PARC Publications
In Press
2006 2005 2004 2003 2002 2001 2000
1999 1998 1997 1996
Reprints or PDFs are available for many publications. To request a copy, e-mail: rutledgm@ohsu.edu
Publications In Press
[return to top of page]
Bevins, R. A., & Cunningham, C. L. Place conditioning: A methodological analysis. In: Anderson, M. J. (Ed.) Tasks and Techniques: A Sampling of Methodologies for the Investigation of Animal Learning, Behavior, and Cognition (pp. xx-yy). Hauppauge, NY: Nova Science Publishers, Inc., in press.
Cunningham, C. L., Gremel, C. M., & Groblewski, P. A.. Drug-induced conditioned place preference and aversion in mice. Nature Protocols, in press.
Kamens, H.M., Burkhart-Kasch, S., McKinnon, C.S., Li, N., Reed, C., and Phillips, T.J. (2006) Ethanol-related traits in mice selectively bred for differential sensitivity to methamphetamine-induced activation. Behavioral Neuroscience, in press.
McWeeney, SK, Hitzemann, R, Walter, N, Harrington, C, Buck, KJ and Belknap, JK, Implications of low-level analysis in comparative genomic studies for QTL and gene discovery. Bioinformatics, in press.
Malmanger, B, Lawler, M, Coulombe, S, Davison, r, Cooper, S, Polyakov,Y, Belknap, JK and Hitzemann, R, Further studies on using multiple cross mapping (MCM) to map quantitative trait loci (QTL), Mammalian Genome, in press.
Wahlsten, D., Crabbe, J.C. (200x) Behavioral testing. In J.G. Fox, C. Newcomer, A. Smith, S. Barhold, F. Quimby, and M. Davisson (Eds.) The Mouse in Biomedical Research, 2nd Edition, Vol. 3, Normative Biology, Immunology, and Husbandry, Elsevier, Amsterdam, in press.
Crabbe JC, Phillips TJ, Harris RA, Arends MA, Koob GF (2006). Alcohol-related genes: contributions from studies with genetically engineered mice. Addiction Biology 11:195-269. PubMed Link
Peirce, J. L., Li, H., Wang, J., Manly, K. F., Hitzemann, R. J., Belknap, J. K., et al. (2006). How replicable are mRNA expression QTL? Mammalian Genome 17:643-656. PubMed Link
Wahlsten D, Bachmanov A, Finn DA, Crabbe JC (2006). Stability of inbred mouse strain differences in behavior and brain size between laboratories and across decades. Proceedings of the National Academy of Sciences USA 103:16364–16369. PubMed Link
Gremel, C. M., Gabriel, K. I., & Cunningham, C. L. (2006). Topiramate does not affect the acquisition or expression of ethanol conditioned place preference in DBA/2J or C57BL/6J mice Alcoholism: Clinical and Experimental Research 30:783-790. PubMed Link
Hood HM, Metten P, Crabbe JC, and Buck KJ (2006). Fine mapping of a sedative-hypnotic drug withdrawal locus on mouse chromosome 11. Genes Brain and Behavior 5:1-10. PubMed Link
Cunningham, C. L., Patel, P., & Milner, L. Spatial location is critical for conditioning place preference with visual but not tactile stimuli. Behavioral Neuroscience 120:1115–1132. PubMed Link
Cameron WE, McNerney C (2006). Strategy for engaging the Society for Neuroscience in science education. CBE Life Sciences Education 5:91-93. PubMed Link
Mitchell SH, Reeves JM, Li N, Phillips TJ. (2006). Delay discounting predicts behavioral sensitization to ethanol in outbred WSC mice. Alcoholism: Clinical and Experimental Research 30:429-37. PubMed Link
Bice, PJ, Foroud, T, Carr, LG, Zhang, L, Liu, L, Grahame, NJ, Lumeng, L, Li, T-K and Belknap, JK (2006). Identification of QTLs influencing alcohol preference in the High Alcohol Preferring (HAP) and Low Alcohol Preferring (LAP) mouse lines. Behavior Genetics 36:248-260. PubMed Link
Coste SC, Heard AD, Phillips TJ, Stenzel-Poore MP (2006). Corticotropin-releasing factor receptor type 2-deficient mice display impaired coping behaviors during stress. Genes Brain and Behavior 5:131-8. PubMed Link
Crabbe JC, Metten P, Ponomarev I, Prescott CA, Wahlsten D (2006). Effects of genetic and procedural variation on measurement of alcohol sensitivity in mouse inbred strains. Behavior Genetics 36:536-52. PubMed Link
Crawshaw LI, Wallace HL, O'Connor CS, Yoda T, Crabbe JC (2006). Tolerance and withdrawal in goldfish exposed to ethanol. Physiology and Behavior 87:460-8. PubMed Link
Cunningham, C. L. (2006). If you want to understand alcohol abuse, you must also understand taste aversion conditioning. Highlights Section, Conditioned Taste Aversion: An Annotated Bibliography. URL: http://www.american.edu/academic.depts/cas/psych/Cunningham_Highlight.pdf
Rogers, J., R. Garcia, W. Shelledy, J. Kaplan, A. Arya, Z. Johnson, M. Bergstrom, L. Novakowski, P. Nair, A. Vinson, D. Newman, G. Heckman, J. Cameron (2006). An initial genetic linkage map of the rhesus macaque (Macaca mulatta) genome using human microsatellite loci. Genomics87:30-38. PubMed Link
Fidler, T. L., Clews, T. W., & Cunningham, C. L. (2006). Re-establishing an intragastric ethanol self-infusion model in rats. Alcoholism: Clinical and Experimental Research 30:414-428. PubMed Link
Finn DA, Beadles-Bohling AS, Beckley EH, Ford MM, Gililland KR, Gorin-Meyer RE and Wiren KM (2006). A new look at the 5-reductase inhibitor finasteride. CNS Drug Review 12:53-76. PubMed Link
Finn DA, Douglass AD, Beadles-Bohling AS, Tanchuck MA, Long SL and Crabbe JC (2006). Selected line difference in sensitivity to a GABAergic neurosteroid during ethanol withdrawal. Genes Brain and Behavior 5:53-63. PubMed Link
Kliethermes CL, Crabbe JC (2006). Pharmacological and genetic influences on hole-board behaviors in mice. Pharmacology, Biochemistry and Behavior [Aug 30, Epub ahead of print]. PubMed Link
Kliethermes CL, Crabbe JC (2006). Genetic independence of mouse measures of some aspects of novelty seeking. Proceedings of the National Academy of Sciences USA 103:5018-23. PubMed Link
Lattal, K. M., Radulovic, J. and Lukowiak, K. (2006). 9YExtinction: does it or doesn't it? The requirement of altered gene activity and new protein synthesis. Biological Psychiatry 60, 344-51. PubMed Link
Metten P, Buck KJ, Merril CM, Roberts AJ, Yu CH, Crabbe JC (2006). Use of a novel mouse genotype to model acute benzodiazepine withdrawal. Behavior Genetics DOI 10.1007/s10519-006-9094-3.
Rogers, J., J. Kaplan, R. Garcia, W. Shelledy, S. Nair, J.L. Cameron (2006). Mapping of the serotonin transporter locus (SLC6A4) to rhesus chromosome 16 using genetic linkage. Cytogenetic and Genome Research112:341A 1-3. PubMed Link
Mulligan, Mk, Ponomarev, I, Hitzemann, RJ, Belknap, JK, Tabakoff, B, Harris, RA, Crabbe, JC, Blednov, YA, Grahame, NJ, Phillips, TJ, Finn, DA, Hoffman, PL, Iyer, VR, Koob, GF and Bergeson, SE (2006). Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. Proceedings of the National Academy of Sciences USA 103:6368-6373. PubMed Link
Palmer AA, Lessov-Schlaggar CN, Ponder CA, McKinnon CS, Phillips TJ (2006). Sensitivity to the locomotor-stimulant effects of ethanol and allopregnanolone: A quantitative trait locus study of common genetic influence. Genes Brain and Behavior 5:506-17. PubMed Link
Rhodes JS, Ford MM, Yu C-H, Brown LL, Finn DA, Garland Jr T, Crabbe JC (2006). Mouse inbred strain differences in ethanol drinking to intoxication. Genes Brain and Behavior Published article online: 13-Feb-2006.
