Open Positions

Postdoctoral Researcher - IRC72538

A Postdoctoral Fellow position is available immediately for individuals with a focus on applying
developmental neuroscience and genomic techniques to novel mouse models of key autism risk genes.
The individual in this position will work closely with the laboratories of Dr. Brian J. O’Roak in the
Department of Molecular and Medical Genetics and Dr. Kevin Wright in the Vollum Institute. OHSU is a
highly collaborative environment and fellows will have the opportunity to interact with a large and
vibrant neuroscience community and clinical research programs focused on autism and related
neurodevelopmental disorders.

Currently, there are four years of dedicated R01 funding for this project and mouse lines have already
been generated. Competitive salary support and benefits (including re-location expenses) are available.
Highlights of Dr. O’Roak’s past research successes include: pioneering trio-based exome sequencing
in simplex autism and developing new technologies for rapid and economical targeted resequencing.
The lab is building on this experience by forming a strong and diverse research group focused on
developing and implementing cutting-edge methods to understand the effect of new mutations on
transcriptional regulators that are key regulators of other autism risk genes.

Dr. Wright’s lab takes a multidisciplinary approach to identify the molecular networks that govern the
development of functional neural circuits. Specifically, they are utilizing cutting edge forward and
reverse genetic approaches in mice in conjunction with molecular, cell biological and biochemical
techniques to identify the specific molecules that govern neuronal migration, neurite outgrowth, and
synaptogenesis during neurodevelopment.

Required Qualifications
  • A PhD degree in neuroscience, cell/molecular biology, genetics or related field
  • A strong interest in developmental neuroscience
  • A demonstrated ability to work independently and learn new techniques quickly
  • Candidates must be well organized, self-motivated and dependable
  • Excellent communication skills with the ability to plan, document, analyze and report data
  • Previous experience generating mouse knockouts, neuronal culture, analyzing –omics datasets, and expertise in microscopy are strongly preferred

Interested candidates should email a cover letter, CV, and contact information for three references to: oroak@ohsu.edu or apply at ohsu.edu/jobs and refer to IRC72538

Candidates from diverse backgrounds are especially encouraged to enquire about potential funding
through the OHSU Fellowship for Diversity and Inclusion by contacting OFDIR@ohsu.edu.


Bioinformatics Specialist (Senior Research Assistant) - IRC54045

This is a joint position between the O’Roak and Adey labs that requires a skilled bioinformatician with experience processing and analyzing “next-generation” sequencing datasets. Individual will conduct primary and secondary analyzes that will likely require writing custom scripts/programs and running standard best practice computational pipelines. Initial projects will focus on: genome analysis, targeted resequencing, de novo assembly of viral genomes, and single cell genomics.

Experience with whole-exome or genome sequencing required. Familiarity with genome assembly, statistics, population and gene databases, in silico predictive algorithms, structural variation tools, genetics and genomics is strongly preferred. Experience with RNA-seq and epigenetics data analysis (e.g. ChIP-seq, ATAC-seq, etc..) is strongly preferred. Good communication skills are required.

OHSU is a highly collaborative environment. Researchers will have the opportunity to interact/collaborate with researchers from genetics, neurosciences, the new computational biology program, and clinical research programs focused on neurodevelopmental disorders.

Highlights of Dr. O’Roak’s past research successes include: pioneering trio-based exome sequencing in simplex autism, and developing new technologies for rapid and economical targeted resequencing. His diverse research group focuses on developing and implementing cutting-edge methods and technologies for discovery and replication, molecular diagnosis, functional dissection of pathways, and targeted therapeutics for neurodevelopmental and related disorders.

Highlights of Dr. Adey’s past research include the development and utilization of a number of next-generation sequencing technologies for genomic and epigenomic profiling, including the pioneering of transposase-based next-generation sequencing technologies. His group is focused heavily on single-cell assays and includes recent publications on novel technological advances that are being applied in collaboration with the O’Roak lab and others at OHSU.

Required Qualifications

  • Bachelor's Degree with major courses in field of research and 1 to 3 years of experience in computer science or bioinformatics
  • Experience with whole-exome or genome sequencing
  • Fluent in one or more programing languages
  • Good communication skills
  • Able to work in a team and effectively communicate results to other members

Preferred Qualifications

  • Master's degree in related field
  • Intensive training in the areas of genetics/genomics, computer science, bioinformatics
  • Familiarity with statistics, population and gene databases, in silico predictive algorithms, structural variation tools, genetics and genomics
  • Experience with RNA-seq and ChIP-seq
  • Linux cluster management and architecture

Apply online here and reference job number IRC54045. Please attach CV/Resume, cover letter and list of 3 references.