Phone: 503 418-9300
Fax: 503 418-9311
Center for Health and Healing
Mail code: CH13B
3303 SW Bond Avenue, Rm #13000
Portland, OR 97239
Bachelor's Degree - University of Pennsylvania
Master's Degree - Stanford University
Doctorate - University of Washington
Thrombosis and vascular healing responses are being evaluated in animal models to identify key hemostatic mechanisms, blood component interactions with natural and synthetic surfaces and the effects of blood-flow phenomena. Our ultimate goals are to develop more effective antithrombotic and antiarteriosclerotic drug therapies, and to improve the performance of prosthetic cardiovascular devices.
- Tucker EI, Marzec UM, Hurst S, McCarty JT, Rugonyi S, Gailani D, Gruber A, Hanson SR: Prevention of vascular graft occlusion and thrombus surface-associated thrombin generation by inhibition of factor XI. Blood 113:936-955, 2009
- Hinds MT, Ma MH, Ensley AE, Kladakis SM, Vartanian K, Nerem RM, and Hanson SR: Potential of baboon endothelial progenitor cells for tissue engineered vascular grafts. J Biomed Mater Res A 86:804:812, 2008
- Gruber A, Marzec U, Bush L, Di Cera E, Fernandez JA, Berney E, Tucker E, McCarty OJ, Griffin JH, Hanson SR: Relative Antithrombotic and antihemostatic effects of protein C activator versus low-molecular-weight heparin in primates Blood 109(9):3733-3740, 2007
- Gruber A, Fernandez JA, Bush I, Marzec UM, Griffin JH, Hanson SR, Di Cera E: Limited generation of activated protein C during fusion of the protein C activator thrombin analog W215A/E217A in primates. J Thromb Harmost 4:392-397, 2006
- Gruber AG, Hanson SR: Factor XI-dependent of surface- and tissue factor-initiated thrombus propagation in vivo. Blood 102:953-955, 2003.