Sikela, JM, MacLaren, EJ, Kim, Y, Karimpour-Fard, A, Cai, W-W, Pollack, J, Hitzemann, R, Belknap, JK, McWeeney, S, Kerns, RT, Downing, C,Johnson, TE, Grant, KJ, Tabakoff, B, Hoffman, P, Wu, CC and Miles, MF (2006). DNA microarray and proteomic strategies for understanding alcohol actions. Alcoholism: Clinical and Experimental Research 30:700-708. PubMed Link
Weitemier, A.Z., Ryabinin, A.E. (2006) Urocortin 1 in the dorsal raphe regulates food and fluid consumption, but not ethanol preference in C57BL/6J mice. Neuroscience 137:1439-1445. PubMed Link
Wilhelm, CJ, RA Johnson, AJ Eshleman and A Janowsky. (2006) Hydrogen ion concentration differentiates effects of methamphetamine and dopamine on transporter-mediated efflux. Journal of Neurochemistry 96:1149-59. PubMed Link
Phillips, T. J., Broadbent, J., Burkhart-Kasch, S., Henderson, C., Wenger, C. D., McMullin, C., McKinnon, C. S., & Cunningham, C. L. (2005). Genetic correlational analyses of ethanol reward and aversion phenotypes in short term selected mouse lines bred for ethanol drinking or ethanol-induced conditioned taste aversion. Behavioral Neuroscience 119:892–910. PubMed Link
Crabbe JC, Metten P, Cameron AJ, Wahlsten D (2005). An analysis of the genetics of alcohol intoxication in inbred mice. Neuroscience and Biobehavioral Reviews 28:785-802. PubMed Link
Ford MM, Nickel JD and Finn DA. (2005). Treatment with and withdrawal from finasteride alters ethanol intake patterns in male C57BL/6J mice: potential role of endogenous neurosteroids? Alcohol 37:25-33. PubMed Link
Lovinger DM, Crabbe JC (2005). Laboratory models of alcoholism: treatment target identification and insight into mechanisms. Nature Neuroscience 8:1471-80. PubMed Link
Kozell L, Hitzemann R, Buck KJ (2005). Acute alcohol withdrawal involves c-Fos expression in the basal ganglia and associated circuitry: C57BL/6J and DBA/2J inbred mouse strain analyses. Alcoholism: Clinical and Experimental Research 29:1939-1948. PubMed Link
Turek, V.F., Tsivkovskaia, N.O., Hyytia, P, Harding, S, Le, A.-D., Ryabinin, A.E. (2005) Urocortin 1 expression in five pairs of rat lines selectively bred for differences in alcohol drinking. Psychopharmacology181:511-517. PubMed Link
Bechtholt, A. J., & Cunningham, C. L. (2005). Ethanol-induced conditioned place preference is expressed through a ventral tegmental area dependent mechanism. Behavioral Neuroscience 119:213-223. PubMed Link
Blednov YA, Metten P, Finn DA, Rhodes JS, Bergeson SE, Harris RA, Crabbe JC (2005). Hybrid C57BL/6J x FVB/NJ mice drink more alcohol than do C57BL/6J mice. Alcoholism: Clinical and Experimental Research 29:1949-58. PubMed Link
Cronise K, Finn DA, Metten P, Crabbe JC (2005). Scheduled access to ethanol results in motor impairment and tolerance in female C57BL/6J mice. Pharmacology, Biochemistry and Behavior. 81:943-53. PubMed Link
Fehr C, Shirley R, Crabbe JC, Belknap JK, Buck KJ, and Phillips TJ (2005). The syntaxin binding protein gene (Stxbp1) is a candidate for an ethanol preference drinking locus on mouse chromosome 2. Alcoholism: Clinical and Experimental Research 29: 708-720. PubMed Link
Finn DA, Belknap JK, Cronise K, Yoneyama N, Murillo A, Crabbe JC (2005). A procedure to produce high alcohol intake in mice. Psychopharmacology 178:471-80. PubMed Link
Ford MM, Nickel JD, Phillips TJ, Finn DA (2005). Neurosteroid modulators of GABA(A) receptors differentially modulate Ethanol intake patterns in male C57BL/6J mice. Alcoholism: Clinical and Experimental Research 29:1630-40. PubMed Link
Gabriel, K.I., & Cunningham, C. L. (2005). Effects of topiramate on ethanol and saccharin consumption and preferences in C57BL/6J mice. Alcoholism: Clinical and Experimental Research 29:75-80. PubMed Link
Gorin RE, Crabbe JC, Tanchuck MA, Long SL and Finn DA (2005). Effects of finasteride on chronic and acute ethanol withdrawal severity in the WSP and WSR selected lines. Alcoholism: Clinical and Experimental Research 29:939-48. PubMed Link
Hickman DL, Burkhart-Kasch S, Phillips TJ (2005). The effect of fostering on the genetic expression of locomotor sensitivity to alcohol. Comparative Medicine 55:498-502. PubMed Link
Holstein SE, Pastor R, Meyer PJ, Phillips TJ (2005). Naloxone does not attenuate the locomotor effects of ethanol in FAST, SLOW, or two heterogeneous stocks of mice. Psychopharmacology 182:277-89. PubMed Link
Kamens HM, Phillips TJ, Holstein SE, Crabbe JC (2005). Characterization of the parallel rod floor apparatus to test motor incoordination in mice. Genes Brain and Behavior 4:253-66. PubMed Link
Kamens HM, Burkhart-Kasch S, McKinnon CS, Li N, Reed C, Phillips TJ (2005). Sensitivity to psychostimulants in mice bred for high and low stimulation to methamphetamine. Genes Brain and Behavior 4:110-25. PubMed Link
Kliethermes CL, Cronise K, Crabbe JC (2005). Home cage activity and ingestive behaviors in mice following chronic ethanol vapor inhalation. Physiology and Behavior 85:479-88. PubMed Link
Little, H. J., Stephens, D. N., Ripley, T. L., Borlikova, G., Duka, T., Schubert, M., Albrecht, D., Becker, H. C., Lopez, M. F., Weiss, F., Drummond, C., Peoples, M., & Cunningham, C. L. (2005). Alcohol withdrawal and conditioning. Alcoholism: Clinical and Experimental Research 29:453–464. PubMed Link
Matthews DB, Bhave SV, Belknap JK, Brittingham C, Chesler EJ, Hitzemann RJ, Hoffmann PL, Lu L, McWeeney S, Miles MF, Tabakoff B, Williams RW (2005). Complex genetics of interactions of alcohol and CNS function and behavior. Alcoholism: Clinical and Experimental Research 29:1706-19. PubMed Link
Metten P, Crabbe JC (2005). Alcohol withdrawal severity in inbred mouse (Mus musculus) strains. Behavioral Neuroscience 119:911-25. PubMed Link
Meyer PJ, Palmer AA, McKinnon CS, Phillips TJ (2005). Behavioral sensitization to ethanol is modulated by environmental conditions, but is not associated with cross-sensitization to allopregnanolone or pentobarbital in DBA/2J mice. Neuroscience 131:263-73. PubMed Link
Purdy RH, ValenzuelaCF, Janak PH, Finn DA, Biggio G, Bäckström T (2005). Neuroactive steroids and ethanol. Alcoholism: Clinical and Experimental Research 29:1292-1298. PubMed Link
Rhodes JS, Crabbe JC (2005). Gene expression induced by drugs of abuse. Current Opinion in Pharmacology 5:26-33. PubMed Link
Rhodes JS, Best K, Belknap JK, Finn DA, Crabbe JC (2005). Evaluation of a simple model of ethanol drinking to intoxication in C57BL/6J mice. Physiology and Behavior 84:53-63. PubMed Link
Rhodes, J.S., Ryabinin, A.E., Crabbe, J.C. (2005) Patterns of brain activation associated with contextual conditioning to methamphetamine in mice, Behavioral Neuroscience 119:759-771. PubMed Link
Sharpe AL, Coste SC, Burkhart-Kasch S, Li N, Stenzel-Poore MP, Phillips TJ (2005). Mice deficient in corticotropin-releasing factor receptor type 2 exhibit normal ethanol-associated behaviors. Alcoholism: Clinical and Experimental Research 29:1601-9. PubMed Link
Sharpe, A.L., Tsivkovskaia, N.O., Ryabinin, A.E. (2005) Ataxia and c-Fos expression in mice drinking ethanol in a limited access session, Alcoholism: Clinical and Experimental Research29:1419-1426. PubMed Link
Turek, V.F., Ryabinin, A.E. (2005) Ethanol vs. Lipopolysaccharide-induced hypothermia: involvement of urocortin, Neuroscience 133:1021-1028. PubMed Link
Turek, V.F., Ryabinin, A.E. (2005) Expression of c-Fos in the Edinger-Westphal nucleus following ethanol administration is not secondary to hypothermia or stress, Brain Research 1063:132-139. PubMed Link
Wahlsten D, Cooper SF, Crabbe JC (2005). Different rankings of inbred mouse strains on the Morris maze and a refined 4-arm water escape task. Behavioural Brain Research 165:36-51. PubMed Link
Weitemier, A.Z., Ryabinin, A.E. (2005) Brain region-specific regulation of urocortin 1 innervation and corticotropin-releasing hormone receptor type 2 binding by ethanol exposure. Alcoholism: Clinical and Experimental Research 29:1610-1620. PubMed Link
Weitemier, A.Z., Ryabinin, A.E. (2005) Lesions of the Edinger-Westphal nucleus alter food and water consumption, Behavioral Neuroscience 119:1235-1243. PubMed Link
Weitemier, A.Z., Tsivkovskaia, N.O., Ryabinin, A.E. (2005) Urocortin 1 distribution in mouse brain is strain-dependent, Neuroscience 132:729-740. PubMed Link
2004 [return to top of page]
Kamens, H. M., Phillips, T. J., Holstein, S. E., and Crabbe, J. C. (2004) Characterization of the parallel rod floor apparatus to test motor incoordination in mice. Genes, Brain and Behavior, OnlineEarly 14 September.
Finn, D. A., Ford, M. M., Wiren, K. M., Roselli, C. E., and Crabbe, J. C. (2004). The role of pregnane neurosteroids in ethanol withdrawal: behavioral genetic approaches. Pharmacology and Therapeutics 101: 91-112. PubMed Link
Finn, D. A., Sinnott, R. S., Ford, M. M., Long, S. L., Tanchuck, M. A., and Phillips, T. J. (2004). Sex differences in the effect of ethanol injection and consumption on brain allopregnanolone levels in C57BL/6 mice. Neuroscience 123: 813-819. PubMed Link
Fehr, C., Shirley, R. L., Metten, P., Kosobud, A. E., Belknap, J. K., Crabbe, J. C., and Buck, K. J. (2004). Potential pleiotropic effects of Mpdz on vulnerability to seizures. Genes, Brain and Behavior 3: 8-19. PubMed Link
Klein, R. F., Allard, J., Avnur, Z., Nikolcheva, T., Rotstein, D., Carlos, A. S., Shea, M., Waters, R. V., Belknap, J. K., Peltz, G., and Orwoll, E. S. (2004). Regulation of bone mass in mice by the lipoxygenase gene Alox15. Science 303: 229-232. PubMed Link
Mueller, J. L., Ellenberger, E. A., Vaughn, L. K., Belknap, J. K., and Quock, R. M. (2004). Detection and mapping of quantitative trait loci that determine responsiveness of mice to nitrous oxide antinociception. Neuroscience 123: 743-749. PubMed Link
Weitemier, A. Z. and Ryabinin, A. E. (2004). Subregion-specific differences in hippocampal activity between Delay and Trace fear conditioning: an immunohistochemical analysis. Brain Research 995: 55-65. PubMed Link
Metten, P., Best, K. L., Cameron, A. J., Saultz, A. B., Zuraw, J. M., Yu, C. H., Wahlsten, D., and Crabbe, J. C. (2004). Observer-rated ataxia: Rating scales for assessment of genetic differences in ethanol-induced intoxication in mice. Journal of Applied Physiology Epub ahead of print, March 19th. PubMed Link
Kliethermes, C. L., Metten, P., Belknap, J. K., Buck, K. J., and Crabbe, J. C. (2004). Selection for pentobarbital withdrawal severity: correlated differences in withdrawal from other sedative drugs. Brain Research 1009: 17-25. PubMed Link
Rustay, N. R. and Crabbe, J. C. (2004). Genetic analysis of rapid tolerance to ethanol's incoordinating effects in mice: inbred strains and artificial selection. Behavior Genetics 34: 441-451. PubMed Link
Shirley, R. L., Walter, N. A., Reilly, M. T., Fehr, C., and Buck, K. J. (2004). Mpdz is a quantitative trait gene for drug withdrawal seizures. Nature Neuroscience 7: 699-700. PubMed Link
Buck, K. J., Reilly, M. T., Rogers, L. M., Szeliga, K., Grant, K., and Brodie, M. S. (2004). Serotonin 5-HT2 receptors and alcohol: reward, withdrawal and discrimination. Alcoholism: Clinical and Experimental Research 28: 211-216. PubMed Link
Bechtholt, A. J., Smith, R., Raber, J., and Cunningham, C. L. (2004). Enhanced ethanol-, but not cocaine-induced, conditioned place preference in Apoe-/- mice. Pharmacol Biochem.Behav. 77: 783-792. PubMed Link
Fidler, T. L., Bakner, L., and Cunningham, C. L. (2004). Conditioned place aversion induced by intragastric administration of ethanol in rats. Pharmacol Biochem.Behav. 77: 731-743. PubMed Link
Samson, H. H., Cunningham, C. L., Czachowski, C. L., Chappell, A., Legg, B., and Shannon, E. (2004). Devaluation of ethanol reinforcement. Alcohol 32: 203-212. PubMed Link
Gabriel, K. I., Cunningham, C. L., and Finn, D. A. (2004) Allopregnanolone does not influence ethanol-induced conditioned place preference in DBA/2J mice. Psychopharmacology: 50-56. PubMed Link
Palmer, A. A., Sharpe, A. L., Burkhart-Kasch, S., McKinnon, C. S., Coste, S. C., Stenzel-Poore, M. P., and Phillips, T. J. (2004) Corticotropin-releasing factor overexpression decreases ethanol drinking and increases sensitivity to the sedative effects of ethanol. Psychopharmacology 176: 386-397. PubMed Link
Kliethermes, C. L., Cronise, K., and Crabbe, J. C. (2004). Anxiety-like behavior in mice in two apparatuses during withdrawal from chronic ethanol vapor inhalation. Alcoholism: Clinical and Experimental Research 28: 1012-1019. PubMed Link
Ponomarev, I. and Crabbe, J. C. (2004). Characterization of acute functional tolerance to the hypnotic effects of ethanol in mice. Alcoholism: Clinical and Experimental Research 28: 991-997. PubMed Link
Finn, D. A., Long, S. L., Tanchuck, M. A., and Crabbe, J. C. (2004). Interaction of chronic ethanol exposure and finasteride: sex and strain differences. Pharmacology Biochemistry and Behavior 78: 435-443. PubMed Link
Rutledge-Gorman, M. and Cynkar, D. (2004). Of brains and safety: neuroscience for five year olds. Primary Science Review 84:17-20.
