OHSU

Dr. Marie Davidian Lecture

The Oregon Chapter of the American Statistical Association & Knight Biostatistics Shared Resource Group Proudly presents:

 

2013 President of American Statistical Association- Marie Davidian, PhD, William Neal Reynolds Professor

Department of Statistics, North Carolina State University

Marion Miller Auditorium, Doernbecher Children's Hospital, 11th floor

October 2, 2013 7:30 PM – 8:30 PM


"The Right Treatment for the Right Patient (at the Right Time): Personalized Medicine and Statistics" 


With the advent of the omics era and the ability to collect high-dimensional patient information, the goal of "personalizing" treatment to the patient, that is, selecting the best treatment for a patient from among the available options based on his/her genetic, physiological, demographic, and other characteristics and past history, has become more tantalizing than ever. Personalized medicine involves identifying groups of patients sharing certain characteristics ("the right patient") who are likely to benefit from one treatment option over the others available ("the right treatment"), providing guidance on the treatment decision. In chronic diseases and disorders like cancer or substance abuse, a series of treatment decisions must be made, and the goal is to determine the most beneficial treatment option at each decision point for patients with similar characteristics and responses to previous treatments. This sequential decision-making introduces many complications; for example, treatments chosen early on may affect how well treatments given later will work ("at the right time"). Why is a statistician talking about personalized medicine? The development of optimal, evidence-based personalized treatment strategies is a fascinating statistical problem. Dr. Davidian provides an overview of challenges involved and of the essential role of statistical methods and study designs in the quest for personalized medicine.

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