OHSU

Peter Zuber

Peter Zuber

Email: 
Phone:  503 748-7335
Fax:  503 748-1464
Lab Phone: 503 748-1056

 

Current Appointments

Professor, Division of Environmental and Biomolecular Systems
Affiliate Scientist, Center for Coastal Margin Observation and Prediction

 

Education

B. S., Microbiology, University of Maine, Orono, 1976
Ph.D. Microbiology, University of Virginia School of Medicine, Charlottesville, 1982

 

Biography

  • Harvard University, Cellular and Developmental Biology, Laboratory of Richard Losick, American Cancer Society Postdoctoral Fellow, 1982-85; Research Associate, 1985-86
  • Oklahoma State University, Assistant Professor, Department of Botany and Microbiology, 1986-88
  • Louisiana State University Medical Center at Shreveport, Department of Biochemistry and Molecular Biology, Assistant Professor, 1988-92, Associate Professor, 1992-96, Professor, 1996-98
  • Harvard Medical School, Visiting Professor, Biological Chemistry and Molecular Pharmacology, Laboratory of Christopher T. Walsh, 1996
  • Editorial Board: Journal of Bacteriology
  • Editorial Board: Applied and Environmental Microbiology
  • Advisory Board: Molecular Microbiology
  • Associate Editor: Microbiology

 

Research Interests

Regulation of prokaryotic gene expression and development in response to stress; signal transduction; regulation and mechanism of peptide antibiotic biosynthesis; regulation of genetic competence in Bacillus subtilis.

 

Selected Publications

Lin, A. A. and P. Zuber.  2012.  Evidence that a single monomer of Spx can productively interact with RNA polymerase in Bacillus subtilis.  J. Bacteriol. 194:1697-1707.

Herfort, L., T. D. Peterson, F. G. Prahl, L. A. McCue, J. A. Needoba, B. C. Crump, G. C. Roegner, V. Campbell, and P. Zuber.  2012.  Red waters of Myrionecta rubra are biogeochemical hotspots for the Columbia River estuary with impacts on primary/secondary productions and nutrient cycles.  Est. Coast. 35:878-891.

Chan, C. M., S. Garg, A. A. Lin and P. Zuber.  2012.  Geobacillus thermodenitrificans YjbH recognizes the C-terminal end of Bacillus subtilis Spx to accelerate Spx proteolysis by ClpXP.  Microbiol. 158:1268-1278.

Herfort, L., T. D. Peterson, V. Campbell, S. Futrell and P. Zuber. 2011. Myrionecta rubra bloom initiation in the Columbia River estuary. Est. Coast. and Shelf Sci. 95:440-446.

Fortunato, C. S., L. Herfort, P. Zuber, A. M. Baptista and B. C. Crump. 2011. Spatial variability overwhelms seasonal patterns in bacterioplankton communities across a river to ocean gradient. ISME J. 6:554-563.

Zuber, P., S. Chauhan, P. Pilaka, M. M. Nakano, S. Gurumoorthy, A. A. Lin, S. M. Barendt, B. K. Chi, H. Antelmann, and U. M￤der. 2011. Phenotype enhancement screen of a regulatory spx mutant unveils a role for the ytpQ gene in the control of iron homeostasis. PLoS ONE 6: e25066

Herfort L., T. D. Peterson, L. A. McCue, and P. Zuber. 2011. Protist 18S rRNA gene sequence analysis reveals multiple sources of organic matter contributing to turbidity maxima of the Columbia River estuary, Mar. Ecol. Prog. Ser. 438:19-31

Kommineni S., S. K. Garg, C. M. Chan, and P. Zuber. 2011. YjbH-enhanced proteolysis of Spx by ClpXP in Bacillus subtilis is inhibited by the small protein YirB (YuzO). J. Bacteriol. 193:2133-2140.

Herfort, L., T. D. Peterson, L. A. McCue, B. C. Crump, F. G. Prahl, A. M. Baptista, V. Campbell, R. Warnick, M. Selby, G. C. Roegner, P. Zuber. 2011. Myrionecta rubra population genetic diversity and its cryptophyte chloroplast specificity in recurrent red tides in the Columbia River estuary. Aqu. Microbial Ecol. 62:85-97.

Antelmann, H.; Zuber, P.  (2010). Thiol-based Sensors. pp. 199-230. In S. Spiro and R. Dixon, ed. Sensory Mechanisms in Bacteria: Molecular Aspects of Signal Recognition. Horizon Press.

