Published: The GnRH antagonist degarelix suppresses gonadotropin secretion and pituitary sensitivity in midgestation sheep fetuses

Our collaborators' new paper about sexual differentiation in the brain

What is it about?

Masculinization of the fetal brain depends on testosterone produced by the fetal testis. In turn, production of testosterone by the fetal testis is under the control of other hormones. GnRH is a very important hormone in the regulation of reproductive function in adults, but how early it becomes critical for testicular production of testosterone has been unknown.

Why is it important?

How the brain develops in the fetus has long-lasting consequences for life.

Find this paper in Endocrinology and in Pubmed.