Dennis R. Trune, Ph.D., Professor

Dennis Trune

 

Background

Dennis R.Trune, Ph.D., M.B.A., is a Professor in the Oregon Hearing Research Center. He joined OHSU in 1983.

Overview

Current appointments:

  • Professor in the Department of Otolaryngology-Head and Neck Surgery
  • Adjunct Researcher with the National Center for Rehabilitative Auditory Research, Portland VAMC

Previous appointments:

  • Assistant and Associate Professor in the Department of Otolaryngology-Head and Neck Surgery

 Degrees:

  • B.A. degree in biology from the University of Michigan-Flint
  • M.S. degree in biology from Northern Arizona University
  • M.B.A. degree from Portland State University
  • Ph.D. degree in anatomy from Louisiana State University Medical School; conducted dissertation research at the Kresge Hearing Research Laboratory
  • Postdoctoral fellowship with Dr. David Lim in the Otolaryngology Department at Ohio State University

Summary of current research

Research Interests

  • Immune-mediated inner-ear disease and hearing loss
  • Intratympanic delivery of steroids for improved recovery of hearing loss
  • Development of novel treatments for hearing loss
  • Ion and water transport dysfunction in different forms of hearing loss
  • Control of inflammatory processes of the middle ear
  • Impact on middle-ear inflammation on the inner ear

Major Milestones and Significant Discoveries

  • New treatment for sudden and immune-mediated hearing loss
  • Demonstration that inflammatory processes occur in the inner ear with middle-ear infections
  • Identification of fluid-clearing mechanisms in the middle-ear compromised during infections, leading to the painful effusions found in otitis media
  • Identification of potential gene defects that cause middle-ear infections

Selected publications

  • Trune, DR, Kempton, B, Hausman, F, Larrain, BE, MacArthur, CJ. Correlative mRNA and Protein Expression of Middle and Inner Ear Inflammatory Cytokines during Mouse Acute Otitis Media. Hear Res, 326:49-58, 2015. pdf
  • Lighthall JG, Kempton JB, Hausman F, MacArthur CJ, Trune DR. Control of middle ear inflammatory and ion homeostasis genes by transtympanic steroid treatment. PLoS ONE 10(3): e0119228. doi:10.1371/journal.pone.0119228, 2015. pdf
  • MacArthur CJ, Hausman F, Kempton B, Trune DR. Intra-tympanic steroid treatments may improve hearing via ion homeostasis alterations and not immune suppression. Otol Neurotol, 36:1089-1095, 2015. pdf
  • MacArthur CJ, Wilmot B, Wang LY, Schuller M, Trune DR. Genetic susceptibility to chronic otitis media with effusion (COME): candidate gene SNPs. Laryngoscope, 124:1229-35, 2014. pdf
  • MacArthur CJ, Hausman F, Kempton JB, Choi D, Trune DR. Otitis media impacts hundreds of mouse middle and inner ear genes. PLoS ONE 8(10): e75213. doi:10.1371/journal.pone.0075213. 2013. pdf
  • Trune DR, Canlon B. Corticosteroid therapy for hearing and balance disorders. Anat Rec, 295:1928-43, 2012.7. Trune DR, Nguyen-Huynh A. Vascular pathophysiology in hearing disorders. Sem Hear, 33:242-50, 2012. pdf
  • MacArthur CJ, Hausman F, Kempton JB, Sautter N, Trune DR. Inner ear tissue remodeling and ion homeostasis gene alteration in murine chronic otitis media. Otol Neurotol, 34:338-46, 2013. pdf
  • Morris, LM, DeGagne JM, Kempton, JB, Hausman, F, Trune, DR. Mouse middle ear ion homeostasis channels and intercellular junctions. PLoS One 7(6): e39004. Doi:10.1371/journal.pone.0039004, 2012. Correction PLoS ONE. 2013;8(4). doi: 10.1371. Epub 2013 Apr 1. pdf

  To access more of Dr. Trune's publications see PubMed.