PARC Publications
In Press
2013 2012 2011
2010 2009 2008 2007 2006
2005 2004 2003 2002 2001
2000 1999 1998 1997 1996
Reprints or PDFs are available for many publications. To request a copy, e-mail: rutledgm@ohsu.edu
Publications In Press
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Ryabinin AE (201X) Editorial: Evolutionary Perspectives on animal model of addiction: diverse models are welcome. Journal of Addiction Research and Therapy, in press.
Phillips TJ (201X) Biochemical Genetics / Alcoholism. In: S. Maloy and K. Hughes (Eds.), Brenner’s Online Encyclopedia of Genetics, 2nd Edition. Academic Press, Elsevier Inc., Oxford, UK, in press.
Phillips TJ (201X) Coisogenic. In: S. Maloy and K. Hughes (Eds.), Brenner’s Online Encyclopedia of Genetics, 2nd Edition. Academic Press, Elsevier Inc., Oxford, UK, in press.
Crabbe JC (200X) Mouse genetic models relevant for alcohol use disorders. In W.E. Crusio, F. Sluyter, and R.T. Gerlai (Eds.). Handbook of Behavior Genetics of the Mouse, Vol. 2, Genetic Mouse Models of Neurobehavioral Disorders, Cambridge University Press, Cambridge, in press.
Crabbe JC, Phillips TJ (201X) Genetic animal models. In: K. Sher (Ed). The Oxford Handbook of Substance Use Disorders, Oxford University Press, New York, in press.
Wahlsten D, Crabbe JC (201X) Replicability and reliability of behavioral tests. In W.E. Crusio, F. Sluyter, and R.T. Gerlai (Eds.). Handbook of Behavior Genetics of the Mouse, Vol. 1, Genetics of Behavioral Phenotypes, Cambridge University Press, Cambridge, in press.
2013 [return to top of page]
Crabbe JC, Kendler KS, Hitzemann RJ (2013) Modeling the diagnostic criteria for alcohol dependence with genetic animal models. Current Topics in Behavioral Neuroscience 13:187-221. PMID: 21910077 PubMed Link
Holstein SE, Li N, Eshleman AJ, Phillips TJ (2013) GABAB receptor activation attenuates the stimulant but not mesolimbic dopamine response to ethanol in FAST mice. Behavioural Brain Research 237C:49-58. PMID: 22982185 PubMed Link
2012 [return to top of page]
Ary AA, Cozzoli DK, Finn DA, Crabbe JC, Dehoff MH, Worley PF and Szumlinski KK (2012) Ethanol up-regulates nucleus accumbens neuronal activity dependent pentraxin (Narp): implications for alcohol-induced behavioral plasticity. Alcohol 46:377-387. PMID: 22444953 PubMed Link
Barkley-Levenson AM, Crabbe JC (2012) Ethanol drinking microstructure of a high drinking in the dark selected mouse line. Alcoholism: Clinical and Experimental Research 36:1330-9. PMID: 22524154 PubMed Link
Barkley-Levenson AM, Crabbe, JC (2012) Bridging animal and human models: Translating from (and to) animal genetics. Alcohol Research: Current Reviews 34:325-335.
Free full text link: http://pubs.niaaa.nih.gov/publications/arcr343/325-335.htm
Buck KJ, Milner LC, Denmark DL, Grant SGN and Kozell LB (2012) Discovering Genes Involved in Alcohol Dependence and Other Alcohol Responses. Alcohol Research: Current Reviews 34:367-374.
Free full text link: http://pubs.niaaa.nih.gov/publications/arcr343/367-374.htm
Cozzoli DK, Courson J, Caruana AL, Miller BW, Greentree DI, Thompson AB, Wroten MG, Zhang PW, Xiao B, Hu JH, Klugmann M, Metten P, Worley PF, Crabbe JC, Szumlinski KK (2012) Nucleus accumbens mGluR5-associated signaling regulates binge alcohol drinking under Drinking-in-the-Dark procedures. Alcoholism: Clinical and Experimental Research 36:1623-33. PMID: 22432643 PubMed Link
Crabbe JC (2012) Translational behaviour-genetic studies of alcohol: are we there yet? Genes Brain and Behavior 11:375-86. PMID: 22510368 PubMed Link
Crabbe JC, Colville AM, Kruse LM, Cameron AJ, Spence SE, Schlumbohm JP, Huang LC, Metten P (2012) Ethanol Tolerance and Withdrawal Severity in High Drinking in the Dark Selectively Bred Mice. Alcoholism: Clinical and Experimental Research 36:1152-1161. PMID: 22309139 PubMed Link
Crabbe JC, Harkness JH, Spence SE, Huang LC, Metten P (2012) Intermittent availability of ethanol does not necessarily lead to increased intake in mice. Alcohol and Alcoholism 47:509-17. PMID: 22717273 PubMed Link
Crabbe JC, Kruse LM, Colville AM, Cameron AJ, Spence SE, Schlumbohm JP, Huang LC, Metten P (2012) Ethanol Sensitivity in High Drinking in the Dark Selectively Bred Mice. Alcoholism: Clinical and Experimental Research 36:1162-1170. PMID: 22316249 PubMed Link
Crabbe JC, Metten P, Huang LC, Schlumbohm JP, Spence SE, Barkley-Levenson AM, Finn DA, Rhodes JS and Cameron AJ (2012) Ethanol withdrawal-associated drinking and drinking in the dark: Common and discrete genetic contributions, Addiction Genetics, published online Oct 19. Free full text link: http://www.degruyter.com/view/j/addge.2012.1.issue/addge-2012-0002/addge-2012-0002.xml?format=INT
Cruz, M.T., Herman, M.A., Cote, D.M., Ryabinin, A.E., Roberto, M. (2012) Ghrelin increases GABAergic transmission and interacts with ethanol actions in the rat central nucleus of the amygdala. Neuropsychopharmacology, Sept 12, ePub ahead of print. PMID: 22968812 PubMed Link
Cservenka, A., Herting, M.M., Nagel, B.J. (2012) Atypical frontal lobe activity during verbal working memory in youth with a family history of alcoholism. Drug and Alcohol Dependence 123:98-104. PMID: 22088655 PubMed Link
Cservenka, A., Nagel, B.J. (2012) Risky decision-making: An fMRI study of youth at high risk for alcoholism. Alcoholism: Clinical and Experimental Research 36:604-615. PMID: 22250647 PubMed Link
Cunningham, C. L., Fidler, T. L., Murphy, K. V., Mulgrew, J. A., & Smitasin, P. J. (2012) Time-dependent negative reinforcement of ethanol intake by alleviation of acute withdrawal. Biological Psychiatry, Sept 18, ePub ahead of print. PMID: 22999529 PubMed Link
Ferguson B, Hunter JH, Street SL, Woodall A, Luty J, Grant K (2012) Genetic load is associated with hypothalamic-pituitary-adrenal axis dysregulation in macaques. Genes Brain and Behavior, Sept 21, ePub ahead of print. PMID: 22998353 PubMed Link
Fidler, T. L., Powers, M. S., Ramirez, J. J., Crane, A. T., Mulgrew, J. A., Smitasin, P. J., & Cunningham, C. L. (2012) Dependence induced increases in Intragastric Alcohol Consumption (IGAC) in mice. Addiction Biology 17:13-32. PMCID: 21955048 PubMed Link
Fish, E.W., Robinson, J.E., Krouse, M.C., Hodge, C.W., Reed, C., Phillips, T.J. and Malanga, C.J. (2012) Intracranial self-stimulation in FAST and SLOW mice: Effects of alcohol and cocaine. Psychopharmacology 220:719-730. PMCID: 21983918 PubMed Link
Font L, Cunningham CL (2012) Post-retrieval propranolol treatment does not modulate reconsolidation or extinction of ethanol-induced conditioned place preference. Pharmacology, Biochemistry & Behavior 101:222–230. PMCID: 22285323 PubMed Link
Ford, M.M., McCracken, A.D., Wolf, N.T., Ryabinin, A.E., Grant, K.A. (2012) Discrimination of ethanol-nicotine drug mixtures in mice: dual interactive mechanisms of overshadowing and potentiation. Psychopharmacology, Jul 5, ePub ahead of print. PMCID: 22763667 PubMed Link
Foroud T, Phillips TJ (2012) Overview: Assessing the Genetic Risk for Alcohol Use Disorders Alcohol Research: Current Reviews 34:266-272.
Free full text link: http://pubs.niaaa.nih.gov/publications/arcr343/266-273.htm
Gallego X, Ruiz-Medina J, Valverde O, Molas S, Robles N, Sabrià J, Crabbe JC, Dierssen M (2012) Transgenic over expression of nicotinic receptor alpha 5, alpha 3, and beta 4 subunit genes reduces ethanol intake in mice. Alcohol 46:205-15. PMCID: 22459873 PubMed Link
Giardino, W.J., Cote, D.M., Li, J., Ryabinin, A.E. (2012) Characterization of genetic differences within the centrally-projecting Edinger-Westphal nucleus of C57BL/6J and DBA/2J mice by expression profiling. Frontiers in Neuroanatomy, Epub. 6:5.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278674/
Groblewski, P. A., & Cunningham, C. L. (2012) Repeated microinjections into the medial prefrontal cortex (mPFC) impair extinction of conditioned place preference in mice. Behavioural Brain Research 230:299– 303. PMCID: 22342490 PubMed Link
Groblewski PA, Ryabinin AE, Cunningham CL (2012) Activation and role of the medial prefrontal cortex (mPFC) in extinction of ethanol-induced associative learning in mice. Neurobiology of Learning and Memory:97:37-46. PMID: 21951632 PubMed Link
Gubner, N.R., McKinnon, C.S., Reed, C. and Phillips, T.J. (2012) Accentuating effects of nicotine on ethanol response in mice with high genetic predisposition to ethanol-induced locomotor stimulation. Drug and Alcohol Dependence Jul 11 2012 [Epub ahead of print]. PMID: 22795175 PubMed Link
Helms CM, Rossi D, Grant KA (2012) Neurosteroid effects on sensitivity to ethanol. Frontiers in Endocrinology (Lausanne) 3:10.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356014/
Helms CM, McClintick MN, Grant KA (2012) Social rank, chronic ethanol self-administration, and diurnal pituitary-adrenal activity in cynomolgus monkeys. Psychopharmacology 224:133-43. PMID: 22526537 PubMed Link
Hostetler CM, Ryabinin AE (2012) Commentary: Love and addiction: the devil is in the differences. Psychopharmacology 224: 27-29. PMID: 22948669 PubMed Link
Iancu OD, Darakjian P, Kawane S, Bottomly D, Hitzemann R, McWeeney S (2012) Detection of expression quantitative trait Loci in complex mouse crosses: impact and alleviation of data quality and complex population substructure. Frontiers in Genetics 3:157.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427913/
Iancu OD, Kawane S, Bottomly D, Searles R, Hitzemann R, McWeeney S (2012) Utilizing RNA-Seq data for de novo coexpression network inference. Bioinformatics 28:1592-7. PMID: 22556371 PubMed Link
Kaur, S, Li, J., Stenzel-Poore, M.P., Ryabinin, A.E. (2012) Corticotropin releasing factor acting on corticotropin releasing factor receptor type 1 is critical for binge alcohol drinking in mice. Alcoholism: Clinical and Experimental Research 36:369-376. PMID: 21895713 PubMed Link
Kendler, K.S., Aggen, S., Prescott, C.A., Crabbe, J.C., Neale, M.C. (2012) Evidence for multiple genetic factors underlying the DSM-IV criteria for alcohol dependence. Molecular Psychiatry 17:1306-1315 . PMID: 22105626 PubMed Link
Mackiewicz-Seghete, K., Cservenka, A., Herting, M.M., Nagel, B.J. (2012) Atypical spatial working memory and task-general brain activity in adolescents with a family history of alcoholism. Alcoholism: Clinical and Experimental Research, Oct 18, ePub ahead of print. PMID: 23078615 PubMed Link
Mitchell SH, Wilson VB (2012) Differences in delay discounting between smokers and nonsmokers remain when both rewards are delayed. Psychopharmacology 219:549–562. PMID: 21983917 PubMed Link
Moschak, T. M., Stang, K. A., Phillips, T. J., & Mitchell, S. H. (2012) Behavioral inhibition in mice bred for high vs low levels of methamphetamine consumption or sensitization. Psychopharmacology 222:353‐65. PMID: 22311384 PubMed Link
Moschak, T. M., & Mitchell, S. H. (2012) Acute ethanol administration and reinforcer magnitude reduction both reduce responding and increase response latency in a Go/No‐Go task. Alcoholism: Clinical and Experimental Research 36:1803‐1810. PMID: 22486407 PubMed Link
Olson CR, Owen DC, Ryabinin AE, Mello CV (2012) Poster: Drinking Songs! The efficacy of songbirds in alcohol research. Society for Neuroscience Annual Meeting, New Orleans, LA.
