Selected publications

Homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epithelium. 
Van Winkle JA, Wheadon MJ, Ingle H, Desai C, Constant DA, Wright AP, Li L, Artyomov M, Lee S, Baldridge MT*, Nice TJ*.
Elife. 2022 Feb 9;11:e74072.

Transcriptional and Cytotoxic Responses of Human Intestinal Organoids to Interferon Types I, II, and III.
Constant DA, Van Winkle JA, VanderHoek E, Dekker SE, Sofia MA, Regner E, Modiano N, Tsikitis VL, Nice TJ*. 
 Immunohorizons. 2022 Jul 5;6(7):416-429. 

Selective interferon responses of intestinal epithelial cells minimize TNFα cytotoxicity. 
Van Winkle JA, Constant DA, Li L, Nice TJ*. 
Journal of Virology. 2020 Aug 26;JVI.00603-20.

Caspase-mediated cleavage of murine norovirus NS1/2 potentiates apoptosis and is required for persistent infection of intestinal epithelial cells. 
Robinson BA, Van Winkle JA, Peters AM, McCune BT, Nice TJ*. 
PLoS Pathogens. 2019 Jul 22;15(7):e1007940.

Persistence of Systemic Murine Norovirus Is Maintained by Inflammatory Recruitment of Susceptible Myeloid Cells.
Van Winkle JA, Robinson BA, Peters AM, Li L, Nouboussi RV, Mack M, Nice TJ*. 
Cell Host Microbe. 2018 Nov 14;24(5):665-676.e4. 

Expression of Ifnlr1 on Intestinal Epithelial Cells Is Critical to the Antiviral Effects of Interferon Lambda against Norovirus and Reovirus.
Baldridge MT, Lee S, Brown JJ, McAllister N, Urbanek K, Dermody TS, Nice TJ*, Virgin HW*.
Journal of Virology. 2017 Mar 13;91(7):e02079-16.

Type I Interferon Receptor Deficiency in Dendritic Cells Facilitates Systemic Murine Norovirus Persistence Despite Enhanced Adaptive Immunity.
Nice TJ*, Osborne LC, Tomov VT, Artis D, Wherry EJ, Virgin HW*. 
PLoS Pathogens. 2016 Jun 21;12(6):e1005684. 

Interferon-λ cures persistent murine norovirus infection in the absence of adaptive immunity. 
Nice TJ, Baldridge MT, McCune BT, Norman JM, Lazear HM, Artyomov M, Diamond MS, Virgin HW*. 
Science. 2015 Jan 16;347(6219):269-73. 

Commensal microbes and interferon-λ determine persistence of enteric murine norovirus infection.
Baldridge MT, Nice TJ, McCune BT, Yokoyama CC, Kambal A, Wheadon M, Diamond MS, Ivanova Y, Artyomov M, Virgin HW*.
Science. 2015 Jan 16;347(6219):266-9.

A single-amino-acid change in murine norovirus NS1/2 is sufficient for colonic tropism and persistence. 
Nice TJ, Strong DW, McCune BT, Pohl CS, Virgin HW*. 
Journal of Virology. 2013 Jan;87(1):327-34. 

* denotes corresponding authorship