OHSU

Lisa Coussens, Ph.D.

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Summary of Current Research

Dr. Coussens was recently awarded two sequential Era of Hope Scholar Awards from the Department of Defense Breast Cancer Research Program. She also recently received a Susan G. Komen Promise Grant to conduct, in conjunction with Drs. Shelley Hwang and Hope Rugo of UCSF, a multi-center clinical trial to evaluate novel therapeutic approaches emerging from her research on the tumor microenvironment. Awards made through the Promise grant mechanism are for research programs identified as having significant potential to reduce breast cancer incidence and/or mortality within a decade.

At OHSU, Dr. Coussens will expand this research program in ways that focus both on improving outcomes for cancer patients and on supporting a highly collaborative, multi-disciplinary scientific culture at OHSU. Her recruitment is a key element in meeting the OHSU Knight Cancer Institute’s strategic plan and supports the vision of the School of Medicine Research Roadmap – both of which are, in part, designed to enhance scientific creativity, translational success and collaboration across our missions and units.


Selected Publications

"A listeria vaccine and depletion of t-regulatory cells activate immunity against early stage pancreatic intraepithelial neoplasms and prolong survival of mice," Gastroenterology (Vol: 146, Issue: 7, Page 1784-1794.e6) - 2014

"B cells regulate macrophage phenotype and response to chemotherapy in squamous carcinomas," Cancer Cell (Vol: 25, Issue: 6, Page 809-821) - 2014

"B cells and their mediators as targets for therapy in solid tumors," Experimental Cell Research (Vol: 319, Issue: 11, Page 1644-1649) - 2013

"Cathepsin C is a tissue-specific regulator of squamous carcinogenesis," Genes and Development (Vol: 27, Issue: 19, Page 2086-2098) - 2013

"CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8+ T cells," OncoImmunology (Vol: 2, Issue: 12, ) - 2013

 

Contact

  Email Lisa Coussens

503 494-9336