PARC Publications

In Press
2013
2012 2011
2010 2009 2008 2007 2006
2005 2004 2003 2002 2001
2000 1999 1998 1997 1996

Reprints or PDFs are available for many publications. To request a copy, e-mail: rutledgm@ohsu.edu


Publications In Press
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Ryabinin AE (201X) Editorial: Evolutionary Perspectives on animal model of addiction: diverse models are welcome. Journal of Addiction Research and Therapy, in press.

Phillips TJ (201X) Biochemical Genetics / Alcoholism. In: S. Maloy and K. Hughes (Eds.), Brenner’s Online Encyclopedia of Genetics, 2nd Edition. Academic Press, Elsevier Inc., Oxford, UK, in press.

Phillips TJ (201X) Coisogenic. In: S. Maloy and K. Hughes (Eds.), Brenner’s Online Encyclopedia of Genetics, 2nd Edition. Academic Press, Elsevier Inc., Oxford, UK, in press.

Crabbe JC (200X) Mouse genetic models relevant for alcohol use disorders. In W.E. Crusio, F. Sluyter, and R.T. Gerlai (Eds.). Handbook of Behavior Genetics of the Mouse, Vol. 2, Genetic Mouse Models of Neurobehavioral Disorders, Cambridge University Press, Cambridge, in press.

Crabbe JC, Phillips TJ (201X) Genetic animal models. In: K. Sher (Ed). The Oxford Handbook of Substance Use Disorders, Oxford University Press, New York, in press.

Wahlsten D, Crabbe JC (201X) Replicability and reliability of behavioral tests. In W.E. Crusio, F. Sluyter, and R.T. Gerlai (Eds.). Handbook of Behavior Genetics of the Mouse, Vol. 1, Genetics of Behavioral Phenotypes, Cambridge University Press, Cambridge, in press.


2013 [return to top of page]

Crabbe JC, Kendler KS, Hitzemann RJ (2013) Modeling the diagnostic criteria for alcohol dependence with genetic animal models. Current Topics in Behavioral Neuroscience 13:187-221. PMID: 21910077  PubMed Link

Holstein SE, Li N, Eshleman AJ, Phillips TJ (2013) GABAB receptor activation attenuates the stimulant but not mesolimbic dopamine response to ethanol in FAST mice. Behavioural Brain Research 237C:49-58.  PMID: 22982185  PubMed Link


2012 [return to top of page]

Ary AA, Cozzoli DK, Finn DA, Crabbe JC, Dehoff MH, Worley PF and Szumlinski KK (2012) Ethanol up-regulates nucleus accumbens neuronal activity dependent pentraxin (Narp): implications for alcohol-induced behavioral plasticity. Alcohol 46:377-387. PMID: 22444953  PubMed Link

Barkley-Levenson AM, Crabbe JC (2012) Ethanol drinking microstructure of a high drinking in the dark selected mouse line. Alcoholism: Clinical and Experimental Research 36:1330-9. PMID: 22524154 PubMed Link

Barkley-Levenson AM, Crabbe, JC (2012) Bridging animal and human models: Translating from (and to) animal genetics. Alcohol Research: Current Reviews 34:325-335.
Free full text link: http://pubs.niaaa.nih.gov/publications/arcr343/325-335.htm

Buck KJ, Milner LC, Denmark DL, Grant SGN and Kozell LB (2012) Discovering Genes Involved in Alcohol Dependence and Other Alcohol Responses. Alcohol Research: Current Reviews 34:367-374.
Free full text link: http://pubs.niaaa.nih.gov/publications/arcr343/367-374.htm

Cozzoli DK, Courson J, Caruana AL, Miller BW, Greentree DI, Thompson AB, Wroten MG, Zhang PW, Xiao B, Hu JH, Klugmann M, Metten P, Worley PF, Crabbe JC, Szumlinski KK (2012) Nucleus accumbens mGluR5-associated signaling regulates binge alcohol drinking under Drinking-in-the-Dark procedures. Alcoholism: Clinical and Experimental Research 36:1623-33. PMID: 22432643 PubMed Link

Crabbe JC (2012) Translational behaviour-genetic studies of alcohol: are we there yet? Genes Brain and Behavior 11:375-86. PMID: 22510368 PubMed Link

Crabbe JC, Colville AM, Kruse LM, Cameron AJ, Spence SE, Schlumbohm JP, Huang LC, Metten P (2012) Ethanol Tolerance and Withdrawal Severity in High Drinking in the Dark Selectively Bred Mice.  Alcoholism: Clinical and Experimental Research 36:1152-1161. PMID: 22309139 PubMed Link

Crabbe JC, Harkness JH, Spence SE, Huang LC, Metten P (2012) Intermittent availability of ethanol does not necessarily lead to increased intake in mice.  Alcohol and Alcoholism 47:509-17. PMID: 22717273  PubMed Link

Crabbe JC, Kruse LM, Colville AM, Cameron AJ, Spence SE, Schlumbohm JP, Huang LC, Metten P (2012) Ethanol Sensitivity in High Drinking in the Dark Selectively Bred Mice.  Alcoholism: Clinical and Experimental Research 36:1162-1170.  PMID: 22316249 PubMed Link

Crabbe JC, Metten P, Huang LC, Schlumbohm JP, Spence SE, Barkley-Levenson AM, Finn DA, Rhodes JS and Cameron AJ (2012) Ethanol withdrawal-associated drinking and drinking in the dark: Common and discrete genetic contributions, Addiction Genetics, published online Oct 19. Free full text link: http://www.degruyter.com/view/j/addge.2012.1.issue/addge-2012-0002/addge-2012-0002.xml?format=INT

Cruz, M.T., Herman, M.A., Cote, D.M., Ryabinin, A.E., Roberto, M. (2012) Ghrelin increases GABAergic transmission and interacts with ethanol actions in the rat central nucleus of the amygdala. Neuropsychopharmacology, Sept 12, ePub ahead of print. PMID: 22968812  PubMed Link

Cservenka, A., Herting, M.M., Nagel, B.J. (2012) Atypical frontal lobe activity during verbal working memory in youth with a family history of alcoholism. Drug and Alcohol Dependence 123:98-104. PMID: 22088655 PubMed Link

Cservenka, A., Nagel, B.J. (2012) Risky decision-making: An fMRI study of youth at high risk for alcoholism. Alcoholism: Clinical and Experimental Research 36:604-615. PMID: 22250647 PubMed Link

Cunningham, C. L., Fidler, T. L., Murphy, K. V., Mulgrew, J. A., & Smitasin, P. J. (2012) Time-dependent negative reinforcement of ethanol intake by alleviation of acute withdrawal. Biological Psychiatry, Sept 18, ePub ahead of print.  PMID: 22999529 PubMed Link

Ferguson B, Hunter JH, Street SL, Woodall A, Luty J, Grant K (2012) Genetic load is associated with hypothalamic-pituitary-adrenal axis dysregulation in macaques.  Genes Brain and Behavior, Sept 21, ePub ahead of print.  PMID: 22998353  PubMed Link

Fidler, T. L., Powers, M. S., Ramirez, J. J., Crane, A. T.,  Mulgrew, J. A., Smitasin, P. J., & Cunningham, C. L. (2012) Dependence induced increases in Intragastric Alcohol Consumption (IGAC) in mice. Addiction Biology 17:13-32. PMCID: 21955048  PubMed Link

Fish, E.W., Robinson, J.E., Krouse, M.C., Hodge, C.W., Reed, C., Phillips, T.J. and Malanga, C.J. (2012) Intracranial self-stimulation in FAST and SLOW mice: Effects of alcohol and cocaine. Psychopharmacology 220:719-730. PMCID: 21983918 PubMed Link

Font L, Cunningham CL (2012) Post-retrieval propranolol treatment does not modulate reconsolidation or extinction of ethanol-induced conditioned place preference. Pharmacology, Biochemistry & Behavior 101:222–230. PMCID: 22285323  PubMed Link

Ford, M.M., McCracken, A.D., Wolf, N.T., Ryabinin, A.E., Grant, K.A. (2012) Discrimination of ethanol-nicotine drug mixtures in mice: dual interactive mechanisms of overshadowing and potentiation. Psychopharmacology, Jul 5, ePub ahead of print. PMCID: 22763667  PubMed Link

Foroud T, Phillips TJ (2012) Overview: Assessing the Genetic Risk for Alcohol Use Disorders Alcohol Research: Current Reviews 34:266-272. 
Free full text link: http://pubs.niaaa.nih.gov/publications/arcr343/266-273.htm

Gallego X, Ruiz-Medina J, Valverde O, Molas S, Robles N, Sabrià J, Crabbe JC, Dierssen M (2012) Transgenic over expression of nicotinic receptor alpha 5, alpha 3, and beta 4 subunit genes reduces ethanol intake in mice. Alcohol 46:205-15. PMCID: 22459873  PubMed Link

Giardino, W.J., Cote, D.M., Li, J., Ryabinin, A.E. (2012) Characterization of genetic differences within the centrally-projecting Edinger-Westphal nucleus of C57BL/6J and DBA/2J mice by expression profiling. Frontiers in Neuroanatomy, Epub. 6:5.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278674/

Groblewski, P. A., & Cunningham, C. L. (2012) Repeated microinjections into the medial prefrontal cortex (mPFC) impair extinction of conditioned place preference in mice. Behavioural Brain Research 230:299– 303. PMCID: 22342490  PubMed Link

Groblewski PA, Ryabinin AE, Cunningham CL (2012) Activation and role of the medial prefrontal cortex (mPFC) in extinction of ethanol-induced associative learning in mice.  Neurobiology of Learning and Memory:97:37-46. PMID: 21951632   PubMed Link

Gubner, N.R., McKinnon, C.S., Reed, C. and Phillips, T.J. (2012) Accentuating effects of nicotine on ethanol response in mice with high genetic predisposition to ethanol-induced locomotor stimulation. Drug and Alcohol Dependence Jul 11 2012 [Epub ahead of print]. PMID: 22795175  PubMed Link

Helms CM, Rossi D, Grant KA (2012)  Neurosteroid effects on sensitivity to ethanol.  Frontiers in Endocrinology (Lausanne) 3:10.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356014/

Helms CM, McClintick MN, Grant KA (2012) Social rank, chronic ethanol self-administration, and diurnal pituitary-adrenal activity in cynomolgus monkeys. Psychopharmacology 224:133-43. PMID: 22526537   PubMed Link

Hostetler CM, Ryabinin AE (2012) Commentary: Love and addiction: the devil is in the differences. Psychopharmacology 224: 27-29.  PMID: 22948669  PubMed Link

Iancu OD, Darakjian P, Kawane S, Bottomly D, Hitzemann R, McWeeney S (2012) Detection of expression quantitative trait Loci in complex mouse crosses: impact and alleviation of data quality and complex population substructure. Frontiers in Genetics 3:157.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427913/

Iancu OD, Kawane S, Bottomly D, Searles R, Hitzemann R, McWeeney S (2012) Utilizing RNA-Seq data for de novo coexpression network inference. Bioinformatics 28:1592-7. PMID: 22556371  PubMed Link

Kaur, S, Li, J., Stenzel-Poore, M.P., Ryabinin, A.E. (2012) Corticotropin releasing factor acting on corticotropin releasing factor receptor type 1 is critical for binge alcohol drinking in mice. Alcoholism: Clinical and Experimental Research 36:369-376.  PMID: 21895713  PubMed Link

Kendler, K.S., Aggen, S., Prescott, C.A., Crabbe, J.C., Neale, M.C. (2012) Evidence for multiple genetic factors underlying the DSM-IV criteria for alcohol dependence. Molecular Psychiatry 17:1306-1315 . PMID: 22105626 PubMed Link

Mackiewicz-Seghete, K., Cservenka, A., Herting, M.M., Nagel, B.J. (2012) Atypical spatial working memory and task-general brain activity in adolescents with a family history of alcoholism. Alcoholism: Clinical and Experimental Research, Oct 18, ePub ahead of print. PMID: 23078615 PubMed Link

Mitchell SH, Wilson VB (2012) Differences in delay discounting between smokers and nonsmokers remain when both rewards are delayed. Psychopharmacology 219:549–562. PMID: 21983917   PubMed Link

Moschak, T. M., Stang, K. A., Phillips, T. J., & Mitchell, S. H. (2012) Behavioral inhibition in mice bred for high vs low levels of methamphetamine consumption or sensitization. Psychopharmacology 222:353‐65. PMID: 22311384  PubMed Link

Moschak, T. M., & Mitchell, S. H. (2012) Acute ethanol administration and reinforcer magnitude reduction both reduce responding and increase response latency in a Go/No‐Go task. Alcoholism: Clinical and Experimental Research 36:1803‐1810. PMID: 22486407  PubMed Link

Olson CR, Owen DC, Ryabinin AE, Mello CV (2012) Poster: Drinking Songs! The efficacy of songbirds in alcohol research. Society for Neuroscience Annual Meeting, New Orleans, LA.   
SfN story: http://www.newscientist.com/article/dn22389-zebra-finches-sing-sloppily-when-drunk.ht

Pastor, R., Reed, C., Meyer, P.J., McKinnon, C., Ryabinin, A.E. and Phillips, T.J. (2012) Role of corticotropin releasing factor and corticosterone in behavioral sensitization to ethanol.  Journal of Pharmacology and Experimental Therapeutics 341:455-63. PMID: 22333290  PubMed Link

Philibin SD, Cameron AJ, Schlumbohm, JP, Metten P, Crabbe JC (2012) Ethanol Withdrawal-Induced Motor Impairment in Mice. Psychopharmacology 220:367-378. PMID: 21947288  PubMed Link

Rosenwasser AM, Fixaris MC, Crabbe JC, Brooks PC, Ascheid S (2012) Escalation of intake under intermittent ethanol access in diverse mouse genotypes. Addiction Biology, Aug 2, ePub ahead of print. PMID: 22862671  PubMed Link

Ryabinin, A.E., Tsoory. M.M., Kozicz, T., Thiele, T.E., Neufeld-Cohen, A., Chen, A., Lowery, E.G., Giardino, W.J., Kaur, S. (2012) Urocortins: CRF’s siblings and their potential role in anxiety, depression and alcohol drinking behavior. Alcohol 46:349-357. PMID: 22444954 PubMed Link

Tanchuck MA, Cozzoli DK, He I, Kaufman KR, Snelling C, Crabbe JC, Mark GP and Finn DA (2012) Local changes in neurosteroid levels in the substantia nigra pars reticulata and the ventral tegmental area alter chronic ethanol withdrawal severity in male Withdrawal Seizure-Prone mice, Alcoholism: Clinical and Experimental Research, Dec 20, ePub ahead of print. PMID: 23278716 PubMed Link

Wilhelm, C. J., & Mitchell, S. H. (2012) Acute ethanol does not always affect delay discounting in rats selected to prefer or avoid ethanol. Alcohol and Alcoholism 47:518‐24. PMID: 22645038  PubMed Link

Yankelevitz, R. L., Mitchell, S. H. & Zhang, Y. (2012) Gender differences in factors associated with alcohol drinking: Delay discounting and perception of others' drinking. Drug and Alcohol Dependence 123:273‐6. PMID: 22154359  PubMed Link


2011 [return to top of page]

Anacker AM, Loftis JM, Ryabinin AE (2011) Alcohol Intake in Prairie Voles is Influenced by the Drinking Level of a Peer. Alcoholism: Clinical and Experimental Research 35:1884-1890.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158264/

Anacker AM, Loftis JM, Kaur S, Ryabinin AE (2011) Prairie voles as a novel model of socially facilitated excessive drinking. Addiction Biology 16:92-107.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950896/

Beckley EH, Scibelli AC, Finn DA (2011) Progesterone receptor antagonist CDB-4124 increases depression-like behavior in mice without affecting locomotor ability. Psychoneuroendocrinology 36:824-833.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081939/

Bottomly D, Walter NA, Hunter JE, Darakjian P, Kawane S, Buck KJ , Searles RP, Mooney M, McWeeney SK, Hitzemann R (2011) Evaluating gene expression in C57BL/6J and DBA/2J mouse striatum using RNA-Seq and microarrays. PLoS One 6:e17820.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063777/?tool=pubmed

Chen G, Cuzon Carlson VC, Wang J, Beck A, Heinz A, Ron D, Lovinger DM, Buck KJ ( 2011) Striatal involvement in human alcoholism and alcohol consumption, and withdrawal in animal models. Alcoholism: Clinical and Experimental Research 35:1739-1748. 
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276303/

Chen G, Kozell LB, Buck KJ (2011) Substantia nigra pars reticulata is crucially involved in barbiturate and ethanol withdrawal in mice. Behavioural Brain Research 218:152-157. 
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075943/

Crabbe JC, Harris RA, Koob GF (2011) Preclinical studies of alcohol binge drinking. Annals of the New York Acad Sci 1216:24-40. 
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076900/

Crabbe JC, Spence SE, Brown LL, Metten P ( 2011) Alcohol preference drinking in a mouse line selectively bred for high drinking in the dark. Alcohol 45:427-440.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395368/

Cunningham CL, Groblewski PA, Voorhees CM (2011) Place conditionig, M. C. Olmstead (Ed.), Animal models of drug addiction (pp. 167-189), Neuromethods, vol. 53. Totowa, NJ: Humana Press.