SfN story: http://www.newscientist.com/article/dn22389-zebra-finches-sing-sloppily-when-drunk.ht
Pastor, R., Reed, C., Meyer, P.J., McKinnon, C., Ryabinin, A.E. and Phillips, T.J. (2012) Role of corticotropin releasing factor and corticosterone in behavioral sensitization to ethanol. Journal of Pharmacology and Experimental Therapeutics 341:455-63. PMID: 22333290 PubMed Link
Philibin SD, Cameron AJ, Schlumbohm, JP, Metten P, Crabbe JC (2012) Ethanol Withdrawal-Induced Motor Impairment in Mice. Psychopharmacology 220:367-378. PMID: 21947288 PubMed Link
Rosenwasser AM, Fixaris MC, Crabbe JC, Brooks PC, Ascheid S (2012) Escalation of intake under intermittent ethanol access in diverse mouse genotypes. Addiction Biology, Aug 2, ePub ahead of print. PMID: 22862671 PubMed Link
Ryabinin, A.E., Tsoory. M.M., Kozicz, T., Thiele, T.E., Neufeld-Cohen, A., Chen, A., Lowery, E.G., Giardino, W.J., Kaur, S. (2012) Urocortins: CRF’s siblings and their potential role in anxiety, depression and alcohol drinking behavior. Alcohol 46:349-357. PMID: 22444954 PubMed Link
Tanchuck MA, Cozzoli DK, He I, Kaufman KR, Snelling C, Crabbe JC, Mark GP and Finn DA (2012) Local changes in neurosteroid levels in the substantia nigra pars reticulata and the ventral tegmental area alter chronic ethanol withdrawal severity in male Withdrawal Seizure-Prone mice, Alcoholism: Clinical and Experimental Research, Dec 20, ePub ahead of print. PMID: 23278716 PubMed Link
Wilhelm, C. J., & Mitchell, S. H. (2012) Acute ethanol does not always affect delay discounting in rats selected to prefer or avoid ethanol. Alcohol and Alcoholism 47:518‐24. PMID: 22645038 PubMed Link
Yankelevitz, R. L., Mitchell, S. H. & Zhang, Y. (2012) Gender differences in factors associated with alcohol drinking: Delay discounting and perception of others' drinking. Drug and Alcohol Dependence 123:273‐6. PMID: 22154359 PubMed Link
2011 [return to top of page]
Anacker AM, Loftis JM, Ryabinin AE (2011) Alcohol Intake in Prairie Voles is Influenced by the Drinking Level of a Peer. Alcoholism: Clinical and Experimental Research 35:1884-1890.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158264/
Anacker AM, Loftis JM, Kaur S, Ryabinin AE (2011) Prairie voles as a novel model of socially facilitated excessive drinking. Addiction Biology 16:92-107.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950896/
Beckley EH, Scibelli AC, Finn DA (2011) Progesterone receptor antagonist CDB-4124 increases depression-like behavior in mice without affecting locomotor ability. Psychoneuroendocrinology 36:824-833.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081939/
Bottomly D, Walter NA, Hunter JE, Darakjian P, Kawane S, Buck KJ , Searles RP, Mooney M, McWeeney SK, Hitzemann R (2011) Evaluating gene expression in C57BL/6J and DBA/2J mouse striatum using RNA-Seq and microarrays. PLoS One 6:e17820.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063777/?tool=pubmed
Chen G, Cuzon Carlson VC, Wang J, Beck A, Heinz A, Ron D, Lovinger DM, Buck KJ ( 2011) Striatal involvement in human alcoholism and alcohol consumption, and withdrawal in animal models. Alcoholism: Clinical and Experimental Research 35:1739-1748.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276303/
Chen G, Kozell LB, Buck KJ (2011) Substantia nigra pars reticulata is crucially involved in barbiturate and ethanol withdrawal in mice. Behavioural Brain Research 218:152-157.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075943/
Crabbe JC, Harris RA, Koob GF (2011) Preclinical studies of alcohol binge drinking. Annals of the New York Acad Sci 1216:24-40.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076900/
Crabbe JC, Spence SE, Brown LL, Metten P ( 2011) Alcohol preference drinking in a mouse line selectively bred for high drinking in the dark. Alcohol 45:427-440.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395368/
Cunningham CL, Groblewski PA, Voorhees CM (2011) Place conditionig, M. C. Olmstead (Ed.), Animal models of drug addiction (pp. 167-189), Neuromethods, vol. 53. Totowa, NJ: Humana Press.
Fei SS, Wilmarth PA, Hitzemann RJ, McWeeney SK, Belknap JK, David LL (2011) Protein Database and Quantitative Analysis Considerations when Integrating Genetics and Proteomics to Compare Mouse Strains. Journal of Proteome Research 10:2905-2912.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128464/?tool=pubmed
Fidler TL, Dion AM, Powers MS, Ramirez JJ, Mulgrew JA, Smitasin PJ, Crane AT, Cunningham CL (2011) Intragastric self-infusion of ethanol in high- and low-drinking mouse genotypes after passive ethanol exposure. Genes, Brain and Behavior 10:264-275.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070055/
Ford MM, Fretwell AM, Anacker AM, Crabbe JC, Mark GP, Finn DA (2011) The influence of selection for ethanol withdrawal severity on traits associated with ethanol self-administration and reinforcement. Alcoholism: Clinical and Experimental Research 35:326-337.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058687/
Giardino WJ, Cocking DL, Kaur S, Cunningham CL, Ryabinin AE (2011) Urocortin-1 in the centrally-projecting Edinger-Westphal nucleus is critical for ethanol preference. PLoS ONE.
Free full text link: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0026997
Giardino, W.J., Pastor, R., Anacker, A.M.J., Spangler, E., Cote, D.M., Li, J., Stenzel-Poore, M., Phillips, T.J., Ryabinin, A.E. (2011) Dissection of corticotropin-releasing factor system involvement in locomotor sensitivity to methamphetamine. Genes, Brain and Behavior 10:78-89. [PARC Animal Core provided animals]
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025045/
Giardino, W.J., Ryabinin, A.E. (2011) Commentary: Corticotropin-releasing factor: Innocent until proven guilty. Nature Reviews Neuroscience, 13:70.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365568/
Gremel CM, Young EA, Cunningham CL (2011) Blockade of opioid receptors in anterior cingulate cortex disrupts ethanol-seeking behavior in mice. Behavioural Brain Research 219:358-362. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062680/
Groblewski PA, Franken FH, Cunningham CL (2011) Inhibition of extracellular signal-regulated kinase (ERK) activity with SL327 does not prevent acquisition, expression, and extinction of ethanol-seeking behavior in mice. Behavioural Brain Research 217:399-407.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3019767/
Helms CM, Grant KA (2011) The effect of age on the discriminative stimulus effects of ethanol and its GABA(A) receptor mediation in cynomolgus monkeys. Psychopharmacology 216:333-43.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134136/
Herting MM, Fair D, Nagel BJ (2011) Altered fronto-cerebellar connectivity in alcohol-naive youth with a family history of alcoholism. Neuroimage 54:2582-2589.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150517/
Johnson BA, Messing RO, Charness ME, Crabbe JC, Goldman MS, Harris RA, Kranzler HR, Mitchell MC Jr, Nixon SJ, Riley EP, Schuckit MA, Sher KJ, Thomas JD (2011) Should the reorganization of addiction-related research across all the National Institutes of Health be structural?--The devil is truly in the details. Alcoholism: Clinical and Experimental Research 35:572-580. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068603/
Johnson BA, Messing RO, Charness ME, Crabbe JC, Goldman MS, Harris RA et al. (2011) How Should Addiction-Related Research at the National Institutes of Health be Reorganized? Frontiers in Psychiatry 2:2.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098615/?tool=pubmed
Laderas TG, Walter NA, Mooney M, Vartanian K, Darakjian P, Buck K, Harrington CA, Belknap J, Hitzemann R, McWeeney SK (2011) Computational detection of alternative exon usage. Frontiers in Neuroscience 5:69.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097375/?tool=pubmed
Metten P, Brown LL, Crabbe JC. 2011. Limited access ethanol drinking in the dark in adolescent and adult mice. Pharmacology, Biochemistry and Behavior 98:279-285.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057404/
Mitchell SH. 2011. The genetic basis of delay discounting and its genetic relationship to alcohol dependence. Behavioral Processes 87:10-17.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081405/
Mulligan MK, Rhodes JS, Crabbe JC, Mayfield RD, Adron HR, Ponomarev I. 2011. Molecular profiles of drinking alcohol to intoxication in C57BL/6J mice. Alcoholism: Clinical and Experimental Research 35:659-670.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066294/?tool=pubmed
Munn E, Bunning M, Prada S, Bohlen M, Crabbe JC, Wahlsten D. 2011. Reversed light-dark cycle and cage enrichment effects on ethanol-induced deficits in motor coordination assessed in inbred mouse strains with a compact battery of refined tests. Behavioural Brain Research 224:259-71. PMID: 21664382 PubMed Link
Pastor, R., Reed, C., Burkhart-Kasch, S., Li, N., Sharpe, A.L., Coste, S.C., Stenzel-Poore, M.P., Phillips, T.J. (2011) Ethanol concentration-dependent effects and the role of stress on ethanol drinking in corticotropin-releasing factor type 1 and double type 1 and 2 receptor knockout mice. Psychopharmacology 218:169-177. PMID: 21487655 PubMed Link
Pastor, R., Font, L., Miquel, M., Phillips, T.J., Aragon, C.M.G. (2011) Involvement of the beta-endorphin neurons of the hypothalamic arcuate nucleus in ethanol-induced place preference conditioning in mice. Alcoholism: Clinical and Experimental Research 35:1-11. PMID: 22014186 PubMed Link
Phillips TJ, Pastor R, Scibelli AC, Reed C, Tarragón E (2011) Behavioral sensitization to addictive drugs: Clinical relevance and methodological aspects. In J. Raber (ed.), Animal Models of Behavioral Analysis, Neuromethods Vol. 50 (pp. 267-305). Humana Press, New York.