Hitzemann, R., Reed, C., Malmanger, B., Lawler, M., Hitzemann, B., Cunningham, B., Belknap, J.K., Buck, K.J., Phillips, T.J., and Crabbe, J.C. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. Alcoholism: Clinical and Experimental Research 28: 1437-1448. PubMed Link
Bachtell, R.K., Weitemier, A.Z., and Ryabinin, A.E. (2004) Lesions of the Edinger-Westphal nucleus in C57BL/6J mice disrupt ethanol-induced hypothermia and ethanol consumption. European Journal of Neuroscience 20: 1613-1623. PubMed Link
Boyce-Rustay, J.M., and Cunningham, C.L. (2004) The role of NMDA receptor binding sites in ethanol place conditioning. Behavioral Neuroscience 118: 822-834. PubMed Link
Hayward, M. D., Hansen, S. T., Pintar, J. E., and Low, M. J. (2004) Operant self-administration of ethanol in C57BL/6 mice lacking beta-endorphin and enkephalin. Pharmacology Biochemistry and Behavior 79: 171-181. PubMed Link
Williams, R. W., Bennett, B., Lu, L., Gu, J., DeFries, J. C., Carosone-Link, P. J., Rikke, B. A., Belknap, J. K., and Johnson, T. E. (2004) Genetic structure of the LXS panel of recombinant inbred mouse strains: a powerful resource for complex trait analysis. Mammalian Genome 15: 637-647. PubMed Link
Phillips, T. J. and Crabbe, J. C. (2004) Let's not discourage innovative approaches to complex questions. Alcoholism: Clinical and Experimental Research 28: 1607-1608. PubMed Link
Churchill, G. A., Airey, D. C., Allayee, H., Angel, J. M., Attie, A. D., Beatty, J., Beavis, W. D., Belknap, J. K., Bennett, B., Berrettini, W., Bleich, A., Bogue, M., Broman, K. W., Buck, K. J., Buckler, E., Burmeister, M., Chesler, E. J., Cheverud, J. M., Clapcote, S., Cook, M. N., Cox, R. D., Crabbe, J. C., Crusio, W. E., Darvasi, A., Deschepper, C. F., Doerge, R. W., Farber, C. R., Forejt, J., Gaile, D., Garlow, S. J., Geiger, H., Gershenfeld, H., Gordon, T., Gu, J., Gu, W., de Haan, G., Hayes, N. L., Heller, C., Himmelbauer, H., Hitzemann, R., Hunter, K., Hsu, H. C., Iraqi, F. A., Ivandic, B., Jacob, H. J., Jansen, R. C., Jepsen, K. J., Johnson, D. K., Johnson, T. E., Kempermann, G., Kendziorski, C., Kotb, M., Kooy, R. F., Llamas, B., Lammert, F., Lassalle, J. M., Lowenstein, P. R., Lu, L., Lusis, A., Manly, K. F., Marcucio, R., Matthews, D., Medrano, J. F., Miller, D. R., Mittleman, G., Mock, B. A., Mogil, J. S., Montagutelli, X., Morahan, G., Morris, D. G., Mott, R., Nadeau, J. H., Nagase, H., Nowakowski, R. S., O'Hara, B. F., Osadchuk, A. V., Page, G. P., Paigen, B., Paigen, K., Palmer, A. A., Pan, H. J., Peltonen-Palotie, L., Peirce, J., Pomp, D., Pravenec, M., Prows, D. R., Qi, Z., Reeves, R. H., Roder, J., Rosen, G. D., Schadt, E. E., Schalkwyk, L. C., Seltzer, Z., Shimomura, K., Shou, S., Sillanpaa, M. J., Siracusa, L. D., Snoeck, H. W., Spearow, J. L., Svenson, K., Tarantino, L. M., Threadgill, D., Toth, L. A., Valdar, W., de Villena, F. P., Warden, C., Whatley, S., Williams, R. W., Wiltshire, T., Yi, N., Zhang, D., Zhang, M., and Zou, F. (2004) The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nature Genetics 36: 1133-1137. PubMed Link
Bechtholt, A. J., Gremel, C. M., and Cunningham, C. L. (2004) Handling blocks expression of conditioned place aversion but not conditioned place preference produced by ethanol in mice. Pharmacology Biochemistry and Behavior 79: 739-744. PubMed Link
Crabbe, J. C. and Morris, R. G. (2004) Festina lente: late-night thoughts on high-throughput screening of mouse behavior. Nature Neuroscience 7: 1175-1179. PubMed Link
Kale, A., Amende, I., Meyer, G. P., Crabbe, J. C., and Hampton, T. G. (2004) Ethanol's effects on gait dynamics in mice investigated by ventral plane videography. Alcoholism: Clinical and Experimental Research 28: 1839-1848. PubMed Link
Zucker, S., Crabbe, J. C., Cooper, G., Finkelman, F., Largman, C., McCarley, R. W., Rice, L., Rubin, J., Richardson, B., Seil, F., Snider, G. L., and Vandenbark, A. A. (2004) Veterans Administration support for medical research: opinions of the endangered species of physician-scientists. FASEB 18: 1481-1486. PubMed Link
Crabbe, J. C. and Phillips, T. J. (2004). Pharmacogenetic studies of alcohol self administration and withdrawal. Psychopharmacology 174: 539-560. PubMed Link
Cunningham, C. L. and Phillips, T. J. (2003). Genetic basis of ethanol reward. In: Maldonado, R. (Eds.), Molecular Biology of Drug Addiction, Humana Press, Totowa, N.J., pp. 263-294.
Crabbe, J. C. (2003). Finding genes for complex behaviors: progress in mouse models of the addictions. In: Plomin, R., DeFries, J. C., Craig, I. W., and McGuffin, P. (Eds.), Behavioral Genetics in the Postgenomic Era, American Psychological Association, WashingtAmerican Psychological Associationon, D.C., pp. 291-308.
Crabbe, J. C. (2003). Current strategies for identifying genes for alcohol sensitivity. In: Maldonado, R. (Eds.), Molecular Biology of Drug Addiction, Humana Press, Totowa, N.J., pp. 249-261.