Fei SS, Wilmarth PA, Hitzemann RJ, McWeeney SK, Belknap JK, David LL (2011) Protein Database and Quantitative Analysis Considerations when Integrating Genetics and Proteomics to Compare Mouse Strains. Journal of Proteome Research 10:2905-2912.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128464/?tool=pubmed

Fidler TL, Dion AM, Powers MS, Ramirez JJ, Mulgrew JA, Smitasin PJ, Crane AT, Cunningham CL (2011) Intragastric self-infusion of ethanol in high- and low-drinking mouse genotypes after passive ethanol exposure. Genes, Brain and Behavior 10:264-275.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070055/

Ford MM, Fretwell AM, Anacker AM, Crabbe JC, Mark GP, Finn DA (2011) The influence of selection for ethanol withdrawal severity on traits associated with ethanol self-administration and reinforcement. Alcoholism: Clinical and Experimental Research 35:326-337.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058687/

Giardino WJ, Cocking DL, Kaur S, Cunningham CL, Ryabinin AE (2011) Urocortin-1 in the centrally-projecting Edinger-Westphal nucleus is critical for ethanol preference. PLoS ONE
Free full text link: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0026997

Giardino, W.J., Pastor, R., Anacker, A.M.J., Spangler, E., Cote, D.M., Li, J., Stenzel-Poore, M., Phillips, T.J., Ryabinin, A.E. (2011) Dissection of corticotropin-releasing factor system involvement in locomotor sensitivity to methamphetamine. Genes, Brain and Behavior 10:78-89.    [PARC Animal Core provided animals]
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025045/

Giardino, W.J., Ryabinin, A.E. (2011) Commentary: Corticotropin-releasing factor: Innocent until proven guilty. Nature Reviews Neuroscience, 13:70.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365568/

Gremel CM, Young EA, Cunningham CL (2011) Blockade of opioid receptors in anterior cingulate cortex disrupts ethanol-seeking behavior in mice. Behavioural Brain Research 219:358-362. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062680/

Groblewski PA, Franken FH, Cunningham CL (2011) Inhibition of extracellular signal-regulated kinase (ERK) activity with SL327 does not prevent acquisition, expression, and extinction of ethanol-seeking behavior in mice. Behavioural Brain Research 217:399-407. 
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3019767/

Helms CM, Grant KA (2011) The effect of age on the discriminative stimulus effects of ethanol and its GABA(A) receptor mediation in cynomolgus monkeys. Psychopharmacology 216:333-43.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134136/

Herting MM, Fair D, Nagel BJ (2011) Altered fronto-cerebellar connectivity in alcohol-naive youth with a family history of alcoholism. Neuroimage 54:2582-2589.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150517/

Johnson BA, Messing RO, Charness ME, Crabbe JC, Goldman MS, Harris RA, Kranzler HR, Mitchell MC Jr, Nixon SJ, Riley EP, Schuckit MA, Sher KJ, Thomas JD (2011) Should the reorganization of addiction-related research across all the National Institutes of Health be structural?--The devil is truly in the details. Alcoholism: Clinical and Experimental Research 35:572-580. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068603/

Johnson BA, Messing RO, Charness ME, Crabbe JC, Goldman MS, Harris RA et al. (2011) How Should Addiction-Related Research at the National Institutes of Health be Reorganized? Frontiers in Psychiatry 2:2.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098615/?tool=pubmed

Laderas TG, Walter NA, Mooney M, Vartanian K, Darakjian P, Buck K, Harrington CA, Belknap J, Hitzemann R, McWeeney SK (2011) Computational detection of alternative exon usage. Frontiers in Neuroscience 5:69.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097375/?tool=pubmed

Metten P, Brown LL, Crabbe JC. 2011. Limited access ethanol drinking in the dark in adolescent and adult mice. Pharmacology, Biochemistry and Behavior 98:279-285.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057404/

Mitchell SH. 2011. The genetic basis of delay discounting and its genetic relationship to alcohol dependence. Behavioral Processes 87:10-17.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081405/

Mulligan MK, Rhodes JS, Crabbe JC, Mayfield RD, Adron HR, Ponomarev I. 2011. Molecular profiles of drinking alcohol to intoxication in C57BL/6J mice. Alcoholism: Clinical and Experimental Research 35:659-670.   
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066294/?tool=pubmed

Munn E, Bunning M, Prada S, Bohlen M, Crabbe JC, Wahlsten D. 2011. Reversed light-dark cycle and cage enrichment effects on ethanol-induced deficits in motor coordination assessed in inbred mouse strains with a compact battery of refined tests. Behavioural Brain Research 224:259-71. PMID: 21664382   PubMed Link

Pastor, R., Reed, C., Burkhart-Kasch, S., Li, N., Sharpe, A.L., Coste, S.C., Stenzel-Poore, M.P., Phillips, T.J. (2011) Ethanol concentration-dependent effects and the role of stress on ethanol drinking in corticotropin-releasing factor type 1 and double type 1 and 2 receptor knockout mice. Psychopharmacology 218:169-177.  PMID: 21487655  PubMed Link

Pastor, R., Font, L., Miquel, M., Phillips, T.J., Aragon, C.M.G. (2011) Involvement of the beta-endorphin neurons of the hypothalamic arcuate nucleus in ethanol-induced place preference conditioning in mice. Alcoholism: Clinical and Experimental Research 35:1-11.  PMID: 22014186  PubMed Link

Phillips TJ, Pastor R, Scibelli AC, Reed C, Tarragón E (2011) Behavioral sensitization to addictive drugs: Clinical relevance and methodological aspects. In J. Raber (ed.), Animal Models of Behavioral Analysis, Neuromethods Vol. 50 (pp. 267-305). Humana Press, New York.

Roselli CE, Finn TJ, Ronnekleiv-Kelly SM, Tanchuck MA, Kaufman KR, Finn DA. 2011. Localization of brain 5a-reductase messenger RNA in mice selectively bred for high chronic alcohol withdrawal severity. Alcohol 45:763-772. PMID: 21917407  PubMed Link

Voorhees CM, Cunningham CL. 2011. Involvement of the orexin/hypocretin system in ethanol conditioned place preference. Psychopharmacology 214:805-818. 
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063857/

Welsh JP, Han VZ, Rossi DJ, Mohr C, Odagiri M, Daunais JB, Grant KA (2011) Bidirectional plasticity in the primate inferior olive induced by chronic ethanol intoxication and sustained abstinence. Proceedings of the National Academy of Sciences USA 108:10314-10319. 
Free full text link:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121872/?tool=pubmed


2010 [return to top of page]

Blednov YA, Ozburn AR, Walker D, Ahmed S, Belknap JK, Harris RA. (2010) Hybrid mice as genetic models of high alcohol consumption. Behavior Genetics 40:93-110. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038337/?tool=pubmed

Boudreau E, Chen G, Li X, Buck K, Hitzemann R, Hickman D. (2010) Intraperitoneal catheter placement for pharmacological imaging studies in conscious mice. Lab Animal (NY) 39:23-25. PMID: 20023678  PubMed Link

Chen G, Buck KJ. (2010) Rostroventral caudate putamen involvement in ethanol withdrawal is influenced by a chromosome 4 locus. Genes, Brain and Behavior 9:768-776. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970669/?tool=pubmed

Crabbe JC. (2010) Consilience of rodent and human phenotypes relevant for alcohol dependence. Addiction Biology 15:103-108. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853473/?tool=pubmed

Crabbe JC, Phillips TJ, Belknap JK. (2010) The complexity of alcohol drinking: studies in rodent genetic models. Behavior Genetics 40:737-750. PMID: 20552264  PubMed Link

Crabbe JC, Bell RL, Ehlers CL. (2010) Human and laboratory rodent low response to alcohol: is better consilience possible? Addiction Biology 15:125-144. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853481/?tool=pubmed

Crabbe JC. (2010) Neurogenetic studies of alcohol addiction. Philos Trans R Soc Lond B Biol Sci 363:3201-3211. Reprinted in T.W. Robbins, B.J. Everitt, D.J. Nutt,, (Eds) Neurobiology of Addiction: New Vistas, Oxford University Press, New York, pp. 153-169.

Cservenka A, Spangler E, Cote DM, Ryabinin AE (2010). Postnatal developmental profile of urocortin 1 and cocaine- and amphetamine-regulated transcript in the perioculomotor region of C57BL/6J mice. Brain Research 1319:33-43. PubMed Link

Cunningham CL. (2010) Alcohol preference tests.  In I. Stolerman (Ed.), Encyclopedia of psychopharmacology, Part 1. (pp. 61-64).  Berlin Heidelberg: Springer-Verlag.

Dick D M, Smith G, Olausson P, Mitchell SH, Leeman RF, O'Malley SS, Sher K. (2010) Understanding the construct of impulsivity and its relationship to alcohol use disorders. Addiction Biology 15:217-226. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895996/?tool=pubmed

Ehlers CL, Walter NA, Dick DM, Buck KJ, Crabbe JC. (2010) A comparison of selected quantitative trait loci associated with alcohol use phenotypes in humans and mouse models. Addiction Biology 15:185-199. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848508/?tool=pubmed

Finn DA, Beckley EH, Kaufman KR and Ford MM. (2010) Manipulation of GABAergic steroids: Sex differences in the effects on alcohol drinking- and withdrawal-related behaviors. Hormones and Behavior57:12-22. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813380/?tool=pubmed

Flory GS, O'Malley J, Grant KA, Park B, Kroenke CD. (2010) Quantification of ethanol methyl (1)H magnetic resonance signal intensity following intravenous ethanol administration in primate brain. Methods 50:189-198. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828522/?tool=pubmed

Gremel CM, Cunningham CL. (2010) Effects of disconnection of amygdala dopamine and nucleus accumbens N-methyl-d-aspartate receptors on ethanol-seeking behavior in mice. European Journal of Neuroscience 31:148-155. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908034/?tool=pubmed

Gubner NR, Wilhelm CJ, Phillips TJ, Mitchell SH. (2010) Strain differences in behavioral inhibition in a Go/No-go task demonstrated using 15 inbred mouse strains. Alcoholism: Clinical and Experimental Research 34:1353-1362. PMID: 20491731  PubMed Link

Heilig M, Egli M, Crabbe JC, Becker HC. (2010) Acute withdrawal, protracted abstinence and negative affect in alcoholism: are they linked? Addiction Biology 15:169-184. PMID: 20148778  PubMed Link

Herting MM, Schwartz D, Mitchell SH, Nagel BJ. (2010) Delay discounting behavior and white matter microstructure abnormalities in youth with a family history of alcoholism. Alcoholism: Clinical and Experimental Research 34:1590-1602. PMID: 20586754  PubMed Link

Iancu OD, Darakjian P, Walter NA, Malmanger B, Oberbeck D, Belknap J, McWeeney S, Hitzemann R. (2010) Genetic diversity and striatal gene networks: focus on the heterogeneous stock-collaborative cross (HS-CC) mouse. BMC Genomics 11:585. Free full text link: http://www.biomedcentral.com/1471-2164/11/585

Kaufman KR, Tanchuck MA, Strong MN, Finn DA. (2010) Replacement with GABAergic steroid precursors restores the acute ethanol withdrawal profile in ADX/GDX mice. Neuroscience 166:5-14. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815158/?tool=pubmed

Lebold KM, Grant KA, Freeman WM, Wiren KM, Miller GW, Kiley C, Leonard SW, Traber MG. (2010) Individual differences in hyperlipidemia and vitamin E status in response to chronic alcohol self-administration in cynomolgus monkeys. Alcoholism: Clinical and Experimental Research 35:474-483. PMID: 21118275  PubMed Link

Leeman RF, Heilig M, Cunningham CL, Stephens DN, Duka T, O'Malley SS. (2010) Ethanol consumption: how should we measure it? Achieving consilience between human and animal phenotypes. Addiction Biology 15:109-124. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861719/?tool=pubmed

Lejuez CW, Magidson JF, Mitchell SH, Sinha R, Stevens MC, deWit H. (2010) Behavioral and biological indicators of impulsivity in the development of alcohol use, problems, and disorders. Alcoholism: Clinical and Experimental Research 34:1334-1345. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182265/?tool=pubmed

Metten P, Sorensen ML, Cameron AJ, Yu CH, Crabbe JC. (2010) Withdrawal severity after chronic intermittent ethanol in inbred mouse strains. Alcoholism: Clinical and Experimental Research 34:1552-1564. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929298/?tool=pubmed

Meyer AC, Rahman S, Charnigo RJ, Dwoskin LP, Crabbe JC, Bardo MT. (2010) Genetics of novelty seeking, amphetamine self-administration and reinstatement using inbred rats. Genes, Brain and Behavior 9:790-798. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965303/?tool=pubmed

Milner LC, Buck KJ. (2010) Identifying quantitative trait loci (QTLs) and genes (QTGs) for alcohol-related phenotypes in mice. International Review of Neurobiology 91:173-204. PMID: 20813243  PubMed Link

Pastor R, Kamens HM, McKinnon CS, Ford MM, Phillips TJ. (2010) Repeated ethanol administration modifies the temporal structure of sucrose intake patterns in mice: effects associated with behavioral sensitization. Addiction Biology 15:324-335. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904994/?tool=pubmed

Phillips TJ, Reed C, Burkhart-Kasch S, Li N, Hitzemann R, Yu CH, Brown LL, Helms ML, Crabbe JC, Belknap JK. (2010) A method for mapping intralocus interactions influencing excessive alcohol drinking. Mammalian Genome 21:39-51. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850100/?tool=pubmed

Sher KJ, Dick DM, Crabbe JC, Hutchison KE, O'Malley SS, Heath AC. (2010) Consilient research approaches in studying gene x environment interactions in alcohol research. Addiction Biology 15:200-216. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883915/?tool=pubmed

Stephens DN, Duka T, Crombag HS, Cunningham CL, Heilig M, Crabbe JC. (2010) Reward sensitivity: issues of measurement, and achieving consilience between human and animal phenotypes. Addiction Biology 15:145-168. PMID: 20148777  PubMed Link

Tambour S, Crabbe JC. (2010) Pharmacogenetics. In I.P. Stolerman (Ed.). Encyclopedia of Psychopharmacology, Part 16, Springer, New York, pp. 998-1001.


2009 [return to top of page]

Crabbe JC, Metten P, Rhodes JS, Yu CH, Brown LL, Phillips TJ, Finn DA. (2009) A line of mice selected for high blood ethanol concentrations shows drinking in the dark to intoxication.Biol Psychiatry 65:662-70.  PubMed Link 

Walter NA, Bottomly D, Laderas T, Mooney MA, Darakjian P, Searles RP, Harrington CA, McWeeney SK, Hitzemann R, Buck KJ. (2009) High throughput sequencing in mice: a platform comparison identifies a preponderance of cryptic SNPs. BMC Genomics 10:379.  PubMed Link Free full text link:  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743714/?tool=pubmed

Bohlen M, Cameron A, Metten P, Crabbe JC, Wahlsten D. (2009) Calibration of rotational acceleration for the rotarod test of rodent motor coordination. J Neurosci Methods 178:10-4.  PubMed Link 

Meyer PJ, Meshul CK, Phillips TJ. (2009) Ethanol- and cocaine-induced locomotion are genetically related to increases in accumbal dopamine. Genes Brain Behav 8:346-355. PubMed Link 

Beckstead MJ, Phillips TJ. (2009) Mice selectively bred for high- or low-alcohol-induced locomotion exhibit differences in dopamine neuron function. J Pharmacol Exp Ther 329:342-9.  PubMed Link

Scibelli AC, Phillips TJ. (2009) Combined scopolamine and ethanol treatment results in a locomotor stimulant response suggestive of synergism that is not blocked by dopamine receptor antagonists. Alcohol Clin Exp Res 33:435-47.  PubMed Link

Holstein SE, Dobbs L, Phillips TJ. (2009) Attenuation of the stimulant response to ethanol is associated with enhanced ataxia for a GABA, but not a GABA, receptor agonist. Alcohol Clin Exp Res 33:108-20.  PubMed Link 

Hitzemann R, Edmunds S, Wu W, Malmanger B, Walter N, Belknap J, Darakjian P, McWeeney S. (2009) Detection of reciprocal quantitative trait loci for acute ethanol withdrawal and ethanol consumption in heterogeneous stock mice. Psychopharmacology (Berl) 203:713-22.  PubMed Link 

Strong MN, Kaufman KR, Crabbe JC, Finn DA. (2009) Sex differences in acute ethanol withdrawal severity after adrenalectomy and gonadectomy in Withdrawal Seizure-Prone and Withdrawal Seizure-Resistant mice. Alcohol 43:367-77.  PubMed Link 

Cozzoli DK, Goulding SP, Zhang PW, Xiao B, Hu JH, Ary AW, Obara I, Rahn A, Abou-Ziab H, Tyrrel B, Marini C, Yoneyama N, Metten P, Snelling C, Dehoff MH, Crabbe JC, Finn DA, Klugmann M, Worley PF, Szumlinski KK. (2009) Binge drinking upregulates accumbens mGluR5-Homer2-PI3K signaling: functional implications for alcoholism. J Neurosci 29:8655-68.  PubMed Link 

Ford MM, Fretwell AM, Anacker A, Crabbe JC, Mark GP and Finn DA (2009). Withdrawal Seizure-Prone (WSP) and -Resistant (WSR) mice differ in operant responding for ethanol and reinstatement following conditioned cue presentation. Alcohol Clin Exp Res 33:222A.

Helms CM, Rogers LS, Grant KA. (2009) Antagonism of the ethanol-like discriminative stimulus effects of ethanol, pentobarbital, and midazolam in cynomolgus monkeys reveals involvement of specific GABA(A) receptor subtypes. Journal of Pharmacology and Experimental Therapeutics 331:142-152.  Free full text link:  http://jpet.aspetjournals.org/content/331/1/142.long

Tanchuck MA, Long SL, Ford MM, Hashimoto J, Crabbe JC, Roselli CE, Wiren KM, Finn DA. (2009) Selected Line Difference in the Effects of Ethanol Dependence and Withdrawal on Allopregnanolone Levels and 5alpha-Reductase Enzyme Activity and Expression. Alcohol Clin Exp Res 33:2077-2087. PubMed Link  Free full text link:  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789917/?tool=pubmed 

Finn DA, Beckley EH, Kaufman KR, Ford MM. (2009) Manipulation of GABAergic steroids: Sex differences in the effects on alcohol drinking- and withdrawal-related behaviors. Horm Behav. Jul 15. Epub ahead of print].  PubMed Link 

Chen G, Reilly MT, Kozell LB, Hitzemann R, Buck KJ (2009). Differential activation of limbic circuitry associated with chronic ethanol withdrawal in DBA/2J and C57BL/6J mice.  Alcohol 43:411-420. NIHMSID: NIHMS138669  PubMed Link 

Metten P, Crabbe JC, Belknap JK. (2009) Genetic correlates of morphine withdrawal in 14 inbred mouse strains. Drug Alcohol Depend 99:123-31.  PubMed Link 

Wilhelm CJ, Mitchell SH. (2009) Strain differences in delay discounting using inbred rats. Genes Brain Behav 8:426-34.  PubMed Link

Sharpe AL, Phillips TJ. (2009) Central urocortin 3 administration decreases limited-access ethanol intake in nondependent mice. Behav Pharmacol 20:346-51.  PubMed Link  

Carney PA, Bunce AE, Perrin N, Howarth LC, Beemsterboer P, Griest S, Cameron W. (2009) Educating the public about research funded by the National Institutes of Health using a partnership between an academic medical center and community-based science museum. J Commun Health 34:246–254.  PubMed Link  Free full text link:  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696630/?tool=pubmed

Bunce AE, Griest S, Howarth LC, Beemsterboer P, Cameron W, Carney PA. (2009) Educating youth about research funded by the National Institutes of Health using a partnership between an academic medical center and community-based science museum. J Commun Health 34:262–270.  PubMed Link  Free full text link:  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748739/?tool=pubmed

Gremel CM. Cunningham CL. (2009) Involvement of amygdala dopamine- and nucleus accumbens NMDA- receptors in ethanol-seeking behavior in mice. Neuropsychopharmacology 34:1443-1453.  PubMed Link 

Groblewski PA, Lattal KM, Cunningham CL. (2009) Effects of D-Cycloserine on the extinction and reconditioning of ethanol-seeking behavior in mice. Alcoholism: Clinical & Experimental Research  33:772-782.  PubMed Link 

Fidler TL, Oberlin BG, Struthers AM, Cunningham CL. (2009) Schedule of passive ethanol exposure affects subsequent intragastric ethanol self-infusion. Alcoholism: Clinical & Experimental Research 33:1909-1923.  PubMed Link  

Kozell LB, Walter NAR, Milner LC, Wickman K, Buck KJ (2009). Mapping a barbiturate withdrawal locus to a 0.44 Mb interval and analysis of a novel null mutant identify a role for Kcnj9 (GIRK3) in withdrawal from pentobarbital, zolpidem, and ethanol. Journal of Neuroscience 29:11662–11673.  PMC Journal - In Process  PubMed Link 

Kamens HM, McKinnon CS, Li N, Helms ML, Belknap JK, Phillips TJ (2009) The α3 subunit gene of the nicotinic acetylcholine receptor is a candidate gene for ethanol stimulation. Genes Brain Behav 8:600-609.  PubMed Link

Strong MN, Yoneyama N, Fretwell AM, Snelling C, Tanchuck MA, Finn DA (2009). “Binge” drinking experience in adolescent mice shows sex differences and elevated ethanol intake in adulthood. Horm Behav [Oct 23, Epub ahead of print].  PubMed Link

Dhaher R, Finn DA, Oberbeck DL, Yoneyama N, Snelling CC, Wu W, Hitzemann RJ (2009) Electrolytic lesions of the medial nucleus accumbens shell selectively decrease ethanol consumption without altering preference in a limited access procedure in C57BL/6J mice. Pharmacol Biochem Behav 92:335-342. PubMed Link

Blednov, YA, Ozburn, AR, Walker, D, Ahmed, S, Belknap, JK, Harris, RA. (2009) Hybrid mice as genetic models of high alcohol consumption.  Behavior Genetics, epub ahead of print.


