H, Wilmarth PA, Choi D, David LL, Auer M, Barr-Gillespie PG. (2013) Nature Neurosci. 16, 365–374.
PDZD7-MYO7A complex identified in enriched stereocilia membranes
Morgan CP, Krey JF, Grati M, Zhao B, Fallen S, Kannan-Sundhari A, Liu XZ, Choi D, Müller U, Barr-Gillespie PG. (2016) eLife 5, e18312.