Featured Technology
David Kabat, PhD
Antiviral Drug Discovery for AIDS: The HIV-1 Vif Protein
Virion infectivity factor (Vif) is a regulatory protein produced by lentiviruses. Targeting the human DNA-editing enzyme, APOBEC3G, a host defense factor that inhibits viral replication, Vif binds to APOBEC3G and prevents it from functioning properly in host defense. Therefore, inhibition of Vif-mediated degradation of APOBEC3G is a new avenue for anti-HIV drug development.
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Industry Collaboration Opportunities
Eli Lilly PD2 Initiative
Eli Lilly has created the Phenotypic Drug Discovery (PD2) Initiative as one mechanism to collaborate with academic institutes. The initiative provides a means for screening potentially therapeutic compounds developed at academic research centers in Lilly's proprietary assay system. Lilly will screen compounds in a set of assay modules that include a primary phenotypic screening and secondary biochemical and cellular assays in the following areas:
- Alzheimer's Disease (ApoE secretion)
- Cancer (anti-angiogenesis)
- Cancer (cell cycle G2/M arrest)
- Bone Formation (Wnt pathway)
- Diabetes (insulin secretion)