2008 [return to top of page]

Belknap, J. K., Metten, P., Beckley, E. H., and Crabbe, J. C. (2008). Multivariate analyses reveal common and drug-specific genetic influences on responses to four drugs of abuse. Trends Pharmacol.Sci., Sept 4, Epub ahead of print.  PubMed Link 

Porter, J. H., Walentiny, D. M., Philibin, S. D., Vunck, S. A., and Crabbe, J. C. (2008). A comparison of the discriminative stimulus properties of the atypical antipsychotic drug clozapine in DBA/2 and C57BL/6 inbred mice. Behav.Pharmacol. 19: 530-542.  PubMed Link  

Crabbe, J. C. (2008). Review. Neurogenetic studies of alcohol addiction. Philos.Trans.R.Soc.Lond B Biol.Sci. 363: 3201-3211.  PubMed Link Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2607330/?tool=pubmed

Kamens, H. M. and Phillips, T. J. (2008). A role for neuronal nicotinic acetylcholine receptors in ethanol-induced stimulation, but not cocaine- or methamphetamine-induced stimulation. Psychopharmacology (Berl) 196: 377-387.  PubMed Link

Groblewski, P. A., Bax, L. S., and Cunningham, C. L. (2008). Reference-dose place conditioning with ethanol in mice: empirical and theoretical analysis. Psychopharmacology 201:97-106.  PubMed Link 

Wilhelm, C. J. and Mitchell, S. H. (2008). Rats bred for high alcohol drinking are more sensitive to delayed and probabilistic outcomes. Genes Brain Behav., Jun 2, Epub ahead of print.  PubMed Link

Hitzemann, R., Malmanger, B., Belknap, J., Darakjian, P., and McWeeney, S. (2008). Short-term selective breeding for High and Low prepulse inhibition of the acoustic startle response; pharmacological characterization and QTL mapping in the selected lines. Pharmacol.Biochem.Behav. 90:525-33.  PubMed Link Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2591930/?tool=pubmed 

Helms, C. M., Gubner, N. R., Wilhelm, C. J., Mitchell, S. H., and Grandy, D. K. (2008). D4 receptor deficiency in mice has limited effects on impulsivity and novelty seeking. Pharmacol.Biochem.Behav. 90: 387-393.  PubMed Link Free full text link:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603181/?tool=pubmed 

Helms, C. M. and Mitchell, S. H. (2008). Basolateral amygdala lesions and sensitivity to reinforcer magnitude in concurrent chains schedules. Behav.Brain Res. 191: 210-218.  PubMed Link Free full text link:  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475334/?tool=pubmed 

Crabbe, J. C., Cameron, A. J., Munn, E., Bunning, M., and Wahlsten, D. (2008). Overview of mouse assays of ethanol intoxication. Curr.Protoc.Neurosci. Chapter 9: Unit 9.26.  PubMed Link 

Gremel, C. M. and Cunningham, C. L. (2008). Roles of the nucleus accumbens and amygdala in the acquisition and expression of ethanol-conditioned behavior in mice. J.Neurosci. 28: 1076-1084.  PubMed Link Free full text link:  http://www.jneurosci.org/cgi/content/full/28/5/1076 

Mulligan, M. K., Ponomarev, I., Boehm, S. L., Owen, J. A., Levin, P. S., Berman, A. E., Blednov, Y. A., Crabbe, J. C., Williams, R. W., Miles, M. F., and Bergeson, S. E. (2008). Alcohol trait and transcriptional genomic analysis of C57BL/6 substrains. Genes Brain Behav. 7: 677-689.  PubMed Link  

Kozell, L., Belknap, J. K., Hofstetter, J. R., Mayeda, A., and Buck, K. J. (2008). Mapping a locus for alcohol physical dependence and associated withdrawal to a 1.1 Mb interval of mouse chromosome 1 syntenic with human chromosome 1q23.2-23.3. Genes Brain Behav. 7: 560-567.  PubMed Link 

Denmark, D. L. and Buck, K. J. (2008). Molecular analyses and identification of promising candidate genes for loci on mouse chromosome 1 affecting alcohol physical dependence and associated withdrawal. Genes Brain Behav. 7: 599-608.  PubMed Link 

Yoneyama, N., Crabbe, J. C., Ford, M. M., Murillo, A., and Finn, D. A. (2008). Voluntary ethanol consumption in 22 inbred mouse strains. Alcohol 42: 149-160.  PubMed Link Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396347/?tool=pubmed 

Philibin, S. D., Cameron, A. J., Metten, P., and Crabbe, J. C. (2008). Motor impairment: a new ethanol withdrawal phenotype in mice.  Behav.Pharmacol. 19: 604-614.  PubMed Link 

Reilly, M. T., Milner, L. C., Shirley, R. L., Crabbe, J. C., and Buck, K. J. (2008). 5-HT2C and GABAB receptors influence handling-induced convulsion severity in chromosome 4 congenic and DBA/2J background strain mice. Brain Res. 1198: 124-131.  PubMed Link Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2322873/?tool=pubmed 

Gabriel, K. I. and Cunningham, C. L. (2008). Effects of maternal strain on ethanol responses in reciprocal F1 C57BL/6J and DBA/2J hybrid mice. Genes Brain Behav. 7: 276-287.  PubMed Link 

Milner, L. C. and Crabbe, J. C. (2008). Three murine anxiety models: results from multiple inbred strain comparisons. Genes Brain Behav. 7: 496-505.  PubMed Link

Dhaher, R., Finn, D., Snelling, C., and Hitzemann, R. (2008). Lesions of the extended amygdala in C57BL/6J mice do not block the intermittent ethanol vapor-induced increase in ethanol consumption. Alcohol Clin.Exp.Res. 32: 197-208.  PubMed Link  

Beckley, E. H., Fretwell, A. M., Tanchuck, M. A., Gililland, K. R., Crabbe, J. C., and Finn, D. A. (2008). Decreased anticonvulsant efficacy of allopregnanolone during ethanol withdrawal in female Withdrawal Seizure-Prone vs. Withdrawal Seizure-Resistant mice. Neuropharmacology 54: 365-374.  PubMed Link  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2262286/?tool=pubmed 

Uhl, G. R., Drgon, T., Johnson, C., Fatusin, O. O., Liu, Q. R., Contoreggi, C., Li, C. Y., Buck, K., and Crabbe, J. (2008). "Higher order" addiction molecular genetics: convergent data from genome-wide association in humans and mice. Biochem.Pharmacol. 75: 98-111.  PubMed Link 

Hofstetter, J. R., Hitzemann, R. J., Belknap, J. K., Walter, N. A., McWeeney, S. K., and Mayeda, A. R. (2008). Characterization of the quantitative trait locus for haloperidol-induced catalepsy on distal mouse chromosome 1. Genes Brain Behav. 7: 214-223. PubMed Link 

Chen, G., Kozell, L.B., Hitzemann, R., Buck, K.J. (2008) Involvement of the limbic basal ganglia in ethanol withdrawal convulsivity in mice is influenced by a chromosome 4 locus. J Neurosci. 28:9840-9.  PubMed Link   

Tambour, S., Brown, L.L., Crabbe, J.C. (2008) Gender and Age at Drinking Onset Affect Voluntary Alcohol Consumption but Neither the Alcohol Deprivation Effect nor the Response to Stress in Mice. Alcohol Clin Exp Res. 32:1-7.  PubMed Link 

Hashimoto JG, Wiren KM. (2008) Neurotoxic consequences of chronic alcohol withdrawal: expression profiling reveals importance of gender over withdrawal severity. Neuropsychopharmacology 33:1084-96.   PubMed Link 

Belknap JK, Metten P, Beckley EH, Crabbe JC. (2008) Multivariate analyses reveal common and drug-specific genetic influences on responses to four drugs of abuse. Trends Pharmacol Sci 29:537-43.  PubMed Link 

Gililland-Kaufman KR, Tanchuck MA, Ford MM, Crabbe JC, Beadles-Bohling AS, Snelling C, Mark GP, Finn DA. (2008) The neurosteroid environment in the hippocampus exerts bi-directional effects on seizure susceptibility in mice. Brain Res 1243:113-23.  PubMed Link 

Wilhelm CJ, Mitchell SH. (2008) Rats bred for high alcohol drinking are more sensitive to delayed and probabilistic outcomes. Genes Brain Behav 7:705-13.  PubMed Link 

Denmark DL, Milner LC, Buck KJ (2008). Interval-specific congenic animals for high-resolution QTL mapping.  Alcohol Research & Health, 31:266-269.  Free full text link: http://pubs.niaaa.nih.gov/publications/arh313/266-269.pdf

Walter NAR, McWeeney SK, Peters ST, Belknap JK, Hitzemann R, Buck KJ (2008). SNP masking.  Alcohol Research & Health, 31:270-274. Free full text link: http://pubs.niaaa.nih.gov/publications/arh313/270-271.pdf

Ford MM, Beckley EH, Nickel JD, Eddy S, Finn DA. (2008) Ethanol intake patterns in female mice: influence of allopregnanolone and the inhibition of its synthesis. Drug Alcohol Depend 97:73-85.  PubMed Link   Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577122/?tool=pubmed

Cunningham CL, Gremel CM, Groblewski PA. (2008) Genetic influences on conditioned taste aversion. In S Reilly & TR Schachtman (Eds.), Conditioned taste aversion: Behavioral and neural processes (pp. 387-421). New York: Oxford University Press.

Ryabinin AE, Yoneyama N, Tanchuck MA, Mark GP, Finn DA (2008) Urocortin 1 microinjection into the mouse lateral septum regulates the acquisition and expression of alcohol consumption. Neuroscience 151:780-790. PubMed Link Free Full Text:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2262916/?tool=pubmed


2007 [return to top of page]

Bhave, S. V., Hornbaker, C., Phang, T. L., Saba, L., Lapadat, R., Kechris, K., Gaydos, J., McGoldrick, D., Dolbey, A., Leach, S., Soriano, B., Ellington, A., Ellington, E., Jones, K., Mangion, J., Belknap, J. K., Williams, R. W., Hunter, L. E., Hoffman, P. L., and Tabakoff, B. (2007). The PhenoGen Informatics website: tools for analyses of complex traits. BMC.Genet. 8: 59.  PubMed Link Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034588/?tool=pubmed

Crabbe, J. C. and Cunningham, C. L. (2007). Trait or state? Science 317: 1033-1035.  PubMed Link

Cunningham, C. L. and Patel, P. (2007). Rapid induction of Pavlovian approach to an ethanol-paired visual cue in mice. Psychopharmacology (Berl) 192: 231-241.  PubMed Link 

Finn, D. A., Snelling, C., Fretwell, A. M., Tanchuck, M. A., Underwood, L., Cole, M., Crabbe, J. C., and Roberts, A. J. (2007). Increased drinking during withdrawal from intermittent ethanol exposure is blocked by the CRF receptor antagonist D-Phe-CRF(12-41). Alcohol Clin.Exp.Res. 31: 939-949.  PubMed Link  

Ford, M. M., Mark, G. P., Nickel, J. D., Phillips, T. J., and Finn, D. A. (2007). Allopregnanolone influences the consummatory processes that govern ethanol drinking in C57BL/6J mice. Behav.Brain Res. 179: 265-272.  PubMed Link Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906740/?tool=pubmed

Gremel, C. M. and Cunningham, C. L. (2007). Role of test activity in ethanol-induced disruption of place preference expression in mice. Psychopharmacology (Berl) 191: 195-202.  PubMed Link 

Hill, K. G., Ryabinin, A. E., and Cunningham, C. L. (2007). FOS expression induced by an ethanol-paired conditioned stimulus. Pharmacol.Biochem.Behav. 87: 208-221.  PubMed Link Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2025694/?tool=pubmed  

Kamens, H. M. and Crabbe, J. C. (2007). The parallel rod floor test: a measure of ataxia in mice. Nat.Protoc. 2: 277-281.  PubMed Link

Kliethermes, C. L., Kamens, H. M., and Crabbe, J. C. (2007). Drug reward and intake in lines of mice selectively bred for divergent exploration of a hole board apparatus. Genes Brain Behav. 6:608-618.  PubMed Link 

Ford MM, Fretwell AM, Mark GP, Finn DA. Influence of reinforcement schedule on ethanol consumption patterns in non-food restricted male C57BL/6J mice. Alcohol 41:21-29, 2007. PubMed Link   Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2013928/?tool=pubmed 

Beckley EH, Finn DA. (2007) Inhibition of progesterone metabolism mimics the effect of progesterone withdrawal on forced swim test immobility. Pharmacol Biochem Behav 87:412-419.  PubMed Link Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2020505/?tool=pubmed

Gililland KR, Finn DA. (2007) The impact of gonadectomy and adrenalectomy on acute withdrawal severity in male and female C57BL/6 and DBA/2 mice following a single high dose of ethanol. Alcohol Clin Exp Res 31:1846-1857.  PubMed Link 

Gorin-Meyer RE, Wiren KM, Tanchuck MA, Long SL, Yoneyama N, Finn DA. (2007) Sex differences in the effect of finasteride on acute ethanol withdrawal severity in C57BL/6J and DBA/2J mice. Neuroscience 146:1302-15.  PubMed Link Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1963463/?tool=pubmed

Metten, P., Buck, K. J., Merrill, C. M., Roberts, A. J., Yu, C. H., and Crabbe, J. C. (2007). Use of a novel mouse genotype to model acute benzodiazepine withdrawal. Behav.Genet. 37: 160-170.  PubMed Link 

Meyer, P. J. and Phillips, T. J. (2007). Behavioral sensitization to ethanol does not result in cross-sensitization to NMDA receptor antagonists. Psychopharmacology 195:103-115.  PubMed Link

Ponder, C. A., Kliethermes, C. L., Drew, M. R., Muller, J., Das, K., Risbrough, V. B., Crabbe, J. C., Gilliam, T. C., and Palmer, A. A. (2007). Selection for contextual fear conditioning affects anxiety-like behaviors and gene expression. Genes Brain Behav., Epub – Feb 13.  PubMed Link

Rhodes, J. S., Ford, M. M., Yu, C. H., Brown, L. L., Finn, D. A., Garland, T., Jr., and Crabbe, J. C. (2007). Mouse inbred strain differences in ethanol drinking to intoxication. Genes Brain Behav. 6: 1-18.  PubMed Link 

Wahlsten, D., Crabbe, J.C. (2007) Behavioral testing. In J.G. Fox, C. Newcomer, A. Smith, S. Barhold, F. Quimby, and M. Davisson (Eds.) The Mouse in Biomedical Research, 2nd Edition, Vol. 3, Normative Biology, Immunology, and Husbandry, Elsevier, Amsterdam, pp. 513-534.

Walter, N. A., McWeeney, S. K., Peters, S. T., Belknap, J. K., Hitzemann, R., and Buck, K. J. (2007). SNPs matter: impact on detection of differential expression. Nat.Methods 4: 679-680.  PubMed Link 

Wilhelm, C. J., Reeves, J. M., Phillips, T. J., and Mitchell, S. H. (2007). Mouse Lines Selected for Alcohol Consumption Differ on Certain Measures of Impulsivity. Alcohol Clin.Exp.Res. 31:1839-1845. PubMed Link 

Laderas T, McWeeney S  (2007) Consensus framework for exploring microarray data using multiple clustering methods. OMICS 11(1):116-28 PubMed Link

Lattal KM (2007) Effects of ethanol on encoding, consolidation, and expression of extinction following contextual fear conditioning. Behav Neurosci 121:1280-1292. PubMed Link


2006 [return to top of page]

Crabbe JC, Phillips TJ, Harris RA, Arends MA, Koob GF (2006). Alcohol-related genes: contributions from studies with genetically engineered mice. Addict Biol. 11(3-4):195-269. PubMed Link 

Peirce, J. L., Li, H., Wang, J., Manly, K. F., Hitzemann, R. J., Belknap, J. K., et al. (2006). How replicable are mRNA expression QTL? Mamm Genome 17(6), 643-656.  PubMed Link

Wahlsten D, Bachmanov A, Finn DA, Crabbe JC (2006). Stability of inbred mouse strain differences in behavior and brain size between laboratories and across decades. Proc Natl Acad Sci USA 103:16364–16369.  PubMed Link  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1618164/?tool=pubmed

Gremel, C. M., Gabriel, K. I., & Cunningham, C. L. (2006). Topiramate does not affect the acquisition or expression of ethanol conditioned place preference in DBA/2J or C57BL/6J mice Alcoholism: Clinical & Experimental Research 30, 783-790.  PubMed Link

Hood HM, Metten P, Crabbe JC, and Buck KJ (2006).  Fine mapping of a sedative-hypnotic drug withdrawal locus on mouse chromosome 11. Genes Brain Behav 5:1-10.  PubMed Link 

Cunningham, C. L., Patel, P., & Milner, L. (2006). Spatial location is critical for conditioning place preference with visual but not tactile stimuli. Behavioral Neuroscience 120:1115–1132.  PubMed Link 

Cameron WE, McNerney C (2006). Strategy for engaging the Society for Neuroscience in science education. CBE Life Sciences Education 5:91-93.  PubMed Link Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1618521/?tool=pubmed

Mitchell SH, Reeves JM, Li N, Phillips TJ. (2006). Delay discounting predicts behavioral sensitization to ethanol in outbred WSC mice. Alcohol Clin Exp Res. 30(3):429-37.  PubMed Link 

Bice, PJ, Foroud, T, Carr, LG, Zhang, L, Liu, L, Grahame, NJ, Lumeng, L, Li, T-K and Belknap, JK (2006). Identification of QTLs influencing alcohol preference in the High Alcohol Preferring (HAP) and Low Alcohol Preferring (LAP) mouse lines.  Behavior Genetics 36:248-260.  PubMed Link 