Roselli CE, Finn TJ, Ronnekleiv-Kelly SM, Tanchuck MA, Kaufman KR, Finn DA. 2011. Localization of brain 5a-reductase messenger RNA in mice selectively bred for high chronic alcohol withdrawal severity. Alcohol 45:763-772. PMID: 21917407 PubMed Link
Voorhees CM, Cunningham CL. 2011. Involvement of the orexin/hypocretin system in ethanol conditioned place preference. Psychopharmacology 214:805-818.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063857/
Welsh JP, Han VZ, Rossi DJ, Mohr C, Odagiri M, Daunais JB, Grant KA (2011) Bidirectional plasticity in the primate inferior olive induced by chronic ethanol intoxication and sustained abstinence. Proceedings of the National Academy of Sciences USA 108:10314-10319.
Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121872/?tool=pubmed
Blednov YA, Ozburn AR, Walker D, Ahmed S, Belknap JK, Harris RA. (2010) Hybrid mice as genetic models of high alcohol consumption. Behavior Genetics 40:93-110. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038337/?tool=pubmed
Boudreau E, Chen G, Li X, Buck K, Hitzemann R, Hickman D. (2010) Intraperitoneal catheter placement for pharmacological imaging studies in conscious mice. Lab Animal (NY) 39:23-25. PMID: 20023678 PubMed Link
Chen G, Buck KJ. (2010) Rostroventral caudate putamen involvement in ethanol withdrawal is influenced by a chromosome 4 locus. Genes, Brain and Behavior 9:768-776. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970669/?tool=pubmed
Crabbe JC. (2010) Consilience of rodent and human phenotypes relevant for alcohol dependence. Addiction Biology 15:103-108. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853473/?tool=pubmed
Crabbe JC, Phillips TJ, Belknap JK. (2010) The complexity of alcohol drinking: studies in rodent genetic models. Behavior Genetics 40:737-750. PMID: 20552264 PubMed Link
Crabbe JC, Bell RL, Ehlers CL. (2010) Human and laboratory rodent low response to alcohol: is better consilience possible? Addiction Biology 15:125-144. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853481/?tool=pubmed
Crabbe JC. (2010) Neurogenetic studies of alcohol addiction. Philos Trans R Soc Lond B Biol Sci 363:3201-3211. Reprinted in T.W. Robbins, B.J. Everitt, D.J. Nutt,, (Eds) Neurobiology of Addiction: New Vistas, Oxford University Press, New York, pp. 153-169.
Cservenka A, Spangler E, Cote DM, Ryabinin AE (2010). Postnatal developmental profile of urocortin 1 and cocaine- and amphetamine-regulated transcript in the perioculomotor region of C57BL/6J mice. Brain Research 1319:33-43. PubMed Link
Cunningham CL. (2010) Alcohol preference tests. In I. Stolerman (Ed.), Encyclopedia of psychopharmacology, Part 1. (pp. 61-64). Berlin Heidelberg: Springer-Verlag.
Dick D M, Smith G, Olausson P, Mitchell SH, Leeman RF, O'Malley SS, Sher K. (2010) Understanding the construct of impulsivity and its relationship to alcohol use disorders. Addiction Biology 15:217-226. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895996/?tool=pubmed
Ehlers CL, Walter NA, Dick DM, Buck KJ, Crabbe JC. (2010) A comparison of selected quantitative trait loci associated with alcohol use phenotypes in humans and mouse models. Addiction Biology 15:185-199. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848508/?tool=pubmed
Finn DA, Beckley EH, Kaufman KR and Ford MM. (2010) Manipulation of GABAergic steroids: Sex differences in the effects on alcohol drinking- and withdrawal-related behaviors. Hormones and Behavior57:12-22. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813380/?tool=pubmed
Flory GS, O'Malley J, Grant KA, Park B, Kroenke CD. (2010) Quantification of ethanol methyl (1)H magnetic resonance signal intensity following intravenous ethanol administration in primate brain. Methods 50:189-198. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828522/?tool=pubmed
Gremel CM, Cunningham CL. (2010) Effects of disconnection of amygdala dopamine and nucleus accumbens N-methyl-d-aspartate receptors on ethanol-seeking behavior in mice. European Journal of Neuroscience 31:148-155. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908034/?tool=pubmed
Gubner NR, Wilhelm CJ, Phillips TJ, Mitchell SH. (2010) Strain differences in behavioral inhibition in a Go/No-go task demonstrated using 15 inbred mouse strains. Alcoholism: Clinical and Experimental Research 34:1353-1362. PMID: 20491731 PubMed Link
Heilig M, Egli M, Crabbe JC, Becker HC. (2010) Acute withdrawal, protracted abstinence and negative affect in alcoholism: are they linked? Addiction Biology 15:169-184. PMID: 20148778 PubMed Link
Herting MM, Schwartz D, Mitchell SH, Nagel BJ. (2010) Delay discounting behavior and white matter microstructure abnormalities in youth with a family history of alcoholism. Alcoholism: Clinical and Experimental Research 34:1590-1602. PMID: 20586754 PubMed Link
Iancu OD, Darakjian P, Walter NA, Malmanger B, Oberbeck D, Belknap J, McWeeney S, Hitzemann R. (2010) Genetic diversity and striatal gene networks: focus on the heterogeneous stock-collaborative cross (HS-CC) mouse. BMC Genomics 11:585. Free full text link: http://www.biomedcentral.com/1471-2164/11/585
Kaufman KR, Tanchuck MA, Strong MN, Finn DA. (2010) Replacement with GABAergic steroid precursors restores the acute ethanol withdrawal profile in ADX/GDX mice. Neuroscience 166:5-14. Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815158/?tool=pubmed
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Palmer AA, Lessov-Schlaggar CN, Ponder CA, McKinnon CS, Phillips TJ (2006). Sensitivity to the locomotor-stimulant effects of ethanol and allopregnanolone: A quantitative trait locus study of common genetic influence. Genes Brain Behav. 5(7):506-17. PubMed Link
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Holstein, S. E. and Phillips, T. J. (2006). GABAB receptor stimulation accentuates the locomotor effects of morphine in mice bred for extreme sensitivity to the stimulant effects of ethanol. Pharmacol.Biochem.Behav. 85: 697-704. PubMed Link Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1805633/?tool=pubmed
Kamens, H. M., Burkhart-Kasch, S., McKinnon, C. S., Li, N., Reed, C., and Phillips, T. J. (2006). Ethanol-related traits in mice selectively bred for differential sensitivity to methamphetamine-induced activation. Behav.Neurosci. 120: 1356-1366. PubMed Link
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Saba, L., Bhave, S. V., Grahame, N., Bice, P., Lapadat, R., Belknap, J., Hoffman, P. L., and Tabakoff, B. (2006). Candidate genes and their regulatory elements: alcohol preference and tolerance. Mamm.Genome 17: 669-688. PubMed Link
Crabbe JC, Metten P, Cameron AJ, Wahlsten D (2005). An analysis of the genetics of alcohol intoxication in inbred mice. Neuroscience and Biobehavioral Reviews 28:785-802. PubMed Link
Ford MM, Nickel JD and Finn DA. (2005). Treatment with and withdrawal from finasteride alters ethanol intake patterns in male C57BL/6J mice: potential role of endogenous neurosteroids? Alcohol 37:25-33. PubMed Link Free full text link:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1533880/?tool=pubmed
Lovinger DM, Crabbe JC (2005). Laboratory models of alcoholism: treatment target identification and insight into mechanisms. Nature Neuroscience 8:1471-80. PubMed Link
Kozell L, Hitzemann R, Buck KJ (2005). Acute alcohol withdrawal involves c-Fos expression in the basal ganglia and associated circuitry: C57BL/6J and DBA/2J inbred mouse strain analyses. Alcoholism: Clinical and Experimental Research 29:1939-1948. PubMed Link
Turek, V.F., Tsivkovskaia, N.O., Hyytia, P, Harding, S, Le, A.-D., Ryabinin, A.E. (2005) Urocortin 1 expression in five pairs of rat lines selectively bred for differences in alcohol drinking. Psychopharmacology181:511-517. PubMed Link
Bechtholt, A. J., & Cunningham, C. L. (2005). Ethanol-induced conditioned place preference is expressed through a ventral tegmental area dependent mechanism. Behavioral Neuroscience 119:213-223. PubMed Link
Blednov YA, Metten P, Finn DA, Rhodes JS, Bergeson SE, Harris RA, Crabbe JC (2005). Hybrid C57BL/6J x FVB/NJ mice drink more alcohol than do C57BL/6J mice. Alcoholism: Clinical and Experimental Research 29:1949-58. PubMed Link
Cronise K, Finn DA, Metten P, Crabbe JC (2005). Scheduled access to ethanol results in motor impairment and tolerance in female C57BL/6J mice. Pharmacology, Biochemistry and Behavior. 81:943-53. PubMed Link
Fehr C, Shirley R, Crabbe JC, Belknap JK, Buck KJ, and Phillips TJ (2005). The syntaxin binding protein gene (Stxbp1) is a candidate for an ethanol preference drinking locus on mouse chromosome 2. Alcoholism: Clinical and Experimental Research 29: 708-720. PubMed Link
Finn DA, Belknap JK, Cronise K, Yoneyama N, Murillo A, Crabbe JC (2005). A procedure to produce high alcohol intake in mice. Psychopharmacology 178:471-80. PubMed Link
Ford MM, Nickel JD, Phillips TJ, Finn DA (2005). Neurosteroid modulators of GABA(A) receptors differentially modulate Ethanol intake patterns in male C57BL/6J mice. Alcoholism: Clinical and Experimental Research 29:1630-40. PubMed Link Free full text link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1540354/?tool=pubmed
Gabriel, K.I., & Cunningham, C. L. (2005). Effects of topiramate on ethanol and saccharin consumption and preferences in C57BL/6J mice. Alcoholism: Clinical and Experimental Research 29:75-80. PubMed Link
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Hickman DL, Burkhart-Kasch S, Phillips TJ (2005). The effect of fostering on the genetic expression of locomotor sensitivity to alcohol. Comparative Medicine 55:498-502. PubMed Link
Holstein SE, Pastor R, Meyer PJ, Phillips TJ (2005). Naloxone does not attenuate the locomotor effects of ethanol in FAST, SLOW, or two heterogeneous stocks of mice. Psychopharmacology 182:277-89. PubMed Link
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Kamens HM, Burkhart-Kasch S, McKinnon CS, Li N, Reed C, Phillips TJ (2005). Sensitivity to psychostimulants in mice bred for high and low stimulation to methamphetamine. Genes Brain and Behavior 4:110-25. PubMed Link
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2004 [return to top of page]
Kamens, H. M., Phillips, T. J., Holstein, S. E., and Crabbe, J. C. (2004) Characterization of the parallel rod floor apparatus to test motor incoordination in mice. Genes, Brain and Behavior, OnlineEarly 14 September.