Bachtell, R. K., Tsivkovskaia, N. O., and Ryabinin, A. E. (2003). Identification of temperature-sensitive neural circuits in mice using c-Fos expression mapping. Brain Research 960: 157-164. PubMed Link
Wahlsten, D., Metten, P., Phillips, T. J., Boehm, S. L., Burkhart-Kasch, S., Dorow, J., Doerksen, S., Downing, C., Fogarty, J., Rodd-Henricks, K., Hen, R., McKinnon, C. S., Merrill, C. M., Nolte, C., Schalomon, M., Schlumbohm, J. P., Sibert, J. R., Wenger, C. D., Dudek, B. C., and Crabbe, J. C. (2003). Different data from different labs: lessons from studies of gene-environment interaction. Journal of Neurobiology 54: 283-311. PubMed Link
Wahlsten, D., Rustay, N. R., Metten, P., and Crabbe, J. C. (2003). In search of a better mouse test. Trends in Neurosciences 26: 132-136. PubMed Link
Rustay, N. R., Wahlsten, D., and Crabbe, J. C. (2003). Assessment of genetic susceptibility to ethanol intoxication in mice. Proceedings of the National Academy of Sciences USA 100: 2917-2922. PubMed Link
Kiianmaa, K., Hyytia, P., Samson, H. H., Engel, J. A., Svensson, L., Soderpalm, B., Larsson, A., Colombo, G., Vacca, G., Finn, D. A., Bachtell And RK, and Ryabinin, A. E. (2003). New neuronal networks involved in ethanol reinforcement. Alcoholism: Clinical and Experimental Research 27: 209-219. PubMed Link
Ryabinin, A. E., Galvan-Rosas, A., Bachtell, R. K., and Risinger, F. O. (2003). High alcohol/sucrose consumption during dark circadian phase in C57BL/6J mice: involvement of hippocampus, lateral septum and urocortin-positive cells of the Edinger-Westphal nucleus. Psychopharmacology 165: 296-305. PubMed Link
Bachtell, R. K., Weitemier, A. Z., Galvan-Rosas, A., Tsivkovskaia, N. O., Risinger, F. O., Phillips, T. J., Grahame, N. J., and Ryabinin, A. E. (2003). The Edinger-Westphal-lateral septum urocortin pathway and its relationship to alcohol consumption. Journal of Neruoscience 23: 2477-2487. PubMed Link
Herson, P. S., Virk, M., Rustay, N. R., Bond, C. T., Crabbe, J. C., Adelman, J. P., and Maylie, J. (2003). A mouse model of episodic ataxia type-1. Nature Neuroscience 6: 378-383. PubMed Link
Crabbe, J. C. and Wahlsten, D. (2003). Of mice and their environments (Letter). Science 299: 1313-1314. PubMed Link
Lessov, C. N. and Phillips, T. J. (2003). Cross-sensitization between the locomotor stimulant effects of ethanol and those of morphine and cocaine in mice. Alcoholism: Clinical and Experimental Research 27: 616-627. PubMed Link
Crabbe, J. C. and Phillips, T. J. (2003). Mother nature meets mother nurture. Nature Neuroscience 6: 440-442. PubMed Link
Wahlsten, D., Metten, P., and Crabbe, J. C. (2003). Survey of 21 inbred mouse strains in two laboratories reveals that BTBR T/+ tf/tf has severely reduced hippocampal commissure and absent corpus callosum. Brain Research 971: 47-54. PubMed Link
Finn, D. A., Rutledge-Gorman, M. T., and Crabbe, J. C. (2003). Genetic animal models of anxiety. Neurogenetics 4: 109-135. PubMed Link
Dickinson, S. D., Lee, E. L., Rindal, K., and Cunningham, C. L. (2003). Lack of effect of dopamine receptor blockade on expression of ethanol-induced conditioned place preference in mice. Psychopharmacology 165: 238-244. PubMed Link
Risinger, F. O. (2003). Genetic analyses of ethanol-induced hyperglycemia. Alcoholism: Clinical and Experimental Research 27: 756-764. PubMed Link
Palmer, A. A., Low, M. J., Grandy, D. K., and Phillips, T. J. (2003). Effects of a Drd2 deletion mutation on ethanol-induced locomotor stimulation and sensitization suggest a role for epistasis. Behavior Genetics 33: 311-324. PubMed Link
Meyer, P. J. and Phillips, T. J. (2003). Bivalent effects of MK-801 on ethanol-induced sensitization do not parallel its effects on ethanol-induced tolerance. Behavioral Neuroscience 117: 641-649. PubMed Link
Boyce-Rustay, J. M. and Risinger, F. O. (2003). Dopamine D3 receptor knockout mice and the motivational effects of ethanol. Pharmacology, Biochemistry and Behavior 75: 373-379. PubMed Link
Fehr, C., Rademacher, B. L., and Buck, K. J. (2003). Evaluation of the glutamate decarboxylase genes Gad1 and Gad2 as candidate genes for acute ethanol withdrawal severity in mice. Prog.Neuropsychopharmacol.Biol.Psychiatry 27: 467-472. PubMed Link
Bergeson, S. E., Kyle, Warren R., Crabbe, J. C., Metten, P., Gene, Erwin, V, and Belknap, J. K. (2003). Chromosomal loci influencing chronic alcohol withdrawal severity. Mammalian Genome 14: 454-463. PubMed Link
Crabbe, J. C., Cotnam, C. J., Cameron, A. J., Schlumbohm, J. P., Rhodes, J. S., Metten, P., and Wahlsten, D. (2003). Strain differences in three measures of ethanol intoxication in mice: the screen, dowel and grip strength tests. Genes Brain, and Behavior 2: 201-213. PubMed Link
Crabbe, J. C. and Phillips, T. J. (2003). Pharmacogenetic studies of alcohol self-administration and withdrawal. Psychopharmacology : On-Line First, October 9th. PubMed Link
Wahlsten, D., Metten, P., and Crabbe, J. C. (2003). A rating scale for wildness and ease of handling laboratory mice: results for 21 inbred strains tested in two laboratories. Genes Brain, and Behavior 2: 71-79. PubMed Link
Kliethermes, C. L., Finn, D. A., and Crabbe, J. C. (2003). Validation of a modified mirrored chamber sensitive to anxiolytics and anxiogenics in mice. Psychopharmacology 169: 190-197. PubMed Link
Goldsmith, H., Crabbe, J., Dawson, G., Gottesman, I. I., Hewitt, J., McGue, M., Pedersen, N., Plomin, R., Rose, R., and Swanson, J. (2003). Research psychologists' roles in the genetic revolution. AmericanPsychologist 58: 318-319. PubMed Link
Rustay, N. R., Wahlsten, D., and Crabbe, J. C. (2003). Influence of task parameters on rotarod performance and sensitivity to ethanol in mice. Behavioural Brain Research 141: 237-249. PubMed Link
Weitemier, A. Z. and Ryabinin, A. E. (2003). Alcohol-induced memory impairment in trace fear conditioning: a hippocampus-specific effect. Hippocampus 13: 305-315. PubMed Link
Hill, K. G., Alva, H., Blednov, Y. A., and Cunningham, C. L. (2003). Reduced ethanol-induced conditioned taste aversion and conditioned place preference in GIRK2 null mutant mice. Psychopharmacology 169: 108-114. PubMed Link
Cunningham, C. L., Ferree, N. K., and Howard, M. A. (9-2-2003). Apparatus bias and place conditioning with ethanol in mice. Psychopharmacology. PubMed Link
Crabbe, J. C. and Wiren, K. M. (2003). Molecular and genetic bases of the addictions. In: Rosenberg, R. N., Prusiner, S. B., DiMauro, S., Barchi, R. L., and Nestler, E. J. (Eds.), The Molecular and Genetic Bases of Neurologic and Psychiatric Disease, Butterworth Heinemann, Philadelphia, pp. 779-789.
Kelly, M. A., Low, M. J., Phillips, T. J., Wakeland, E. K., and Yanagisawa, M. (2003). The mapping of quantitative trait loci underlying strain differences in locomotor activity between 129S6 and C57BL/6J mice. Mammalian Genome 14: 692-702. PubMed Link
Bergstrom, H. C., Palmer, A. A., Wood, R. D., Burkhart-Kasch, S., McKinnon, C. S., and Phillips, T. J. (2003). Reverse selection for differential response to the locomotor stimulant effects of ethanol provides evidence for pleiotropic genetic influence on locomotor response to other drugs of abuse. Alcoholism: Clinical and Experimental Research 27: 1535-1547. PubMed Link
Meyer, P. J. and Phillips, T. J. (2003). Sensitivity to ketamine, alone or in combination with ethanol, is altered in mice selectively bred for sensitivity to ethanol's locomotor effects. Alcoholism: Clinical and Experimental Research 27: 1701-1709. PubMed Link
Abiola, O., Angel, J. M., Avner, P., Bachmanov, A. A., Belknap, J. K., Bennett, B., Blankenhorn, E. P., Blizard, D. A., Bolivar, V., Brockmann, G. A., Buck, K. J., Bureau, J. F., Casley, W. L., Chesler, E. J., Cheverud, J. M., Churchill, G. A., Cook, M., Crabbe, J. C., et al. (2003). The nature and identification of quantitative trait loci: a community's view. Nature Reviews Genetics 4: 911-916. PubMed Link
Phillips, T. J., Belknap, J. K., Hitzemann, R., Buck, K. J., Cunningham, C. L., and Crabbe, J. C. (2003). Appendix 5A: Internet resources for genomic, bioinformatics, and medical genetics information. Current Protocols in Neuroscience Online Appendix 5 Databases.
Belknap, J. K. (2003). Chromosome substitution strains: some quantitative considerations for genome scans and fine mapping. Mammalian Genome 14: 723-732. PubMed Link
Hitzemann, R., Malmanger, B., Reed, C., Lawler, M., Hitzemann, B., Coulombe, S., Buck, K., Rademacher, B., Walter, N., Polyakov, Y., Sikela, J., Gensler, B., Burgers, S., Williams, R. W., Manly, K., Flint, J., and Talbot, C. (2003). A strategy for the integration of QTL, gene expression, and sequence analyses. Mammalian Genome 14: 733-747. PubMed Link
Cunningham, C. L., Smith, R., and McMullin, C. (2003). Competition between ethanol-induced reward and aversion in place conditioning. Learning and Behavior 31: 273-280. PubMed Link
Phillips, T. J. (2003). Addiction and genes: animal models. In: Cooper,D. N. (Eds.), Nature Encyclopedia of the Human Genome, Nature Publishing group, New York, pp. 7-15.
Rhodes, J.S. and Crabbe, J.C. (2003) Progress towards finding genes for alcoholism in mice. Clinical Neuroscience Research, 3:315-323.
Finn, D.A., Roberts, A.J., Long, S., Tanchuck, M. and Phillips, T.J. (2003) Neurosteroid consumption has anxiolytic effects in mice. Pharmacology Biochemistry and Behavior 76:451-462. PubMed Link
Finn DA, Purdy RH and Koob GF. (2003) Animal models of anxiety and stress-induced behavior: Effects of neuroactive steroids. In: Smith, S. (Ed.), Neurosteroid Effects in the Central Nervous System: The Role of the GABAA Receptor, CRC Press, Boca Raton, pp. 317-338.
2002 [return to top of page]
Phillips, T. J. (2002). Animal models for the genetic study of human alcohol phenotypes. Alcohol Research and Health 26: 202-207. NIAAA link
Phillips, T. J., Belknap, J. K., Hitzemann, R. J., Buck, K. J., Cunningham, C. L., and Crabbe, J. C. (2002). Harnessing the mouse to unravel the genetics of human disease. Genes, Brain and Behavior 1: 14-26. PubMed Link
Daniels, G. M. and Buck, K. J. (2002). Expression profiling identifies strain-specific changes associated with ethanol withdrawal in mice. Genes, Brain and Behavior 1: 35-45. PubMed Link
Crabbe, J. C. (2002). Genetic contributions to addiction. Annual Review of Psychology 53: 435-462. PubMed Link
Palmer, A. A. and Phillips, T. J. (2002). Quantitative trait locus (QTL) mapping in mice. In: Liu, Y. and Lovinger, D. M. (Eds.), Methods in Alcohol-related Neuroscience Research, CRC Press, Boca Raton FL, pp. 1-30.