Coste SC, Heard AD, Phillips TJ, Stenzel-Poore MP (2006). Corticotropin-releasing factor receptor type 2-deficient mice display impaired coping behaviors during stress. Genes Brain Behav. 5(2):131-8.  PubMed Link  

Crabbe JC, Metten P, Ponomarev I, Prescott CA, Wahlsten D (2006). Effects of genetic and procedural variation on measurement of alcohol sensitivity in mouse inbred strains. Behav Genet. 36(4):536-52.  PubMed Link  

Crawshaw LI, Wallace HL, O'Connor CS, Yoda T, Crabbe JC (2006). Tolerance and withdrawal in goldfish exposed to ethanol. Physiol Behav. 87(3):460-8.  PubMed Link 

Cunningham, C. L. (2006). If you want to understand alcohol abuse, you must also understand taste aversion conditioning.  Highlights Section, Conditioned Taste Aversion: An Annotated Bibliography.  URL:  [http://www.american.edu/academic.depts/cas/psych/Cunningham_Highlight.pdf] 

Rogers, J., R. Garcia, W. Shelledy, J. Kaplan, A. Arya, Z. Johnson, M. Bergstrom, L. Novakowski, P. Nair, A. Vinson, D. Newman, G. Heckman and J. Cameron (2006). An initial genetic linkage map of the rhesus macaque (Macaca mulatta) genome using human microsatellite loci. Genomics87:30-38.  PubMed Link 

Fidler, T. L., Clews, T. W., & Cunningham, C. L. (2006). Reestablishing an intragastric ethanol self-infusion model in rats. Alcoholism: Clinical & Experimental Research 30, 414-428.  PubMed Link

Finn DA, Beadles-Bohling AS, Beckley EH, Ford MM, Gililland KR, Gorin-Meyer RE and Wiren KM (2006). A new look at the 5-reductase inhibitor finasteride. CNS Drug Rev. 12:53-76.  PubMed Link 

Finn DA, Douglass AD, Beadles-Bohling AS, Tanchuck MA, Long SL and Crabbe JC (2006).  Selected line difference in sensitivity to a GABAergic neurosteroid during ethanol withdrawal. Genes Brain Behav. 5:53-63.  PubMed Link 

Kliethermes CL, Crabbe JC (2006).  Pharmacological and genetic influences on hole-board behaviors in mice. Pharmacol Biochem Behav. [Aug 30, Epub ahead of print].  PubMed Link

Kliethermes CL, Crabbe JC (2006). Genetic independence of mouse measures of some aspects of novelty seeking. Proc Natl Acad Sci U S A. 103(13):5018-23.  PubMed Link  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1405908/?tool=pubmed

Lattal, K. M., Radulovic, J. and Lukowiak, K. (2006). Extinction: does it or doesn't it? The requirement of altered gene activity and new protein synthesis. Biological Psychiatry 60, 344-51.  PubMed Link  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761679/?tool=pubmed 

Metten P, Buck KJ, Merril CM, Roberts AJ, Yu CH, Crabbe JC (2006). Use of a novel mouse genotype to model acute benzodiazepine withdrawal. Behavior Genet DOI 10.1007/s10519-006-9094-3.  PubMed Link 

Rogers, J., J. Kaplan, R. Garcia, W. Shelledy, S. Nair and J.L. Cameron (2006). Mapping of the serotonin transporter locus (SLC6A4) to rhesus chromosome 16 using genetic linkage. Cytogenetic and Genome Research112:341A 1-3.  PubMed Link

Mulligan, Mk, Ponomarev, I, Hitzemann, RJ, Belknap, JK, Tabakoff, B, Harris, RA, Crabbe, JC, Blednov, YA, Grahame, NJ, Phillips, TJ, Finn, DA, Hoffman, PL, Iyer, VR, Koob, GF and Bergeson, SE (2006). Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis, Proc Nat’l Acad Sci USA 103:6368-6373.  PubMed Link Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1458884/?tool=pubmed 

Beadles-Bohling AS, Wiren KM. (2006) Anticonvulsive effects of kappa-opioid receptor modulation in an animal model of ethanol withdrawal. Genes Brain Behav 5:483-96. .  PubMed Link

Palmer AA, Lessov-Schlaggar CN, Ponder CA, McKinnon CS, Phillips TJ (2006). Sensitivity to the locomotor-stimulant effects of ethanol and allopregnanolone: A quantitative trait locus study of common genetic influence. Genes Brain Behav. 5(7):506-17.  PubMed Link 

Sikela, JM, MacLaren, EJ, Kim, Y, Karimpour-Fard, A, Cai, W-W, Pollack, J, Hitzemann, R, Belknap, JK, McWeeney, S, Kerns, RT, Downing, C,Johnson, TE, Grant, KJ, Tabakoff, B, Hoffman, P, Wu, CC and Miles, MF (2006). DNA microarray and proteomic strategies for understanding alcohol actions. Alc: Clin Exp Res 30:700-708.  PubMed Link  Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709534/?tool=pubmed 

Crabbe, J.C. (2006) Identifying genes affecting addiction research in animal models. In B.K. Madras, C.M. Colvis, J.D. Pollock,  J.L. Rutter, D. Shurtleff, and M. von Zastrow, (Eds) Cell Biology of Addiction, Cold Springs Harbor Laboratory Press, New York, pp. 45-61.

Weitemier, A.Z., Ryabinin, A.E.  (2006) Urocortin 1 in the dorsal raphe regulates food and fluid consumption, but not ethanol preference in C57BL/6J mice. Neuroscience 137: 1439-1445.  PubMed Link 

Wilhelm, CJ, RA Johnson, AJ Eshleman and A Janowsky. (2006) Hydrogen ion concentration differentiates effects of methamphetamine and dopamine on transporter-mediated efflux.  J Neurochemistry 96:1149-59.  PubMed Link

Cunningham, C. L. and Gremel, C. M. (2006). Proximal ethanol pretreatment interferes with acquisition of ethanol-induced conditioned place preference. Pharmacol.Biochem.Behav. 85: 612-619.  PubMed Link   Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797418/?tool=pubmed  

Cunningham, C. L., Gremel, C. M., and Groblewski, P. A. (2006). Drug-induced conditioned place preference and aversion in mice. Nat.Protoc. 1: 1662-1670. PubMed Link

Holstein, S. E. and Phillips, T. J. (2006). GABAB receptor stimulation accentuates the locomotor effects of morphine in mice bred for extreme sensitivity to the stimulant effects of ethanol. Pharmacol.Biochem.Behav. 85: 697-704. PubMed Link Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1805633/?tool=pubmed 

Kamens, H. M., Burkhart-Kasch, S., McKinnon, C. S., Li, N., Reed, C., and Phillips, T. J. (2006). Ethanol-related traits in mice selectively bred for differential sensitivity to methamphetamine-induced activation. Behav.Neurosci. 120: 1356-1366. PubMed Link 

Malmanger, B., Lawler, M., Coulombe, S., Murray, R., Cooper, S., Polyakov, Y., Belknap, J., and Hitzemann, R. (2006). Further studies on using multiple-cross mapping (MCM) to map quantitative trait loci. Mamm.Genome 17: 1193-1204. PubMed Link 

Saba, L., Bhave, S. V., Grahame, N., Bice, P., Lapadat, R., Belknap, J., Hoffman, P. L., and Tabakoff, B. (2006). Candidate genes and their regulatory elements: alcohol preference and tolerance. Mamm.Genome 17: 669-688.  PubMed Link


2005 [return to top of page]

Phillips, T. J., Broadbent, J., Burkhart-Kasch, S., Henderson, C., Wenger, C. D., McMullin, C., McKinnon, C. S., & Cunningham, C. L. (2005). Genetic correlational analyses of ethanol reward and aversion phenotypes in short term selected mouse lines bred for ethanol drinking or ethanol-induced conditioned taste aversion. Behavioral Neuroscience 119:892–910.  PubMed Link

Crabbe JC, Metten P, Cameron AJ, Wahlsten D (2005). An analysis of the genetics of alcohol intoxication in inbred mice. Neuroscience and Biobehavioral Reviews 28:785-802.  PubMed Link

Ford MM, Nickel JD and Finn DA. (2005). Treatment with and withdrawal from finasteride alters ethanol intake patterns in male C57BL/6J mice: potential role of endogenous neurosteroids? Alcohol 37:25-33.  PubMed Link Free full text link:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1533880/?tool=pubmed

Lovinger DM, Crabbe JC (2005). Laboratory models of alcoholism: treatment target identification and insight into mechanisms. Nature Neuroscience 8:1471-80.  PubMed Link

Kozell L, Hitzemann R, Buck KJ (2005). Acute alcohol withdrawal involves c-Fos expression in the basal ganglia and associated circuitry: C57BL/6J and DBA/2J inbred mouse strain analyses. Alcoholism: Clinical and Experimental Research 29:1939-1948.  PubMed Link

Turek, V.F.,  Tsivkovskaia, N.O., Hyytia, P, Harding, S, Le, A.-D., Ryabinin, A.E.  (2005) Urocortin 1 expression in five pairs of rat lines selectively bred for differences in alcohol drinking. Psychopharmacology181:511-517.  PubMed Link
 
Bechtholt, A. J., & Cunningham, C. L. (2005). Ethanol-induced conditioned place preference is expressed through a ventral tegmental area dependent mechanism. Behavioral Neuroscience 119:213-223.  PubMed Link

Blednov YA, Metten P, Finn DA, Rhodes JS, Bergeson SE, Harris RA, Crabbe JC (2005). Hybrid C57BL/6J x FVB/NJ mice drink more alcohol than do C57BL/6J mice. Alcoholism: Clinical and Experimental Research 29:1949-58.  PubMed Link

Cronise K, Finn DA, Metten P, Crabbe JC (2005). Scheduled access to ethanol results in motor impairment and tolerance in female C57BL/6J mice. Pharmacology, Biochemistry and Behavior. 81:943-53.  PubMed Link

Fehr C, Shirley R, Crabbe JC, Belknap JK, Buck KJ, and Phillips TJ (2005). The syntaxin binding protein gene (Stxbp1) is a candidate for an ethanol preference drinking locus on mouse chromosome 2.  Alcoholism: Clinical and Experimental Research 29: 708-720.  PubMed Link

Finn DA, Belknap JK, Cronise K, Yoneyama N, Murillo A, Crabbe JC (2005). A procedure to produce high alcohol intake in mice. Psychopharmacology 178:471-80.  PubMed Link

Ford MM, Nickel JD, Phillips TJ, Finn DA (2005). Neurosteroid modulators of GABA(A) receptors differentially modulate Ethanol intake patterns in male C57BL/6J mice. Alcoholism: Clinical and Experimental Research 29:1630-40.  PubMed Link Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1540354/?tool=pubmed

Gabriel, K.I., & Cunningham, C. L. (2005). Effects of topiramate on ethanol and saccharin consumption and preferences in C57BL/6J mice. Alcoholism: Clinical and Experimental Research 29:75-80.  PubMed Link

Gorin RE, Crabbe JC, Tanchuck MA, Long SL and Finn DA (2005). Effects of finasteride on chronic and acute ethanol withdrawal severity in the WSP and WSR selected lines. Alcoholism: Clinical and Experimental Research 29:939-48.  PubMed Link

Hickman DL, Burkhart-Kasch S, Phillips TJ (2005). The effect of fostering on the genetic expression of locomotor sensitivity to alcohol. Comparative Medicine 55:498-502.  PubMed Link

Holstein SE, Pastor R, Meyer PJ, Phillips TJ (2005). Naloxone does not attenuate the locomotor effects of ethanol in FAST, SLOW, or two heterogeneous stocks of mice. Psychopharmacology 182:277-89. PubMed Link

Kamens HM, Phillips TJ, Holstein SE, Crabbe JC (2005). Characterization of the parallel rod floor apparatus to test motor incoordination in mice. Genes Brain and Behavior 4:253-66.  PubMed Link

Kamens HM, Burkhart-Kasch S, McKinnon CS, Li N, Reed C, Phillips TJ (2005). Sensitivity to psychostimulants in mice bred for high and low stimulation to methamphetamine. Genes Brain and Behavior 4:110-25.  PubMed Link

Kliethermes CL, Cronise K, Crabbe JC (2005). Home cage activity and ingestive behaviors in mice following chronic ethanol vapor inhalation. Physiology and Behavior 85:479-88.  PubMed Link

Cronise, K., Crabbe, J.C. (2005) Murine models of substance and alcohol dependence: unraveling genetic complexities. In G. Peltz (Ed.) Computational Genetics and Genomics: Tools for Understanding Disease, Humana Press, Totowa, N.J., pp 177-198.

Little, H. J., Stephens, D. N., Ripley, T. L., Borlikova, G., Duka, T., Schubert, M., Albrecht, D., Becker, H. C., Lopez, M. F., Weiss, F., Drummond, C., Peoples, M., & Cunningham, C. L. (2005). Alcohol withdrawal and conditioning. Alcoholism: Clinical and Experimental Research 29:453–464. PubMed Link

Matthews DB, Bhave SV, Belknap JK, Brittingham C, Chesler EJ, Hitzemann RJ, Hoffmann PL, Lu L, McWeeney S, Miles MF, Tabakoff B, Williams RW (2005). Complex genetics of interactions of alcohol and CNS function and behavior. Alcoholism: Clinical and Experimental Research 29:1706-19.  PubMed Link

Metten P, Crabbe JC (2005). Alcohol withdrawal severity in inbred mouse (Mus musculus) strains. Behavioral Neuroscience 119:911-25.  PubMed Link

Meyer PJ, Palmer AA, McKinnon CS, Phillips TJ (2005).  Behavioral sensitization to ethanol is modulated by environmental conditions, but is not associated with cross-sensitization to allopregnanolone or pentobarbital in DBA/2J mice. Neuroscience 131:263-73.  PubMed Link

Purdy RH, ValenzuelaCF, Janak PH, Finn DA, Biggio G, Bäckström T (2005). Neuroactive steroids and ethanol. Alcoholism: Clinical and Experimental Research 29:1292-1298.  PubMed Link

Rhodes JS, Crabbe JC (2005). Gene expression induced by drugs of abuse. Current Opinion in Pharmacology 5:26-33.  PubMed Link
 
Rhodes JS, Best K, Belknap JK, Finn DA, Crabbe JC (2005). Evaluation of a simple model of ethanol drinking to intoxication in C57BL/6J mice. Physiology and Behavior 84:53-63.  PubMed Link

Rhodes, J.S., Ryabinin, A.E., Crabbe, J.C. (2005) Patterns of brain activation associated with contextual conditioning to methamphetamine in mice, Behavioral Neuroscience 119:759-771.  PubMed Link

Sharpe AL, Coste SC, Burkhart-Kasch S, Li N, Stenzel-Poore MP, Phillips TJ (2005). Mice deficient in corticotropin-releasing factor receptor type 2 exhibit normal ethanol-associated behaviors. Alcoholism: Clinical and Experimental Research 29:1601-9.  PubMed Link

Sharpe, A.L., Tsivkovskaia, N.O., Ryabinin, A.E. (2005) Ataxia and c-Fos expression in mice drinking ethanol in a limited access session, Alcoholism: Clinical and Experimental Research29:1419-1426.  PubMed Link

Turek, V.F., Ryabinin, A.E. (2005) Ethanol vs. Lipopolysaccharide-induced hypothermia: involvement of urocortin, Neuroscience 133:1021-1028.  PubMed Link

Turek, V.F., Ryabinin, A.E. (2005) Expression of c-Fos in the Edinger-Westphal nucleus following ethanol administration is not secondary to hypothermia or stress, Brain Research 1063:132-139.  PubMed Link

Wahlsten D, Cooper SF, Crabbe JC (2005). Different rankings of inbred mouse strains on the Morris maze and a refined 4-arm water escape task. Behavioural Brain Research 165:36-51.  PubMed Link

Weitemier, A.Z., Ryabinin, A.E. (2005) Brain region-specific regulation of urocortin 1 innervation and corticotropin-releasing hormone receptor type 2 binding by ethanol exposure. Alcoholism: Clinical and Experimental Research 29:1610-1620.  PubMed Link

Weitemier, A.Z., Ryabinin, A.E. (2005) Lesions of the Edinger-Westphal nucleus alter food and water consumption, Behavioral Neuroscience 119:1235-1243.  PubMed Link

Weitemier, A.Z., Tsivkovskaia, N.O., Ryabinin, A.E. (2005) Urocortin 1 distribution in mouse brain is strain-dependent, Neuroscience 132:729-740.  PubMed Link


2004 [return to top of page]

Kamens, H. M., Phillips, T. J., Holstein, S. E., and Crabbe, J. C. (2004) Characterization of the parallel rod floor apparatus to test motor incoordination in mice. Genes, Brain and Behavior, OnlineEarly 14 September.

