Graduate Studies Faculty

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Amanda Lund, Ph.D.

Assistant Professor
Admin Unit: SOM-Cell, Developmental & Cancer Biology Department
Phone: 503-494-1095
Office: RJH 6514
Mail Code: L215
Programs:
Cell & Developmental Biology
Program in Molecular & Cellular Biosciences
Cancer Biology
Research Interests:
lymphangiogenesis, T cell trafficking, immunotherapy, tumor microenvironment, melanoma, dermatopathology » Click here for more about Dr. Lund's research » PubMed Listing
Preceptor Rotations
Academic Term Available Fall 2017 Yes Winter 2018 Yes Spring 2018 Yes
Faculty Mentorship
Dr. Lund is available as a mentor for 2017-2018.
Profile

The tumor microenvironment presents a significant obstacle to the efficacy of clinical cancer therapy. Recently we demonstrated that the lymphatic endothelium plays an active and dynamic role in regulating anti-tumor immunity. Lymphatic growth in the context of tumor formation alters local interstitial flows, cell trafficking and antigen delivery to the sentinel node; all of which may alter local immune responses. Our group explores the hypothesis that tumor-associated lymphangiogenesis directly manipulates local lymphocytes, which in turn, remodel the tumor microenvironment. This regulatory feedback maintains immune suppression in the context of a growing tumor and prevents newly activated lymphocytes from functioning locally. We specifically explore these mechanisms in the context of the skin using mouse models of cutaneous acute viral infection and melanoma as well as patient samples. Understanding these mechanisms of regulation will provide novel therapeutic targets that synergize with existing immunotherapies.