Sara Courtneidge, Ph.D.
Associate Director for Translational Sciences, Knight Cancer Institute
Professor, Departments of Cell, Developmental & Cancer Biology and Biomedical Engineering
Member, OHSU Center for Spatial Systems Biomedicine
Email Dr. Courtneidge
Graduate Program Memberships
Sara A. Courtneidge was born in the UK, and received her B.Sc. from the University of Leeds and her Ph.D. from the National Institute for Medical Research, London. Following postdoctoral study at the University of California, San Francisco, and an independent position at the National Institute for Medical Research, she joined the European Molecular Biology Laboratory in Heidelberg, Germany in 1985, where she rose to the position of Senior Scientist. Changing course in 1994, Dr. Courtneidge joined SUGEN Inc., where as Chief Scientist she guided novel kinase discovery and validation efforts in oncology. From 2001-2005 she was Distinguished Scientific Investigator at the Van Andel Research Institute in Grand Rapids, Michigan, and from 2005-2014 she served as Professor and Director of the Tumor Microenvironment and Metastasis Program, and Director of Academic Affairs, at the Sanford|Burnham Medical Research Institute. She joined OHSU in 2014, where she is an Associate Director of Translational Sciences for the Knight Cancer Institute, a Professor in the Department of Cell, Developmental & Cancer Biology, and a member of the Center for Spatial Systems Biomedicine. Dr. Courtneidge’s laboratory has studied the Src family of protein tyrosine kinases for a number of years, and has contributed to the understanding of Src transformation, regulation, substrate selection and function. Currently, her research on Src and it substrates focuses on cancer invasion and metastasis, with particular emphasis on the role of membrane structures called podosomes or invadopodia. She also retains an interest in translational research, with the goal of defining novel therapeutic points of intervention for cancer treatment. Dr. Courtneidge’s contributions to cancer research have been recognized with numerous honors, including election to the European Molecular Biology Organization, the Jubilee Lecture and Harden Medal of the British Biochemical Society, the Feodor Lynen Lecture and Lynen Medal, an honorary doctorate from the University of Leeds, and, most recently, the 2015 AACR-WICR Charlotte Friend Memorial Lectureship.
Senior Research Associate
Education: Ph.D., 2007, Biophysics and Genetics, University of Colorado Health Sciences Center, Denver, CO
Ronn is Dr. Courtneidge’s lab manager and research coordinator, and responsibilities include ordering laboratory supplies, managing ongoing research projects, and providing research support for postdocs and graduate students. He also helps Dr. Courtneidge with grant proposals, publications and financial budgeting for laboratory expenses. When he's not in the lab he enjoys spending time outdoors, especially fishing and camping.
Alejandra Silva Hernández
Education: B.S., 2015, Microbiology, University of Washington, Seattle, WA
Alejandra was born in Mexico City but grew up in Vancouver, WA. She is a research assistant in Dr. Courtneidge's lab while preparing for medical school. She provides lab support by general lab maintenance, genotyping, and transgenic mouse colony management. Outside of the lab, she enjoys learning new languages, running, and practicing taekwondo.
Assistant Staff Scientist
Education: Ph.D., 2009 Hiroshima University, Japan; D.D.S., 2005 Kanagawa Dental University Japan
Shinji is a postdoctoral researcher in Dr. Courtneidge’s lab. He joined the lab in 2011 and moved with the lab to OHSU in 2014 from Sanford-Burnham Medical Research Institute in La Jolla, CA. His research interest is the regulation of invadopodia in cancer cells and how invadopodia structures regulate cancer progression.
Arthur J. Kuipers, Ph.D.
Arthur was born in The Netherlands, where he did his B.Sc. and M.Sc. in Biomedical Sciences at the Radboud university medical center in Nijmegen. His Ph.D. project, also at the Radboud university medical center, revolved around understanding the role of the channel-kinase TRPM7 in (breast) cancer metastasis. In the Courtneidge lab, Arthur will study how macrophage podosomes affect tumor progression using in vitro and in vivo methods. In his free time, Arthur likes to spend time outdoors, to watch TV-series and to discover as many good Portland food carts and breweries as possible.
Education: B.S., 2009, Biochemistry & Biology, Loyola Marymount University, Los Angeles, CA; Ph.D., 2015, Biomedical Sciences, University of California Irvine, Irvine, CA.
Elyse was born and raised in Los Angeles, CA. She moved to Orange County after completing her B.S. degree to pursue her Ph.D. at the University of California, Irvine. For her Ph.D. work, she investigated a novel role for retinoids in the regulation of melanogenesis under the guidance of Dr. Anand Ganesan. While in the Courtneidge lab, Elyse will utilize in vitro and in vivo methods to study how invadopodia control melanoma formation, progression and metastasis. In her free time, she enjoys playing with her cats, watching sports, reading, crafting, listening to music and exploring her new home.
Priyanka Saini, Ph.D.
Priyanka was born and brought up in India. She pursued B.Sc (H) in Biomedical Sciences and M.Sc in Biotechnology in India. She received her PhD degree in Germany where she investigated new fundamental links in the canonical DNA damage signaling pathways in tumor cells upon chemotherapeutic treatment. With Courtneidge lab she’ll be performing in-vivo studies to establish a novel mechanism of Src kinase and find a signaling pathway for invadopodia formation. When not working, she enjoys painting, sketching, improving her cooking and baking skills, traveling around, exploring new things and admiring nature.
Education: Ph.D., 2013, Molecular Biology, Cell Biology, &Biochemistry, Boston University, Boston, MA; M.S., 2002, Biomedical Engineering, University of Wisconsin, Madison, WI; B.S., 1999, Mechanical Engineering, Michigan Technological University, Houghton, MI
Eugene was born and raised in Detroit. He did
his undergrad in Mechanical Engineering while spending summers in various
biomedical research/engineering labs. He then completed his Master's at the
University of Wisconsin where he studied knee ligament hydration and
biomechanics. He then completed his PhD in Boston where he studied cancer stem
cells with microarrays, anti-cancer drug combinations, angiogenesis and tumor
hypoxia. He has one Postdoc in Orthopaedic Surgery at the University where he
studied effects of matricellular protein inhibition on bone biology and
biomechanics, and identified genes involved in regulating functional adaptation
in the skeleton during growth and development. In the Courtneidge lab he will
be identifying biomarkers of breast cancer invasion and metastasis using high
throughput gene expression analysis and comparing the effects 2D vs 3D cultures
on metastatic markers in breast cancer cells. Outside of the lab, he does bar
trivia, sees EDM DJs, and marital arts.
Ph.D. Graduate Student (UCSD)
Education: B.S./M.S. Drexel University, Philadelphia
Chris grew up in Pittsburgh, Pennsylvania and received his B.S. and M.S degrees in Biomedical Engineering from Drexel University in Philadelphia where he worked on base excision repair kinetics in cancer. He then worked as a Research Specialist at the University of Pittsburgh Cancer Institute studying the role of cyclin-dependent kinases (CDKs) in melanoma and the potential for their use as a molecular target for therapeutics in melanoma. Chris is currently enrolled in the Biomedical Sciences Graduate Program at the University of California, San Diego (UCSD) where he is pursuing his PhD and completing his thesis research at OHSU. Outside of the lab, Chris is an avid Pittsburgh sports fan and enjoys exploring the Portland brewery scene.
Leann's duties in the Courtneidge lab include providing general administrative support, purchasing, scheduling meetings, travel planning, and budget assistance. In her free time, she enjoys photography, handcrafts, repurposing old things, and the outdoors.