Finn, D. A., Ford, M. M., Wiren, K. M., Roselli, C. E., and Crabbe, J. C. (2004). The role of pregnane neurosteroids in ethanol withdrawal: behavioral genetic approaches. Pharmacology and Therapeutics 101: 91-112. PubMed Link

Finn, D. A., Sinnott, R. S., Ford, M. M., Long, S. L., Tanchuck, M. A., and Phillips, T. J. (2004). Sex differences in the effect of ethanol injection and consumption on brain allopregnanolone levels in C57BL/6 mice. Neuroscience 123: 813-819. PubMed Link

Fehr, C., Shirley, R. L., Metten, P., Kosobud, A. E., Belknap, J. K., Crabbe, J. C., and Buck, K. J. (2004). Potential pleiotropic effects of Mpdz on vulnerability to seizures. Genes, Brain and Behavior 3: 8-19. PubMed Link

Klein, R. F., Allard, J., Avnur, Z., Nikolcheva, T., Rotstein, D., Carlos, A. S., Shea, M., Waters, R. V., Belknap, J. K., Peltz, G., and Orwoll, E. S. (2004). Regulation of bone mass in mice by the lipoxygenase gene Alox15. Science 303: 229-232. PubMed Link

Mueller, J. L., Ellenberger, E. A., Vaughn, L. K., Belknap, J. K., and Quock, R. M. (2004). Detection and mapping of quantitative trait loci that determine responsiveness of mice to nitrous oxide antinociception. Neuroscience 123: 743-749. PubMed Link

Weitemier, A. Z. and Ryabinin, A. E. (2004). Subregion-specific differences in hippocampal activity between Delay and Trace fear conditioning: an immunohistochemical analysis. Brain Research 995: 55-65. PubMed Link

Metten, P., Best, K. L., Cameron, A. J., Saultz, A. B., Zuraw, J. M., Yu, C. H., Wahlsten, D., and Crabbe, J. C. (2004). Observer-rated ataxia: Rating scales for assessment of genetic differences in ethanol-induced intoxication in mice. Journal of Applied Physiology Epub ahead of print, March 19th. PubMed Link

Kliethermes, C. L., Metten, P., Belknap, J. K., Buck, K. J., and Crabbe, J. C. (2004). Selection for pentobarbital withdrawal severity: correlated differences in withdrawal from other sedative drugs. Brain Research 1009: 17-25. PubMed Link

Rustay, N. R. and Crabbe, J. C. (2004). Genetic analysis of rapid tolerance to ethanol's incoordinating effects in mice: inbred strains and artificial selection. Behavior Genetics 34: 441-451. PubMed Link

Shirley, R. L., Walter, N. A., Reilly, M. T., Fehr, C., and Buck, K. J. (2004). Mpdz is a quantitative trait gene for drug withdrawal seizures. Nature Neuroscience 7: 699-700. PubMed Link

Buck, K. J., Reilly, M. T., Rogers, L. M., Szeliga, K., Grant, K., and Brodie, M. S. (2004). Serotonin 5-HT2 receptors and alcohol: reward, withdrawal and discrimination. Alcoholism: Clinical and Experimental Research 28: 211-216. PubMed Link

Bechtholt, A. J., Smith, R., Raber, J., and Cunningham, C. L. (2004). Enhanced ethanol-, but not cocaine-induced, conditioned place preference in Apoe-/- mice. Pharmacol Biochem.Behav. 77: 783-792. PubMed Link

Fidler, T. L., Bakner, L., and Cunningham, C. L. (2004). Conditioned place aversion induced by intragastric administration of ethanol in rats. Pharmacol Biochem.Behav. 77: 731-743. PubMed Link

Samson, H. H., Cunningham, C. L., Czachowski, C. L., Chappell, A., Legg, B., and Shannon, E. (2004). Devaluation of ethanol reinforcement. Alcohol 32: 203-212. PubMed Link

Gabriel, K. I., Cunningham, C. L., and Finn, D. A. (2004) Allopregnanolone does not influence ethanol-induced conditioned place preference in DBA/2J mice. Psychopharmacology: 50-56. PubMed Link

Palmer, A. A., Sharpe, A. L., Burkhart-Kasch, S., McKinnon, C. S., Coste, S. C., Stenzel-Poore, M. P., and Phillips, T. J. (2004) Corticotropin-releasing factor overexpression decreases ethanol drinking and increases sensitivity to the sedative effects of ethanol. Psychopharmacology 176: 386-397. PubMed Link

Kliethermes, C. L., Cronise, K., and Crabbe, J. C. (2004). Anxiety-like behavior in mice in two apparatuses during withdrawal from chronic ethanol vapor inhalation. Alcoholism: Clinical and Experimental Research 28: 1012-1019. PubMed Link

Ponomarev, I. and Crabbe, J. C. (2004). Characterization of acute functional tolerance to the hypnotic effects of ethanol in mice. Alcoholism: Clinical and Experimental Research 28: 991-997. PubMed Link

Finn, D. A., Long, S. L., Tanchuck, M. A., and Crabbe, J. C. (2004). Interaction of chronic ethanol exposure and finasteride: sex and strain differences. Pharmacology Biochemistry and Behavior 78: 435-443. PubMed Link

Rutledge-Gorman, M. and Cynkar, D. (2004). Of brains and safety: neuroscience for five year olds. Primary Science Review 84:17-20.

Hitzemann, R., Reed, C., Malmanger, B., Lawler, M., Hitzemann, B., Cunningham, B., Belknap, J.K., Buck, K.J., Phillips, T.J., and Crabbe, J.C. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. Alcoholism: Clinical and Experimental Research 28: 1437-1448. PubMed Link

Bachtell, R.K., Weitemier, A.Z., and Ryabinin, A.E. (2004) Lesions of the Edinger-Westphal nucleus in C57BL/6J mice disrupt ethanol-induced hypothermia and ethanol consumption. European Journal of Neuroscience 20: 1613-1623. PubMed Link

Boyce-Rustay, J.M., and Cunningham, C.L. (2004) The role of NMDA receptor binding sites in ethanol place conditioning. Behavioral Neuroscience 118: 822-834. PubMed Link

Hayward, M. D., Hansen, S. T., Pintar, J. E., and Low, M. J. (2004) Operant self-administration of ethanol in C57BL/6 mice lacking beta-endorphin and enkephalin. Pharmacology Biochemistry and Behavior 79: 171-181. PubMed Link

Williams, R. W., Bennett, B., Lu, L., Gu, J., DeFries, J. C., Carosone-Link, P. J., Rikke, B. A., Belknap, J. K., and Johnson, T. E. (2004) Genetic structure of the LXS panel of recombinant inbred mouse strains: a powerful resource for complex trait analysis. Mammalian Genome 15: 637-647. PubMed Link

Phillips, T. J. and Crabbe, J. C. (2004) Let's not discourage innovative approaches to complex questions. Alcoholism: Clinical and Experimental Research 28: 1607-1608. PubMed Link

Churchill, G. A., Airey, D. C., Allayee, H., Angel, J. M., Attie, A. D., Beatty, J., Beavis, W. D., Belknap, J. K., Bennett, B., Berrettini, W., Bleich, A., Bogue, M., Broman, K. W., Buck, K. J., Buckler, E., Burmeister, M., Chesler, E. J., Cheverud, J. M., Clapcote, S., Cook, M. N., Cox, R. D., Crabbe, J. C., Crusio, W. E., Darvasi, A., Deschepper, C. F., Doerge, R. W., Farber, C. R., Forejt, J., Gaile, D., Garlow, S. J., Geiger, H., Gershenfeld, H., Gordon, T., Gu, J., Gu, W., de Haan, G., Hayes, N. L., Heller, C., Himmelbauer, H., Hitzemann, R., Hunter, K., Hsu, H. C., Iraqi, F. A., Ivandic, B., Jacob, H. J., Jansen, R. C., Jepsen, K. J., Johnson, D. K., Johnson, T. E., Kempermann, G., Kendziorski, C., Kotb, M., Kooy, R. F., Llamas, B., Lammert, F., Lassalle, J. M., Lowenstein, P. R., Lu, L., Lusis, A., Manly, K. F., Marcucio, R., Matthews, D., Medrano, J. F., Miller, D. R., Mittleman, G., Mock, B. A., Mogil, J. S., Montagutelli, X., Morahan, G., Morris, D. G., Mott, R., Nadeau, J. H., Nagase, H., Nowakowski, R. S., O'Hara, B. F., Osadchuk, A. V., Page, G. P., Paigen, B., Paigen, K., Palmer, A. A., Pan, H. J., Peltonen-Palotie, L., Peirce, J., Pomp, D., Pravenec, M., Prows, D. R., Qi, Z., Reeves, R. H., Roder, J., Rosen, G. D., Schadt, E. E., Schalkwyk, L. C., Seltzer, Z., Shimomura, K., Shou, S., Sillanpaa, M. J., Siracusa, L. D., Snoeck, H. W., Spearow, J. L., Svenson, K., Tarantino, L. M., Threadgill, D., Toth, L. A., Valdar, W., de Villena, F. P., Warden, C., Whatley, S., Williams, R. W., Wiltshire, T., Yi, N., Zhang, D., Zhang, M., and Zou, F. (2004) The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nature Genetics 36: 1133-1137. PubMed Link

Bechtholt, A. J., Gremel, C. M., and Cunningham, C. L. (2004) Handling blocks expression of conditioned place aversion but not conditioned place preference produced by ethanol in mice. Pharmacology Biochemistry and Behavior 79: 739-744. PubMed Link

Crabbe, J. C. and Morris, R. G. (2004) Festina lente: late-night thoughts on high-throughput screening of mouse behavior. Nature Neuroscience 7: 1175-1179. PubMed Link

Kale, A., Amende, I., Meyer, G. P., Crabbe, J. C., and Hampton, T. G. (2004) Ethanol's effects on gait dynamics in mice investigated by ventral plane videography. Alcoholism: Clinical and Experimental Research 28: 1839-1848. PubMed Link

Zucker, S., Crabbe, J. C., Cooper, G., Finkelman, F., Largman, C., McCarley, R. W., Rice, L., Rubin, J., Richardson, B., Seil, F., Snider, G. L., and Vandenbark, A. A. (2004) Veterans Administration support for medical research: opinions of the endangered species of physician-scientists. FASEB 18: 1481-1486. PubMed Link

Crabbe, J. C. and Phillips, T. J. (2004). Pharmacogenetic studies of alcohol self administration and withdrawal. Psychopharmacology 174: 539-560. PubMed Link


2003 [return to top of page]

Cunningham, C. L. and Phillips, T. J. (2003). Genetic basis of ethanol reward. In: Maldonado, R. (Eds.), Molecular Biology of Drug Addiction, Humana Press, Totowa, N.J., pp. 263-294.

Crabbe, J. C. (2003). Finding genes for complex behaviors: progress in mouse models of the addictions. In: Plomin, R., DeFries, J. C., Craig, I. W., and McGuffin, P. (Eds.), Behavioral Genetics in the Postgenomic Era, American Psychological Association, WashingtAmerican Psychological Associationon, D.C., pp. 291-308.

Crabbe, J. C. (2003). Current strategies for identifying genes for alcohol sensitivity. In: Maldonado, R. (Eds.), Molecular Biology of Drug Addiction, Humana Press, Totowa, N.J., pp. 249-261.

Bachtell, R. K., Tsivkovskaia, N. O., and Ryabinin, A. E. (2003). Identification of temperature-sensitive neural circuits in mice using c-Fos expression mapping. Brain Research 960: 157-164. PubMed Link

Wahlsten, D., Metten, P., Phillips, T. J., Boehm, S. L., Burkhart-Kasch, S., Dorow, J., Doerksen, S., Downing, C., Fogarty, J., Rodd-Henricks, K., Hen, R., McKinnon, C. S., Merrill, C. M., Nolte, C., Schalomon, M., Schlumbohm, J. P., Sibert, J. R., Wenger, C. D., Dudek, B. C., and Crabbe, J. C. (2003). Different data from different labs: lessons from studies of gene-environment interaction. Journal of Neurobiology 54: 283-311. PubMed Link

Wahlsten, D., Rustay, N. R., Metten, P., and Crabbe, J. C. (2003). In search of a better mouse test. Trends in Neurosciences 26: 132-136. PubMed Link

Rustay, N. R., Wahlsten, D., and Crabbe, J. C. (2003). Assessment of genetic susceptibility to ethanol intoxication in mice. Proceedings of the National Academy of Sciences USA 100: 2917-2922. PubMed Link

Kiianmaa, K., Hyytia, P., Samson, H. H., Engel, J. A., Svensson, L., Soderpalm, B., Larsson, A., Colombo, G., Vacca, G., Finn, D. A., Bachtell And RK, and Ryabinin, A. E. (2003). New neuronal networks involved in ethanol reinforcement. Alcoholism: Clinical and Experimental Research 27: 209-219. PubMed Link

Ryabinin, A. E., Galvan-Rosas, A., Bachtell, R. K., and Risinger, F. O. (2003). High alcohol/sucrose consumption during dark circadian phase in C57BL/6J mice: involvement of hippocampus, lateral septum and urocortin-positive cells of the Edinger-Westphal nucleus. Psychopharmacology 165: 296-305. PubMed Link

Bachtell, R. K., Weitemier, A. Z., Galvan-Rosas, A., Tsivkovskaia, N. O., Risinger, F. O., Phillips, T. J., Grahame, N. J., and Ryabinin, A. E. (2003). The Edinger-Westphal-lateral septum urocortin pathway and its relationship to alcohol consumption. Journal of Neruoscience 23: 2477-2487. PubMed Link

Herson, P. S., Virk, M., Rustay, N. R., Bond, C. T., Crabbe, J. C., Adelman, J. P., and Maylie, J. (2003). A mouse model of episodic ataxia type-1. Nature Neuroscience 6: 378-383. PubMed Link

Crabbe, J. C. and Wahlsten, D. (2003). Of mice and their environments (Letter). Science 299: 1313-1314. PubMed Link

Lessov, C. N. and Phillips, T. J. (2003). Cross-sensitization between the locomotor stimulant effects of ethanol and those of morphine and cocaine in mice. Alcoholism: Clinical and Experimental Research 27: 616-627. PubMed Link

Crabbe, J. C. and Phillips, T. J. (2003). Mother nature meets mother nurture. Nature Neuroscience 6: 440-442. PubMed Link

Wahlsten, D., Metten, P., and Crabbe, J. C. (2003). Survey of 21 inbred mouse strains in two laboratories reveals that BTBR T/+ tf/tf has severely reduced hippocampal commissure and absent corpus callosum. Brain Research 971: 47-54. PubMed Link

Finn, D. A., Rutledge-Gorman, M. T., and Crabbe, J. C. (2003). Genetic animal models of anxiety. Neurogenetics 4: 109-135. PubMed Link

Dickinson, S. D., Lee, E. L., Rindal, K., and Cunningham, C. L. (2003). Lack of effect of dopamine receptor blockade on expression of ethanol-induced conditioned place preference in mice. Psychopharmacology 165: 238-244. PubMed Link

Risinger, F. O. (2003). Genetic analyses of ethanol-induced hyperglycemia. Alcoholism: Clinical and Experimental Research 27: 756-764. PubMed Link

Palmer, A. A., Low, M. J., Grandy, D. K., and Phillips, T. J. (2003). Effects of a Drd2 deletion mutation on ethanol-induced locomotor stimulation and sensitization suggest a role for epistasis. Behavior Genetics 33: 311-324. PubMed Link

Meyer, P. J. and Phillips, T. J. (2003). Bivalent effects of MK-801 on ethanol-induced sensitization do not parallel its effects on ethanol-induced tolerance. Behavioral Neuroscience 117: 641-649. PubMed Link

Boyce-Rustay, J. M. and Risinger, F. O. (2003). Dopamine D3 receptor knockout mice and the motivational effects of ethanol. Pharmacology, Biochemistry and Behavior 75: 373-379. PubMed Link

Fehr, C., Rademacher, B. L., and Buck, K. J. (2003). Evaluation of the glutamate decarboxylase genes Gad1 and Gad2 as candidate genes for acute ethanol withdrawal severity in mice. Prog.Neuropsychopharmacol.Biol.Psychiatry 27: 467-472. PubMed Link

Bergeson, S. E., Kyle, Warren R., Crabbe, J. C., Metten, P., Gene, Erwin, V, and Belknap, J. K. (2003). Chromosomal loci influencing chronic alcohol withdrawal severity. Mammalian Genome 14: 454-463. PubMed Link

Crabbe, J. C., Cotnam, C. J., Cameron, A. J., Schlumbohm, J. P., Rhodes, J. S., Metten, P., and Wahlsten, D. (2003). Strain differences in three measures of ethanol intoxication in mice: the screen, dowel and grip strength tests. Genes Brain, and Behavior 2: 201-213. PubMed Link

Crabbe, J. C., Metten, P., Yu, C. H., Schlumbohm, J. P., Cameron, A. J., and Wahlsten, D. (2003). Genotypic differences in ethanol sensitivity in two tests of motor incoordination. Journal of Applied Physiology 95: 1338-1351. PubMed Link

Crabbe, J. C. and Phillips, T. J. (2003). Pharmacogenetic studies of alcohol self-administration and withdrawal. Psychopharmacology : On-Line First, October 9th. PubMed Link

Wahlsten, D., Metten, P., and Crabbe, J. C. (2003). A rating scale for wildness and ease of handling laboratory mice: results for 21 inbred strains tested in two laboratories. Genes Brain, and Behavior 2: 71-79. PubMed Link

Kliethermes, C. L., Finn, D. A., and Crabbe, J. C. (2003). Validation of a modified mirrored chamber sensitive to anxiolytics and anxiogenics in mice. Psychopharmacology 169: 190-197. PubMed Link

Goldsmith, H., Crabbe, J., Dawson, G., Gottesman, I. I., Hewitt, J., McGue, M., Pedersen, N., Plomin, R., Rose, R., and Swanson, J. (2003). Research psychologists' roles in the genetic revolution. AmericanPsychologist 58: 318-319. PubMed Link

Rustay, N. R., Wahlsten, D., and Crabbe, J. C. (2003). Influence of task parameters on rotarod performance and sensitivity to ethanol in mice. Behavioural Brain Research 141: 237-249. PubMed Link

Weitemier, A. Z. and Ryabinin, A. E. (2003). Alcohol-induced memory impairment in trace fear conditioning: a hippocampus-specific effect. Hippocampus 13: 305-315. PubMed Link

Hill, K. G., Alva, H., Blednov, Y. A., and Cunningham, C. L. (2003). Reduced ethanol-induced conditioned taste aversion and conditioned place preference in GIRK2 null mutant mice. Psychopharmacology 169: 108-114. PubMed Link

Cunningham, C. L., Ferree, N. K., and Howard, M. A. (9-2-2003). Apparatus bias and place conditioning with ethanol in mice. Psychopharmacology. PubMed Link

Crabbe, J. C. and Wiren, K. M. (2003). Molecular and genetic bases of the addictions. In: Rosenberg, R. N., Prusiner, S. B., DiMauro, S., Barchi, R. L., and Nestler, E. J. (Eds.), The Molecular and Genetic Bases of Neurologic and Psychiatric Disease, Butterworth Heinemann, Philadelphia, pp. 779-789.

Kelly, M. A., Low, M. J., Phillips, T. J., Wakeland, E. K., and Yanagisawa, M. (2003). The mapping of quantitative trait loci underlying strain differences in locomotor activity between 129S6 and C57BL/6J mice. Mammalian Genome 14: 692-702. PubMed Link

Bergstrom, H. C., Palmer, A. A., Wood, R. D., Burkhart-Kasch, S., McKinnon, C. S., and Phillips, T. J. (2003). Reverse selection for differential response to the locomotor stimulant effects of ethanol provides evidence for pleiotropic genetic influence on locomotor response to other drugs of abuse. Alcoholism: Clinical and Experimental Research 27: 1535-1547. PubMed Link

Meyer, P. J. and Phillips, T. J. (2003). Sensitivity to ketamine, alone or in combination with ethanol, is altered in mice selectively bred for sensitivity to ethanol's locomotor effects. Alcoholism: Clinical and Experimental Research 27: 1701-1709. PubMed Link

Abiola, O., Angel, J. M., Avner, P., Bachmanov, A. A., Belknap, J. K., Bennett, B., Blankenhorn, E. P., Blizard, D. A., Bolivar, V., Brockmann, G. A., Buck, K. J., Bureau, J. F., Casley, W. L., Chesler, E. J., Cheverud, J. M., Churchill, G. A., Cook, M., Crabbe, J. C., et al. (2003). The nature and identification of quantitative trait loci: a community's view. Nature Reviews Genetics 4: 911-916. PubMed Link

Phillips, T. J., Belknap, J. K., Hitzemann, R., Buck, K. J., Cunningham, C. L., and Crabbe, J. C. (2003). Appendix 5A: Internet resources for genomic, bioinformatics, and medical genetics information. Current Protocols in Neuroscience Online Appendix 5 Databases.

