Jeffrey T. Jensen
Jeffrey Jensen's clinical experience in family planning inspires his dedication to the development of new methods of contraception. He and his staff focus on translational research designed to bring the advances of the lab into clinical practice. Building on research in rodents, Jensen's group has documented that the phosphodiesterase (PDE) 3 inhibitor, ORG 9935, can prevent maturation of the oocyte both in the culture dish and during stimulated ovarian cycles, and can act as a contraceptive in breeding groups of macaques. It has the advantage of being a nonhormonal strategy that does not affect menstrual cycles. Future experiments in monkeys are needed to determine if the approach is feasible in women. Additional studies with novel inhibitors of oocyte maturation are in progress in the lab as part of the NICHD Contraceptive Research Development Center at ONPRC. Dr. Jensen is a Co-Principal Investigator of this grant that is investigating the biology of several highly specific and novel contraceptive strategies, and testing promising applications in the breeding groups.
Globally, surgical sterilization (permanent contraception) is the most common and effective method of birth control. Because access to this important method is limited by its high cost, the scarcity of providers, and certain surgical risks, particularly in lesser-developed nations, there is a need for a non-surgical method of non surgical permanent contraception (NSPC). A number of chemical agents have been evaluated for that role, but only quinacrine has been tested in humans. The World Health Organization has placed a moratorium on funding further clinical quinacrine studies, pending more animal studies of its long-term safety. Dr. Jensen has investigated Polidocanol, a synthetic, long-chain, fatty alcohol used as a sclerosing agent, for its potential in NSPC. Experiments in progress funded by the Bill and Melinda Gates Foundation are exploring this approach using the nonhuman primate model. Dr. Jensen and Dr. Ov Slayden recently received Gates funding to establish the Oregon Permanent Contraception Research Center (OPERM) https://www.ohsu.edu/xd/research/centers-institutes/oregon-permanent-contraception-research-center/ at the ONPRC to expand this work and evaluate other novel approaches to permanent contraception using the nonhuman primate model.
Jeffrey T. Jensen is a Professor in the Division of Reproductive & Developmental Sciences at the Oregon National Primate Research Center, Leon Speroff Professor and Vice Chair for Research, Department of Obstetrics & Gynecology in the School of Medicine, OHSU, and Director of the Women's Health Research Unit of the Center for Women's Health at OHSU. He completed medical school at Emory University (1984), an internship at Santa Clara Valley Medical Center (1985), and residency training in Obstetrics and Gynecology at OHSU (1988) before entering active duty military service in the United States Navy. He became a member of the OHSU faculty in 1992. Jensen received a Master of Public Health degree from the University of Washington in 1997, and he joined the ONPRC staff in 1999 as a Women's Reproductive Health Research Fellow.
Jensen, JT, Hanna, C, Yao, S, Thompson, E, Bauer, C, and Slayden, OD. (2016) Transcervical administration of polidocanol foam prevents pregnancy in female baboons. Contraception 10.1016/j.contraception.2016.07.008. PMID: 27421766. PMC in process
Jensen, JT, Hanna, C, Yao, S, Bauer, C, Morgan, TK, and Slayden, OD (2015) Characterization of tubal occlusion after transcervical polidocanol foam (PF) infusion in baboons. Contraception 92, 96-102. PMCID: PMC4521910.
Hanna CB, Yao S, Ramsey CM, Hennebold JD, Zelinski MB, Jensen JT. (2015) Phosphodiesterase 3 (PDE3) inhibition with Cilostazol does not block in vivo oocyte maturation in rhesus macaques (Macaca mulatta). Contraception, 91,418-422. PMCID: PMC25645461.
See a full listing of Dr. Jensen's publications