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Finn, D. A., Sinnott, R. S., Ford, M. M., Long, S. L., Tanchuck, M. A., and Phillips, T. J. (2004). Sex differences in the effect of ethanol injection and consumption on brain allopregnanolone levels in C57BL/6 mice. Neuroscience 123: 813-819. PubMed Link
Fehr, C., Shirley, R. L., Metten, P., Kosobud, A. E., Belknap, J. K., Crabbe, J. C., and Buck, K. J. (2004). Potential pleiotropic effects of Mpdz on vulnerability to seizures. Genes, Brain and Behavior 3: 8-19. PubMed Link
Klein, R. F., Allard, J., Avnur, Z., Nikolcheva, T., Rotstein, D., Carlos, A. S., Shea, M., Waters, R. V., Belknap, J. K., Peltz, G., and Orwoll, E. S. (2004). Regulation of bone mass in mice by the lipoxygenase gene Alox15. Science 303: 229-232. PubMed Link
Mueller, J. L., Ellenberger, E. A., Vaughn, L. K., Belknap, J. K., and Quock, R. M. (2004). Detection and mapping of quantitative trait loci that determine responsiveness of mice to nitrous oxide antinociception. Neuroscience 123: 743-749. PubMed Link
Weitemier, A. Z. and Ryabinin, A. E. (2004). Subregion-specific differences in hippocampal activity between Delay and Trace fear conditioning: an immunohistochemical analysis. Brain Research 995: 55-65. PubMed Link
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Kliethermes, C. L., Metten, P., Belknap, J. K., Buck, K. J., and Crabbe, J. C. (2004). Selection for pentobarbital withdrawal severity: correlated differences in withdrawal from other sedative drugs. Brain Research 1009: 17-25. PubMed Link
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Buck, K. J., Reilly, M. T., Rogers, L. M., Szeliga, K., Grant, K., and Brodie, M. S. (2004). Serotonin 5-HT2 receptors and alcohol: reward, withdrawal and discrimination. Alcoholism: Clinical and Experimental Research 28: 211-216. PubMed Link
Bechtholt, A. J., Smith, R., Raber, J., and Cunningham, C. L. (2004). Enhanced ethanol-, but not cocaine-induced, conditioned place preference in Apoe-/- mice. Pharmacol Biochem.Behav. 77: 783-792. PubMed Link
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Palmer, A. A., Sharpe, A. L., Burkhart-Kasch, S., McKinnon, C. S., Coste, S. C., Stenzel-Poore, M. P., and Phillips, T. J. (2004) Corticotropin-releasing factor overexpression decreases ethanol drinking and increases sensitivity to the sedative effects of ethanol. Psychopharmacology 176: 386-397. PubMed Link
Kliethermes, C. L., Cronise, K., and Crabbe, J. C. (2004). Anxiety-like behavior in mice in two apparatuses during withdrawal from chronic ethanol vapor inhalation. Alcoholism: Clinical and Experimental Research 28: 1012-1019. PubMed Link
Ponomarev, I. and Crabbe, J. C. (2004). Characterization of acute functional tolerance to the hypnotic effects of ethanol in mice. Alcoholism: Clinical and Experimental Research 28: 991-997. PubMed Link
Finn, D. A., Long, S. L., Tanchuck, M. A., and Crabbe, J. C. (2004). Interaction of chronic ethanol exposure and finasteride: sex and strain differences. Pharmacology Biochemistry and Behavior 78: 435-443. PubMed Link
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Hitzemann, R., Reed, C., Malmanger, B., Lawler, M., Hitzemann, B., Cunningham, B., Belknap, J.K., Buck, K.J., Phillips, T.J., and Crabbe, J.C. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. Alcoholism: Clinical and Experimental Research 28: 1437-1448. PubMed Link
Bachtell, R.K., Weitemier, A.Z., and Ryabinin, A.E. (2004) Lesions of the Edinger-Westphal nucleus in C57BL/6J mice disrupt ethanol-induced hypothermia and ethanol consumption. European Journal of Neuroscience 20: 1613-1623. PubMed Link
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Bechtholt, A. J., Gremel, C. M., and Cunningham, C. L. (2004) Handling blocks expression of conditioned place aversion but not conditioned place preference produced by ethanol in mice. Pharmacology Biochemistry and Behavior 79: 739-744. PubMed Link
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Kale, A., Amende, I., Meyer, G. P., Crabbe, J. C., and Hampton, T. G. (2004) Ethanol's effects on gait dynamics in mice investigated by ventral plane videography. Alcoholism: Clinical and Experimental Research 28: 1839-1848. PubMed Link
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Crabbe, J. C. and Phillips, T. J. (2004). Pharmacogenetic studies of alcohol self administration and withdrawal. Psychopharmacology 174: 539-560. PubMed Link
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Crabbe, J. C. (2003). Finding genes for complex behaviors: progress in mouse models of the addictions. In: Plomin, R., DeFries, J. C., Craig, I. W., and McGuffin, P. (Eds.), Behavioral Genetics in the Postgenomic Era, American Psychological Association, WashingtAmerican Psychological Associationon, D.C., pp. 291-308.
Crabbe, J. C. (2003). Current strategies for identifying genes for alcohol sensitivity. In: Maldonado, R. (Eds.), Molecular Biology of Drug Addiction, Humana Press, Totowa, N.J., pp. 249-261.
Bachtell, R. K., Tsivkovskaia, N. O., and Ryabinin, A. E. (2003). Identification of temperature-sensitive neural circuits in mice using c-Fos expression mapping. Brain Research 960: 157-164. PubMed Link
Wahlsten, D., Metten, P., Phillips, T. J., Boehm, S. L., Burkhart-Kasch, S., Dorow, J., Doerksen, S., Downing, C., Fogarty, J., Rodd-Henricks, K., Hen, R., McKinnon, C. S., Merrill, C. M., Nolte, C., Schalomon, M., Schlumbohm, J. P., Sibert, J. R., Wenger, C. D., Dudek, B. C., and Crabbe, J. C. (2003). Different data from different labs: lessons from studies of gene-environment interaction. Journal of Neurobiology 54: 283-311. PubMed Link
Wahlsten, D., Rustay, N. R., Metten, P., and Crabbe, J. C. (2003). In search of a better mouse test. Trends in Neurosciences 26: 132-136. PubMed Link
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Ryabinin, A. E., Galvan-Rosas, A., Bachtell, R. K., and Risinger, F. O. (2003). High alcohol/sucrose consumption during dark circadian phase in C57BL/6J mice: involvement of hippocampus, lateral septum and urocortin-positive cells of the Edinger-Westphal nucleus. Psychopharmacology 165: 296-305. PubMed Link
Bachtell, R. K., Weitemier, A. Z., Galvan-Rosas, A., Tsivkovskaia, N. O., Risinger, F. O., Phillips, T. J., Grahame, N. J., and Ryabinin, A. E. (2003). The Edinger-Westphal-lateral septum urocortin pathway and its relationship to alcohol consumption. Journal of Neruoscience 23: 2477-2487. PubMed Link
Herson, P. S., Virk, M., Rustay, N. R., Bond, C. T., Crabbe, J. C., Adelman, J. P., and Maylie, J. (2003). A mouse model of episodic ataxia type-1. Nature Neuroscience 6: 378-383. PubMed Link
Crabbe, J. C. and Wahlsten, D. (2003). Of mice and their environments (Letter). Science 299: 1313-1314. PubMed Link
Lessov, C. N. and Phillips, T. J. (2003). Cross-sensitization between the locomotor stimulant effects of ethanol and those of morphine and cocaine in mice. Alcoholism: Clinical and Experimental Research 27: 616-627. PubMed Link
Crabbe, J. C. and Phillips, T. J. (2003). Mother nature meets mother nurture. Nature Neuroscience 6: 440-442. PubMed Link
Wahlsten, D., Metten, P., and Crabbe, J. C. (2003). Survey of 21 inbred mouse strains in two laboratories reveals that BTBR T/+ tf/tf has severely reduced hippocampal commissure and absent corpus callosum. Brain Research 971: 47-54. PubMed Link
Finn, D. A., Rutledge-Gorman, M. T., and Crabbe, J. C. (2003). Genetic animal models of anxiety. Neurogenetics 4: 109-135. PubMed Link
Dickinson, S. D., Lee, E. L., Rindal, K., and Cunningham, C. L. (2003). Lack of effect of dopamine receptor blockade on expression of ethanol-induced conditioned place preference in mice. Psychopharmacology 165: 238-244. PubMed Link
Risinger, F. O. (2003). Genetic analyses of ethanol-induced hyperglycemia. Alcoholism: Clinical and Experimental Research 27: 756-764. PubMed Link
Palmer, A. A., Low, M. J., Grandy, D. K., and Phillips, T. J. (2003). Effects of a Drd2 deletion mutation on ethanol-induced locomotor stimulation and sensitization suggest a role for epistasis. Behavior Genetics 33: 311-324. PubMed Link
Meyer, P. J. and Phillips, T. J. (2003). Bivalent effects of MK-801 on ethanol-induced sensitization do not parallel its effects on ethanol-induced tolerance. Behavioral Neuroscience 117: 641-649. PubMed Link
Boyce-Rustay, J. M. and Risinger, F. O. (2003). Dopamine D3 receptor knockout mice and the motivational effects of ethanol. Pharmacology, Biochemistry and Behavior 75: 373-379. PubMed Link
Fehr, C., Rademacher, B. L., and Buck, K. J. (2003). Evaluation of the glutamate decarboxylase genes Gad1 and Gad2 as candidate genes for acute ethanol withdrawal severity in mice. Prog.Neuropsychopharmacol.Biol.Psychiatry 27: 467-472. PubMed Link
Bergeson, S. E., Kyle, Warren R., Crabbe, J. C., Metten, P., Gene, Erwin, V, and Belknap, J. K. (2003). Chromosomal loci influencing chronic alcohol withdrawal severity. Mammalian Genome 14: 454-463. PubMed Link
Crabbe, J. C., Cotnam, C. J., Cameron, A. J., Schlumbohm, J. P., Rhodes, J. S., Metten, P., and Wahlsten, D. (2003). Strain differences in three measures of ethanol intoxication in mice: the screen, dowel and grip strength tests. Genes Brain, and Behavior 2: 201-213. PubMed Link
Crabbe, J. C. and Phillips, T. J. (2003). Pharmacogenetic studies of alcohol self-administration and withdrawal. Psychopharmacology : On-Line First, October 9th. PubMed Link
Wahlsten, D., Metten, P., and Crabbe, J. C. (2003). A rating scale for wildness and ease of handling laboratory mice: results for 21 inbred strains tested in two laboratories. Genes Brain, and Behavior 2: 71-79. PubMed Link
Kliethermes, C. L., Finn, D. A., and Crabbe, J. C. (2003). Validation of a modified mirrored chamber sensitive to anxiolytics and anxiogenics in mice. Psychopharmacology 169: 190-197. PubMed Link
Goldsmith, H., Crabbe, J., Dawson, G., Gottesman, I. I., Hewitt, J., McGue, M., Pedersen, N., Plomin, R., Rose, R., and Swanson, J. (2003). Research psychologists' roles in the genetic revolution. AmericanPsychologist 58: 318-319. PubMed Link
Rustay, N. R., Wahlsten, D., and Crabbe, J. C. (2003). Influence of task parameters on rotarod performance and sensitivity to ethanol in mice. Behavioural Brain Research 141: 237-249. PubMed Link
Weitemier, A. Z. and Ryabinin, A. E. (2003). Alcohol-induced memory impairment in trace fear conditioning: a hippocampus-specific effect. Hippocampus 13: 305-315. PubMed Link
Hill, K. G., Alva, H., Blednov, Y. A., and Cunningham, C. L. (2003). Reduced ethanol-induced conditioned taste aversion and conditioned place preference in GIRK2 null mutant mice. Psychopharmacology 169: 108-114. PubMed Link
Cunningham, C. L., Ferree, N. K., and Howard, M. A. (9-2-2003). Apparatus bias and place conditioning with ethanol in mice. Psychopharmacology. PubMed Link
Crabbe, J. C. and Wiren, K. M. (2003). Molecular and genetic bases of the addictions. In: Rosenberg, R. N., Prusiner, S. B., DiMauro, S., Barchi, R. L., and Nestler, E. J. (Eds.), The Molecular and Genetic Bases of Neurologic and Psychiatric Disease, Butterworth Heinemann, Philadelphia, pp. 779-789.