Belknap, J. K. (2003). Chromosome substitution strains: some quantitative considerations for genome scans and fine mapping. Mammalian Genome 14: 723-732. PubMed Link

Hitzemann, R., Malmanger, B., Reed, C., Lawler, M., Hitzemann, B., Coulombe, S., Buck, K., Rademacher, B., Walter, N., Polyakov, Y., Sikela, J., Gensler, B., Burgers, S., Williams, R. W., Manly, K., Flint, J., and Talbot, C. (2003). A strategy for the integration of QTL, gene expression, and sequence analyses. Mammalian Genome 14: 733-747. PubMed Link

Cunningham, C. L., Smith, R., and McMullin, C. (2003). Competition between ethanol-induced reward and aversion in place conditioning. Learning and Behavior 31: 273-280. PubMed Link

Phillips, T. J. (2003). Addiction and genes: animal models. In: Cooper,D. N. (Eds.), Nature Encyclopedia of the Human Genome, Nature Publishing group, New York, pp. 7-15.

Rhodes, J.S. and Crabbe, J.C. (2003) Progress towards finding genes for alcoholism in mice. Clinical Neuroscience Research, 3:315-323.

Finn, D.A., Roberts, A.J., Long, S., Tanchuck, M. and Phillips, T.J. (2003) Neurosteroid consumption has anxiolytic effects in mice. Pharmacology Biochemistry and Behavior 76:451-462. PubMed Link

Finn DA, Purdy RH and Koob GF. (2003) Animal models of anxiety and stress-induced behavior: Effects of neuroactive steroids. In: Smith, S. (Ed.), Neurosteroid Effects in the Central Nervous System: The Role of the GABAA Receptor, CRC Press, Boca Raton, pp. 317-338.


2002 [return to top of page]

Phillips, T. J. (2002). Animal models for the genetic study of human alcohol phenotypes. Alcohol Research and Health 26: 202-207. NIAAA link

Phillips, T. J., Belknap, J. K., Hitzemann, R. J., Buck, K. J., Cunningham, C. L., and Crabbe, J. C. (2002). Harnessing the mouse to unravel the genetics of human disease. Genes, Brain and Behavior 1: 14-26. PubMed Link

Daniels, G. M. and Buck, K. J. (2002). Expression profiling identifies strain-specific changes associated with ethanol withdrawal in mice. Genes, Brain and Behavior 1: 35-45. PubMed Link

Crabbe, J. C. (2002). Genetic contributions to addiction. Annual Review of Psychology 53: 435-462. PubMed Link

Palmer, A. A. and Phillips, T. J. (2002). Quantitative trait locus (QTL) mapping in mice. In: Liu, Y. and Lovinger, D. M. (Eds.), Methods in Alcohol-related Neuroscience Research, CRC Press, Boca Raton FL, pp. 1-30.

Palmer, A. A., Miller, M. N., McKinnon, C. S., and Phillips, T. J. (2002). Sensitivity to the locomotor stimulant effects of ethanol and allopregnanolone is influenced by common genes. Behavioral Neuroscience 116: 126-137. PubMed Link

Buck, K. J., Rademacher, B. L. S., Metten, P., and Crabbe, J. C. (2002). Mapping murine loci for physical dependence on ethanol. Psychopharmacology 160: 398-407. PubMed Link

Fehr, C., Shirley, R. L., Belknap, J. K., Crabbe, J. C., and Buck, K. J. (2002). Congenic mapping of alcohol and pentobarbital withdrawal liability Loci to a <1 centimorgan interval of murine chromosome 4: identification of Mpdz as a candidate gene. Journal of Neruoscience 22: 3730-3738. PubMed Link

Cunningham, C. L., Clemans, J. M., and Fidler, T. L. (2002). Injection timing determines whether intragastric ethanol produces conditioned place preference or aversion in mice. Pharmacology, Biochemistry and Behavior 72: 659-668. PubMed Link

Cunningham, C. L., Tull, L. E., Rindal, K. E., and Meyer, P. J. (2002). Distal and proximal pre-exposure to ethanol in the place conditioning task: tolerance to aversive effect, sensitization to activating effect, but no change in rewarding effect. Psychopharmacology 160: 414-424. PubMed Link

Broadbent, J., Muccino, K. J., and Cunningham, C. L. (2002). Ethanol-induced conditioned taste aversion in 15 inbred mouse strains. Behavioral Neuroscience 116: 138-148. PubMed Link

II Boehm, S. L., Reed, C. L., McKinnon, C. S., and Phillips, T. J. (2002). Shared genes influence sensitivity to the effects of ethanol on locomotor and anxiety-like behaviors, and the stress axis. Psychopharmacology 161: 54-63. PubMed Link

Phillips, T. J., Shen, E. H., McKinnon, C. S., Burkhart-Kasch, S., Lessov, C. N., and Palmer, A. A. (2002). Forward, relaxed, and reverse selection for reduced and enhanced sensitivity to ethanol's locomotor stimulant effects in mice. Alcoholism: Clinical and Experimental Research 26: 593-602. PubMed Link

Phillips, T. J. and Belknap, J. K. (2002). Complex-trait genetics: emergence of multivariate strategies. Nature Reviews Neuroscience 3: 478-485. PubMed Link

Grisel, J. E., Metten, P., Wenger, C. D., Merrill, C. M., and Crabbe, J. C. (2002). Mapping of quantitative trait loci underlying ethanol metabolism in BXD recombinant inbred mouse strains. Alcoholism: Clinical and Experimental Research 26: 610-616. PubMed Link

Ryabinin, A. E., Miller, M. N., and Durrant, S. (2002). Effects of acute alcohol administration on object recognition learning in C57BL/6J mice. Pharmacology, Biochemistry and Behavior 71: 315-320. PubMed Link

Ryabinin, A. E., Bachtell, R. K., Heinrichs, S. C., Lee, S., Rivier, C., Olive, M. F., Mehmert, K. K., Camarini, R., Kim, J. A., Koenig, H. N., Nannini, M. A., Hodge, C. W., Roberts, A. J., and Koob, G. F. (2002). The corticotropin-releasing factor/urocortin system and alcohol. Alcoholism: Clinical and Experimental Research 26: 714-722. PubMed Link

Risinger, F. O. and Boyce, J. M. (2002). Conditioning tastant and the acquisition of conditioned taste avoidance to drugs of abuse in DBA/2J mice. Psychopharmacology 160: 225-232. PubMed Link

Chester, J. A. and Cunningham, C. L. (2002). GABA(A) receptor modulation of the rewarding and aversive effects of ethanol. Alcohol 26: 131-143. PubMed Link

Palmer, A. A., Moyer, M. R., Crabbe, J. C., and Phillips, T. J. (2002). Initial sensitivity, tolerance and cross-tolerance to allopregnanolone- and ethanol-induced hypothermia in selected mouse lines. Psychopharmacology 162: 313-322. PubMed Link

Ponomarev, I. and Crabbe, J. C. (2002). A novel method to assess initial sensitivity and acute functional tolerance to hypnotic effects of ethanol. Journal of Pharmacology and Experimental Therapeutics 302: 257-263. PubMed Link

Crabbe, J. C., Metten, P., Gallaher, E. J., and Belknap, J. K. (2002). Genetic determinants of sensitivity to pentobarbital in inbred mice. Psychopharmacology 161: 408-416. PubMed Link

Sinnott, R. S., Phillips, T. J., and Finn, D. A. (2002). Alteration of voluntary ethanol and saccharin consumption by the neurosteroid allopregnanolone in mice. Psychopharmacology 162: 438-447. PubMed Link

Mark, G. P. and Finn, D. A. (2002). The relationship between hippocampal acetylcholine release and cholinergic convulsant sensitivity in Withdrawal Seizure-Prone and Withdrawal Seizure-Resistant selected mouse lines. Alcoholism: Clinical and Experimental Research 26: 1141-1152. PubMed Link

Bachtell, R. K., Tsivkovskaia, N. O., and Ryabinin, A. E. (2002). Strain differences in urocortin expression in the Edinger-Westphal nucleus and its relation to alcohol-induced hypothermia. Neuroscience 113: 421-434. PubMed Link

Bachtell, R. K., Tsivkovskaia, N. O., and Ryabinin, A. E. (2002). Alcohol-induced c-Fos expression in the Edinger-Westphal nucleus: pharmacological and signal transduction mechanisms. Journal of Pharmacology and Experimental Therapeutics 302: 516-524. PubMed Link

Palmer, A. A. and Phillips, T. J. (2002). Effect of forward and reverse selection for ethanol-induced locomotor response on other measures of ethanol sensitivity. Alcoholism: Clinical and Experimental Research 26: 1322-1329. PubMed Link

Maiya, R., Buck, K. J., Harris, R. A., and Mayfield, R. D. (2002). Ethanol-sensitive sites on the human dopamine transporter. Journal of Biological Chemistry 277: 30724-30729. PubMed Link

Sinnott, R. S., Mark, G. P., and Finn, D. A. (2002). Reinforcing effects of the neurosteroid allopregnanolone in rats. Pharmacology, Biochemistry and Behavior 72: 923-929. PubMed Link

Boehm, S. L., Piercy, M. M., Bergstrom, H. C., and Phillips, T. J. (2002). Ventral tegmental area region governs GABA(B) receptor modulation of ethanol-stimulated activity in mice. Neuroscience 115: 185-200. PubMed Link

Crabbe, J. C. (2002). Alcohol and genetics: New models. American Journal of Medical Genetics (Neuropsychiatric Genetics) 114: 969-974. PubMed Link

Risinger, F. O., Cunningham, C. L., Bevins, R. A., and Holloway, F. A. (2002). Place conditioning: what does it add to our understanding of ethanol reward? Alcoholism: Clinical and Experimental Research 26: 1444-1452. PubMed Link

Marshall, K. E., Godden, E. L., Yang, F., Burgers, S., Buck, K. J., and Sikela, J. M. (2002). In silico discovery of gene-coding variants in murine quantitative trait loci using strain-specific genome sequence databases. Genome Biology 3: 1-9. PubMed Link

Hitzemann, R., Malmanger, B., Cooper, S., Coulombe, S., Reed, C., Demarest, K., Koyner, J., Cipp, L., Flint, J., Talbot, C., Rademacher, B., Buck, K., and McCaughran, J. (2002). Multiple cross mapping (MCM) markedly improves the localization of a QTL for ethanol-induced activation. Genes, Brain and Behavior 1: 214-222. PubMed Link

Palmer, A. A., McKinnon, C. S., Bergstrom, H. C., and Phillips, T. J. (2002). Locomotor activity responses to ethanol, other alcohols, and GABA-A acting compounds in forward- and reverse-selected FAST and SLOW mouse lines. Behavioral Neuroscience 116: 958-967. PubMed Link

Ponomarev, I and Crabbe, J. C. (2002). Ethanol-induced activation and rapid development of tolerance may have some underlying genes in common. Genes, Brain and Behavior 1: 82-87. PubMed Link


2001 [return to top of page]

Crabbe, J. C. (2001). Use of genetic analyses to refine phenotypes related to alcohol tolerance and dependence. Alcoholism: Clinical and Experimental Research 25: 288-292. PubMed Link

Lessov, C. N., Risinger, F. O., and Phillips, T. J. (2001). Attenuation of ethanol-induced conditioned taste aversion in mice sensitized to the locomotor stimulant effects of ethanol. Behavioral Neuroscience 115: 146-153. PubMed Link

Schafer, G. L., Crabbe, J. C., and Wiren, K. M. (2001). Ethanol-regulated gene expression of neuroendocrine specific protein in mice: brain region and genotype specificity. Brain Research 897: 139-149. PubMed Link

Klein, R. F., Shea, M., Gunness, M. E., Pelz, G. B., Belknap, J. K., and Orwoll, E. S. (2001). Phenotypic characterization of mice bred for high and low peak bone mass. Journal of Bone and Mineral Research 16: 63-71. PubMed Link

Lessov, C. N., Palmer, A. A., Quick, E. A., and Phillips, T. J. (2001). Voluntary ethanol drinking in C57BL/6J and DBA/2J mice before and after sensitization to the locomotor stimulant effects of ethanol. Psychopharmacology 155: 91-99. PubMed Link

Mason, J. N., Eshleman, A. J., Belknap, J. K., Crabbe, J. C., Loftis, J. M., Macey, T. A., and Janowsky, A. (2001). NMDA receptor subunit mRNA and protein expression in ethanol-Withdrawal Seizure-Prone and -Resistant Mice. Alcoholism: Clinical and Experimental Research 25: 651-660. PubMed Link

Weitemier, A. Z., Woerner, A., Backstrom, P., Hyytia, And P., and Ryabinin, A. E. (2001). Expression of c-Fos in Alko Alcohol Rats Responding for Ethanol in an Operant Paradigm. Alcoholism: Clinical and Experimental Research 25: 704-710. PubMed Link

Le, A. D., Kiianmaa, K., Cunningham, C. L., Engel, J. A., Ericson, M., Soderpalm, B., Koob, G. F., Roberts, A. J., Weiss, F., Hyytia, P., Janhunen, S., Mikkola, J., Backstrom, P., Ponomarev, I., and Crabbe, J. C. (2001). Neurobiological processes in alcohol addiction. Alcoholism: Clinical and Experimental Research 25: 144S-151S. PubMed Link

Hoffman, P. L., Yagi, T., Tabakoff, B., Phillips, T. J., Kono, H., Messing, R. O., and Choi, D. S. (2001). Transgenic and gene "knockout" models in alcohol research. Alcoholism: Clinical and Experimental Research 25: 60S-66S. PubMed Link

Suwaki, H., Kalant, H., Higuchi, S., Crabbe, J. C., Ohkuma, S., Katsura, M., Yoshimura, M., Stewart, R. C., Li, T. K., and Weiss, F. (2001). Recent research on alcohol tolerance and dependence. Alcoholism: Clinical and Experimental Research 25: 189S-196S. PubMed Link

Grupe, A., Germer, S., Usuka, J., Aud, D., Belknap, J. K., Klein, R. F., Ahluwalia, M. K., Higuchi, R., and Peltz, G. (2001). In silico mapping of complex disease-related traits in mice. Science 292: 1915-1918. PubMed Link

Buck, K. J. and Finn, D. A. (2001). Genetic factors in addiction: QTL mapping and candidate gene studies implicate GABAergic genes in alcohol and barbiturate withdrawal in mice. Addiction 96: 139-149. PubMed Link

Reilly, M. T., Fehr, C., and Buck, K. J. (2001). Alcohol and gene expression in the central nervous system. In: Moussa-Moustaid, N. and Berdanier, C. D. (Eds.), Nutrient-Gene Interactions in Health and Disease, CRC Press, Boca Raton FL, pp. 131-162.

Belknap, J. K., Hitzemann, R., Crabbe, J. C., Phillips, T. J., Buck, K. J., and Williams, R. W. (2001). QTL analysis and genomewide mutagenesis in mice: Complementary genetic approaches to the dissection of complex traits. Behavior Genetics 31: 5-15. PubMed Link

Hood, H. M., Belknap, J. K., Crabbe, J. C., and Buck, K. J. (2001). Genomewide search for epistasis in a complex trait: Pentobarbital withdrawal convulsions in mice. Behavior Genetics 31: 93-100. PubMed Link

Bergeson, S. E., Helms, M. L., O'Toole, L. A., Jarvis, M. W., Hain, H. S., Mogil, J. S., and Belknap, J. K. (2001). Quantitative trait loci influencing morphine antinociception in four mapping populations. Mammalian Genome 12: 546-553. PubMed Link

Rustay, N. R., Boehm, S. L., Schafer, G. L., Browman, K. E., Erwin, V. G., and Crabbe, J. C. (2001). Sensitivity and tolerance to ethanol-induced incoordination and hypothermia in HAFT and LAFT mice. Pharmacology, Biochemistry and Behavior 70: 167-174. PubMed Link

Janowsky, A., Mah, C., Johnson, R. A., Cunningham, C. L., Phillips, T. J., Crabbe, J. C., Eshleman, A. J., and Belknap, J. K. (2001). Mapping genes that regulate density of dopamine transporters and correlated behaviors in recombinant inbred mice. Journal of Pharmacology and Experimental Therapeutics 298: 634-643. PubMed Link

Atkins, A. L., Helms, M. L., O'Toole, L. A., and Belknap, J. K. (2001). Stereotypic behaviors in mice selectively bred for high and low methamphetamine-induced stereotypic chewing. Psychopharmacology 157: 96-104. PubMed Link

Bachtell, R. K. and Ryabinin, A. E. (2001). Interactive effects of nicotine and alcohol co-administration on expression of inducible transcription factors in mouse brain. Neuroscience 103: 941-954. PubMed Link

Ryabinin, A. E., Bachtell, R. K., Freeman, P., and Risinger, F. O. (2001). ITF expression in mouse brain during acquisition of alcohol self- administration. Brain Research 890: 192-195. PubMed Link

Ueno, S., Harris, R. A., Messing, R. O., Sanchez-Perez, A. M., Hodge, C. W., McMahon, T., Wang, D., Mehmert, K. K., Kelley, S. P., Haywood, A., Olive, M. F., Buck, K. J., Hood, H. M., Blednov, Y., Findlay, G., and Mascia, M. P. (2001). Alcohol actions on GABA(A) receptors: from protein structure to mouse behavior. Alcoholism: Clinical and Experimental Research 25: 76S-81S. PubMed Link

Murray, S. E., Lallman, H. R., Heard, A. D., Rittenberg, M. B., and Stenzel-Poore, M. P. (2001). A genetic model of stress displays decreased lymphocytes and impaired antibody responses without altered susceptibility to Streptococcus pneumoniae. Journal of Immunology 167: 691-698. PubMed Link

Coste, S. C., Murray, S. E., and Stenzel-Poore, M. P. (2001). Animal models of CRH excess and CRH receptor deficiency display altered adaptations to stress. Peptides 22: 733-741. PubMed Link

Murray, S. E., Coste, S. C., Lindberg, I., and Stenzel-Poore, M. P. (2001). Genetic mutants with dysregulation of corticotropin pathways. Transgenic Models in Endocrinology, Kluwer Academic, Dordrecht, the Netherlands, pp. 143-173.

Crawshaw, L. I. and Wallace, H. L. (2001). Thermoregulation. In: Auerbach, P. S. (Eds.), Wilderness Medicine, Mosby, St. Louis.

Risinger, F. O., Freeman, P. A., Greengard, P., and Fienberg, A. A. (2001). Motivational effects of ethanol in DARPP-32 knock-out mice. Journal of Neuroscience 21: 340-348. PubMed Link

Belknap, J. K. and Atkins, A. L. (2001). The replicability of QTLs for murine alcohol preference drinking behavior across eight independent studies. Mammalian Genome 12: 893-899. PubMed Link

Wahlsten, D., Crabbe, J. C., and Dudek, B. C. (2001). Behavioural testing of standard inbred and 5HT(1B) knockout mice: implications of absent corpus callosum. Behavioural Brain Research 125: 23-32. PubMed Link

Crawshaw, L. I., Wallace, H. L., Christensen, R., and Crabbe, J. C. (2001). Influence of ethanol on thermoregulation: mapping quantitative trait loci. Physiological Genomics 7: 159-169. PubMed Link

Finn, D. A. (2001). Dissecting GABAergic and serotonergic involvement in anxiety. Behav Pharmacol 12: 467-470. PubMed Link


2000 [return to top of page]

Finn, D. A., Gallaher, E. J., and Crabbe, J. C. (2000). Differential change in neuroactive steroid sensitivity during ethanol withdrawal. Journal of Pharmacology and Experimental Therapeutics 292: 394-405. PubMed Link

McMahon, T., Andersen, R., Metten, P., Crabbe, J.C., and Messing, R. O. (2000). Protein kinase C epsilon mediates up-regulation of N-type calcium channels by ethanol. Molecular Pharmacology 57: 53-58. PubMed Link

Buck, K. J., Crabbe, J. C., and Belknap, J. K. (2000). Alcohol and other abused drugs. In: Pfaff, D. W., Berrettini, W. H., Joh, T. H., and Maxson, S. C. (Eds.), Genetic Influences on Neural and Behavioral Functions, CRC Press, Boca Raton FL, pp. 159-183.

