“I have been overwhelmed by the amount of support from the nurses, fellows, faculty, and Division as a whole in my pursuits outside of the NICU. Everyone has been more than supportive in my goals of getting my MPH during fellowship as well as pursuing my research in international neonatology." -Jamie B. Warren, MD
A large part of our fellowship mission at Oregon Health and Science University is to train fellows in the proper conduct of research, helping fellows lay the foundation for academic careers in neonatology. Fellows are encouraged to choose a research mentor and project in the first three months of fellowship, and faculty with complementary interests are chosen for the Scholarship Oversight Committee (SOC) for each fellow. Mentors can be chosen from within Division of Neonatology or from established research laboratories at the Oregon Health and Sciences University as well as the Oregon National Primate Research Center http://www.ohsu.edu/xd/research/centers-institutes/onprc/, and fellows choose from a broad array of basic science, clinical, and health outcomes research options. Our nursery also participates in the Vermont Oxford Network database, measuring comparative clinical outcomes internationally and collecting data on all neonates.
As part of their career development, many fellows choose to pursue a Masters Degree during fellowship, and fellows have obtained Masters of Public Health and Clinical Research in the past. Many are available through the Oregon Health and Science University or online.
Fellows are encouraged and supported to present their work locally and nationally, participating in Fellow Research Night at Doernbecher Children’s, the Western SPR, and at national meetings (PAS/SPR and ATS).
As one of the eight National Primate Research Centers in the United States, our mandate as a Center is to provide Nonhuman Primate (NHP) resources for the very best scientific programs, both within the Oregon Health & Science University community and beyond.
Dr. McEvoy is a physician scientist with a long-term research goal to advance the understanding and treatment of the fetal origins of neonatal and infant lung disease. She is accomplishing this goal by conducting clinical and translational projects that incorporate the use of newborn and infant pulmonary function tests (PFTs). She has conducted a number of randomized clinical trials examining the impact of different regimes of antenatal and postnatal steroids on newborn pulmonary function and bronchopulmonary dysplasia (BPD). She recently completed a randomized trial demonstrating that daily supplemental vitamin C given to pregnant smokers improved their newborn’s PFTs and decreased the incidence of wheezing through one year of age. This improvement was influenced by nicotine receptor polymorphisms. With her current R01 funding ( www.vcsip.org ), she is collaborating with Indiana University to measure forced expiratory flows in infants born to pregnant smokers randomized to vitamin C versus placebo and with the Oregon National Primate Research Center to investigate the mechanism of
action of vitamin C in the face of in-utero smoke exposure. Dr. McEvoy is also interested in the impact of late preterm delivery, extended duration of continuous positive airway pressure, and the impact of maternal obesity on infant respiratory disease and PFTs. She is collaborating with Dr. Kelvin MacDonald to investigate the effect of maternal diet and obesity on PFTs in a murine model and working with Dr. Peta Grigsby in a primate model of antenatal Ureaplasma colonization. These projects reach across many campuses in the Pacific Northwest including the Oregon National Primate Research Center, the Kaiser Research Center, and Obstetric clinics in both Portland, Oregon and Vancouver, Washington. Dr. McEvoy is also a member of an International Collaborative Study Group conducting an individual patient data (IPD) meta-analysis on repeat dosing of antenatal steroids and recently served on a NIH task force on the primary prevention of BPD.
Mike Powers Lab
The Powers' lab uses a mouse model of retinopathy of prematurity (ROP) to investigate the balance between angiogenic cytokines and pro-apoptotic factors in retinal neovascularization.
Dr. JoDee Anderson is an Associate Professor and the Medical Director of the Neonatal Intensive Care Unit at Oregon Health & Science University. She completed her pediatric residency and neonatal-perinatal fellowship at Stanford University where she focused on the development of simulation-based curricula in neonatal resuscitation, pediatric advanced life support, ECMO crisis management, and crisis resource management behaviors. She obtained a masters degree in education through University of Cincinnati as she worked to validate expert modeling as a strategy to improve skill acquisition in simulation. JoDee serves as the Director of Pediatric Simulation Education at OHSU. She serves as Chair of the Education Committee for the Society for Simulation in Healthcare; she was a member of the Board of Directors for the Oregon Simulation Alliance, and she was an investigator in the EXPRESS trial. She has more than 16 years of experience in simulation and has developed interprofessional simulation curricula to improve the performance of interprofessional teams in high-risk environments.
In 2011, JoDee was appointed as the Medical Director for The S.T.A.B.L.E Simulation Program, an internationally-renowned resuscitation-training program in neonatal care. She was also instrumental in the development of the Simulation Instructor DVD for The AAP Neonatal Resuscitation Program. Together with colleagues she developed and validated the Behavioral Assessment Tool (BAT) for simulation, a widely used and accepted instrument in simulation education and research. JoDee has directly mentored 4 neonatology fellows in educational research. Under her mentorship, her fellows have presented 26 abstracts at National meetings and published 15 peer-reviewed manuscripts and 8 case reports. She is currently involved in the development of tele-simulation curricula for distance resuscitation training. She is a member of the INSPIRE network and actively engaged in several research projects within the network. She loves working with fellows and strives to support the individual needs and interests of each mentee.
