SIREN Resources
SIREN Coordinating Center Website - https://siren.network/
March 2020
Ellen Underwood, MS will present: Dmitrienki A and D’Agostino RB. Multiplicity Considerations in Clinical Trials. NEJM 2018;378:2115-22.
Valerie Durkalski-Mauldin, PhD will present: Yadav K and Lewis RJ. Gatekeeping Strategies for Avoiding False-Positive Results in Clinical Trials with Many Comparisons. JAMA 2017;318(14):1385-86.
Additional Reading: US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research, CBER, & Center for Biologics Evaluation and Research. (DRAFT) Guidance for Industry. January 2017.
January 2020
D. Mark Courtney, MD, MSc will present: Kearon C, de Wit K, Parpia S, Schulman S, Afilalo M, Hirsch A, et al. Diagnosis of Pulmonary Embolism with D-Dimer Adjusted to Clinical Probability. NEJM 2019;381:2125-34.
Jaideep Kapur, MB, BS, PhD will present: Kapur J, Elm J, Chamberlain JM, Barsan W, Cloyd J, Lowenstein D, et al. Randomized Trial of Three Aniconvulsant Medications for Status Epilepticus. NEJM 2019;381:2103-13.
October 2019
June 2019
Karen Hirsch, MD, and Melissa Ann Vogelsong, MD will present: Nordberg P, Silvio Taccone F, Truhlar A, Forsberg S, Hollenberg J, Johnsson M, et al. Effect of Trans-Nasal Evaporative Intra-arrest Cooling on Functional Neurologic Outcome in Out-of-Hospital Cardiac Arrest – The PRINCESS Randomized Clinical Trial. JAMA. 2019;321(17):1677-85.
May 2019
James Chamberlain, MD will present: Dalziel SR, Borland ML, Furyk J, Bonisch M, Neutze J, Donath S, et al. Levetiracetam versus phenytoin for second-line treatment of convulsive status epilepticus in children (ConSEPT): an open-label, multicenter, randomized controlled trial. Published Online April 17, 2019 http://dx.doi.org/10.1016/S0140-6736(19)30722-6
Shlomo Shinnar, MD, PhD will present: Lyttle MD, Rainford NEA, Messahel S, Humphreys A, Hickey H, Woolfall K, et al. Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicenter, open-label, randomized trial. Published Online April 17, 2019 http://dx.doi.org/10.1016/S0140-6736(19)30724-X
Editorial: Silbergleit R and Elm J. Levetiracetam no better than phenytoin in children with convulsive status epilepticus. Published Online April 17, 2019 http://dx.doi.org/10.1016/S0140-6736(19)30896-7
April 2019
Benjamin Abella, MD and David Gaieski, MD will present: Lemkes JS, Janssens GN, van der Hoeven NW, Jewbali LSD, Dubois EA, et al. Coronary Angiography after Cardiac Arrest without ST-Segment Elevation. NEJM, March 18, 2019; DOI: 10.1056/NEFMoa1816897.
Mackenzie Cervenka, MD will present: Cervenka MC, Hocker S, Koenig M, Bar B, Henry-Barron B, et al. Phase I/II Multicenter Ketogenic Diet Study for Adult Superrefractory Status Epilepticus. Neurology 2017;88:938-43.
March 2019
Valerie Durkalski-Mauldin,PhD will present: Woodcock J and LaVange LM. Master Protocols to Study Multiple Therapies, Multiple Diseases, or Both. NEJM 2017;377:62-70.
Jordan Elm, PhD will present: Hemming K, Haines TP, Chilton PJ, Girling AJ, and Lilford RJ. The Stepped Wedge Cluster Randomised Trial: Rationale, Design, Analysis, and Reporting. BMJ 2015;351:h391.
January 2019
Kees Polderman, MD will present: Cooper J, Nichol AD, Bailey M, Bernard S, Cameron PA, Pili-Floury S, et al. Effect of Early Sustained Prophylactic Hypothermia on Neurologic Outcomes Among Patients with Severe Traumatic Brain Injury. JAMA 2018;320(21):2211-20.
TBA will present: Moseby-Knappe M, Mattsson N, Nielsen N, Zetterberg H, Blennow K, Dankiewicz J, et al. Serum Neurofilament Light Chain for Prognosis of Outcome After Cardiac Arrest. JAMA 2018 Oct 29. doi: 10.1001/jamaneurol.2018.3223. [Epub ahead of print]
November 2018
October 2018
September 2018
June 2018
April 2018
Meinzer C, Martin R and Suarez JI. Bayesian Dose Selection Design for a Binary Outcome Using Restricted Response-Adaptive Randomization. Trials 2017:18;420-30.
March 2018
Nogueira RG, Jadhav AP, Haussen A Bonafe, Budzik RF, Bhuva P, et al. Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct. NEJM 2018;378(1);11-21.