Postdoctoral Researcher - IRC72538
- A PhD degree in neuroscience, cell/molecular biology, genetics or related field
- A strong interest in developmental neuroscience
- A demonstrated ability to work independently and learn new techniques quickly
- Candidates must be well organized, self-motivated and dependable
- Excellent communication skills with the ability to plan, document, analyze and report data
- Previous experience generating mouse knockouts, neuronal culture, analyzing –omics datasets, and expertise in microscopy are strongly preferred
Bioinformatics Specialist (Senior Research Assistant) - IRC54045
This is a joint position between the O’Roak and Adey labs that requires a skilled bioinformatician with experience processing and analyzing “next-generation” sequencing datasets. Individual will conduct primary and secondary analyzes that will likely require writing custom scripts/programs and running standard best practice computational pipelines. Initial projects will focus on: genome analysis, targeted resequencing, de novo assembly of viral genomes, and single cell genomics.
Experience with whole-exome or genome sequencing required. Familiarity with genome assembly, statistics, population and gene databases, in silico predictive algorithms, structural variation tools, genetics and genomics is strongly preferred. Experience with RNA-seq and epigenetics data analysis (e.g. ChIP-seq, ATAC-seq, etc..) is strongly preferred. Good communication skills are required.
OHSU is a highly collaborative environment. Researchers will have the opportunity to interact/collaborate with researchers from genetics, neurosciences, the new computational biology program, and clinical research programs focused on neurodevelopmental disorders.
Highlights of Dr. O’Roak’s past research successes include: pioneering trio-based exome sequencing in simplex autism, and developing new technologies for rapid and economical targeted resequencing. His diverse research group focuses on developing and implementing cutting-edge methods and technologies for discovery and replication, molecular diagnosis, functional dissection of pathways, and targeted therapeutics for neurodevelopmental and related disorders.
Highlights of Dr. Adey’s past research include the development and utilization of a number of next-generation sequencing technologies for genomic and epigenomic profiling, including the pioneering of transposase-based next-generation sequencing technologies. His group is focused heavily on single-cell assays and includes recent publications on novel technological advances that are being applied in collaboration with the O’Roak lab and others at OHSU.
- Bachelor's Degree with major courses in field of research and 1 to 3 years of experience in computer science or bioinformatics
- Experience with whole-exome or genome sequencing
- Fluent in one or more programing languages
- Good communication skills
- Able to work in a team and effectively communicate results to other members
- Master's degree in related field
- Intensive training in the areas of genetics/genomics, computer science, bioinformatics
- Familiarity with statistics, population and gene databases, in silico predictive algorithms, structural variation tools, genetics and genomics
- Experience with RNA-seq and ChIP-seq
- Linux cluster management and architecture