Palmer, A. A., Miller, M. N., McKinnon, C. S., and Phillips, T. J. (2002). Sensitivity to the locomotor stimulant effects of ethanol and allopregnanolone is influenced by common genes. Behavioral Neuroscience 116: 126-137. PubMed Link
Buck, K. J., Rademacher, B. L. S., Metten, P., and Crabbe, J. C. (2002). Mapping murine loci for physical dependence on ethanol. Psychopharmacology 160: 398-407. PubMed Link
Fehr, C., Shirley, R. L., Belknap, J. K., Crabbe, J. C., and Buck, K. J. (2002). Congenic mapping of alcohol and pentobarbital withdrawal liability Loci to a <1 centimorgan interval of murine chromosome 4: identification of Mpdz as a candidate gene. Journal of Neruoscience 22: 3730-3738. PubMed Link
Cunningham, C. L., Clemans, J. M., and Fidler, T. L. (2002). Injection timing determines whether intragastric ethanol produces conditioned place preference or aversion in mice. Pharmacology, Biochemistry and Behavior 72: 659-668. PubMed Link
Cunningham, C. L., Tull, L. E., Rindal, K. E., and Meyer, P. J. (2002). Distal and proximal pre-exposure to ethanol in the place conditioning task: tolerance to aversive effect, sensitization to activating effect, but no change in rewarding effect. Psychopharmacology 160: 414-424. PubMed Link
Broadbent, J., Muccino, K. J., and Cunningham, C. L. (2002). Ethanol-induced conditioned taste aversion in 15 inbred mouse strains. Behavioral Neuroscience 116: 138-148. PubMed Link
II Boehm, S. L., Reed, C. L., McKinnon, C. S., and Phillips, T. J. (2002). Shared genes influence sensitivity to the effects of ethanol on locomotor and anxiety-like behaviors, and the stress axis. Psychopharmacology 161: 54-63. PubMed Link
Phillips, T. J., Shen, E. H., McKinnon, C. S., Burkhart-Kasch, S., Lessov, C. N., and Palmer, A. A. (2002). Forward, relaxed, and reverse selection for reduced and enhanced sensitivity to ethanol's locomotor stimulant effects in mice. Alcoholism: Clinical and Experimental Research 26: 593-602. PubMed Link
Phillips, T. J. and Belknap, J. K. (2002). Complex-trait genetics: emergence of multivariate strategies. Nature Reviews Neuroscience 3: 478-485. PubMed Link
Grisel, J. E., Metten, P., Wenger, C. D., Merrill, C. M., and Crabbe, J. C. (2002). Mapping of quantitative trait loci underlying ethanol metabolism in BXD recombinant inbred mouse strains. Alcoholism: Clinical and Experimental Research 26: 610-616. PubMed Link
Ryabinin, A. E., Miller, M. N., and Durrant, S. (2002). Effects of acute alcohol administration on object recognition learning in C57BL/6J mice. Pharmacology, Biochemistry and Behavior 71: 315-320. PubMed Link
Ryabinin, A. E., Bachtell, R. K., Heinrichs, S. C., Lee, S., Rivier, C., Olive, M. F., Mehmert, K. K., Camarini, R., Kim, J. A., Koenig, H. N., Nannini, M. A., Hodge, C. W., Roberts, A. J., and Koob, G. F. (2002). The corticotropin-releasing factor/urocortin system and alcohol. Alcoholism: Clinical and Experimental Research 26: 714-722. PubMed Link
Risinger, F. O. and Boyce, J. M. (2002). Conditioning tastant and the acquisition of conditioned taste avoidance to drugs of abuse in DBA/2J mice. Psychopharmacology 160: 225-232. PubMed Link
Chester, J. A. and Cunningham, C. L. (2002). GABA(A) receptor modulation of the rewarding and aversive effects of ethanol. Alcohol 26: 131-143. PubMed Link
Palmer, A. A., Moyer, M. R., Crabbe, J. C., and Phillips, T. J. (2002). Initial sensitivity, tolerance and cross-tolerance to allopregnanolone- and ethanol-induced hypothermia in selected mouse lines. Psychopharmacology 162: 313-322. PubMed Link
Ponomarev, I. and Crabbe, J. C. (2002). A novel method to assess initial sensitivity and acute functional tolerance to hypnotic effects of ethanol. Journal of Pharmacology and Experimental Therapeutics 302: 257-263. PubMed Link
Crabbe, J. C., Metten, P., Gallaher, E. J., and Belknap, J. K. (2002). Genetic determinants of sensitivity to pentobarbital in inbred mice. Psychopharmacology 161: 408-416. PubMed Link
Sinnott, R. S., Phillips, T. J., and Finn, D. A. (2002). Alteration of voluntary ethanol and saccharin consumption by the neurosteroid allopregnanolone in mice. Psychopharmacology 162: 438-447. PubMed Link
Mark, G. P. and Finn, D. A. (2002). The relationship between hippocampal acetylcholine release and cholinergic convulsant sensitivity in Withdrawal Seizure-Prone and Withdrawal Seizure-Resistant selected mouse lines. Alcoholism: Clinical and Experimental Research 26: 1141-1152. PubMed Link
Bachtell, R. K., Tsivkovskaia, N. O., and Ryabinin, A. E. (2002). Strain differences in urocortin expression in the Edinger-Westphal nucleus and its relation to alcohol-induced hypothermia. Neuroscience 113: 421-434. PubMed Link
Bachtell, R. K., Tsivkovskaia, N. O., and Ryabinin, A. E. (2002). Alcohol-induced c-Fos expression in the Edinger-Westphal nucleus: pharmacological and signal transduction mechanisms. Journal of Pharmacology and Experimental Therapeutics 302: 516-524. PubMed Link
Palmer, A. A. and Phillips, T. J. (2002). Effect of forward and reverse selection for ethanol-induced locomotor response on other measures of ethanol sensitivity. Alcoholism: Clinical and Experimental Research 26: 1322-1329. PubMed Link
Maiya, R., Buck, K. J., Harris, R. A., and Mayfield, R. D. (2002). Ethanol-sensitive sites on the human dopamine transporter. Journal of Biological Chemistry 277: 30724-30729. PubMed Link
Sinnott, R. S., Mark, G. P., and Finn, D. A. (2002). Reinforcing effects of the neurosteroid allopregnanolone in rats. Pharmacology, Biochemistry and Behavior 72: 923-929. PubMed Link
Boehm, S. L., Piercy, M. M., Bergstrom, H. C., and Phillips, T. J. (2002). Ventral tegmental area region governs GABA(B) receptor modulation of ethanol-stimulated activity in mice. Neuroscience 115: 185-200. PubMed Link
Crabbe, J. C. (2002). Alcohol and genetics: New models. American Journal of Medical Genetics (Neuropsychiatric Genetics) 114: 969-974. PubMed Link
Risinger, F. O., Cunningham, C. L., Bevins, R. A., and Holloway, F. A. (2002). Place conditioning: what does it add to our understanding of ethanol reward? Alcoholism: Clinical and Experimental Research 26: 1444-1452. PubMed Link
Marshall, K. E., Godden, E. L., Yang, F., Burgers, S., Buck, K. J., and Sikela, J. M. (2002). In silico discovery of gene-coding variants in murine quantitative trait loci using strain-specific genome sequence databases. Genome Biology 3: 1-9. PubMed Link
Hitzemann, R., Malmanger, B., Cooper, S., Coulombe, S., Reed, C., Demarest, K., Koyner, J., Cipp, L., Flint, J., Talbot, C., Rademacher, B., Buck, K., and McCaughran, J. (2002). Multiple cross mapping (MCM) markedly improves the localization of a QTL for ethanol-induced activation. Genes, Brain and Behavior 1: 214-222. PubMed Link
Palmer, A. A., McKinnon, C. S., Bergstrom, H. C., and Phillips, T. J. (2002). Locomotor activity responses to ethanol, other alcohols, and GABA-A acting compounds in forward- and reverse-selected FAST and SLOW mouse lines. Behavioral Neuroscience 116: 958-967. PubMed Link
Ponomarev, I and Crabbe, J. C. (2002). Ethanol-induced activation and rapid development of tolerance may have some underlying genes in common. Genes, Brain and Behavior 1: 82-87. PubMed Link
2001 [return to top of page]
Crabbe, J. C. (2001). Use of genetic analyses to refine phenotypes related to alcohol tolerance and dependence. Alcoholism: Clinical and Experimental Research 25: 288-292. PubMed Link
Lessov, C. N., Risinger, F. O., and Phillips, T. J. (2001). Attenuation of ethanol-induced conditioned taste aversion in mice sensitized to the locomotor stimulant effects of ethanol. Behavioral Neuroscience 115: 146-153. PubMed Link
Schafer, G. L., Crabbe, J. C., and Wiren, K. M. (2001). Ethanol-regulated gene expression of neuroendocrine specific protein in mice: brain region and genotype specificity. Brain Research 897: 139-149. PubMed Link
Klein, R. F., Shea, M., Gunness, M. E., Pelz, G. B., Belknap, J. K., and Orwoll, E. S. (2001). Phenotypic characterization of mice bred for high and low peak bone mass. Journal of Bone and Mineral Research 16: 63-71. PubMed Link
Lessov, C. N., Palmer, A. A., Quick, E. A., and Phillips, T. J. (2001). Voluntary ethanol drinking in C57BL/6J and DBA/2J mice before and after sensitization to the locomotor stimulant effects of ethanol. Psychopharmacology 155: 91-99. PubMed Link
Mason, J. N., Eshleman, A. J., Belknap, J. K., Crabbe, J. C., Loftis, J. M., Macey, T. A., and Janowsky, A. (2001). NMDA receptor subunit mRNA and protein expression in ethanol-Withdrawal Seizure-Prone and -Resistant Mice. Alcoholism: Clinical and Experimental Research 25: 651-660. PubMed Link
Weitemier, A. Z., Woerner, A., Backstrom, P., Hyytia, And P., and Ryabinin, A. E. (2001). Expression of c-Fos in Alko Alcohol Rats Responding for Ethanol in an Operant Paradigm. Alcoholism: Clinical and Experimental Research 25: 704-710. PubMed Link
Le, A. D., Kiianmaa, K., Cunningham, C. L., Engel, J. A., Ericson, M., Soderpalm, B., Koob, G. F., Roberts, A. J., Weiss, F., Hyytia, P., Janhunen, S., Mikkola, J., Backstrom, P., Ponomarev, I., and Crabbe, J. C. (2001). Neurobiological processes in alcohol addiction. Alcoholism: Clinical and Experimental Research 25: 144S-151S. PubMed Link
Hoffman, P. L., Yagi, T., Tabakoff, B., Phillips, T. J., Kono, H., Messing, R. O., and Choi, D. S. (2001). Transgenic and gene "knockout" models in alcohol research. Alcoholism: Clinical and Experimental Research 25: 60S-66S. PubMed Link
Suwaki, H., Kalant, H., Higuchi, S., Crabbe, J. C., Ohkuma, S., Katsura, M., Yoshimura, M., Stewart, R. C., Li, T. K., and Weiss, F. (2001). Recent research on alcohol tolerance and dependence. Alcoholism: Clinical and Experimental Research 25: 189S-196S. PubMed Link
Grupe, A., Germer, S., Usuka, J., Aud, D., Belknap, J. K., Klein, R. F., Ahluwalia, M. K., Higuchi, R., and Peltz, G. (2001). In silico mapping of complex disease-related traits in mice. Science 292: 1915-1918. PubMed Link
Buck, K. J. and Finn, D. A. (2001). Genetic factors in addiction: QTL mapping and candidate gene studies implicate GABAergic genes in alcohol and barbiturate withdrawal in mice. Addiction 96: 139-149. PubMed Link
Reilly, M. T., Fehr, C., and Buck, K. J. (2001). Alcohol and gene expression in the central nervous system. In: Moussa-Moustaid, N. and Berdanier, C. D. (Eds.), Nutrient-Gene Interactions in Health and Disease, CRC Press, Boca Raton FL, pp. 131-162.
