Paired recordings from neocortical neurons, courtesy Steve Smith Lab
Our faculty, fellows and students are involved in a wide variety of basic science research in labs, and clinical trials funded by the NIH, non-profit foundations, and industry. Our faculty have labs on the Marquam hill campus of OHSU, and at Portland VA Medical Center. We collaborate with other hospitals in the area, and researchers across the country and around the world. We are justifiably proud of our research programs. Areas of active laboratory and/or clinical research include:
- acute lung injury
- allergic responses in the airways
- improving electronic health record use in ICUs
- cannaboid neural signaling
- COPD, chronic obstructive pulmonary disease
- cystic fibrosis
- destructive lung diseases
- environmental pollutants' effects on the lungs
- lung cancer
- nitric oxide physiology in the lungs and upper airway
- outcomes in the critically ill
- smoking cessation
- surfactant biophysics
- tuberculosis immunology and vaccine development
- viral infections of the lungs
Oregon Tuburculosis Research LabOTBRL has brought together investigators in Oregon who share this common purpose. These include Drs. David and Deborah Lewinsohn, Dr. Chris Lancioni, Dr. Georgiana Purdy, Dr. Melanie Harriff, Dr. Kevin Winthrop, Dr. Marielle Gold, and Dr. Luis Burmudez.
In addition, members of the OTBRL, are actively collaborating with groups around the world. These collaborations include: David Sherman (SeattleBiomed); Payam Nahid (UCSF); William Hildebrand (OUHSC); Karen Dobos (CSU), Bill Bishai, (K-RITH), Henry Boom (Case Western Reserve University); Harriet Myanja (Makerere University), Sarah Kiguli (Makerere University), Louis Picker (OHSU) and Avigdor Shafferman (IIBR).
The Critical Care Academic Associates Program (CCAAP) has its home in the division of Pulmonary and Critical Care Medicine. This unique program exposes volunteers to the world of medical research and clinical trials through patient screening and data collection at the OHSU Hospital Intensive Care Units.
A list of recently published articles by our faculty, students and staff. This list is by no means comprehensive.
C. Williams, W. Chen, C.H. Lee, D. Yaeger, N.P. Vyleta, Stephen M. Smith. Coactivation of multiple tightly coupled calcium channels triggers spontaneous release of GABA. Nat Neurosci. 2012 Aug 12;15(9):1195-7.
Bart C. Moulton, Alan F. Barker. Pathogenesis of bronchiectasis. Clin Chest Med. 2012 Jun;33(2):211-7.
Christopher G. Slatore, E.R. Goy, Daniel J. O?Hearn, E.A. Boudreau, J. P. O?Malley, D. Peters , L. Ganzini. Sleep quality and its association with delirium among veterans enrolled in hospice. Am J Geriatr Psychiatry. 2012 Apr;20(4):317-26.
Hamed Khoojinian, Jim P. Goodarzi, Stephen B. Hall. Aligning pitch for measurements of the shape of captive bubbles. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2012;397():59-62.
Jennifer L. Letourneau, J. Pinney, Charles R. Phillips. Extravascular lung water predicts progression to acute lung injury in patients with increased risk.* Critical Care Medicine 2012;40(3):847-854.
Josh A.Robertson, D Sauer, Jeffrey A. Gold, Stephanie A. Nonas. The role of cyclooxygenase-2 in mechanical ventilation-induced lung injury.Am J Respir Cell Mol Biol. 2012 Sep;47(3):387-94.
Kalmia S. Buels, David B. Jacoby, Allison D. Fryer. Non-bronchodilating mechanisms of tiotropium prevent airway hyperreactivity in a guinea-pig model of allergic asthma. British Journal of Pharmacology 2012;165(5):1501-1514.
L. Hansen, N. Press, S.J. Rosenkranz, J.G. Baggs, J. Kendall, A. Kerber, A. Williamson, Mark S. Chesnutt. Life-sustaining treatment decisions in the ICU for patients with ESLD: A prospective investigation. Res Nurs Health. 2012 May 11.
Melanie J Harriff, G.E. Purdy, David M. Lewinsohn. Escape from the Phagosome: The Explanation for MHC-I Processing of Mycobacterial Antigens? Front Immunol. 2012;3:40.
R. Hooper, P. Burney, W.M. Vollmer, M.A. McBurnie, T. Gislason, W.C. Tan, A. Jithoo, A. Kocabas, T. Weltee, A. Sonia Buist. Risk factors for COPD spirometrically defined from the lower limit of normal in the BOLD project. European Respiratory Journal 2012;39(6):1343-1353