Dr. Magda Petryniak is an Assistant Professor of Pediatrics. She completed her Pediatric residency at the St. Louis University Children’s Hospital and received her Neonatology training at UCSF. When not caring for patients, Dr. Petryniak is head of her laboratory and is a member of the OHSU Neuroscience training program.
Congenital and acquired diseases characterized by loss or damage to myelin affect tens of thousands of children and are a major cause of neurologic morbidity in the pediatric population. These range from periventricular white matter loss associated with preterm birth, hereditary leukodystrophies and primary disorders of myelin formation, as well as immune-based diseases such as multiple sclerosis. Dr. Petryniak’s lab is interested in understanding the immune mechanisms that regulate myelin loss in leukodystrophies, and current investigations utilize a new mouse model of Krabbe disease that genetically matches a human Krabbe disease mutation. She suspects that insight into the immune mechanisms mediating myelin loss in Krabbe disease will provide insight into immune function in other leukodystrophies as well as allow rational approach for use of immune modulators in this group of disorders.
Additionally, Dr. Petryniak’s lab is interested in the molecular mechanisms that regulate oligodendrocyte production and differentiation. The lab utilizes transgenic and knock-out mouse models, cellular transplantation, in vitro myelination assays, immunohistochemistry, in situ hybridization and a diverse range of molecular neurobiology techniques to connect the basic biology of myelination and innate immune function with pathophysiological events that occur in leukodystrophies.
Dr. Jamie Warren is an Assistant Professor of Pediatrics and serves as the Rotation Director for residents and students who rotate through the NICU at Oregon Health & Science University. She completed her Pediatric Residency and Neonatal-Perinatal medicine fellowship at OHSU.
Dr. Warren obtained her Master of Public Health degree with a concentration in Global Health from OHSU during her fellowship, and her research focus since fellowship has been in neonatal global health. Projects have included an epidemiological survey in the Loreto Province of Peru to discover neonatal and perinatal mortality rates as well as risk factors and causes of neonatal and perinatal death; use of plastic bags to prevent hypothermia in preterm and low birth weight infants in Lusaka, Zambia; and a needs assessment of neonatal care services in Cartagena, Colombia. As the resident and student Education Director in the NICU, Jamie is working to develop an educational curriculum to best fit the needs of residents and students who spend time in the NICU.
Robert L. Schelonka
Dr Schelonka holds the Credit Union for Kids Endowed Professorship in Pediatrics, and is the Division Chief for Neonatology at OHSU. He received his MD at Case Western Reserve University (Case) in Cleveland, OH, and completed his pediatric residency and neonatology fellowship at Wilford Hall Medical Center in San Antonio, TX. He completed his military obligation as a neonatologist and Head of Neonatology and Pediatrics at the US Naval Hospital in Okinawa, Japan. Upon returning to the United States in 2000, Dr. Schelonka joined the faculty at the University of Alabama at Birmingham (UAB). In 2009, Dr. Schelonka accepted the position of Head of the Division of Neonatology at the Oregon Health and Sciences University where he is actively growing the academic and clinical programs.
Under his leadership the Division of Neonatology has assumed medical direction and coverage for two additional regional, level III nurseries. In addition, he co-founded the Oregon Perinatal and Neonatal Network to improve perinatal and neonatal care throughout Oregon and in Southwest Washington by real-time telehealth consultation, coordination of care, research and education. He has been invited to give keynote addresses at the Southern and Western Societies for Pediatric Research and been an invited speaker at the Pediatrics Academic Societies annual meeting. He has served on grant review committees for the Thrasher Foundation and the American Heart Association. He is often invited to be an international speaker and teacher, having served in such diverse places as Japan, Guam, Canada, Chile, El Salvador, Peru, Argentina, Austria and Saudi Arabia. He has served as an ad hoc reviewer for more than a dozen journals and is Editor-in-Chief of the peer-reviewed, open access journal, Research and Reports in Neonatology.
Dr. Schelonka’s research focuses on the developing immune system and the newborn infant’s unusually high predilection to infection. This work has resulted in more than 80 peerreviewed publications, state-of the art-reviews, commentaries and chapters. His research group currently utilizes a non-human primate model of intra-amniotic infection to better understand thefetal origins of later lung disease and central nervous system injury leading to developmental disability. A unique resource in this research is the Primate NICU at the Oregon National Primate Research Center (ONPRC). He has served as (site) principal investigator for a number of clinical trials examining the diagnosis, treatment and prevention of neonatal infectious diseases.
Dr Schelonka continues to find his greatest satisfaction at the bedside, taking care of patients, and teaching the next generation of neonatologists the art and science of medicine.
Dr. Howard Cohen received his Pediatric and Neonatology training at the University of Chicago. Following that, he held a variety of clinical and administrative positions and academic positions during his extensive career. He also participated in two post graduate programs at Virginia Commonwealth University and the University of Illinois focused on patient safety. He is the Medical Director of the Neonatal Intensive Care Unit at Salem Hospital in capitol city of Oregon.