Kelly, M. A., Low, M. J., Phillips, T. J., Wakeland, E. K., and Yanagisawa, M. (2003). The mapping of quantitative trait loci underlying strain differences in locomotor activity between 129S6 and C57BL/6J mice. Mammalian Genome 14: 692-702. PubMed Link
Bergstrom, H. C., Palmer, A. A., Wood, R. D., Burkhart-Kasch, S., McKinnon, C. S., and Phillips, T. J. (2003). Reverse selection for differential response to the locomotor stimulant effects of ethanol provides evidence for pleiotropic genetic influence on locomotor response to other drugs of abuse. Alcoholism: Clinical and Experimental Research 27: 1535-1547. PubMed Link
Meyer, P. J. and Phillips, T. J. (2003). Sensitivity to ketamine, alone or in combination with ethanol, is altered in mice selectively bred for sensitivity to ethanol's locomotor effects. Alcoholism: Clinical and Experimental Research 27: 1701-1709. PubMed Link
Abiola, O., Angel, J. M., Avner, P., Bachmanov, A. A., Belknap, J. K., Bennett, B., Blankenhorn, E. P., Blizard, D. A., Bolivar, V., Brockmann, G. A., Buck, K. J., Bureau, J. F., Casley, W. L., Chesler, E. J., Cheverud, J. M., Churchill, G. A., Cook, M., Crabbe, J. C., et al. (2003). The nature and identification of quantitative trait loci: a community's view. Nature Reviews Genetics 4: 911-916. PubMed Link
Phillips, T. J., Belknap, J. K., Hitzemann, R., Buck, K. J., Cunningham, C. L., and Crabbe, J. C. (2003). Appendix 5A: Internet resources for genomic, bioinformatics, and medical genetics information. Current Protocols in Neuroscience Online Appendix 5 Databases.
Belknap, J. K. (2003). Chromosome substitution strains: some quantitative considerations for genome scans and fine mapping. Mammalian Genome 14: 723-732. PubMed Link
Hitzemann, R., Malmanger, B., Reed, C., Lawler, M., Hitzemann, B., Coulombe, S., Buck, K., Rademacher, B., Walter, N., Polyakov, Y., Sikela, J., Gensler, B., Burgers, S., Williams, R. W., Manly, K., Flint, J., and Talbot, C. (2003). A strategy for the integration of QTL, gene expression, and sequence analyses. Mammalian Genome 14: 733-747. PubMed Link
Cunningham, C. L., Smith, R., and McMullin, C. (2003). Competition between ethanol-induced reward and aversion in place conditioning. Learning and Behavior 31: 273-280. PubMed Link
Phillips, T. J. (2003). Addiction and genes: animal models. In: Cooper,D. N. (Eds.), Nature Encyclopedia of the Human Genome, Nature Publishing group, New York, pp. 7-15.
Rhodes, J.S. and Crabbe, J.C. (2003) Progress towards finding genes for alcoholism in mice. Clinical Neuroscience Research, 3:315-323.
Finn, D.A., Roberts, A.J., Long, S., Tanchuck, M. and Phillips, T.J. (2003) Neurosteroid consumption has anxiolytic effects in mice. Pharmacology Biochemistry and Behavior 76:451-462. PubMed Link
Finn DA, Purdy RH and Koob GF. (2003) Animal models of anxiety and stress-induced behavior: Effects of neuroactive steroids. In: Smith, S. (Ed.), Neurosteroid Effects in the Central Nervous System: The Role of the GABAA Receptor, CRC Press, Boca Raton, pp. 317-338.
2002 [return to top of page]
Phillips, T. J. (2002). Animal models for the genetic study of human alcohol phenotypes. Alcohol Research and Health 26: 202-207. NIAAA link
Phillips, T. J., Belknap, J. K., Hitzemann, R. J., Buck, K. J., Cunningham, C. L., and Crabbe, J. C. (2002). Harnessing the mouse to unravel the genetics of human disease. Genes, Brain and Behavior 1: 14-26. PubMed Link
Daniels, G. M. and Buck, K. J. (2002). Expression profiling identifies strain-specific changes associated with ethanol withdrawal in mice. Genes, Brain and Behavior 1: 35-45. PubMed Link
Crabbe, J. C. (2002). Genetic contributions to addiction. Annual Review of Psychology 53: 435-462. PubMed Link
Palmer, A. A. and Phillips, T. J. (2002). Quantitative trait locus (QTL) mapping in mice. In: Liu, Y. and Lovinger, D. M. (Eds.), Methods in Alcohol-related Neuroscience Research, CRC Press, Boca Raton FL, pp. 1-30.
Palmer, A. A., Miller, M. N., McKinnon, C. S., and Phillips, T. J. (2002). Sensitivity to the locomotor stimulant effects of ethanol and allopregnanolone is influenced by common genes. Behavioral Neuroscience 116: 126-137. PubMed Link
Buck, K. J., Rademacher, B. L. S., Metten, P., and Crabbe, J. C. (2002). Mapping murine loci for physical dependence on ethanol. Psychopharmacology 160: 398-407. PubMed Link
Fehr, C., Shirley, R. L., Belknap, J. K., Crabbe, J. C., and Buck, K. J. (2002). Congenic mapping of alcohol and pentobarbital withdrawal liability Loci to a <1 centimorgan interval of murine chromosome 4: identification of Mpdz as a candidate gene. Journal of Neruoscience 22: 3730-3738. PubMed Link
Cunningham, C. L., Clemans, J. M., and Fidler, T. L. (2002). Injection timing determines whether intragastric ethanol produces conditioned place preference or aversion in mice. Pharmacology, Biochemistry and Behavior 72: 659-668. PubMed Link
Cunningham, C. L., Tull, L. E., Rindal, K. E., and Meyer, P. J. (2002). Distal and proximal pre-exposure to ethanol in the place conditioning task: tolerance to aversive effect, sensitization to activating effect, but no change in rewarding effect. Psychopharmacology 160: 414-424. PubMed Link
Broadbent, J., Muccino, K. J., and Cunningham, C. L. (2002). Ethanol-induced conditioned taste aversion in 15 inbred mouse strains. Behavioral Neuroscience 116: 138-148. PubMed Link
II Boehm, S. L., Reed, C. L., McKinnon, C. S., and Phillips, T. J. (2002). Shared genes influence sensitivity to the effects of ethanol on locomotor and anxiety-like behaviors, and the stress axis. Psychopharmacology 161: 54-63. PubMed Link
Phillips, T. J., Shen, E. H., McKinnon, C. S., Burkhart-Kasch, S., Lessov, C. N., and Palmer, A. A. (2002). Forward, relaxed, and reverse selection for reduced and enhanced sensitivity to ethanol's locomotor stimulant effects in mice. Alcoholism: Clinical and Experimental Research 26: 593-602. PubMed Link
Phillips, T. J. and Belknap, J. K. (2002). Complex-trait genetics: emergence of multivariate strategies. Nature Reviews Neuroscience 3: 478-485. PubMed Link
Grisel, J. E., Metten, P., Wenger, C. D., Merrill, C. M., and Crabbe, J. C. (2002). Mapping of quantitative trait loci underlying ethanol metabolism in BXD recombinant inbred mouse strains. Alcoholism: Clinical and Experimental Research 26: 610-616. PubMed Link
Ryabinin, A. E., Miller, M. N., and Durrant, S. (2002). Effects of acute alcohol administration on object recognition learning in C57BL/6J mice. Pharmacology, Biochemistry and Behavior 71: 315-320. PubMed Link
Ryabinin, A. E., Bachtell, R. K., Heinrichs, S. C., Lee, S., Rivier, C., Olive, M. F., Mehmert, K. K., Camarini, R., Kim, J. A., Koenig, H. N., Nannini, M. A., Hodge, C. W., Roberts, A. J., and Koob, G. F. (2002). The corticotropin-releasing factor/urocortin system and alcohol. Alcoholism: Clinical and Experimental Research 26: 714-722. PubMed Link
Risinger, F. O. and Boyce, J. M. (2002). Conditioning tastant and the acquisition of conditioned taste avoidance to drugs of abuse in DBA/2J mice. Psychopharmacology 160: 225-232. PubMed Link
Chester, J. A. and Cunningham, C. L. (2002). GABA(A) receptor modulation of the rewarding and aversive effects of ethanol. Alcohol 26: 131-143. PubMed Link
Palmer, A. A., Moyer, M. R., Crabbe, J. C., and Phillips, T. J. (2002). Initial sensitivity, tolerance and cross-tolerance to allopregnanolone- and ethanol-induced hypothermia in selected mouse lines. Psychopharmacology 162: 313-322. PubMed Link
Ponomarev, I. and Crabbe, J. C. (2002). A novel method to assess initial sensitivity and acute functional tolerance to hypnotic effects of ethanol. Journal of Pharmacology and Experimental Therapeutics 302: 257-263. PubMed Link
Crabbe, J. C., Metten, P., Gallaher, E. J., and Belknap, J. K. (2002). Genetic determinants of sensitivity to pentobarbital in inbred mice. Psychopharmacology 161: 408-416. PubMed Link
Sinnott, R. S., Phillips, T. J., and Finn, D. A. (2002). Alteration of voluntary ethanol and saccharin consumption by the neurosteroid allopregnanolone in mice. Psychopharmacology 162: 438-447. PubMed Link
Mark, G. P. and Finn, D. A. (2002). The relationship between hippocampal acetylcholine release and cholinergic convulsant sensitivity in Withdrawal Seizure-Prone and Withdrawal Seizure-Resistant selected mouse lines. Alcoholism: Clinical and Experimental Research 26: 1141-1152. PubMed Link
Bachtell, R. K., Tsivkovskaia, N. O., and Ryabinin, A. E. (2002). Strain differences in urocortin expression in the Edinger-Westphal nucleus and its relation to alcohol-induced hypothermia. Neuroscience 113: 421-434. PubMed Link
Bachtell, R. K., Tsivkovskaia, N. O., and Ryabinin, A. E. (2002). Alcohol-induced c-Fos expression in the Edinger-Westphal nucleus: pharmacological and signal transduction mechanisms. Journal of Pharmacology and Experimental Therapeutics 302: 516-524. PubMed Link