Browman, K. E. and Crabbe, J. C. (2000). Quantitative trait loci affecting ethanol sensitivity in BXD recombinant inbred mice. Alcoholism: Clinical and Experimental Research 24: 17-23. PubMed Link

Cunningham, C. L. and Dworkin, S. I. (2000). Alcoholism and drug addiction: What determines vulnerability? Molecular Medicine Today 6: 101-103.

Rausch, R. N., Crawshaw, L. I., and Wallace, H. L. (2000). Effects of hypoxia, anoxia, and endogenous ethanol on thermoregulation in goldfish, Carassius auratus. American Journal of Physiology: Regulatory, Integrative, and Comparative Physiology 278: R545-R555. PubMed Link

Boehm, S. L., Schafer, G. L., Phillips, T. J., Browman, K. E., and Crabbe, J. C. (2000). Sensitivity to ethanol-induced motor incoordination in 5-HT(1B) receptor null mutant mice is task-dependent: implications for behavioral assessment of genetically altered mice. Behavioral Neuroscience 114: 401-409. PubMed Link

Coste, S. C., Kesterson, R. A., Heldwein, K. A., Stevens, S. L., Heard, A. D., Hollis, J. H., Murray, S. E., Hill, J. K., Pantely, G. A., Hohimer, A. R., Hatton, D. C., Phillips, T. J., Finn, D. A., Low, M. J., Rittenberg, M. B., Stenzel, P., and Stenzel-Poore, M. P. (2000). Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2. Nature Genetics 24: 403-409. PubMed Link

Hain, H. S., Crabbe, J. C., Bergeson, S. E., and Belknap, J. K. (2000). Cocaine-induced seizure thresholds: quantitative trait loci detection and mapping in two populations derived from the C57BL/6 and DBA/2 mouse strains. Journal of Pharmacology and Experimental Therapeutics 293: 180-187. PubMed Link

Boehm, S. L., Crabbe, J. C., and Phillips, T. J. (2000). Sensitivity to ethanol-induced motor incoordination in FAST and SLOW selectively bred mice. Pharmacology, Biochemistry and Behavior 66: 241-247. PubMed Link

Hood, H. M. and Buck, K. J. (2000). Allelic variation in the GABA A receptor gamma2 subunit is associated with genetic susceptibility to ethanol-induced motor incoordination and hypothermia, conditioned taste aversion, and withdrawal in BXD/Ty recombinant inbred mice. Alcoholism: Clinical and Experimental Research 24: 1327-1334. PubMed Link

Ryabinin, A. E., Wang, Y., Bachtell, R. K., Kinney, A. E., Grubb, M. C., and Mark, G. P. (2000). Cocaine- and alcohol-mediated expression of inducible transcription factors is blocked by pentobarbital anesthesia. Brain Research 877: 251-261. PubMed Link

Hatton, D. C., Qi, Y., and Belknap, J. K. (2000). Heritability of the blood pressure response to acute ethanol exposure in five inbred strains of mice. Alcoholism: Clinical and Experimental Research 24: 1483-1487. PubMed Link

Buck, K., Lischka, T., Dorow, J., and Crabbe, J. (2000). Mapping quantitative trait loci that regulate sensitivity and tolerance to quinpirole, a dopamine mimetic selective for D(2)/D(3) receptors. American Journal of Medical Genetics 96: 696-705. PubMed Link

Boyce, J. M. and Risinger, F. O. (2000). Enhancement of ethanol reward by dopamine D3 receptor blockade. Brain Research 880: 202-206. PubMed Link

Beadles-Bohling, A. S., Crabbe, J. C., and Wiren, K. M. (2000). Elevated prodynorphin expression associated with ethanol withdrawal convulsions. Neurochemistry International 37: 463-472. PubMed Link

Ron, D., Vagts, A. J., Dohrman, D. P., Yaka, R., Jiang, Z., Yao, L., Crabbe, J., Grisel, J. E., and Diamond, I. (2000). Uncoupling of bIIPKC from its targeting protein RACK1 in response to ethanol in cultured cells and mouse brain. FASEB Journal 14: 2303-2314. PubMed Link

Reilly, M. T. and Buck, K. J. (2000). GABA(A) receptor beta(2) subunit mRNA content is differentially regulated in ethanol-dependent DBA/2J and C57BL/6J mice. Neurochemistry International 37: 443-452. PubMed Link

Hoffman, P. L., Morrow, A. L., Phillips, T. J., and Siggins, G. R. (2000). Neuroadaptation to ethanol at the molecular and cellular levels. NIAAA Research Monograph 34: 85-188.

Browman, K. E., Crabbe, J. C., and Li, T.-K. (2000). Genetic strategies in preclinical substance abuse research. In: Bloom, F. E. and Kupfer, D. J. (Eds.), Psychopharmacology: A Fourth Generation of Progress, Lippincott, Williams, & Wilkins, New York.

Plomin, R. and Crabbe, J. (2000). DNA. Psychological Bulletin 126: 806-828. PubMed Link

Risinger, F. O. and Cunningham, C. L. (2000). DBA/2J mice develop stronger lithium chloride-induced conditioned taste and place aversions than C57BL/6J mice. Pharmacology, Biochemistry and Behavior 67: 17-24. PubMed Link

Cunningham, C. L. and Henderson, C. M. (2000). Ethanol-induced conditioned place aversion in mice. Behavioural Pharmacology 11: 591-602. PubMed Link

Cunningham, C. L., Fidler, T. L., and Hill, K. G. (2000). Animal models of alcohol's motivational effects. Alcohol Research and Health 24: 85-92. PubMed Link

Risinger, F. O., Freeman, P. A., Rubinstein, M., Low, M. J., and Grandy, D. K. (2000). Lack of operant ethanol self-administration in dopamine D2 receptor knockout mice. Psychopharmacology 152: 343-350. PubMed Link

Morikawa, H., Manzoni, O. J., Crabbe, J. C., and Williams, J. T. (2000). Regulation of central synaptic transmission by 5-HT(1B) auto- and heteroreceptors. Molecular Pharmacology 58: 1271-1278. PubMed Link

Ryabinin, A. E. (2000). ITF mapping after drugs of abuse: Pharmacological versus perceptional effects. Acta Neurobiologiae Experimentalis 60: 547-555. PubMed Link

Cunningham, C. L., Howard, M. A., Gill, S. J., Rubinstein, M., Low, M. J., and Grandy, D. K. (2000). Ethanol-conditioned place preference is reduced in dopamine D2 receptor- deficient mice. Pharmacology, Biochemistry and Behavior 67: 693-699. PubMed Link

Reilly, M. T., Crabbe, J. C., Rustay, N. R., and Finn, D. A. (2000). Acute neuroactive steroid withdrawal in withdrawal seizure-prone and withdrawal seizure-resistant mice. Pharmacology, Biochemistry and Behavior 67: 709-717. PubMed Link

Browman, K. E., Rustay, N. R., Nikolaidis, N., Crawshaw, L., and Crabbe, J. C. (2000). Sensitivity and tolerance to ethanol in mouse lines selected for ethanol-induced hypothermia. Pharmacology, Biochemistry and Behavior 67: 821-829. PubMed Link

Risinger, F. O., Quick, E., and Belknap, J. K. (2000). Quantitative trait loci for acute behavioral sensitivity to paraoxon. Neurotoxicology and Teratology 22: 667-674. PubMed Link

Mogil, J. S., Grisel, J. E., Hayward, M. D., Bales, J. R., Rubinstein, M., Belknap, J. K., and Low, M. J. (2000). Disparate spinal and supraspinal opioid antinociceptive responses in beta-endorphin-deficient mutant mice. Neuroscience 101: 709-717. PubMed Link

Atkins, A. L., Rustay, N. R., and Crabbe, J. C. (2000). Anxiety and sensitivity to ethanol and pentobarbital in alcohol withdrawal seizure-prone and withdrawal seizure-resistant mice. Alcoholism: Clinical and Experimental Research 24: 1743-1749. PubMed Link

Crabbe, J. C. (2000). Genetic modification as a tool for the study of behavioral consequences of signaling processes. NIAAA Research Monograph 35: 137-144.

Crabbe, J. C. (2000). And a mouse is miracle enough to stagger sextillions of infidels. (Review of "What's Wrong with My Mouse?"). Trends in Genetics 16: 365-366.

Crabbe, J. C. (2000). Review of alcohol and alcoholism: Effects on brain development. Journal of Studies on Alcohol 61: 484-485.


1999 [return to top of page]

Finn, D. A. and Crabbe, J. C. (1999). Chronic ethanol differentially alters susceptibility to chemically induced convulsions in withdrawal seizure-prone and -resistant mice. Journal of Pharmacology and Experimental Therapeutics 288: 782-790. PubMed Link

Risinger, F. O., Doan, A. M., and Vickrey, A. C. (1999). Oral operant ethanol self-administration in 5-HT1b knockout mice. Behavioural Brain Research 102: 211-215. PubMed Link

Wood, R. D., Shen, E. H., Chester, J. A., and Phillips, T. J. (1999). Ontogeny of ethanol-induced locomotor activity and hypothermia differences in selectively bred FAST and SLOW mice. Pharmacology, Biochemistry and Behavior 62: 339-347. PubMed Link

Broadbent, J. and Harless, W. E. (1999). Differential effects of GABA(A) and GABA(B) agonists on sensitization to the locomotor stimulant effects of ethanol in DBA/2 J mice. Psychopharmacology 141: 197-205. PubMed Link

Crabbe, J. C. (1999). Psychopharmacogenetics of alcohol. In: Mormede, P. and Jones, B. C. (Eds.), Neurobehavioral Genetics: Methods and Applications, CRC Press, Boca Raton FL, pp. 329-339.

Crabbe, J. C. (1999). Animal models in neurobehavioral genetics: Methods for estimating genetic correlation. In: Mormede, P. and Jones, B. C. (Eds.), Neurobehavioral Genetics: Methods and Applications, CRC Press, Boca Raton FL, pp. 121-138.

Mark, G. P., Hajnal, A., Kinney, A. E., and Keys, A. S. (1999). Self-administration of cocaine increases the release of acetylcholine to a greater extent than response-independent cocaine in the nucleus accumbens of rats. Psychopharmacology 143: 47-53. PubMed Link

Ryabinin, A. E., Wang, Y. M., Freeman, P., and Risinger, F. O. (1999). Selective effects of alcohol drinking on restraint-induced expression of immediate early genes in mouse brain. Alcoholism: Clinical and Experimental Research 23: 1272-1280. PubMed Link

Thrasher, M. J., Freeman, P. A., and Risinger, F. O. (1999). Clozapine's effects on ethanol's motivational properties. Alcoholism: Clinical and Experimental Research 23: 1377-1385. PubMed Link

Crabbe, J. C., Wahlsten, D., and Dudek, B. C. (1999). Genetics of mouse behavior: Interactions with laboratory environment. Science 284: 1670-1672. PubMed Link

Ryabinin, A. E., Wang, Y. M., and Finn, D. A. (1999). Different levels of Fos immunoreactivity after repeated handling and injection stress in two inbred strains of mice. Pharmacology, Biochemistry and Behavior 63: 143-151. PubMed Link

Risinger, F. O., Brown, M. M., Oakes, R. A., and Love, J. A. (1999). Effects of haloperidol or SCH-23390 on ethanol-induced conditioned taste aversion. Alcohol 18: 139-145. PubMed Link

Chester, J. A. and Cunningham, C. L. (1999). Baclofen alters ethanol-stimulated activity but not conditioned place preference or taste aversion in mice. Pharmacology, Biochemistry and Behavior 63: 325-331. PubMed Link

Buck, K., Metten, P., Belknap, J., and Crabbe, J. (1999). Quantitative trait loci affecting risk for pentobarbital withdrawal map near alcohol withdrawal loci on mouse chromosomes 1, 4, and 11. Mammalian Genome 10: 431-437. PubMed Link

Mark, G. P., Kinney, A. E., Grubb, M. C., and Keys, A. S. (1999). Involvement of acetylcholine in the nucleus accumbens in cocaine reinforcement. Annals of the New York Academy of Sciences 877: 792-795. PubMed Link

Metten, P. and Crabbe, J. C. (1999). Genetic determinants of severity of acute withdrawal from diazepam in mice: Commonality with ethanol and pentobarbital. Pharmacology, Biochemistry and Behavior 63: 473-479. PubMed Link

Broadbent, J. and Weitemier, A. Z. (1999). Dizocilpine (MK-801) prevents the development of sensitization to ethanol in DBA/2J mice. Alcohol and Alcoholism 34: 283-288. PubMed Link

Buckman, J. F., Meshul, C. K., Finn, D. A., and Janowsky, A. (1999). Glutamate uptake in mice bred for ethanol withdrawal severity. Psychopharmacology 143: 174-182. PubMed Link

Crabbe, J. C. (1999). Molecular genetics of addiction. In: Charney, D. S., Nestler, E. J., and Bunney, B. S. (Eds.), Neurobiology of Mental Illness, Oxford Univ. Press, New York, pp. 591-600.

Grisel, J. E., Mogil, J. S., Grahame, N. J., Rubinstein, M., Belknap, J. K., Crabbe, J. C., and Low, M. J. (1999). Ethanol oral self-administration is increased in mutant mice with decreased beta-endorphin expression. Brain Research 835: 62-67. PubMed Link

Chester, J. A. and Cunningham, C. L. (1999). GABA(A) receptors modulate ethanol-induced conditioned place preference and taste aversion in mice. Psychopharmacology 144: 363-372. PubMed Link

Browman, K. E. and Crabbe, J. C. (1999). Alcohol and genetics: New animal models. Molecular Medicine Today 5: 310-318. PubMed Link

Crabbe, J. C., Phillips, T. J., Buck, K. J., Cunningham, C. L., and Belknap, J. K. (1999). Identifying genes for alcohol and drug sensitivity: recent progress and future directions. Trends in Neurosciences 22: 173-179. PubMed Link

Crabbe, J. C. and Cunningham, C. L. (1999). Drug and alcohol dependence-related behaviors. In: Crusio, W. E. and Gerlai, R. T. (Eds.), Handbook of Molecular-Genetic Techniques for Brain and Behavior Research, Elsevier, Amsterdam, pp. 652-666.

Ponomarev, I. and Crabbe, J. C. (1999). Genetic association between chronic ethanol withdrawal severity and acoustic startle parameters WSP and WSR mice. Alcoholism: Clinical and Experimental Research 23: 1730-1735. PubMed Link

Phillips, T. J., Hen, R., and Crabbe, J. C. (1999). Complications associated with genetic background effects in research using knockout mice. Psychopharmacology 147: 5-7. PubMed Link

Bachtell, R. K., Wang, Y. M., Freeman, P., Risinger, F. O., and Ryabinin, A. E. (1999). Alcohol drinking produces brain region-selective changes in expression of inducible transcription factors. Brain Research 847: 157-165. PubMed Link

Buckman, J. F. and Meshul, C. K. (1999). Glial differences between naive Withdrawal Seizure-Prone and -Resistant mice. Alcoholism: Clinical and Experimental Research 23: 1905-1913. PubMed Link

Cunningham, C. L., Dickinson, S. D., Grahame, N. J., Okorn, D. M., and McMullin, C. S. (1999). Genetic differences in cocaine-induced conditioned place preference in mice depend on conditioning trial duration. Psychopharmacology 146: 73-80. PubMed Link

Mogil, J. S., Wilson, S. G., Bon, K., Lee, S. E., Chung, K., Raber, P., Pieper, J. O., Hain, H. S., Belknap, J. K., Hubert, L., Elmer, G. I., Chung, J. M., and Devor, M. (1999). Heritability of nociception I: responses of 11 inbred mouse strains on 12 measures of nociception. Pain 80: 67-82. PubMed Link

Mogil, J. S., Wilson, S. G., Bon, K., Lee, S. E., Chung, K., Raber, P., Pieper, J. O., Hain, H. S., Belknap, J. K., Hubert, L., Elmer, G. I., Chung, J. M., and Devor, M. (1999). Heritability of nociception II. 'Types' of nociception revealed by genetic correlation analysis. Pain 80: 83-93. PubMed Link

Kest, B., Jenab, S., Brodsky, M., Sadowski, B., Belknap, J. K., Mogil, J. S., and Inturrisi, C. E. (1999). Mu and delta opioid receptor analgesia, binding density, and mRNA levels in mice selectively bred for high and low analgesia. Brain Research 816: 381-389. PubMed Link

Burrows, K. B. and Meshul, C. K. (1999). High-dose methamphetamine treatment alters presynaptic GABA and glutamate immunoreactivity. Neuroscience 90: 833-850. PubMed Link

Demarest, K., McCaughran, J., Mahjubi, E., Cipp, L., and Hitzemann, R. (1999). Identification of an acute ethanol response quantitative trait locus on mouse chromosome 2. Journal of Neuroscience 19: 549-561. PubMed Link

Hain, H. S., Belknap, J. K., and Mogil, J. S. (1999). Pharmacogenetic evidence for the involvement of 5-hydroxytryptamine (Serotonin)-1B receptors in the mediation of morphine antinociceptive sensitivity. Journal of Pharmacology and Experimental Therapeutics 291: 444-449. PubMed Link


1998 [return to top of page]

Dickinson, S. D. and Cunningham, C. L. (1998). Altered ambient temperature and ethanol-induced conditioned place preference in mice. Alcohol 16: 13-18. PubMed Link

Phillips, T. J., Brown, K. J., Burkhart-Kasch, S., Wenger, C. D., Kelly, M. A., Rubinstein, M., Grandy, D. K., and Low, M. J. (1998). Alcohol preference and sensitivity are markedly reduced in mice lacking dopamine D2 receptors. Nature Neuroscience 1: 610-615. PubMed Link

Rocha, B. A., Scearce-Levie, K., Lucas, J. J., Hiroi, N., Castanon, N., Crabbe, J. C., Nestler, E. J., and Hen, R. (1998). Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor. Nature 393: 175-178. PubMed Link

Belknap, J. K. (1998). Effect of within-strain sample size on QTL detection and mapping using recombinant inbred mouse strains. Behavior Genetics 28: 29-38. PubMed Link

Buck, K. J. and Amara, S. G. (1998). In vivo generation of chimeras. Methods in Enzymology 296: 466-475. PubMed Link

