Selected publications

Reversible suppression of T cell function in the bone marrow microenvironment of acute myeloid leukemia.
Lamble AJ, Kosaka Y, Laderas T, Maffit A, Kaempf A, Brady LK, Wang W, Long N, Saultz JN, Mori M, Soong D, LeFave CV, Huang F, Adams H 3rd, Loriaux MM, Tognon CE, Lo P, Tyner JW, Fan G, McWeeney SK, Druker BJ, Lind EF.
Proc Natl Acad Sci U S A. 2020 Jun 23;117(25):14331-14341. doi: 10.1073/pnas.1916206117. Epub 2020 Jun 8.

PMID: 32513686

Immunomodulatory effects of pevonedistat, a NEDD8-activating enzyme inhibitor, in chronic lymphocytic leukemia-derived T cells.
Best S, Lam V, Liu T, Bruss N, Kittai A, Danilova OV, Murray S, Berger A, Pennock ND, Lind EF, Danilov AV.
Leukemia. 2020 Mar 16. doi: 10.1038/s41375-020-0794-0. Online ahead of print.

PMID: 32203139

Acute myeloid leukemia-induced T-cell suppression can be reversed by inhibition of the MAPK pathway.
Moshofsky KB, Cho HJ, Wu G, Romine KA, Newman MT, Kosaka Y, McWeeney SK, Lind EF.
Blood Adv. 2019 Oct 22;3(20):3038-3051. doi: 10.1182/bloodadvances.2019000574.
PMID: 31648326

CSF1R inhibitors exhibit antitumor activity in acute myeloid leukemia by blocking paracrine signals from support cells.
Edwards DK 5th, Watanabe-Smith K, Rofelty A, Damnernsawad A, Laderas T, Lamble A, Lind EF, Kaempf A, Mori M, Rosenberg M, d'Almeida A, Long N, Agarwal A, Sweeney DT, Loriaux M, McWeeney SK, Tyner JW.
Blood. 2019 Feb 7;133(6):588-599. doi: 10.1182/blood-2018-03-838946. Epub 2018 Nov 13.
PMID: 30425048

Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms.
Zhang H, Savage S, Schultz AR, Bottomly D, White L, Segerdell E, Wilmot B, McWeeney SK, Eide CA, Nechiporuk T, Carlos A, Henson R, Lin C, Searles R, Ho H, Lam YL, Sweat R, Follit C, Jain V, Lind E, Borthakur G, Garcia-Manero G, Ravandi F, Kantarjian HM, Cortes J, Collins R, Buelow DR, Baker SD, Druker BJ, Tyner JW.
Nat Commun. 2019 Jan 16;10(1):244. doi: 10.1038/s41467-018-08263-x.
PMID: 30651561 

Timed Regulation of 3BP2 Induction Is Critical for Sustaining CD8+ T Cell Expansion and Differentiation.
Dimitriou ID, Lee K, Akpan I, Lind EF, Barr VA, Ohashi PS, Samelson LE, Rottapel R.
Cell Rep. 2018 Jul 31;24(5):1123-1135. doi: 10.1016/j.celrep.2018.06.075.
PMID: 30067970

Targeting the Immune Microenvironment in Acute Myeloid Leukemia: A Focus on T Cell Immunity.
Lamble AJ, Lind EF.
Front Oncol. 2018 Jun 13;8:213. doi: 10.3389/fonc.2018.00213. eCollection 2018. Review.
PMID: 29951373 

Integrated functional and mass spectrometry-based flow cytometric phenotyping to describe the immune microenvironment in acute myeloid leukemia.
Lamble AJ, Dietz M, Laderas T, McWeeney S, Lind EF. J Immunol Methods. 2017 Nov 23. pii: S0022-1759(17)30496-9. doi: 10.1016/j.jim.2017.11.010. [Epub ahead of print.] 
PMID: 29175391 

Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.
Inoue S, Li WY, Tseng A, Beerman I, Elia AJ, Bendall SC, Lemonnier F, Kron KJ, Cescon DW, Hao Z, Lind EF, Takayama N, Planello AC, Shen SY, Shih AH, Larsen DM, Li Q, Snow BE, Wakeham A, Haight J, Gorrini C, Bassi C, Thu KL, Murakami K, Elford AR, Ueda T, Straley K, Yen KE, Melino G, Cimmino L, Aifantis I, Levine RL, De Carvalho DD, Lupien M, Rossi DJ, Nolan GP, Cairns RA, Mak TW.
Cancer Cell. 2016 Aug 8;30(2):337-348. doi: 10.1016/j.ccell.2016.05.018. Epub 2016 Jul 14.
PMID: 27424808

Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio.
Itsumi M, Inoue S, Elia AJ, Murakami K, Sasaki M, Lind EF, Brenner D, Harris IS, Chio II, Afzal S, Cairns RA, Cescon DW, Elford AR, Ye J, Lang PA, Li WY, Wakeham A, Duncan GS, Haight J, You-Ten A, Snow B, Yamamoto K, Ohashi PS, Mak TW.
Cell Death Differ. 2015 Nov;22(11):1837-45. doi: 10.1038/cdd.2015.38. Epub 2015 Apr 17.
PMID: 25882048 

miR-155 Upregulation in Dendritic Cells Is Sufficient To Break Tolerance In Vivo by Negatively Regulating SHIP1.
Lind EF, Millar DG, Dissanayake D, Savage JC, Grimshaw NK, Kerr WG, Ohashi PS.
J Immunol. 2015 Nov 15;195(10):4632-40. doi: 10.4049/jimmunol.1302941. Epub 2015 Oct 7.
PMID: 26447227 

Mir-155, a central modulator of T-cell responses.
Lind EF, Ohashi PS. Eur J Immunol. 2014 Jan;44(1):11-5. Review. 
PMID: 24571026

The interaction between caveolin-1 and Rho-GTPases promotes metastasis by controlling the expression of alpha5-integrin and the activation of Src, Ras and Erk.
Arpaia E, Blaser H, Quintela-Fandino M, Duncan G, Leong HS, Ablack A, Nambiar SC, Lind EF, Silvester J, Fleming CK, Rufini A, Tusche MW, Brüstle A, Ohashi PS, Lewis JD, Mak TW.
Oncogene. 2012 Feb 16;31(7):884-96. doi: 10.1038/onc.2011.288. Epub 2011 Jul 18.
PMID: 21765460

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics.
Sasaki M, Knobbe CB, Munger JC, Lind EF, Brenner D, Brüstle A, Harris IS, Holmes R, Wakeham A, Haight J, You-Ten A, Li WY, Schalm S, Su SM, Virtanen C, Reifenberger G, Ohashi PS, Barber DL, Figueroa ME, Melnick A, Zúñiga-Pflücker JC, Mak TW. Nature. 2012 Aug 30;488(7413):656-9. doi: 10.1038/nature11323.

Micro-RNA 155 is required for optimal CD8+ T cell responses to acute viral and intracellular bacterial challenges.
Lind EF, Elford AR, Ohashi PS. J Immunol. 2013 Feb 1;190(3):1210-6. doi: 10.4049/jimmunol.1202700. Epub 2012 Dec 28.

Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo.
Kamizono S, Duncan GS, Seidel MG, Morimoto A, Hamada K, Grosveld G, Akashi K, Lind EF, Haight JP, Ohashi PS, Look AT, Mak TW.
J Exp Med. 2009 Dec 21;206(13):2977-86. doi: 10.1084/jem.20092176. Epub 2009 Dec 7.
PMID: 19995955 

Dendritic cells require the NF-kappaB2 pathway for cross-presentation of soluble antigens.
Lind EF, Ahonen CL, Wasiuk A, Kosaka Y, Becher B, Bennett KA, Noelle RJ. J Immunol. 2008 Jul 1;181(1):354-63.

Mast cells are essential intermediaries in regulatory T-cell tolerance.
Lu LF, Lind EF, Gondek DC, Bennett KA, Gleeson MW, Pino-Lagos K, Scott ZA, Coyle AJ, Reed JL, Van Snick J, Strom TB, Zheng XX, Noelle RJ.
Nature. 2006 Aug 31;442(7106):997-1002. Epub 2006 Aug 20.
PMID: 16921386

Runx1 expression marks long-term repopulating hematopoietic stem cells in the midgestation mouse embryo.
North TE, de Bruijn MF, Stacy T, Talebian L, Lind E, Robin C, Binder M, Dzierzak E, Speck NA.
Immunity. 2002 May;16(5):661-72.
PMID: 12049718

The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cells.
Ahonen C, Manning E, Erickson LD, O'Connor B, Lind EF, Pullen SS, Kehry MR, Noelle RJ.
Nat Immunol. 2002 May;3(5):451-6. Epub 2002 Apr 22.
PMID: 11967542 

Mapping precursor movement through the postnatal thymus reveals specific microenvironments supporting defined stages of early lymphoid development.
Lind EF, Prockop SE, Porritt HE, Petrie HT. J Exp Med. 2001 Jul 16;194(2):127-34.