Publications

Click here for a complete list of publications in PubMed.

G-Protein-Coupled Receptor SRBC-48 Protects against Dendrite Degeneration and Reduced Longevity Due to Infection.
Kaur S, Aballay A. Cell Rep. 2020 May 19;31(7):107662. doi: 10.1016/j.celrep.2020.107662.

Cholesterol Regulates Innate Immunity via Nuclear Hormone Receptor NHR-8.
Otarigho B, Aballay A. iScience. 2020 May 22;23(5):101068. doi: 10.1016/j.isci.2020.101068. Epub 2020 Apr 18.

Host Mucin Is Exploited by Pseudomonas aeruginosa To Provide Monosaccharides Required for a Successful Infection.
Hoffman CL, Lalsiamthara J, Aballay A. 
mBio. 2020 Mar 3;11(2):e00060-20. doi: 10.1128/mBio.00060-20.

Intestinal infection regulates behavior and learning via neuroendocrine signaling. 
Singh, J. and Aballay, A. (2019). eLife. Nov 1;8. pii: e50033.  Review

Non-proteolytic activity of 19S proteasome subunit RPT-6 regulates GATA transcription during response to infection.
Olaitan, A.O. and Aballay, A. (2018). PLOS Genetics. Sep 28;14(9):e1007693. doi: 10.1371/journal.pgen.1007693.

Distinct Roles of Sensory Neurons in Mediating Pathogen Avoidance and Neuropeptide-Dependent Immune Regulation.
Cao X, Kajino-Sakamoto R, Doss A, Aballay A. Cell Rep. 2017 Nov 7;21(6):1442-1451. doi: 10.1016/j.celrep.2017.10.050. PMID: 29117551

Endoplasmic Reticulum Stress Caused by Lipoprotein Accumulation Suppresses Immunity against Bacterial Pathogens and Contributes to Immunosenescence.
Singh J, Aballay A. MBio. 2017 May 30;8(3). pii: e00778-17. doi: 10.1128/mBio.00778-17. PMID: 28559483 

Natural Genetic Variation in the Caenorhabditis elegans Response to Pseudomonas aeruginosa.
Martin N, Singh J, Aballay A. G3 (Bethesda). 2017 Apr 3;7(4):1137-1147. doi: 10.1534/g3.117.039057. PMID: 28179390 

Neural Inhibition of Dopaminergic Signaling Enhances Immunity in a Cell-Non-autonomous Manner.
Cao, X. and Aballay, A. (2016). Curr Biol. Aug 9. pii: S0960-9822(16)30675-3. doi: 10.1016/j.cub.2016.06.036. [Epub ahead of print] 

Genetic screen reveals link between the maternal-effect sterile gene mes-1 and P. aeruginosa-induced neurodegeneration in C. elegans.
Wu, Q., Cao, X., Yan, D., Wang, D., and Aballay, A. (2015). J Biol Chem. Oct 16. pii: jbc.M115.674259 

Recovery from an acute infection in C. elegans requires the GATA transcription factor ELT-2.
Head, B. and Aballay, A. (2014). PLOS Genetics, Oct 23. doi:10.1371/journal.pgen.1004609.

Whole-animal chemical screen identifies colistin as a new immunomodulator that targets conserved pathways.
Cai, Y., Cao, X., Aballay A. (2014). mBio, Aug 12;5(4). pii: e01235-14. doi: 10.1128/mBio.01235-14.

Organismal regulation of XBP-1-mediated unfolded protein response during development and immune activation.
Sun J., Liu Y, Aballay A. (2012). EMBO Rep, Aug 31;13(9):855-60. Epub 2012 Jul 13. Review

ER stress pathway required for immune homeostasis is neurally controlled by arrestin-1.
Singh, V. and Aballay, A. (2012). J Biol Chem, Epub ahead of print Aug 8. 

Neuronal GPCR controls innate immunity by regulating non-canonical unfolded protein response genes.
Sun, J., Singh, V., Kajino-Sakamoto, R., and Aballay, A. (2011). Science, Epub 2011 April 7. Review.