Belknap, J. K., Hitzemann, R., Crabbe, J. C., Phillips, T. J., Buck, K. J., and Williams, R. W. (2001). QTL analysis and genomewide mutagenesis in mice: Complementary genetic approaches to the dissection of complex traits. Behavior Genetics 31: 5-15. PubMed Link
Hood, H. M., Belknap, J. K., Crabbe, J. C., and Buck, K. J. (2001). Genomewide search for epistasis in a complex trait: Pentobarbital withdrawal convulsions in mice. Behavior Genetics 31: 93-100. PubMed Link
Bergeson, S. E., Helms, M. L., O'Toole, L. A., Jarvis, M. W., Hain, H. S., Mogil, J. S., and Belknap, J. K. (2001). Quantitative trait loci influencing morphine antinociception in four mapping populations. Mammalian Genome 12: 546-553. PubMed Link
Rustay, N. R., Boehm, S. L., Schafer, G. L., Browman, K. E., Erwin, V. G., and Crabbe, J. C. (2001). Sensitivity and tolerance to ethanol-induced incoordination and hypothermia in HAFT and LAFT mice. Pharmacology, Biochemistry and Behavior 70: 167-174. PubMed Link
Janowsky, A., Mah, C., Johnson, R. A., Cunningham, C. L., Phillips, T. J., Crabbe, J. C., Eshleman, A. J., and Belknap, J. K. (2001). Mapping genes that regulate density of dopamine transporters and correlated behaviors in recombinant inbred mice. Journal of Pharmacology and Experimental Therapeutics 298: 634-643. PubMed Link
Atkins, A. L., Helms, M. L., O'Toole, L. A., and Belknap, J. K. (2001). Stereotypic behaviors in mice selectively bred for high and low methamphetamine-induced stereotypic chewing. Psychopharmacology 157: 96-104. PubMed Link
Bachtell, R. K. and Ryabinin, A. E. (2001). Interactive effects of nicotine and alcohol co-administration on expression of inducible transcription factors in mouse brain. Neuroscience 103: 941-954. PubMed Link
Ryabinin, A. E., Bachtell, R. K., Freeman, P., and Risinger, F. O. (2001). ITF expression in mouse brain during acquisition of alcohol self- administration. Brain Research 890: 192-195. PubMed Link
Ueno, S., Harris, R. A., Messing, R. O., Sanchez-Perez, A. M., Hodge, C. W., McMahon, T., Wang, D., Mehmert, K. K., Kelley, S. P., Haywood, A., Olive, M. F., Buck, K. J., Hood, H. M., Blednov, Y., Findlay, G., and Mascia, M. P. (2001). Alcohol actions on GABA(A) receptors: from protein structure to mouse behavior. Alcoholism: Clinical and Experimental Research 25: 76S-81S. PubMed Link
Murray, S. E., Lallman, H. R., Heard, A. D., Rittenberg, M. B., and Stenzel-Poore, M. P. (2001). A genetic model of stress displays decreased lymphocytes and impaired antibody responses without altered susceptibility to Streptococcus pneumoniae. Journal of Immunology 167: 691-698. PubMed Link
Coste, S. C., Murray, S. E., and Stenzel-Poore, M. P. (2001). Animal models of CRH excess and CRH receptor deficiency display altered adaptations to stress. Peptides 22: 733-741. PubMed Link
Murray, S. E., Coste, S. C., Lindberg, I., and Stenzel-Poore, M. P. (2001). Genetic mutants with dysregulation of corticotropin pathways. Transgenic Models in Endocrinology, Kluwer Academic, Dordrecht, the Netherlands, pp. 143-173.
Crawshaw, L. I. and Wallace, H. L. (2001). Thermoregulation. In: Auerbach, P. S. (Eds.), Wilderness Medicine, Mosby, St. Louis.
Risinger, F. O., Freeman, P. A., Greengard, P., and Fienberg, A. A. (2001). Motivational effects of ethanol in DARPP-32 knock-out mice. Journal of Neuroscience 21: 340-348. PubMed Link
Belknap, J. K. and Atkins, A. L. (2001). The replicability of QTLs for murine alcohol preference drinking behavior across eight independent studies. Mammalian Genome 12: 893-899. PubMed Link
Wahlsten, D., Crabbe, J. C., and Dudek, B. C. (2001). Behavioural testing of standard inbred and 5HT(1B) knockout mice: implications of absent corpus callosum. Behavioural Brain Research 125: 23-32. PubMed Link
Crawshaw, L. I., Wallace, H. L., Christensen, R., and Crabbe, J. C. (2001). Influence of ethanol on thermoregulation: mapping quantitative trait loci. Physiological Genomics 7: 159-169. PubMed Link
Finn, D. A. (2001). Dissecting GABAergic and serotonergic involvement in anxiety. Behav Pharmacol 12: 467-470. PubMed Link
2000 [return to top of page]
Finn, D. A., Gallaher, E. J., and Crabbe, J. C. (2000). Differential change in neuroactive steroid sensitivity during ethanol withdrawal. Journal of Pharmacology and Experimental Therapeutics 292: 394-405. PubMed Link
McMahon, T., Andersen, R., Metten, P., Crabbe, J.C., and Messing, R. O. (2000). Protein kinase C epsilon mediates up-regulation of N-type calcium channels by ethanol. Molecular Pharmacology 57: 53-58. PubMed Link
Buck, K. J., Crabbe, J. C., and Belknap, J. K. (2000). Alcohol and other abused drugs. In: Pfaff, D. W., Berrettini, W. H., Joh, T. H., and Maxson, S. C. (Eds.), Genetic Influences on Neural and Behavioral Functions, CRC Press, Boca Raton FL, pp. 159-183.
Browman, K. E. and Crabbe, J. C. (2000). Quantitative trait loci affecting ethanol sensitivity in BXD recombinant inbred mice. Alcoholism: Clinical and Experimental Research 24: 17-23. PubMed Link
Cunningham, C. L. and Dworkin, S. I. (2000). Alcoholism and drug addiction: What determines vulnerability? Molecular Medicine Today 6: 101-103.
Rausch, R. N., Crawshaw, L. I., and Wallace, H. L. (2000). Effects of hypoxia, anoxia, and endogenous ethanol on thermoregulation in goldfish, Carassius auratus. American Journal of Physiology: Regulatory, Integrative, and Comparative Physiology 278: R545-R555. PubMed Link
Boehm, S. L., Schafer, G. L., Phillips, T. J., Browman, K. E., and Crabbe, J. C. (2000). Sensitivity to ethanol-induced motor incoordination in 5-HT(1B) receptor null mutant mice is task-dependent: implications for behavioral assessment of genetically altered mice. Behavioral Neuroscience 114: 401-409. PubMed Link
Coste, S. C., Kesterson, R. A., Heldwein, K. A., Stevens, S. L., Heard, A. D., Hollis, J. H., Murray, S. E., Hill, J. K., Pantely, G. A., Hohimer, A. R., Hatton, D. C., Phillips, T. J., Finn, D. A., Low, M. J., Rittenberg, M. B., Stenzel, P., and Stenzel-Poore, M. P. (2000). Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2. Nature Genetics 24: 403-409. PubMed Link
Hain, H. S., Crabbe, J. C., Bergeson, S. E., and Belknap, J. K. (2000). Cocaine-induced seizure thresholds: quantitative trait loci detection and mapping in two populations derived from the C57BL/6 and DBA/2 mouse strains. Journal of Pharmacology and Experimental Therapeutics 293: 180-187. PubMed Link
Boehm, S. L., Crabbe, J. C., and Phillips, T. J. (2000). Sensitivity to ethanol-induced motor incoordination in FAST and SLOW selectively bred mice. Pharmacology, Biochemistry and Behavior 66: 241-247. PubMed Link
Hood, H. M. and Buck, K. J. (2000). Allelic variation in the GABA A receptor gamma2 subunit is associated with genetic susceptibility to ethanol-induced motor incoordination and hypothermia, conditioned taste aversion, and withdrawal in BXD/Ty recombinant inbred mice. Alcoholism: Clinical and Experimental Research 24: 1327-1334. PubMed Link
Ryabinin, A. E., Wang, Y., Bachtell, R. K., Kinney, A. E., Grubb, M. C., and Mark, G. P. (2000). Cocaine- and alcohol-mediated expression of inducible transcription factors is blocked by pentobarbital anesthesia. Brain Research 877: 251-261. PubMed Link
Hatton, D. C., Qi, Y., and Belknap, J. K. (2000). Heritability of the blood pressure response to acute ethanol exposure in five inbred strains of mice. Alcoholism: Clinical and Experimental Research 24: 1483-1487. PubMed Link
Buck, K., Lischka, T., Dorow, J., and Crabbe, J. (2000). Mapping quantitative trait loci that regulate sensitivity and tolerance to quinpirole, a dopamine mimetic selective for D(2)/D(3) receptors. American Journal of Medical Genetics 96: 696-705. PubMed Link
Boyce, J. M. and Risinger, F. O. (2000). Enhancement of ethanol reward by dopamine D3 receptor blockade. Brain Research 880: 202-206. PubMed Link
Beadles-Bohling, A. S., Crabbe, J. C., and Wiren, K. M. (2000). Elevated prodynorphin expression associated with ethanol withdrawal convulsions. Neurochemistry International 37: 463-472. PubMed Link
Ron, D., Vagts, A. J., Dohrman, D. P., Yaka, R., Jiang, Z., Yao, L., Crabbe, J., Grisel, J. E., and Diamond, I. (2000). Uncoupling of bIIPKC from its targeting protein RACK1 in response to ethanol in cultured cells and mouse brain. FASEB Journal 14: 2303-2314. PubMed Link
Reilly, M. T. and Buck, K. J. (2000). GABA(A) receptor beta(2) subunit mRNA content is differentially regulated in ethanol-dependent DBA/2J and C57BL/6J mice. Neurochemistry International 37: 443-452. PubMed Link
Hoffman, P. L., Morrow, A. L., Phillips, T. J., and Siggins, G. R. (2000). Neuroadaptation to ethanol at the molecular and cellular levels. NIAAA Research Monograph 34: 85-188.
Browman, K. E., Crabbe, J. C., and Li, T.-K. (2000). Genetic strategies in preclinical substance abuse research. In: Bloom, F. E. and Kupfer, D. J. (Eds.), Psychopharmacology: A Fourth Generation of Progress, Lippincott, Williams, & Wilkins, New York.
