Graduate Studies Faculty
Amanda Lund, Ph.D.
Programs:Cell & Developmental Biology
Program in Molecular & Cellular Biosciences
Research Interests:lymphangiogenesis, T cell trafficking, immunotherapy, tumor microenvironment, melanoma, dermatopathology » Click here for more about Dr. Lund's research » PubMed Listing
Preceptor RotationsAcademic Term Available Fall 2017 Yes Winter 2018 Yes Spring 2018 Yes
Faculty MentorshipDr. Lund is available as a mentor for 2017-2018.
The tumor microenvironment presents a significant obstacle to the efficacy of clinical cancer therapy. Recently we demonstrated that the lymphatic endothelium plays an active and dynamic role in regulating anti-tumor immunity. Lymphatic growth in the context of tumor formation alters local interstitial flows, cell trafficking and antigen delivery to the sentinel node; all of which may alter local immune responses. Our group explores the hypothesis that tumor-associated lymphangiogenesis directly manipulates local lymphocytes, which in turn, remodel the tumor microenvironment. This regulatory feedback maintains immune suppression in the context of a growing tumor and prevents newly activated lymphocytes from functioning locally. We specifically explore these mechanisms in the context of the skin using mouse models of cutaneous acute viral infection and melanoma as well as patient samples. Understanding these mechanisms of regulation will provide novel therapeutic targets that synergize with existing immunotherapies.