Nakano, M. M.; Lin, A. T.; Zuber, C. S.; Newberry, K. J.; Brennan, R.G.; Zuber, P. (2010). Promoter recognition by a complex of Spx and the C-terminal domain of the RNA polymerase a subunit. PLoS ONE 5:e8664.

Garg, S.; Kommineni, S.; Henslee, L.; Zhang, Y.; Zuber, P. (2009) YjbH of Bacillus subtilis enhances the ClpXP-catalyzed proteolysis of Spx. J. Bacteriol. 191, 1268-1277.

Zuber, P. (2009) Management of oxidative stress in Bacillus. Annu. Rev. Microbiol. 63, 575-597.

Reyes, D. Y.; Zuber, P. (2008) Activation of transcription initiation by Spx: formation of transcription complex and identification of a Cis-acting element required for transcriptional activation. Mol. Microbiol. 69(3), 765-779.

Leelakriangsak, M.; Nguyen, T. T. H.; Towe, S.; van Duy, N.; Becher, D.; Hecker, M.; Antelmann, H.; Zuber, P. (2008) Regulation of quinone detoxification by the thiol stress sensing DUF24/MarR-like repressor, YodB in Bacillus subtilis. Mol. Microbiol. 67(5), 1108-1124.

Antelmann, H.; Hecker, M.; Zuber, P. (2008) Proteomic signatures uncover thiol-specific electrophile resistance mechanisms in Bacillus subtilis. Expert Rev. Proteomics 5(1), 77-90.

Geng, H.; Zuber, P.; Nakano, M. M. (2007) Regulation of respiratory genes by ResD-ResE signal transduction system in Bacillus subtilis. Methods Enzymol. 422 (Two-Component Signaling Systems, Part A) 448-464.

Zhang, Y.; Zuber, P. (2007) Requirement of the zinc-binding domain of ClpX for Spx proteolysis in Bacillus subtilis and effects of disulfide stress on ClpXP activity. J. Bacteriol. 189(21), 7669-7680.

Toewe, S.; Leelakriangsak, M.; Kobayashi, K.; Van Duy, N.; Hecker, M.; Zuber, P.; Antelmann, H. (2007) The MarR-type repressor MhqR (YkvE) regulates multiple dioxygenases/glyoxalases and an azoreductase which confer resistance to 2-methylhydroquinone and catechol in Bacillus subtilis. Mol. Microbiol. 66(1), 40-54.

Leelakriangsak, M.; Kobayashi, K.; Zuber, P. (2007) Dual negative control of spx transcription initiation from the P3 promoter by repressors PerR and YodB in Bacillus subtilis. J. Bacteriol. 189(5), 1736-1744.

Leelakriangsak, M.; Zuber, P. (2007) Transcription from the P3 promoter of the Bacillus subtilis spx gene is induced in response to disulfide stress. J. Bacteriol. 189(5), 1727-1735.

Choi, S.Y.; Reyes, D.; Leelakriangsak, M.; Zuber, P.. (2006) The global regulator Spx functions in the control of organosulfur metabolism in Bacillus subtilis. J. Bacteriol. 188(16), 5741-5751.

Zhang, Y.; Nakano, S.; Choi, S.Y.; Zuber, P. (2006) Mutational analysis of the Bacillus subtilis RNA polymerase alpha C-terminal domain supports the interference model of Spx-dependent repression. J. Bacteriol. 188(12), 4300-4311.

Weart, R. B.; Nakano, S.; Lane, B. E.; Zuber, P.; Levin, P. A. (2005). The ClpX chaperone modulates assembly of the tubulin-like protein FtsZ. Mol. Microbiol. 57(1), 238-249.

Erwin, Kyle N.; Nakano, S.; Zuber, P. (2005) Sulfate-dependent repression of genes that function in organosulfur metabolism in Bacillus subtilis requires Spx. J. Bacteriol. 187(12), 4042-4049.

Nakano, S.; Erwin, K. N.; Ralle, M.; Zuber, P. (2005) Redox-sensitive transcriptional control by a thiol/disulphide switch in the global regulator, Spx. Mol. Microbiol. 55(2), 498-510.

Nakano, M. M.; Zuber, P.; Editors. (2004) Strict and Facultative Anaerobes: Medical and Environmental Aspects. UK., 392 pp.

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