Plomin, R. and Crabbe, J. (2000). DNA. Psychological Bulletin 126: 806-828. PubMed Link
Risinger, F. O. and Cunningham, C. L. (2000). DBA/2J mice develop stronger lithium chloride-induced conditioned taste and place aversions than C57BL/6J mice. Pharmacology, Biochemistry and Behavior 67: 17-24. PubMed Link
Cunningham, C. L. and Henderson, C. M. (2000). Ethanol-induced conditioned place aversion in mice. Behavioural Pharmacology 11: 591-602. PubMed Link
Cunningham, C. L., Fidler, T. L., and Hill, K. G. (2000). Animal models of alcohol's motivational effects. Alcohol Research and Health 24: 85-92. PubMed Link
Risinger, F. O., Freeman, P. A., Rubinstein, M., Low, M. J., and Grandy, D. K. (2000). Lack of operant ethanol self-administration in dopamine D2 receptor knockout mice. Psychopharmacology 152: 343-350. PubMed Link
Morikawa, H., Manzoni, O. J., Crabbe, J. C., and Williams, J. T. (2000). Regulation of central synaptic transmission by 5-HT(1B) auto- and heteroreceptors. Molecular Pharmacology 58: 1271-1278. PubMed Link
Ryabinin, A. E. (2000). ITF mapping after drugs of abuse: Pharmacological versus perceptional effects. Acta Neurobiologiae Experimentalis 60: 547-555. PubMed Link
Cunningham, C. L., Howard, M. A., Gill, S. J., Rubinstein, M., Low, M. J., and Grandy, D. K. (2000). Ethanol-conditioned place preference is reduced in dopamine D2 receptor- deficient mice. Pharmacology, Biochemistry and Behavior 67: 693-699. PubMed Link
Reilly, M. T., Crabbe, J. C., Rustay, N. R., and Finn, D. A. (2000). Acute neuroactive steroid withdrawal in withdrawal seizure-prone and withdrawal seizure-resistant mice. Pharmacology, Biochemistry and Behavior 67: 709-717. PubMed Link
Browman, K. E., Rustay, N. R., Nikolaidis, N., Crawshaw, L., and Crabbe, J. C. (2000). Sensitivity and tolerance to ethanol in mouse lines selected for ethanol-induced hypothermia. Pharmacology, Biochemistry and Behavior 67: 821-829. PubMed Link
Risinger, F. O., Quick, E., and Belknap, J. K. (2000). Quantitative trait loci for acute behavioral sensitivity to paraoxon. Neurotoxicology and Teratology 22: 667-674. PubMed Link
Mogil, J. S., Grisel, J. E., Hayward, M. D., Bales, J. R., Rubinstein, M., Belknap, J. K., and Low, M. J. (2000). Disparate spinal and supraspinal opioid antinociceptive responses in beta-endorphin-deficient mutant mice. Neuroscience 101: 709-717. PubMed Link
Atkins, A. L., Rustay, N. R., and Crabbe, J. C. (2000). Anxiety and sensitivity to ethanol and pentobarbital in alcohol withdrawal seizure-prone and withdrawal seizure-resistant mice. Alcoholism: Clinical and Experimental Research 24: 1743-1749. PubMed Link
Crabbe, J. C. (2000). Genetic modification as a tool for the study of behavioral consequences of signaling processes. NIAAA Research Monograph 35: 137-144.
Crabbe, J. C. (2000). And a mouse is miracle enough to stagger sextillions of infidels. (Review of "What's Wrong with My Mouse?"). Trends in Genetics 16: 365-366.
Crabbe, J. C. (2000). Review of alcohol and alcoholism: Effects on brain development. Journal of Studies on Alcohol 61: 484-485.
Finn, D. A. and Crabbe, J. C. (1999). Chronic ethanol differentially alters susceptibility to chemically induced convulsions in withdrawal seizure-prone and -resistant mice. Journal of Pharmacology and Experimental Therapeutics 288: 782-790. PubMed Link
Risinger, F. O., Doan, A. M., and Vickrey, A. C. (1999). Oral operant ethanol self-administration in 5-HT1b knockout mice. Behavioural Brain Research 102: 211-215. PubMed Link
Wood, R. D., Shen, E. H., Chester, J. A., and Phillips, T. J. (1999). Ontogeny of ethanol-induced locomotor activity and hypothermia differences in selectively bred FAST and SLOW mice. Pharmacology, Biochemistry and Behavior 62: 339-347. PubMed Link
Broadbent, J. and Harless, W. E. (1999). Differential effects of GABA(A) and GABA(B) agonists on sensitization to the locomotor stimulant effects of ethanol in DBA/2 J mice. Psychopharmacology 141: 197-205. PubMed Link
Crabbe, J. C. (1999). Psychopharmacogenetics of alcohol. In: Mormede, P. and Jones, B. C. (Eds.), Neurobehavioral Genetics: Methods and Applications, CRC Press, Boca Raton FL, pp. 329-339.
Crabbe, J. C. (1999). Animal models in neurobehavioral genetics: Methods for estimating genetic correlation. In: Mormede, P. and Jones, B. C. (Eds.), Neurobehavioral Genetics: Methods and Applications, CRC Press, Boca Raton FL, pp. 121-138.
Mark, G. P., Hajnal, A., Kinney, A. E., and Keys, A. S. (1999). Self-administration of cocaine increases the release of acetylcholine to a greater extent than response-independent cocaine in the nucleus accumbens of rats. Psychopharmacology 143: 47-53. PubMed Link
Ryabinin, A. E., Wang, Y. M., Freeman, P., and Risinger, F. O. (1999). Selective effects of alcohol drinking on restraint-induced expression of immediate early genes in mouse brain. Alcoholism: Clinical and Experimental Research 23: 1272-1280. PubMed Link
Thrasher, M. J., Freeman, P. A., and Risinger, F. O. (1999). Clozapine's effects on ethanol's motivational properties. Alcoholism: Clinical and Experimental Research 23: 1377-1385. PubMed Link
Crabbe, J. C., Wahlsten, D., and Dudek, B. C. (1999). Genetics of mouse behavior: Interactions with laboratory environment. Science 284: 1670-1672. PubMed Link
Ryabinin, A. E., Wang, Y. M., and Finn, D. A. (1999). Different levels of Fos immunoreactivity after repeated handling and injection stress in two inbred strains of mice. Pharmacology, Biochemistry and Behavior 63: 143-151. PubMed Link
Risinger, F. O., Brown, M. M., Oakes, R. A., and Love, J. A. (1999). Effects of haloperidol or SCH-23390 on ethanol-induced conditioned taste aversion. Alcohol 18: 139-145. PubMed Link
Chester, J. A. and Cunningham, C. L. (1999). Baclofen alters ethanol-stimulated activity but not conditioned place preference or taste aversion in mice. Pharmacology, Biochemistry and Behavior 63: 325-331. PubMed Link
Buck, K., Metten, P., Belknap, J., and Crabbe, J. (1999). Quantitative trait loci affecting risk for pentobarbital withdrawal map near alcohol withdrawal loci on mouse chromosomes 1, 4, and 11. Mammalian Genome 10: 431-437. PubMed Link
Mark, G. P., Kinney, A. E., Grubb, M. C., and Keys, A. S. (1999). Involvement of acetylcholine in the nucleus accumbens in cocaine reinforcement. Annals of the New York Academy of Sciences 877: 792-795. PubMed Link
Metten, P. and Crabbe, J. C. (1999). Genetic determinants of severity of acute withdrawal from diazepam in mice: Commonality with ethanol and pentobarbital. Pharmacology, Biochemistry and Behavior 63: 473-479. PubMed Link
Broadbent, J. and Weitemier, A. Z. (1999). Dizocilpine (MK-801) prevents the development of sensitization to ethanol in DBA/2J mice. Alcohol and Alcoholism 34: 283-288. PubMed Link
Buckman, J. F., Meshul, C. K., Finn, D. A., and Janowsky, A. (1999). Glutamate uptake in mice bred for ethanol withdrawal severity. Psychopharmacology 143: 174-182. PubMed Link
Crabbe, J. C. (1999). Molecular genetics of addiction. In: Charney, D. S., Nestler, E. J., and Bunney, B. S. (Eds.), Neurobiology of Mental Illness, Oxford Univ. Press, New York, pp. 591-600.
Grisel, J. E., Mogil, J. S., Grahame, N. J., Rubinstein, M., Belknap, J. K., Crabbe, J. C., and Low, M. J. (1999). Ethanol oral self-administration is increased in mutant mice with decreased beta-endorphin expression. Brain Research 835: 62-67. PubMed Link
Chester, J. A. and Cunningham, C. L. (1999). GABA(A) receptors modulate ethanol-induced conditioned place preference and taste aversion in mice. Psychopharmacology 144: 363-372. PubMed Link
Browman, K. E. and Crabbe, J. C. (1999). Alcohol and genetics: New animal models. Molecular Medicine Today 5: 310-318. PubMed Link
Crabbe, J. C., Phillips, T. J., Buck, K. J., Cunningham, C. L., and Belknap, J. K. (1999). Identifying genes for alcohol and drug sensitivity: recent progress and future directions. Trends in Neurosciences 22: 173-179. PubMed Link
Crabbe, J. C. and Cunningham, C. L. (1999). Drug and alcohol dependence-related behaviors. In: Crusio, W. E. and Gerlai, R. T. (Eds.), Handbook of Molecular-Genetic Techniques for Brain and Behavior Research, Elsevier, Amsterdam, pp. 652-666.
