Paper of the Month

The School of Medicine spotlights a recently published faculty research paper each month. The goals are to highlight the great research happening at OHSU and to share this information across departments, institutes and disciplines.
Thayer Lab

January 2018

It's all about timing

The Paper of the Month for January 2018 is "L1 retrotransposon antisense RNA within ASAR lncRNAs controls chromosome-wide replication timing" published in the Journal of Cell Biology. This project was led by a team from OHSU's Department of Biochemistry and Molecular Biology: Emily Platt, Ph.D., Leslie Smith, and Mathew Thayer, Ph.D., professor biochemistry and molecular biology, OHSU School of Medicine.

The process of DNA replication is complicated and involves multiple coordinated steps. Dr. Thayer's lab has a long-standing interest in understanding the mechanisms driving normal replication timing of chromosomes in human cells. This type of basic science research will have significant implications for improving our fundamental understanding of human genetics. The goal of the present study was to investigate how L1 retrotransposon anti-sense RNA, within two long non-coding RNA genes, helped maintain normal replication timing in human chromosomes. Read more


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