Crabbe, J. C. (1998). Provisional mapping of quantitative trait loci for chronic ethanol withdrawal severity in BXD recombinant inbred mice. Journal of Pharmacology and Experimental Therapeutics 286: 263-271. PubMed Link

Shen, E. H. and Phillips, T. J. (1998). MK-801 potentiates ethanol's effects on locomotor activity in mice. Pharmacology, Biochemistry and Behavior 59: 135-143. PubMed Link

Belknap, J. K., Riggan, J., Cross, S., Young, E. R., Gallaher, E. J., and Crabbe, J. C. (1998). Genetic determinants of morphine activity and thermal responses in 15 inbred mouse strains. Pharmacology, Biochemistry and Behavior 59: 353-360. PubMed Link

Chester, J. A., Risinger, F. O., and Cunningham, C. L. (1998). Ethanol reward and aversion in mice bred for sensitivity to ethanol withdrawal. Alcoholism: Clinical and Experimental Research 22: 468-473. PubMed Link

Risinger, F. O., Brown, M. M., Doan, A. M., and Oakes, R. A. (1998). Mouse strain differences in oral operant ethanol reinforcement under continuous access conditions. Alcoholism: Clinical and Experimental Research 22: 677-684. PubMed Link

Lessov, C. N. and Phillips, T. J. (1998). Duration of sensitization to the locomotor stimulant effects of ethanol in mice. Psychopharmacology 135: 374-382. PubMed Link

Keys, A. S., Mark, G. P., Emre, N., and Meshul, C. K. (1998). Reduced glutamate immunolabeling in the nucleus accumbens following extended withdrawal from self-administered cocaine. Synapse 30: 393-401. PubMed Link

Crabbe, J. C. and Phillips, T. J. (1998). Genetics of alcohol and other abused drugs. Drug and Alcohol Dependence 51: 61-71. PubMed Link

Metten, P., Belknap, J. K., and Crabbe, J. C. (1998). Drug withdrawal convulsions and susceptibility to convulsants after short-term selective breeding for acute ethanol withdrawal. Behavioural Brain Research 95: 113-122. PubMed Link

Keys, A. S. and Mark, G. P. (1998). D1 and D2 dopamine receptor mediation of amphetamine-induced acetylcholine release in nucleus accumbens. Neuroscience 86: 521-531. PubMed Link

Shen, E. H., Dorow, J., Harland, R., Burkhart-Kasch, S., and Phillips, T. J. (1998). Seizure sensitivity and GABAergic modulation of ethanol sensitivity in selectively bred FAST and SLOW mouse lines. Journal of Pharmacology and Experimental Therapeutics 287: 606-615. PubMed Link

Grahame, N. J., Low, M. J., and Cunningham, C. L. (1998). Intravenous self-administration of ethanol in beta-endorphin-deficient mice. Alcoholism: Clinical and Experimental Research 22: 1093-1098. PubMed Link

Crawshaw, L. I., Wallace, H., and Crabbe, J. (1998). Ethanol, body temperature and thermoregulation. Clinical and Experimental Pharmacology and Physiology 25: 150-154. PubMed Link

Ryabinin, A. E. (1998). Role of hippocampus in alcohol-induced memory impairment: Implications from behavioral and immediate early gene studies. Psychopharmacology 139: 34-43. PubMed Link

Risinger, F. O. and Cunningham, C. L. (1998). Ethanol-induced conditioned taste aversion in BXD recombinant inbred mice. Alcoholism: Clinical and Experimental Research 22: 1234-1244. PubMed Link

Cunningham, C. L. (1998). Drug conditioning and drug-seking behavior. In: O'Donohue, W. (Eds.), Learning and Behavior Therapy, Allyn & Bacon, Boston, pp. 518-544.

Crabbe, J. C., Belknap, J. K., Metten, P., Grisel, J. E., and Buck, K. J. (1998). Quantitative trait loci: Mapping drug and alcohol-related genes. Advances in Pharmacology 42: 1033-1037. PubMed Link

Crabbe, J. C., Gallaher, E. J., Cross, S. J., and Belknap, J. K. (1998). Genetic determinants of sensitivity to diazepam in inbred mice. Behavioral Neuroscience 112: 668-677. PubMed Link

Hajnal, A., Mark, G. P., Keys, A. S., and Lenard, L. (1998). Involvement of dopamine and acetylcholine in the interaction between amygdala and nucleus accumbens: chronic microdialysis in rats. Neurobiology 6: 363-367. PubMed Link

Ryabinin, A. E. and Wang, Y-M. (1998). Repeated alcohol administration differentially affects c-Fos and FosB protein immunoreactivity in DBA/2J mice. Alcoholism: Clinical and Experimental Research 22: 1646-1654. PubMed Link

Buck, K. J. (1998). Recent progress toward the identification of genes related to risk for alcoholism. Mammalian Genome 9: 927-928. PubMed Link

Phillips, T. J., Belknap, J. K., Buck, K. J., and Cunningham, C. L. (1998). Genes on mouse chromosomes 2 and 9 determine variation in ethanol consumption. Mammalian Genome 9: 936-941. PubMed Link

Buck, K. J. and Hood, H. M. (1998). Genetic association of a GABA(A) receptor gamma2 subunit variant with severity of acute physiological dependence on alcohol. Mammalian Genome 9: 975-978. PubMed Link

Schafer, G. L., Crabbe, J. C., and Wiren, K. M. (1998). Identification of neuroendocrine-specific protein as an ethanol-regulated gene with mRNA differential display. Mammalian Genome 9: 979-982. PubMed Link

Metten, P., Phillips, T. J., Crabbe, J. C., Tarantino, L. M., McClearn, G. E., Plomin, R., Erwin, V. G., and Belknap, J. K. (1998). High genetic susceptibility to ethanol withdrawal predicts low ethanol consumption. Mammalian Genome 9: 983-990. PubMed Link

Phillips, T. J. (1998). Alcohol-related genetics in animals: Knockouts and antisense technology. Report of a Subcommittee of the National Advisory Council on Alcohol Abuse and Alcoholism on the Review of the Extramural Research Portfolio for Genetics, DHHS, PHS, NIH pp. 38-40.

Chester, J. A. and Cunningham, C. L. (1998). Modulation of corticosterone does not affect the acquisition or expression of ethanol-induced conditioned place preference in DBA/2J mice. Pharmacology, Biochemistry and Behavior 59: 67-75. PubMed Link

Crabbe, J. C. and Belknap, J. K. (1998). Ethical consequences of mapping QTLs for complex human traits. In: Paterson, A. H. (Eds.), Molecular Dissection of Complex Traits, CRC Press, Boca Raton FL, pp. 279-285.

Klein, R. F., Mitchell, S. R., Phillips, T. J., Belknap, J. K., and Orwoll, E. S. (1998). Quantitative trait loci affecting peak bone mineral density in mice. Journal of Bone and Mineral Research 13: 1648-1656. PubMed Link

Phillips, T. J., Huson, M. G., and McKinnon, C. S. (1998). Localization of genes mediating acute and sensitized locomotor responses to cocaine in BXD/Ty recombinant inbred mice. Journal of Neruoscience 18: 3023-3034. PubMed Link

Kelly, M. A., Rubinstein, M., Phillips, T. J., Lessov, C. N., Burkhart-Kasch, S., Zhang, G., Bunzow, J. R., Fang, Y., Gerhardt, G. A., Grandy, D. K., and Low, M. J. (1998). Locomotor activity in D2 dopamine receptor-deficient mice is determined by gene dosage, genetic background, and developmental adaptations. Journal of Neruoscience 18: 3470-3479. PubMed Link


1997[return to top of page]

Crawshaw, L. I., Wallace, H. L., Crabbe, J. C., Ramos, C., Duerr, J., and O'Connor, C. S. (1997). Ethanol disrupts and decreases the regulated body temperature differentially in C57BL/6J and DBA/2J mice. American Journal of Physiology 273: R696-R702. PubMed Link

Burrows, K. B. and Meshul, C. K. (1997). Methamphetamine alters presynaptic glutamate immunoreactivity in the caudate nucleus and motor cortex. Synapse 27: 133-144. PubMed Link

Cunningham, C. L., Okorn, D. M., and Howard, C. E. (1997). Interstimulus interval determines whether ethanol produces conditioned place preference or aversion in mice. Animal Learning and Behavior 25: 31-42.

Rubinstein, M., Phillips, T. J., Bunzow, J. R., Falzone, T. L., Dziewczapolski, G., Zhang, G., Fang, Y., Larson, J. L., McDougall, J. A., Chester, J. A., Saez, C., Pugsley, T. A., Gershanik, O., Low, M. J., and Grandy, D. K. (1997). Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine. Cell 90: 991-1001. PubMed Link

Crabbe, J. C. (1997). Where does alcohol act in the brain? Molecular Psychiatry 2: 17-20. PubMed Link

Phillips, T. J. (1997). Genetic studies with animal models. Contribution to Alcohol and Health, Ninth Special Report to the U.S.Congress from Secretary of Health and Human Services, DHHS, PHS, NIH, NIAAA pp. 40-43.

Grisel, J. E., Belknap, J. K., O'Toole, L. A., Helms, M. L., Wenger, C. D., and Crabbe, J. C. (1997). Quantitative trait loci affecting methamphetamine responses in BXD recombinant inbred mouse strains. Journal of Neuroscience 17: 745-754. PubMed Link

Buck, K. J., Metten, P., Belknap, J. K., and Crabbe, J. C. (1997). Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice. Journal of Neuroscience 17: 3946-3955. PubMed Link

Buckman, J. F. and Meshul, C. K. (1997). Immunocytochemical analysis of glutamate and GABA in selectively bred mice. Brain Research 760: 193-203. PubMed Link

Belknap, J. K., Dubay, C., Crabbe, J. C., and Buck, K. J. (1997). Mapping quantitative trait loci for behavioral traits in the mouse. In: Blum, K. and Noble, E. P. (Eds.), Handbook of Psychiatric Genetics, CRC Press, Boca Raton FL, pp. 435-453.

Phillips, T. J. (1997). Behavior genetics of drug sensitization. Critical Reviews in Neurobiology 11: 21-33.

Finn, D. A., Phillips, T. J., Okorn, D. M., Chester, J. A., and Cunningham, C. L. (1997). Rewarding effect of the neuroactive steroid 3 alpha-hydroxy-5 alpha-pregnan-20-one in mice. Pharmacology, Biochemistry and Behavior 56: 261-264. PubMed Link

Grahame, N. J. and Cunningham, C. L. (1997). Intravenous ethanol self-administration in C57BL/6J and DBA/2J mice. Alcoholism: Clinical and Experimental Research 21: 56-62. PubMed Link

Phillips, T. J., Wenger, C. D., and Dorow, J. D. (1997). Naltrexone effects on ethanol drinking acquisition and on established ethanol consumption in C57BL/6J mice. Alcoholism: Clinical and Experimental Research 21: 691-702. PubMed Link

Finn, D. A. and Crabbe, J. C. (1997). Exploring alcohol withdrawal syndrome. Alcohol Health and Research World 21: 149-156. PubMed Link

Belknap, J. K., Richards, S. P., O'Toole, L. A., Helms, M. L., and Phillips, T. J. (1997). Short-term selective breeding as a tool for QTL mapping: ethanol preference drinking in mice. Behavior Genetics 27: 55-66. PubMed Link

Crawley, J. N., Belknap, J. K., Collins, A., Crabbe, J. C., Frankel, W., Henderson, N., Hitzemann, R. J., Maxson, S. C., Miner, L. L., Silva, A. J., Wehner, J. M., Wynshaw-Boris, A., and Paylor, R. (1997). Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies. Psychopharmacology 132: 107-124. PubMed Link

Hajnal, A., Mark, G. P., Rada, P. V., Lenard, L., and Hoebel, B. G. (1997). Norepinephrine microinjections in the hypothalamic paraventricular nucleus increase extracellular dopamine and decrease acetylcholine in the nucleus accumbens: Relevance to feeding reinforcement. Journal of Neurochemistry 68: 667-674. PubMed Link

Boehm, S. L., II, Lundahl, K. R., Caldwell, J., and Gilliam, D. M. (1997). Ethanol teratogenesis in the C57BL/6J, DBA/2J and A/J inbred mouse strains. Alcohol 14: 389-395. PubMed Link

Finn, D. A., Roberts, A. J., Lotrich, F., and Gallaher, E. J. (1997). Genetic differences in behavioral sensitivity to a neuroactive steroid. Journal of Pharmacology and Experimental Therapeutics 280: 820-828. PubMed Link

Risinger, F. O. (1997). Fluoxetine's effects on ethanol's rewarding, aversive and stimulus properties. Life Sciences 61: PL235-PL242. PubMed Link

Phillips, T. J., Roberts, A. J., and Lessov, C. N. (1997). Behavioral sensitization to ethanol: Genetics and the effects of stress. Pharmacology, Biochemistry and Behavior 57: 487-493. PubMed Link

Keys, A. S. (1997). Structural CNS changes following cocaine: Implications for feedback regulation of mesolimbic circuitry. In: Nahas, G. G. and Burks, T. F. (Eds.), Drug Abuse in the Decade of the Brain, IOS Press, Amsterdam, pp. 223-232.


1996 [return to top of page]

Belknap, J. K., Mitchell, S. R., O'Toole, L. A., Helms, M. L., and Crabbe, J. C. (1996). Type I and type II error rates for quantitative trait loci (QTL) mapping studies using recombinant inbred mouse strains. Behavior Genetics 26: 149-160. PubMed Link

Broadbent, J., Linder, H. V., and Cunningham, C. L. (1996). Genetic differences in naloxone enhancement of ethanol-induced conditioned taste aversion. Psychopharmacology 126: 147-155. PubMed Link

Gallaher, E. J., Jones, G. E., Belknap, J. K., and Crabbe, J. C. (1996). Identification of genetic markers for initial sensitivity and rapid tolerance to ethanol-induced ataxia using quantitative trait locus analysis in BXD recombinant inbred mice. Journal of Pharmacology and Experimental Therapeutics 277: 604-612. PubMed Link

Phillips, T. J., Lessov, C. N., Harland, R. D., and Mitchell, S. R. (1996). Evaluation of potential genetic associations between ethanol tolerance and sensitization in BXD/Ty recombinant inbred mice. Journal of Pharmacology and Experimental Therapeutics 277: 613-623. PubMed Link

Crabbe, J. C., Phillips, T. J., Gallaher, E. J., Crawshaw, L. I., and Mitchell, S. R. (1996). Common genetic determinants of the ataxic and hypothermic effects of ethanol in BXD/Ty recombinant inbred mice: genetic correlations and quantitative trait loci. Journal of Pharmacology and Experimental Therapeutics 277: 624-632. PubMed Link

Crabbe, J. C. (1996). A genetic animal model of alcohol withdrawal. Alcoholism: Clinical and Experimental Research 20: 96A-100A. PubMed Link

Buck, K. J. (1996). New insight into the mechanisms of ethanol effects on GABAA receptor function and expression, and their relevance to behavior. Alcoholism: Clinical and Experimental Research 20: 198A-202A. PubMed Link

Risinger, F. O. and Oakes, R. A. (1996). Mianserin enhancement of ethanol-induced conditioned place preference. Behavioral Pharmacology 7: 294-298. PubMed Link

Shen, E. H., Dorow, J. D., Huson, M., and Phillips, T. J. (1996). Correlated responses to selection in FAST and SLOW mice: Effects of ethanol on ataxia, temperature, sedation, and withdrawal. Alcoholism: Clinical and Experimental Research 20: 688-696. PubMed Link

Lotrich, F. E. and Gallaher, E. J. (1996). Micropharmacokinetics: A system dynamics model of drug diffusion and uptake following localized injection into the brain. In: Anderson, J. G. and Katzper, M. (Eds.), Simulation in the Medical Sciences: Proceedings of the 1996 Western Multiconference, Society for Computer Simulation, San Diego CA, pp. 165-170.

Buck, K. J. (1996). Molecular genetic analysis of the role of GABAergic systems in the behavioral and cellular actions of alcohol. Behavior Genetics 26: 313-323. PubMed Link

Risinger, F. O., Bormann, N. M., and Oakes, R. A. (1996). Reduced sensitivity to ethanol reward, but not ethanol aversion, in mice lacking 5-HT1B receptors. Alcoholism: Clinical and Experimental Research 20: 1401-1405. PubMed Link

Phillips, T. J. and Shen, E. H. (1996). Neurochemical bases of locomotion and ethanol stimulant effects. International Review of Neurobiology 39: 243-282. PubMed Link

Devaud, L. L., Purdy, R. H., Finn, D. A., and Morrow, A. L. (1996). Sensitization of g-aminobutyric acidA receptors to neuroactive steroids in rats during ethanol withdrawal. Journal of Pharmacology and Experimental Therapeutics 278: 510-517. PubMed Link

Crabbe, J. C. (1996). Quantitative Trait Locus gene mapping: A new method for locating alcohol response genes. Addiction Biology 1: 229-235. PubMed Link

Buck, K. J., Lorang, D., and Amara, S. G. (1996). Discrete structural domains and cell-specific expression determine functional selectivity of the dopamine and norepinephrine transporters. NIDA Research Monograph 161: 154-175. PubMed Link

Crabbe, J. C., Buck, K. J., Metten, P., and Belknap, J. K. (1996). Strategies for identifying genes underlying drug abuse susceptibility. NIDA Research Monograph 161: 201-219. PubMed Link

Crabbe, J. C., Phillips, T. J., Feller, D. J., Hen, R., Wenger, C. D., Lessov, C. N., and Schafer, G. L. (1996). Elevated alcohol consumption in null mutant mice lacking 5-HT1B serotonin receptors. Nature Genetics 14: 98-101. PubMed Link

Meshul, C. K., Bunker, G. L., Mason, J. N., Allen, C., and Janowsky, A. (1996). Effects of subchronic clozapine and haloperidol on striatal glutamatergic synapses. Journal of Neurochemistry 67: 1965-1973. PubMed Link

Risinger, F. O. and Brown, M. M. (1996). Genetic differences in nicotine-induced conditioned taste aversion. Life Sciences 58: PL223-PL229. PubMed Link

Schafer, G. L. and Crabbe, J. C. (1996). Sensitivity to ethanol-induced ataxia in HOT and COLD selected lines of mice. Alcoholism: Clinical and Experimental Research 20: 1604-1612. PubMed Link

Watts, V. J. and Neve, K. A. (1996). Sensitization of endogenous and recombinant adenylate cyclase by activation of D2 dopamine receptors. Molecular Pharmacology 50: 966-976. PubMed Link

Metten, P. and Crabbe, J. C. (1996). Dependence and withdrawal. In: Deitrich, R. A. and Erwin, V. G. (Eds.), Pharmacological Effects of Ethanol on the Nervous System, CRC Press, Boca Raton FL, pp. 269-290.

Risinger, F. O. and Oakes, R. A. (1996). Dose- and conditioning trial-dependent ethanol-induced conditioned place preference in Swiss-Webster mice. Pharmacology, Biochemistry and Behavior 55: 117-123. PubMed Link

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by Mark Rutledge-Gorman
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