Dr. Cohen’s main research interests are related to patient safety in the NICU and more broadly across organizations. He is particularly interested in newborn resuscitation and stabilization and the use of video and simulation to improve reliability of technical and teamwork aspects of resuscitation. He is also very interested in quality improvement in the NICU, particularly related to both using the tools and methods, and understanding how NICUs are able to make successful, sustained improvements. To that end, Dr. Cohen has served on the faculty of a multitude of Vermont Oxford Network Quality Collaboratives, and is nationally recognized for his contributions to increasing reliability of care.
Dr. Brian Scottoline is an Assistant Professor of Pediatrics. He completed his pediatric residency training at Stanford University and his neonatology fellowship at Boston Children’s Hospital. He holds a PhD in Biochemistry from Stanford, and his initial research interests were in the biochemistry of DNA recombination reactions and DNA damage repair. He is Director of the Neonatal-Perinatal Fellowship Training Program at OHSU, and is Neonatal Medical Director of the PANDA transport team at Doernbecher Children’s Hospital.
Dr. Scottoline is interested in developing methods to decrease reactive oxygen species (ROS) generation as a means to decrease ischemia-reperfusion injury, which is a significant source if tissue damage in ischemic organs. The target of these efforts is at the level of the mitochondrion, a major source of ROS, and involves both biochemical as well as translational work. He is also collaborating with Cindy McEvoy and Kelvin MacDonald to investigate extended duration continuous positive airway pressure, and is developing studies in conjunction with Dan Morrow to study vascular abnormalities in growth-retarded infants. Additionally, he is working with Kenneth Azarow and Dr. Morrow to study intestinal failure in neonatal patients.
Dr. Dan Morrow is an Assistant Professor of Pediatrics. He completed his Pediatric Residency and Neonatology Fellowship at Oregon Health and Science University. He is involved in quality improvement and education through the collaborative Vermont Oxford Network. This has led to a number of opportunities to help shape collaborative and consistent practice within the Doernbecher Neonatal Care Center and share this work with other NICU’s within the network.
One of his specific areas of basic and clinical research is focused on vascular development in the lungs of premature and growth restricted infants. At the bench he has studied the role of specific apoptotic mediators involved in lung growth and injury. In the clinical setting he is involved in retrospectively evaluating risk factors in premature infants who go on to develop pulmonary hypertension. Furthermore he is working with Neonatologists Amanda Hamilton and Brian Scottoline as well as members from the division of cardiology to develop screening protocols for this same population to better understand pulmonary hypertension in growth restricted babies.
Another area of focus for Dr. Morrow is in the care of the surgical patients within the NICU. He is working directly with the Doernbecher surgical and anesthesia teams to improve the care of patients requiring surgical intervention. Specifically he is involved in quality improvement and retrospective research for patients with gastroschisis. He is also motivated to improve surgical nutrition in patients with short bowel syndrome.
The fellowship program is also extremely supportive of its fellows pursuing continuing education. I have been encouraged in pursuing my Masters of Clinical Research degree for the duration of my fellowship, which I believe will be a great advantage in the advancement of my career as a neonatologist and physician scientist." -Mitzi Go, MD
Recent Publications from Neonatology FellowsMorrow D, Schelonka R, Krol A, Davies M, Kuang A. Type v aplasia cutis congenita: case report, review of the literature, and proposed treatment algorithm. Pediatr Dermatol. 2013 Nov-Dec;30(6):e208-13.
Knapp J, Platteau A. Visual Diagnosis: Newborn With Hypoxia, Respiratory Distress, and Unusual Chest Radiograph. Neoreviews 2013; 14:e153.
Leadford AE, Warren JB, Manasyan A, Chomba E, Salas AA, Schelonka R, Carlo WA. Plastic bags for prevention of hypothermia in preterm and low birth weight infants.
Pediatrics. 2013 Jul;132(1):e128-34.
Warren JB, Lambert WE, Fu R, Anderson JM, Edelman AB. Global neonatal and perinatal mortality: a review and case study for the Loreto Province of Peru. Research and Reports in Neonatology 2012, 2:103-113.
Kair LR, Leonard DT, Anderson JM. Bronchopulmonary dysplasia. Pediatr Rev. 2012 Jun;33(6):255-63.
Warren JB, Phillipi CA. Care of the well newborn. Pediatr Rev. 2012 Jan;33(1):4-18.
Warren JB, Anderson JM. Visual Diagnosis: Severe Hydrocephalus and Respiratory Distress. Neoreviews 2011; 12:e416.
Maheshwari A, Corbin LL, Schelonka RL. Neonatal necrotizing enterocolitis. Research and Reports in Neonatology 2011, 1:39-53
Go HD, Emeis C, Guise JM, Schelonka RL. Fetal and neonatal morbidity and mortality following delivery after previous cesarian. Clin Perinatol. 2011 Jun;38(2):311-9.
Anderson JM, Warren JB. Using Simulation to Enhance the Acquisition and Retention of Clinical Skills in Neonatology. Semin Perinatol. 2011 Apr;35(2):59-67.