BENFRA Publications

Previous publications by BENFRA scientists

Zweig, J.A., Brandes, M.S., Brumbach, B.H., Caruso, M., Wright, K.M., Quinn, J.F., Soumyanath, A., Gray, N.E., Loss of NRF2 accelerates cognitive decline, exacerbates mitochondrial dysfunction and is required for the cognitive enhancing effects of Centella asiatica during aging., Neurobiology of Aging (2021), DOI

Matthews DG, Caruso M, Alcazar Magana A, Wright KM, Maier CS, Stevens JF, Gray NE, Quinn JF, Soumyanath A. Caffeoylquinic Acids in Centella asiatica Reverse Cognitive Deficits in Male 5XFAD Alzheimer’s Disease Model Mice. Nutrients. 2020; 12(11):3488. DOI

Wright KM, Alcazar Magaña A, Laethem RM, et al. Centella asiatica water extract shows low potential for CYP-mediated drug interactions. Drug Metab Dispos. June 24, 2020, dmd.120.090860; DOI

Alcazar Magana A, Wright K, Vaswani A, et al. Integration of mass spectral fingerprinting analysis with precursor ion (MS1) quantification for the characterisation of botanical extracts: application to extracts of Centella asiatica (L.) Urban. Phytochem Anal. 2020 Apr 12. doi: 10.1002/pca.2936.

Matthews DG, Caruso M, Murchison CF, et al. Centella Asiatica improves memory and promotes antioxidative signaling in 5XFAD mice. Antioxidants (Basel). 2019;8(12):630. doi: 10.3390/antiox812063.

Gray NE, Zweig JA, Caruso M, et al. Centella asiatica increases hippocampal synaptic density and improves memory and executive function in aged mice. Brain Behav. 2018;8(7):e01024.

Gray NE, Zweig JA, Caruso M, et al. Centella asiatica attenuates hippocampal mitochondrial dysfunction and improves memory and executive function in beta-amyloid overexpressing mice. Mol Cell Neurosci. 2018;93:1-9.

Gray NE, Zweig JA, Matthews DG, Caruso M, Quinn JF, Soumyanath A. Centella asiatica Attenuates Mitochondrial Dysfunction and Oxidative Stress in Abeta-Exposed Hippocampal Neurons. Oxid Med Cell Longev. 2017;2017:7023091.

Gray NE, Zweig JA, Murchison C, et al. Centella asiatica attenuates Abeta-induced neurodegenerative spine loss and dendritic simplification. Neurosci Lett. 2017;646:24-29.

Gray NE, Harris CJ, Quinn JF, Soumyanath A. Centella asiatica modulates antioxidant and mitochondrial pathways and improves cognitive function in mice. J Ethnopharmacol. 2016;180:78-86.

Gray NE, Sampath H, Zweig JA, Quinn JF, Soumyanath A. Centella asiatica Attenuates Amyloid-beta-Induced Oxidative Stress and Mitochondrial Dysfunction. J Alzheimers Dis. 2015;45:933-946.

Gray NE, Morré J, Kelley J, et al. Caffeoylquinic acids in centella asiatica protect against amyloid-ß toxicity. Journal of Alzheimer's Disease. 2014;40(2):359-373.

Soumyanath A, Zhong YP, Henson E, et al. Centella asiatica extract improves behavioral deficits in a mouse model of Alzheimer's disease: Investigation of a possible mechanism of action. International Journal of Alzheimer's Disease. 2012.

Soumyanath A, Zhong, Y.P., Gold, S.A., Yu, X., Koop, D.R., Bourdette, D. & Gold, B.G.,. Centella asiatica accelerates nerve regeneration upon oral administration and contains multiple active fractions increasing neurite elongation in vitro. Journal of Pharmacy & Pharmacology. 2005;57(9):1221-1229.

BENFRA publications

Alcázar Magaña A, Kamimura N, Soumyanath A, Stevens JF, Maier CS. Caffeoylquinic acids: chemistry, biosynthesis, occurrence, analytical challenges, and bioactivity. Plant J. 2021;107(5):1299-1319. doi:10.1111/tpj.15390