Palmer, A. A. and Phillips, T. J. (2002). Effect of forward and reverse selection for ethanol-induced locomotor response on other measures of ethanol sensitivity. Alcoholism: Clinical and Experimental Research 26: 1322-1329. PubMed Link
Maiya, R., Buck, K. J., Harris, R. A., and Mayfield, R. D. (2002). Ethanol-sensitive sites on the human dopamine transporter. Journal of Biological Chemistry 277: 30724-30729. PubMed Link
Sinnott, R. S., Mark, G. P., and Finn, D. A. (2002). Reinforcing effects of the neurosteroid allopregnanolone in rats. Pharmacology, Biochemistry and Behavior 72: 923-929. PubMed Link
Boehm, S. L., Piercy, M. M., Bergstrom, H. C., and Phillips, T. J. (2002). Ventral tegmental area region governs GABA(B) receptor modulation of ethanol-stimulated activity in mice. Neuroscience 115: 185-200. PubMed Link
Crabbe, J. C. (2002). Alcohol and genetics: New models. American Journal of Medical Genetics (Neuropsychiatric Genetics) 114: 969-974. PubMed Link
Risinger, F. O., Cunningham, C. L., Bevins, R. A., and Holloway, F. A. (2002). Place conditioning: what does it add to our understanding of ethanol reward? Alcoholism: Clinical and Experimental Research 26: 1444-1452. PubMed Link
Marshall, K. E., Godden, E. L., Yang, F., Burgers, S., Buck, K. J., and Sikela, J. M. (2002). In silico discovery of gene-coding variants in murine quantitative trait loci using strain-specific genome sequence databases. Genome Biology 3: 1-9. PubMed Link
Hitzemann, R., Malmanger, B., Cooper, S., Coulombe, S., Reed, C., Demarest, K., Koyner, J., Cipp, L., Flint, J., Talbot, C., Rademacher, B., Buck, K., and McCaughran, J. (2002). Multiple cross mapping (MCM) markedly improves the localization of a QTL for ethanol-induced activation. Genes, Brain and Behavior 1: 214-222. PubMed Link
Palmer, A. A., McKinnon, C. S., Bergstrom, H. C., and Phillips, T. J. (2002). Locomotor activity responses to ethanol, other alcohols, and GABA-A acting compounds in forward- and reverse-selected FAST and SLOW mouse lines. Behavioral Neuroscience 116: 958-967. PubMed Link
Ponomarev, I and Crabbe, J. C. (2002). Ethanol-induced activation and rapid development of tolerance may have some underlying genes in common. Genes, Brain and Behavior 1: 82-87. PubMed Link
2001 [return to top of page]
Crabbe, J. C. (2001). Use of genetic analyses to refine phenotypes related to alcohol tolerance and dependence. Alcoholism: Clinical and Experimental Research 25: 288-292. PubMed Link
Lessov, C. N., Risinger, F. O., and Phillips, T. J. (2001). Attenuation of ethanol-induced conditioned taste aversion in mice sensitized to the locomotor stimulant effects of ethanol. Behavioral Neuroscience 115: 146-153. PubMed Link
Schafer, G. L., Crabbe, J. C., and Wiren, K. M. (2001). Ethanol-regulated gene expression of neuroendocrine specific protein in mice: brain region and genotype specificity. Brain Research 897: 139-149. PubMed Link
Klein, R. F., Shea, M., Gunness, M. E., Pelz, G. B., Belknap, J. K., and Orwoll, E. S. (2001). Phenotypic characterization of mice bred for high and low peak bone mass. Journal of Bone and Mineral Research 16: 63-71. PubMed Link
Lessov, C. N., Palmer, A. A., Quick, E. A., and Phillips, T. J. (2001). Voluntary ethanol drinking in C57BL/6J and DBA/2J mice before and after sensitization to the locomotor stimulant effects of ethanol. Psychopharmacology 155: 91-99. PubMed Link
Mason, J. N., Eshleman, A. J., Belknap, J. K., Crabbe, J. C., Loftis, J. M., Macey, T. A., and Janowsky, A. (2001). NMDA receptor subunit mRNA and protein expression in ethanol-Withdrawal Seizure-Prone and -Resistant Mice. Alcoholism: Clinical and Experimental Research 25: 651-660. PubMed Link
Weitemier, A. Z., Woerner, A., Backstrom, P., Hyytia, And P., and Ryabinin, A. E. (2001). Expression of c-Fos in Alko Alcohol Rats Responding for Ethanol in an Operant Paradigm. Alcoholism: Clinical and Experimental Research 25: 704-710. PubMed Link
Le, A. D., Kiianmaa, K., Cunningham, C. L., Engel, J. A., Ericson, M., Soderpalm, B., Koob, G. F., Roberts, A. J., Weiss, F., Hyytia, P., Janhunen, S., Mikkola, J., Backstrom, P., Ponomarev, I., and Crabbe, J. C. (2001). Neurobiological processes in alcohol addiction. Alcoholism: Clinical and Experimental Research 25: 144S-151S. PubMed Link
Hoffman, P. L., Yagi, T., Tabakoff, B., Phillips, T. J., Kono, H., Messing, R. O., and Choi, D. S. (2001). Transgenic and gene "knockout" models in alcohol research. Alcoholism: Clinical and Experimental Research 25: 60S-66S. PubMed Link
Suwaki, H., Kalant, H., Higuchi, S., Crabbe, J. C., Ohkuma, S., Katsura, M., Yoshimura, M., Stewart, R. C., Li, T. K., and Weiss, F. (2001). Recent research on alcohol tolerance and dependence. Alcoholism: Clinical and Experimental Research 25: 189S-196S. PubMed Link
Grupe, A., Germer, S., Usuka, J., Aud, D., Belknap, J. K., Klein, R. F., Ahluwalia, M. K., Higuchi, R., and Peltz, G. (2001). In silico mapping of complex disease-related traits in mice. Science 292: 1915-1918. PubMed Link
Buck, K. J. and Finn, D. A. (2001). Genetic factors in addiction: QTL mapping and candidate gene studies implicate GABAergic genes in alcohol and barbiturate withdrawal in mice. Addiction 96: 139-149. PubMed Link
Reilly, M. T., Fehr, C., and Buck, K. J. (2001). Alcohol and gene expression in the central nervous system. In: Moussa-Moustaid, N. and Berdanier, C. D. (Eds.), Nutrient-Gene Interactions in Health and Disease, CRC Press, Boca Raton FL, pp. 131-162.
Belknap, J. K., Hitzemann, R., Crabbe, J. C., Phillips, T. J., Buck, K. J., and Williams, R. W. (2001). QTL analysis and genomewide mutagenesis in mice: Complementary genetic approaches to the dissection of complex traits. Behavior Genetics 31: 5-15. PubMed Link
Hood, H. M., Belknap, J. K., Crabbe, J. C., and Buck, K. J. (2001). Genomewide search for epistasis in a complex trait: Pentobarbital withdrawal convulsions in mice. Behavior Genetics 31: 93-100. PubMed Link
Bergeson, S. E., Helms, M. L., O'Toole, L. A., Jarvis, M. W., Hain, H. S., Mogil, J. S., and Belknap, J. K. (2001). Quantitative trait loci influencing morphine antinociception in four mapping populations. Mammalian Genome 12: 546-553. PubMed Link
Rustay, N. R., Boehm, S. L., Schafer, G. L., Browman, K. E., Erwin, V. G., and Crabbe, J. C. (2001). Sensitivity and tolerance to ethanol-induced incoordination and hypothermia in HAFT and LAFT mice. Pharmacology, Biochemistry and Behavior 70: 167-174. PubMed Link
Janowsky, A., Mah, C., Johnson, R. A., Cunningham, C. L., Phillips, T. J., Crabbe, J. C., Eshleman, A. J., and Belknap, J. K. (2001). Mapping genes that regulate density of dopamine transporters and correlated behaviors in recombinant inbred mice. Journal of Pharmacology and Experimental Therapeutics 298: 634-643. PubMed Link
Atkins, A. L., Helms, M. L., O'Toole, L. A., and Belknap, J. K. (2001). Stereotypic behaviors in mice selectively bred for high and low methamphetamine-induced stereotypic chewing. Psychopharmacology 157: 96-104. PubMed Link
Bachtell, R. K. and Ryabinin, A. E. (2001). Interactive effects of nicotine and alcohol co-administration on expression of inducible transcription factors in mouse brain. Neuroscience 103: 941-954. PubMed Link
Ryabinin, A. E., Bachtell, R. K., Freeman, P., and Risinger, F. O. (2001). ITF expression in mouse brain during acquisition of alcohol self- administration. Brain Research 890: 192-195. PubMed Link
Ueno, S., Harris, R. A., Messing, R. O., Sanchez-Perez, A. M., Hodge, C. W., McMahon, T., Wang, D., Mehmert, K. K., Kelley, S. P., Haywood, A., Olive, M. F., Buck, K. J., Hood, H. M., Blednov, Y., Findlay, G., and Mascia, M. P. (2001). Alcohol actions on GABA(A) receptors: from protein structure to mouse behavior. Alcoholism: Clinical and Experimental Research 25: 76S-81S. PubMed Link
Murray, S. E., Lallman, H. R., Heard, A. D., Rittenberg, M. B., and Stenzel-Poore, M. P. (2001). A genetic model of stress displays decreased lymphocytes and impaired antibody responses without altered susceptibility to Streptococcus pneumoniae. Journal of Immunology 167: 691-698. PubMed Link
Coste, S. C., Murray, S. E., and Stenzel-Poore, M. P. (2001). Animal models of CRH excess and CRH receptor deficiency display altered adaptations to stress. Peptides 22: 733-741. PubMed Link
Murray, S. E., Coste, S. C., Lindberg, I., and Stenzel-Poore, M. P. (2001). Genetic mutants with dysregulation of corticotropin pathways. Transgenic Models in Endocrinology, Kluwer Academic, Dordrecht, the Netherlands, pp. 143-173.
Crawshaw, L. I. and Wallace, H. L. (2001). Thermoregulation. In: Auerbach, P. S. (Eds.), Wilderness Medicine, Mosby, St. Louis.