Ponomarev, I. and Crabbe, J. C. (1999). Genetic association between chronic ethanol withdrawal severity and acoustic startle parameters WSP and WSR mice. Alcoholism: Clinical and Experimental Research 23: 1730-1735. PubMed Link
Phillips, T. J., Hen, R., and Crabbe, J. C. (1999). Complications associated with genetic background effects in research using knockout mice. Psychopharmacology 147: 5-7. PubMed Link
Bachtell, R. K., Wang, Y. M., Freeman, P., Risinger, F. O., and Ryabinin, A. E. (1999). Alcohol drinking produces brain region-selective changes in expression of inducible transcription factors. Brain Research 847: 157-165. PubMed Link
Buckman, J. F. and Meshul, C. K. (1999). Glial differences between naive Withdrawal Seizure-Prone and -Resistant mice. Alcoholism: Clinical and Experimental Research 23: 1905-1913. PubMed Link
Cunningham, C. L., Dickinson, S. D., Grahame, N. J., Okorn, D. M., and McMullin, C. S. (1999). Genetic differences in cocaine-induced conditioned place preference in mice depend on conditioning trial duration. Psychopharmacology 146: 73-80. PubMed Link
Mogil, J. S., Wilson, S. G., Bon, K., Lee, S. E., Chung, K., Raber, P., Pieper, J. O., Hain, H. S., Belknap, J. K., Hubert, L., Elmer, G. I., Chung, J. M., and Devor, M. (1999). Heritability of nociception I: responses of 11 inbred mouse strains on 12 measures of nociception. Pain 80: 67-82. PubMed Link
Mogil, J. S., Wilson, S. G., Bon, K., Lee, S. E., Chung, K., Raber, P., Pieper, J. O., Hain, H. S., Belknap, J. K., Hubert, L., Elmer, G. I., Chung, J. M., and Devor, M. (1999). Heritability of nociception II. 'Types' of nociception revealed by genetic correlation analysis. Pain 80: 83-93. PubMed Link
Kest, B., Jenab, S., Brodsky, M., Sadowski, B., Belknap, J. K., Mogil, J. S., and Inturrisi, C. E. (1999). Mu and delta opioid receptor analgesia, binding density, and mRNA levels in mice selectively bred for high and low analgesia. Brain Research 816: 381-389. PubMed Link
Burrows, K. B. and Meshul, C. K. (1999). High-dose methamphetamine treatment alters presynaptic GABA and glutamate immunoreactivity. Neuroscience 90: 833-850. PubMed Link
Demarest, K., McCaughran, J., Mahjubi, E., Cipp, L., and Hitzemann, R. (1999). Identification of an acute ethanol response quantitative trait locus on mouse chromosome 2. Journal of Neuroscience 19: 549-561. PubMed Link
Hain, H. S., Belknap, J. K., and Mogil, J. S. (1999). Pharmacogenetic evidence for the involvement of 5-hydroxytryptamine (Serotonin)-1B receptors in the mediation of morphine antinociceptive sensitivity. Journal of Pharmacology and Experimental Therapeutics 291: 444-449. PubMed Link
1998 [return to top of page]
Dickinson, S. D. and Cunningham, C. L. (1998). Altered ambient temperature and ethanol-induced conditioned place preference in mice. Alcohol 16: 13-18. PubMed Link
Phillips, T. J., Brown, K. J., Burkhart-Kasch, S., Wenger, C. D., Kelly, M. A., Rubinstein, M., Grandy, D. K., and Low, M. J. (1998). Alcohol preference and sensitivity are markedly reduced in mice lacking dopamine D2 receptors. Nature Neuroscience 1: 610-615. PubMed Link
Rocha, B. A., Scearce-Levie, K., Lucas, J. J., Hiroi, N., Castanon, N., Crabbe, J. C., Nestler, E. J., and Hen, R. (1998). Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor. Nature 393: 175-178. PubMed Link
Belknap, J. K. (1998). Effect of within-strain sample size on QTL detection and mapping using recombinant inbred mouse strains. Behavior Genetics 28: 29-38. PubMed Link
Buck, K. J. and Amara, S. G. (1998). In vivo generation of chimeras. Methods in Enzymology 296: 466-475. PubMed Link
Crabbe, J. C. (1998). Provisional mapping of quantitative trait loci for chronic ethanol withdrawal severity in BXD recombinant inbred mice. Journal of Pharmacology and Experimental Therapeutics 286: 263-271. PubMed Link
Shen, E. H. and Phillips, T. J. (1998). MK-801 potentiates ethanol's effects on locomotor activity in mice. Pharmacology, Biochemistry and Behavior 59: 135-143. PubMed Link
Belknap, J. K., Riggan, J., Cross, S., Young, E. R., Gallaher, E. J., and Crabbe, J. C. (1998). Genetic determinants of morphine activity and thermal responses in 15 inbred mouse strains. Pharmacology, Biochemistry and Behavior 59: 353-360. PubMed Link
Chester, J. A., Risinger, F. O., and Cunningham, C. L. (1998). Ethanol reward and aversion in mice bred for sensitivity to ethanol withdrawal. Alcoholism: Clinical and Experimental Research 22: 468-473. PubMed Link
Risinger, F. O., Brown, M. M., Doan, A. M., and Oakes, R. A. (1998). Mouse strain differences in oral operant ethanol reinforcement under continuous access conditions. Alcoholism: Clinical and Experimental Research 22: 677-684. PubMed Link
Lessov, C. N. and Phillips, T. J. (1998). Duration of sensitization to the locomotor stimulant effects of ethanol in mice. Psychopharmacology 135: 374-382. PubMed Link
Keys, A. S., Mark, G. P., Emre, N., and Meshul, C. K. (1998). Reduced glutamate immunolabeling in the nucleus accumbens following extended withdrawal from self-administered cocaine. Synapse 30: 393-401. PubMed Link
Crabbe, J. C. and Phillips, T. J. (1998). Genetics of alcohol and other abused drugs. Drug and Alcohol Dependence 51: 61-71. PubMed Link
Metten, P., Belknap, J. K., and Crabbe, J. C. (1998). Drug withdrawal convulsions and susceptibility to convulsants after short-term selective breeding for acute ethanol withdrawal. Behavioural Brain Research 95: 113-122. PubMed Link
Keys, A. S. and Mark, G. P. (1998). D1 and D2 dopamine receptor mediation of amphetamine-induced acetylcholine release in nucleus accumbens. Neuroscience 86: 521-531. PubMed Link
Shen, E. H., Dorow, J., Harland, R., Burkhart-Kasch, S., and Phillips, T. J. (1998). Seizure sensitivity and GABAergic modulation of ethanol sensitivity in selectively bred FAST and SLOW mouse lines. Journal of Pharmacology and Experimental Therapeutics 287: 606-615. PubMed Link
Grahame, N. J., Low, M. J., and Cunningham, C. L. (1998). Intravenous self-administration of ethanol in beta-endorphin-deficient mice. Alcoholism: Clinical and Experimental Research 22: 1093-1098. PubMed Link
Crawshaw, L. I., Wallace, H., and Crabbe, J. (1998). Ethanol, body temperature and thermoregulation. Clinical and Experimental Pharmacology and Physiology 25: 150-154. PubMed Link
Ryabinin, A. E. (1998). Role of hippocampus in alcohol-induced memory impairment: Implications from behavioral and immediate early gene studies. Psychopharmacology 139: 34-43. PubMed Link
Risinger, F. O. and Cunningham, C. L. (1998). Ethanol-induced conditioned taste aversion in BXD recombinant inbred mice. Alcoholism: Clinical and Experimental Research 22: 1234-1244. PubMed Link
Cunningham, C. L. (1998). Drug conditioning and drug-seking behavior. In: O'Donohue, W. (Eds.), Learning and Behavior Therapy, Allyn & Bacon, Boston, pp. 518-544.
Crabbe, J. C., Belknap, J. K., Metten, P., Grisel, J. E., and Buck, K. J. (1998). Quantitative trait loci: Mapping drug and alcohol-related genes. Advances in Pharmacology 42: 1033-1037. PubMed Link
Crabbe, J. C., Gallaher, E. J., Cross, S. J., and Belknap, J. K. (1998). Genetic determinants of sensitivity to diazepam in inbred mice. Behavioral Neuroscience 112: 668-677. PubMed Link
Hajnal, A., Mark, G. P., Keys, A. S., and Lenard, L. (1998). Involvement of dopamine and acetylcholine in the interaction between amygdala and nucleus accumbens: chronic microdialysis in rats. Neurobiology 6: 363-367. PubMed Link
Ryabinin, A. E. and Wang, Y-M. (1998). Repeated alcohol administration differentially affects c-Fos and FosB protein immunoreactivity in DBA/2J mice. Alcoholism: Clinical and Experimental Research 22: 1646-1654. PubMed Link
Buck, K. J. (1998). Recent progress toward the identification of genes related to risk for alcoholism. Mammalian Genome 9: 927-928. PubMed Link
Phillips, T. J., Belknap, J. K., Buck, K. J., and Cunningham, C. L. (1998). Genes on mouse chromosomes 2 and 9 determine variation in ethanol consumption. Mammalian Genome 9: 936-941. PubMed Link
Buck, K. J. and Hood, H. M. (1998). Genetic association of a GABA(A) receptor gamma2 subunit variant with severity of acute physiological dependence on alcohol. Mammalian Genome 9: 975-978. PubMed Link
Schafer, G. L., Crabbe, J. C., and Wiren, K. M. (1998). Identification of neuroendocrine-specific protein as an ethanol-regulated gene with mRNA differential display. Mammalian Genome 9: 979-982. PubMed Link
Metten, P., Phillips, T. J., Crabbe, J. C., Tarantino, L. M., McClearn, G. E., Plomin, R., Erwin, V. G., and Belknap, J. K. (1998). High genetic susceptibility to ethanol withdrawal predicts low ethanol consumption. Mammalian Genome 9: 983-990. PubMed Link
Phillips, T. J. (1998). Alcohol-related genetics in animals: Knockouts and antisense technology. Report of a Subcommittee of the National Advisory Council on Alcohol Abuse and Alcoholism on the Review of the Extramural Research Portfolio for Genetics, DHHS, PHS, NIH pp. 38-40.
Chester, J. A. and Cunningham, C. L. (1998). Modulation of corticosterone does not affect the acquisition or expression of ethanol-induced conditioned place preference in DBA/2J mice. Pharmacology, Biochemistry and Behavior 59: 67-75. PubMed Link
Crabbe, J. C. and Belknap, J. K. (1998). Ethical consequences of mapping QTLs for complex human traits. In: Paterson, A. H. (Eds.), Molecular Dissection of Complex Traits, CRC Press, Boca Raton FL, pp. 279-285.
Klein, R. F., Mitchell, S. R., Phillips, T. J., Belknap, J. K., and Orwoll, E. S. (1998). Quantitative trait loci affecting peak bone mineral density in mice. Journal of Bone and Mineral Research 13: 1648-1656. PubMed Link
Phillips, T. J., Huson, M. G., and McKinnon, C. S. (1998). Localization of genes mediating acute and sensitized locomotor responses to cocaine in BXD/Ty recombinant inbred mice. Journal of Neruoscience 18: 3023-3034. PubMed Link
Kelly, M. A., Rubinstein, M., Phillips, T. J., Lessov, C. N., Burkhart-Kasch, S., Zhang, G., Bunzow, J. R., Fang, Y., Gerhardt, G. A., Grandy, D. K., and Low, M. J. (1998). Locomotor activity in D2 dopamine receptor-deficient mice is determined by gene dosage, genetic background, and developmental adaptations. Journal of Neruoscience 18: 3470-3479. PubMed Link
1997[return to top of page]
Crawshaw, L. I., Wallace, H. L., Crabbe, J. C., Ramos, C., Duerr, J., and O'Connor, C. S. (1997). Ethanol disrupts and decreases the regulated body temperature differentially in C57BL/6J and DBA/2J mice. American Journal of Physiology 273: R696-R702. PubMed Link
Burrows, K. B. and Meshul, C. K. (1997). Methamphetamine alters presynaptic glutamate immunoreactivity in the caudate nucleus and motor cortex. Synapse 27: 133-144. PubMed Link
Cunningham, C. L., Okorn, D. M., and Howard, C. E. (1997). Interstimulus interval determines whether ethanol produces conditioned place preference or aversion in mice. Animal Learning and Behavior 25: 31-42.
Rubinstein, M., Phillips, T. J., Bunzow, J. R., Falzone, T. L., Dziewczapolski, G., Zhang, G., Fang, Y., Larson, J. L., McDougall, J. A., Chester, J. A., Saez, C., Pugsley, T. A., Gershanik, O., Low, M. J., and Grandy, D. K. (1997). Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine. Cell 90: 991-1001. PubMed Link
Crabbe, J. C. (1997). Where does alcohol act in the brain? Molecular Psychiatry 2: 17-20.