Our research focuses on the role of humoral immunity in cellular senescence and de-novo carcinogenesis, with the ultimate goal of developing effective cancer vaccines. Extensive research and clinical efforts to develop cancer vaccination strategies have so far shown limited results, with efficacy in the single digits. This picture contrasts starkly with the high effectiveness of vaccination against pathogens, one of the biggest successes of modern medicine. Several factors can explain this difference, including the absence of pathogen associated molecular patterns and the ability of tumors to promote peripheral tolerance. Notwithstanding its important function for vaccine effectiveness against infectious diseases, the role of humoral immunity is a less appreciated facet, whose contribution in cancer is still debated. By coupling precise genetic engineering strategies, transgenic mouse models and imaging modalities, we aim to fill this gap.
Graciously funded by:
- Medical Research Foundation
- Collins Medical Trust
- V Foundation Scholar
- OHSU-CRUK early detection award
Our lab is growing
Pucci lab is now hiring all positions. If our work interests you, please get in touch by email.