A basic science department examining cell-intrinsic and cell-extrinsic regulation of cell, developmental and cancer biology. Read about us
CDCB in the news
Congratulations to the following CDCB/OCSSB collaborative pilot grant award recipients:
Kim Beatty, Ph.D., Rosie Sears, Ph.D., for Elucidating metabolic heterogeneity in breast cancer cell lines using fluorescent probes.
Danielle Jorgens, M.S., Ph.D., Kim Beatty, Ph.D., Caroline Enns, Ph.D., Joe Gray, Ph.D., for Spatial localization of transferrin receptor 2 in the liver.
Anke Mulder, Ph.D., Caroline Enns, Ph.D., Joe Gray, Ph.D., for Structural changes associated with transferrin receptor 2 signaling.
Jeff Tyner, Ph.D., Adam Margolin, Ph.D., Evan Lind, Ph.D., Tania Vu, Ph.D., for Predicting effective combinations of tumor intrinsic and immune modulating therapies in AML with enabling single cell miniaturized assays and integrative functional genomic algorithms.
Xiaolin Nan, Ph.D., Lisa Coussens, Ph.D., for Multi-plexed, in situ transcriptome analysis of tumor-associated macrophages in breast cancer with multispectral superresolution microscopy (MSSRM).
Alex Nechiporuk, Ph.D., Danielle Jorgens, M.S., Ph.D., Joe Gray, Ph.D., for Fishing for identity of axonal swellings with cryo-em.
Melissa Wong, Ph.D., Sara Courtneidge, Ph.D., Joe Gray, Ph.D, Danielle Jorgens, M.S., Ph.D., Anke Mulder, Ph.D., for Macrophage-epithelial interactions in mediating active cycling and quiscent intenstinal stem cells.
Congratulations to the following recipients of the NIH Pathway to Independence Award (K99/R00):
Katie Drerup, Ph.D., Postdoctoral Fellow, received from the National Institute of Neurological Disorders and Stroke (NINDS) for her project, Identifying Modulators of Dynein-Based Cargo Motility.
Brian Ruffell, Ph.D., Research Assistant Professor, received from the National Cancer Institute (NCI) for his project, Regulating Intratumoral Leukocytes to Improve Response to Chemotherapy.
Ningning Zhao, Ph.D., Senior Research Associate, received from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) for his project, Mechanisms of iron-dependent regulation of ZIP-14.
Dr. Caroline Enns was elected to the American Association for the Advancement of Science (AAAS) this year for outstanding fundamental research discoveries on the biochemical, cell biological, and physiological mechanisms underlying iron homeostasis and its regulation. Read more
OHSU cancer researcher aims to make cancer a manageable disease
About one in three Americans will be diagnosed with cancer in their lifetimes, and close to 600,000 will die as a result this year. Lisa Coussens hopes to dramatically reduce that number, making cancer a manageable disease instead of a deadly one. While traditional cancer research focuses on the malignant cells themselves, Coussens, a professor at the Knight Cancer Institute at the Oregon Health and Science University, is part of a new wave of biologists investigating the surrounding microenvironment. Read more
OHSU researching new breast cancer drug
Women with the most aggressive form of breast cancer are getting some new hope from research done right here in Portland. Women with triple negative breast cancer don't usually respond to the most traditional therapies. The prognosis is also another five to eight years to live, but this new research is aiming at extending that. Read more