A conserved PMK-1/p38 MAPK is required in Caenorhabditis elegans tissue-specific immune response to Yersinia pestis infection.
Bolz, D.D., Tenor, J.L., and Aballay, A. (2010). J Biol Chem, 285:10832-10840. 

Nucleolar proteins suppress C. elegans innate immunity by inhibiting p53/CEP-1.
Fuhrman, L.E., Kumar Goel, A., Smith, J., Shianna, K.V., Aballay, A. (2009). PLoS Genetics, 5: e1000657. doi:10.1371/journal.pgen.1000657.  

Innate immunity in Caenorhabditis elegans is regulated by neurons expressing NPR-1/GPCR.
Styer, K.L., Singh, V., Macosko, E., Steele, S.E., Bargmann, C.I., and Aballay, A. (2008). Science, 17:460-464. 
PodcastReview. 

Unfolded protein response genes regulated by CED-1 are required for Caenorhabditis elegans innate immunity.
Haskins, K.A., Russell, J.F., Gaddis, N., Dressman, H.K., and Aballay, A. (2008). Dev Cell, 15:87-97. Review.

A conserved Toll-like receptor is required for Caenorhabditis elegans innate immunity.
Tenor, J.L., and Aballay, A. (2008). EMBO Reports, 9:103-109. 

High-throughput isolation and mapping of C. elegans mutants susceptible to pathogen infection.
Fuhrman, L.E., Shianna, K.V., Aballay, A. (2008). PLoS One, 6:e2882.

Study of the role of CCR5 in a mouse model of intranasal challenge with Y. pestis.
Styer, K.L., Click, E.M., Hopkins, G.W., Frothingham, R., and Aballay, A. (2007). Microbes and Infection, 9:1135-1138.

A heat-shock factor HSF-1 response pathway is important for Caenorhabditis elegans immunity against Pseudomonas aeruginosa.
Singh, V. and Aballay, A. (2006). Proc Natl Acad Sci USA, 103:13092-13097. 

The Caenorhabditis elegans ABL-1 tyrosine kinase is required for Shigella flexneri pathogenesis.
Burton, E.A., Pendergast, A.M., and Aballay, A. (2006). Appl Environ Microbiol, 72:5043-51. 

GATA transcription factor required for immunity to bacterial and fungal pathogens.
Kerry, S., TeKippe, M., Gaddis, N.C., and Aballay, A. (2006). Plos ONE, 1:e77. 

Yersinia pestis kills Caenorhabditis elegans by a biofilm-independent process that involves novel virulence factors.
Styer, K.L., Hopkins, G.W., Plano, G.V., Frothingham, R., and Aballay, A. (2005). EMBO Reports, 6:992-997.  

Caenorhabditis elegans-based screen identifies Salmonella virulence factors required for conserved host-pathogen interactions.
Tenor, J.L., McCormick, B.A., Ausubel, F.M., Aballay, A. (2004). Curr Biol, 14:1018-1024. 

Caenorhabditis elegans innate immune response triggered by Salmonella enterica requires intact LPS and is mediated by a MAPK signaling pathway.
Aballay, A., Drenkard, E., Hilbun, L.R., Ausubel, F.M. (2003). Curr Biol, 13:47-52. 

Programmed cell death mediated by ced-3 and ced-4 protects Caenorhabditis elegans from Salmonella typhimurium-mediated killing.
Aballay, A. and Ausubel, F.M. (2001). Proc Natl Acad Sci USA, 98:2735-2739. 

Salmonella typhimurium proliferates and establishes a persistent infection in the intestine of Caenorhabditis elegans.
Aballay, A., Yorgey, P., Ausubel, M.A. (2000). Curr Biol, 30:1539-1542. 

Intracellular transport of Brucella abortus in J774 macrophages.
Arenas, N.A., Staskevich, A.S., Aballay, A., and Mayorga, L.S. (2000). Infect Immun, 68:4255-4263.