Risinger, F. O., Freeman, P. A., Greengard, P., and Fienberg, A. A. (2001). Motivational effects of ethanol in DARPP-32 knock-out mice. Journal of Neuroscience 21: 340-348. PubMed Link
Belknap, J. K. and Atkins, A. L. (2001). The replicability of QTLs for murine alcohol preference drinking behavior across eight independent studies. Mammalian Genome 12: 893-899. PubMed Link
Wahlsten, D., Crabbe, J. C., and Dudek, B. C. (2001). Behavioural testing of standard inbred and 5HT(1B) knockout mice: implications of absent corpus callosum. Behavioural Brain Research 125: 23-32. PubMed Link
Crawshaw, L. I., Wallace, H. L., Christensen, R., and Crabbe, J. C. (2001). Influence of ethanol on thermoregulation: mapping quantitative trait loci. Physiological Genomics 7: 159-169. PubMed Link
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Finn, D. A., Gallaher, E. J., and Crabbe, J. C. (2000). Differential change in neuroactive steroid sensitivity during ethanol withdrawal. Journal of Pharmacology and Experimental Therapeutics 292: 394-405. PubMed Link
McMahon, T., Andersen, R., Metten, P., Crabbe, J.C., and Messing, R. O. (2000). Protein kinase C epsilon mediates up-regulation of N-type calcium channels by ethanol. Molecular Pharmacology 57: 53-58. PubMed Link
Buck, K. J., Crabbe, J. C., and Belknap, J. K. (2000). Alcohol and other abused drugs. In: Pfaff, D. W., Berrettini, W. H., Joh, T. H., and Maxson, S. C. (Eds.), Genetic Influences on Neural and Behavioral Functions, CRC Press, Boca Raton FL, pp. 159-183.
Browman, K. E. and Crabbe, J. C. (2000). Quantitative trait loci affecting ethanol sensitivity in BXD recombinant inbred mice. Alcoholism: Clinical and Experimental Research 24: 17-23. PubMed Link
Cunningham, C. L. and Dworkin, S. I. (2000). Alcoholism and drug addiction: What determines vulnerability? Molecular Medicine Today 6: 101-103.
Rausch, R. N., Crawshaw, L. I., and Wallace, H. L. (2000). Effects of hypoxia, anoxia, and endogenous ethanol on thermoregulation in goldfish, Carassius auratus. American Journal of Physiology: Regulatory, Integrative, and Comparative Physiology 278: R545-R555. PubMed Link
Boehm, S. L., Schafer, G. L., Phillips, T. J., Browman, K. E., and Crabbe, J. C. (2000). Sensitivity to ethanol-induced motor incoordination in 5-HT(1B) receptor null mutant mice is task-dependent: implications for behavioral assessment of genetically altered mice. Behavioral Neuroscience 114: 401-409. PubMed Link
Coste, S. C., Kesterson, R. A., Heldwein, K. A., Stevens, S. L., Heard, A. D., Hollis, J. H., Murray, S. E., Hill, J. K., Pantely, G. A., Hohimer, A. R., Hatton, D. C., Phillips, T. J., Finn, D. A., Low, M. J., Rittenberg, M. B., Stenzel, P., and Stenzel-Poore, M. P. (2000). Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2. Nature Genetics 24: 403-409. PubMed Link
Hain, H. S., Crabbe, J. C., Bergeson, S. E., and Belknap, J. K. (2000). Cocaine-induced seizure thresholds: quantitative trait loci detection and mapping in two populations derived from the C57BL/6 and DBA/2 mouse strains. Journal of Pharmacology and Experimental Therapeutics 293: 180-187. PubMed Link
Boehm, S. L., Crabbe, J. C., and Phillips, T. J. (2000). Sensitivity to ethanol-induced motor incoordination in FAST and SLOW selectively bred mice. Pharmacology, Biochemistry and Behavior 66: 241-247. PubMed Link
Hood, H. M. and Buck, K. J. (2000). Allelic variation in the GABA A receptor gamma2 subunit is associated with genetic susceptibility to ethanol-induced motor incoordination and hypothermia, conditioned taste aversion, and withdrawal in BXD/Ty recombinant inbred mice. Alcoholism: Clinical and Experimental Research 24: 1327-1334. PubMed Link
Ryabinin, A. E., Wang, Y., Bachtell, R. K., Kinney, A. E., Grubb, M. C., and Mark, G. P. (2000). Cocaine- and alcohol-mediated expression of inducible transcription factors is blocked by pentobarbital anesthesia. Brain Research 877: 251-261. PubMed Link
Hatton, D. C., Qi, Y., and Belknap, J. K. (2000). Heritability of the blood pressure response to acute ethanol exposure in five inbred strains of mice. Alcoholism: Clinical and Experimental Research 24: 1483-1487. PubMed Link
Buck, K., Lischka, T., Dorow, J., and Crabbe, J. (2000). Mapping quantitative trait loci that regulate sensitivity and tolerance to quinpirole, a dopamine mimetic selective for D(2)/D(3) receptors. American Journal of Medical Genetics 96: 696-705. PubMed Link
Boyce, J. M. and Risinger, F. O. (2000). Enhancement of ethanol reward by dopamine D3 receptor blockade. Brain Research 880: 202-206. PubMed Link
Beadles-Bohling, A. S., Crabbe, J. C., and Wiren, K. M. (2000). Elevated prodynorphin expression associated with ethanol withdrawal convulsions. Neurochemistry International 37: 463-472. PubMed Link
Ron, D., Vagts, A. J., Dohrman, D. P., Yaka, R., Jiang, Z., Yao, L., Crabbe, J., Grisel, J. E., and Diamond, I. (2000). Uncoupling of bIIPKC from its targeting protein RACK1 in response to ethanol in cultured cells and mouse brain. FASEB Journal 14: 2303-2314. PubMed Link
Reilly, M. T. and Buck, K. J. (2000). GABA(A) receptor beta(2) subunit mRNA content is differentially regulated in ethanol-dependent DBA/2J and C57BL/6J mice. Neurochemistry International 37: 443-452. PubMed Link
Hoffman, P. L., Morrow, A. L., Phillips, T. J., and Siggins, G. R. (2000). Neuroadaptation to ethanol at the molecular and cellular levels. NIAAA Research Monograph 34: 85-188.
Browman, K. E., Crabbe, J. C., and Li, T.-K. (2000). Genetic strategies in preclinical substance abuse research. In: Bloom, F. E. and Kupfer, D. J. (Eds.), Psychopharmacology: A Fourth Generation of Progress, Lippincott, Williams, & Wilkins, New York.
Plomin, R. and Crabbe, J. (2000). DNA. Psychological Bulletin 126: 806-828. PubMed Link
Risinger, F. O. and Cunningham, C. L. (2000). DBA/2J mice develop stronger lithium chloride-induced conditioned taste and place aversions than C57BL/6J mice. Pharmacology, Biochemistry and Behavior 67: 17-24. PubMed Link
Cunningham, C. L. and Henderson, C. M. (2000). Ethanol-induced conditioned place aversion in mice. Behavioural Pharmacology 11: 591-602. PubMed Link
Cunningham, C. L., Fidler, T. L., and Hill, K. G. (2000). Animal models of alcohol's motivational effects. Alcohol Research and Health 24: 85-92. PubMed Link
Risinger, F. O., Freeman, P. A., Rubinstein, M., Low, M. J., and Grandy, D. K. (2000). Lack of operant ethanol self-administration in dopamine D2 receptor knockout mice. Psychopharmacology 152: 343-350. PubMed Link
Morikawa, H., Manzoni, O. J., Crabbe, J. C., and Williams, J. T. (2000). Regulation of central synaptic transmission by 5-HT(1B) auto- and heteroreceptors. Molecular Pharmacology 58: 1271-1278. PubMed Link
Ryabinin, A. E. (2000). ITF mapping after drugs of abuse: Pharmacological versus perceptional effects. Acta Neurobiologiae Experimentalis 60: 547-555. PubMed Link
Cunningham, C. L., Howard, M. A., Gill, S. J., Rubinstein, M., Low, M. J., and Grandy, D. K. (2000). Ethanol-conditioned place preference is reduced in dopamine D2 receptor- deficient mice. Pharmacology, Biochemistry and Behavior 67: 693-699. PubMed Link
Reilly, M. T., Crabbe, J. C., Rustay, N. R., and Finn, D. A. (2000). Acute neuroactive steroid withdrawal in withdrawal seizure-prone and withdrawal seizure-resistant mice. Pharmacology, Biochemistry and Behavior 67: 709-717. PubMed Link
Browman, K. E., Rustay, N. R., Nikolaidis, N., Crawshaw, L., and Crabbe, J. C. (2000). Sensitivity and tolerance to ethanol in mouse lines selected for ethanol-induced hypothermia. Pharmacology, Biochemistry and Behavior 67: 821-829. PubMed Link
Risinger, F. O., Quick, E., and Belknap, J. K. (2000). Quantitative trait loci for acute behavioral sensitivity to paraoxon. Neurotoxicology and Teratology 22: 667-674. PubMed Link
Mogil, J. S., Grisel, J. E., Hayward, M. D., Bales, J. R., Rubinstein, M., Belknap, J. K., and Low, M. J. (2000). Disparate spinal and supraspinal opioid antinociceptive responses in beta-endorphin-deficient mutant mice. Neuroscience 101: 709-717. PubMed Link
Atkins, A. L., Rustay, N. R., and Crabbe, J. C. (2000). Anxiety and sensitivity to ethanol and pentobarbital in alcohol withdrawal seizure-prone and withdrawal seizure-resistant mice. Alcoholism: Clinical and Experimental Research 24: 1743-1749. PubMed Link
Crabbe, J. C. (2000). Genetic modification as a tool for the study of behavioral consequences of signaling processes. NIAAA Research Monograph 35: 137-144.
Crabbe, J. C. (2000). And a mouse is miracle enough to stagger sextillions of infidels. (Review of "What's Wrong with My Mouse?"). Trends in Genetics 16: 365-366.
Crabbe, J. C. (2000). Review of alcohol and alcoholism: Effects on brain development. Journal of Studies on Alcohol 61: 484-485.
Finn, D. A. and Crabbe, J. C. (1999). Chronic ethanol differentially alters susceptibility to chemically induced convulsions in withdrawal seizure-prone and -resistant mice. Journal of Pharmacology and Experimental Therapeutics 288: 782-790. PubMed Link
Risinger, F. O., Doan, A. M., and Vickrey, A. C. (1999). Oral operant ethanol self-administration in 5-HT1b knockout mice. Behavioural Brain Research 102: 211-215. PubMed Link
Wood, R. D., Shen, E. H., Chester, J. A., and Phillips, T. J. (1999). Ontogeny of ethanol-induced locomotor activity and hypothermia differences in selectively bred FAST and SLOW mice. Pharmacology, Biochemistry and Behavior 62: 339-347. PubMed Link
Broadbent, J. and Harless, W. E. (1999). Differential effects of GABA(A) and GABA(B) agonists on sensitization to the locomotor stimulant effects of ethanol in DBA/2 J mice. Psychopharmacology 141: 197-205. PubMed Link
Crabbe, J. C. (1999). Psychopharmacogenetics of alcohol. In: Mormede, P. and Jones, B. C. (Eds.), Neurobehavioral Genetics: Methods and Applications, CRC Press, Boca Raton FL, pp. 329-339.
Crabbe, J. C. (1999). Animal models in neurobehavioral genetics: Methods for estimating genetic correlation. In: Mormede, P. and Jones, B. C. (Eds.), Neurobehavioral Genetics: Methods and Applications, CRC Press, Boca Raton FL, pp. 121-138.
Mark, G. P., Hajnal, A., Kinney, A. E., and Keys, A. S. (1999). Self-administration of cocaine increases the release of acetylcholine to a greater extent than response-independent cocaine in the nucleus accumbens of rats. Psychopharmacology 143: 47-53. PubMed Link
Ryabinin, A. E., Wang, Y. M., Freeman, P., and Risinger, F. O. (1999). Selective effects of alcohol drinking on restraint-induced expression of immediate early genes in mouse brain. Alcoholism: Clinical and Experimental Research 23: 1272-1280. PubMed Link
Thrasher, M. J., Freeman, P. A., and Risinger, F. O. (1999). Clozapine's effects on ethanol's motivational properties. Alcoholism: Clinical and Experimental Research 23: 1377-1385. PubMed Link
Crabbe, J. C., Wahlsten, D., and Dudek, B. C. (1999). Genetics of mouse behavior: Interactions with laboratory environment. Science 284: 1670-1672. PubMed Link
Ryabinin, A. E., Wang, Y. M., and Finn, D. A. (1999). Different levels of Fos immunoreactivity after repeated handling and injection stress in two inbred strains of mice. Pharmacology, Biochemistry and Behavior 63: 143-151. PubMed Link
Risinger, F. O., Brown, M. M., Oakes, R. A., and Love, J. A. (1999). Effects of haloperidol or SCH-23390 on ethanol-induced conditioned taste aversion. Alcohol 18: 139-145. PubMed Link
Chester, J. A. and Cunningham, C. L. (1999). Baclofen alters ethanol-stimulated activity but not conditioned place preference or taste aversion in mice. Pharmacology, Biochemistry and Behavior 63: 325-331. PubMed Link
Buck, K., Metten, P., Belknap, J., and Crabbe, J. (1999). Quantitative trait loci affecting risk for pentobarbital withdrawal map near alcohol withdrawal loci on mouse chromosomes 1, 4, and 11. Mammalian Genome 10: 431-437. PubMed Link
Mark, G. P., Kinney, A. E., Grubb, M. C., and Keys, A. S. (1999). Involvement of acetylcholine in the nucleus accumbens in cocaine reinforcement. Annals of the New York Academy of Sciences 877: 792-795. PubMed Link
Metten, P. and Crabbe, J. C. (1999). Genetic determinants of severity of acute withdrawal from diazepam in mice: Commonality with ethanol and pentobarbital. Pharmacology, Biochemistry and Behavior 63: 473-479. PubMed Link
Broadbent, J. and Weitemier, A. Z. (1999). Dizocilpine (MK-801) prevents the development of sensitization to ethanol in DBA/2J mice. Alcohol and Alcoholism 34: 283-288. PubMed Link
Buckman, J. F., Meshul, C. K., Finn, D. A., and Janowsky, A. (1999). Glutamate uptake in mice bred for ethanol withdrawal severity. Psychopharmacology 143: 174-182. PubMed Link
Crabbe, J. C. (1999). Molecular genetics of addiction. In: Charney, D. S., Nestler, E. J., and Bunney, B. S. (Eds.), Neurobiology of Mental Illness, Oxford Univ. Press, New York, pp. 591-600.
Grisel, J. E., Mogil, J. S., Grahame, N. J., Rubinstein, M., Belknap, J. K., Crabbe, J. C., and Low, M. J. (1999). Ethanol oral self-administration is increased in mutant mice with decreased beta-endorphin expression. Brain Research 835: 62-67. PubMed Link
Chester, J. A. and Cunningham, C. L. (1999). GABA(A) receptors modulate ethanol-induced conditioned place preference and taste aversion in mice. Psychopharmacology 144: 363-372. PubMed Link
Browman, K. E. and Crabbe, J. C. (1999). Alcohol and genetics: New animal models. Molecular Medicine Today 5: 310-318. PubMed Link
Crabbe, J. C., Phillips, T. J., Buck, K. J., Cunningham, C. L., and Belknap, J. K. (1999). Identifying genes for alcohol and drug sensitivity: recent progress and future directions. Trends in Neurosciences 22: 173-179. PubMed Link
Crabbe, J. C. and Cunningham, C. L. (1999). Drug and alcohol dependence-related behaviors. In: Crusio, W. E. and Gerlai, R. T. (Eds.), Handbook of Molecular-Genetic Techniques for Brain and Behavior Research, Elsevier, Amsterdam, pp. 652-666.
Ponomarev, I. and Crabbe, J. C. (1999). Genetic association between chronic ethanol withdrawal severity and acoustic startle parameters WSP and WSR mice. Alcoholism: Clinical and Experimental Research 23: 1730-1735. PubMed Link
Phillips, T. J., Hen, R., and Crabbe, J. C. (1999). Complications associated with genetic background effects in research using knockout mice. Psychopharmacology 147: 5-7. PubMed Link
Bachtell, R. K., Wang, Y. M., Freeman, P., Risinger, F. O., and Ryabinin, A. E. (1999). Alcohol drinking produces brain region-selective changes in expression of inducible transcription factors. Brain Research 847: 157-165. PubMed Link
Buckman, J. F. and Meshul, C. K. (1999). Glial differences between naive Withdrawal Seizure-Prone and -Resistant mice. Alcoholism: Clinical and Experimental Research 23: 1905-1913. PubMed Link
Cunningham, C. L., Dickinson, S. D., Grahame, N. J., Okorn, D. M., and McMullin, C. S. (1999). Genetic differences in cocaine-induced conditioned place preference in mice depend on conditioning trial duration. Psychopharmacology 146: 73-80. PubMed Link
Mogil, J. S., Wilson, S. G., Bon, K., Lee, S. E., Chung, K., Raber, P., Pieper, J. O., Hain, H. S., Belknap, J. K., Hubert, L., Elmer, G. I., Chung, J. M., and Devor, M. (1999). Heritability of nociception I: responses of 11 inbred mouse strains on 12 measures of nociception. Pain 80: 67-82. PubMed Link
Mogil, J. S., Wilson, S. G., Bon, K., Lee, S. E., Chung, K., Raber, P., Pieper, J. O., Hain, H. S., Belknap, J. K., Hubert, L., Elmer, G. I., Chung, J. M., and Devor, M. (1999). Heritability of nociception II. 'Types' of nociception revealed by genetic correlation analysis. Pain 80: 83-93. PubMed Link
Kest, B., Jenab, S., Brodsky, M., Sadowski, B., Belknap, J. K., Mogil, J. S., and Inturrisi, C. E. (1999). Mu and delta opioid receptor analgesia, binding density, and mRNA levels in mice selectively bred for high and low analgesia. Brain Research 816: 381-389. PubMed Link
Burrows, K. B. and Meshul, C. K. (1999). High-dose methamphetamine treatment alters presynaptic GABA and glutamate immunoreactivity. Neuroscience 90: 833-850. PubMed Link
Demarest, K., McCaughran, J., Mahjubi, E., Cipp, L., and Hitzemann, R. (1999). Identification of an acute ethanol response quantitative trait locus on mouse chromosome 2. Journal of Neuroscience 19: 549-561. PubMed Link
Hain, H. S., Belknap, J. K., and Mogil, J. S. (1999). Pharmacogenetic evidence for the involvement of 5-hydroxytryptamine (Serotonin)-1B receptors in the mediation of morphine antinociceptive sensitivity. Journal of Pharmacology and Experimental Therapeutics 291: 444-449. PubMed Link
1998 [return to top of page]
Dickinson, S. D. and Cunningham, C. L. (1998). Altered ambient temperature and ethanol-induced conditioned place preference in mice. Alcohol 16: 13-18. PubMed Link
Phillips, T. J., Brown, K. J., Burkhart-Kasch, S., Wenger, C. D., Kelly, M. A., Rubinstein, M., Grandy, D. K., and Low, M. J. (1998). Alcohol preference and sensitivity are markedly reduced in mice lacking dopamine D2 receptors. Nature Neuroscience 1: 610-615. PubMed Link
Rocha, B. A., Scearce-Levie, K., Lucas, J. J., Hiroi, N., Castanon, N., Crabbe, J. C., Nestler, E. J., and Hen, R. (1998). Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor. Nature 393: 175-178. PubMed Link
Belknap, J. K. (1998). Effect of within-strain sample size on QTL detection and mapping using recombinant inbred mouse strains. Behavior Genetics 28: 29-38. PubMed Link
Buck, K. J. and Amara, S. G. (1998). In vivo generation of chimeras. Methods in Enzymology 296: 466-475. PubMed Link
Crabbe, J. C. (1998). Provisional mapping of quantitative trait loci for chronic ethanol withdrawal severity in BXD recombinant inbred mice. Journal of Pharmacology and Experimental Therapeutics 286: 263-271. PubMed Link
Shen, E. H. and Phillips, T. J. (1998). MK-801 potentiates ethanol's effects on locomotor activity in mice. Pharmacology, Biochemistry and Behavior 59: 135-143. PubMed Link
Belknap, J. K., Riggan, J., Cross, S., Young, E. R., Gallaher, E. J., and Crabbe, J. C. (1998). Genetic determinants of morphine activity and thermal responses in 15 inbred mouse strains. Pharmacology, Biochemistry and Behavior 59: 353-360. PubMed Link
Chester, J. A., Risinger, F. O., and Cunningham, C. L. (1998). Ethanol reward and aversion in mice bred for sensitivity to ethanol withdrawal. Alcoholism: Clinical and Experimental Research 22: 468-473. PubMed Link
Risinger, F. O., Brown, M. M., Doan, A. M., and Oakes, R. A. (1998). Mouse strain differences in oral operant ethanol reinforcement under continuous access conditions. Alcoholism: Clinical and Experimental Research 22: 677-684. PubMed Link
Lessov, C. N. and Phillips, T. J. (1998). Duration of sensitization to the locomotor stimulant effects of ethanol in mice. Psychopharmacology 135: 374-382. PubMed Link
Keys, A. S., Mark, G. P., Emre, N., and Meshul, C. K. (1998). Reduced glutamate immunolabeling in the nucleus accumbens following extended withdrawal from self-administered cocaine. Synapse 30: 393-401. PubMed Link
Crabbe, J. C. and Phillips, T. J. (1998). Genetics of alcohol and other abused drugs. Drug and Alcohol Dependence 51: 61-71. PubMed Link
Metten, P., Belknap, J. K., and Crabbe, J. C. (1998). Drug withdrawal convulsions and susceptibility to convulsants after short-term selective breeding for acute ethanol withdrawal. Behavioural Brain Research 95: 113-122. PubMed Link
Keys, A. S. and Mark, G. P. (1998). D1 and D2 dopamine receptor mediation of amphetamine-induced acetylcholine release in nucleus accumbens. Neuroscience 86: 521-531. PubMed Link
Shen, E. H., Dorow, J., Harland, R., Burkhart-Kasch, S., and Phillips, T. J. (1998). Seizure sensitivity and GABAergic modulation of ethanol sensitivity in selectively bred FAST and SLOW mouse lines. Journal of Pharmacology and Experimental Therapeutics 287: 606-615. PubMed Link
Grahame, N. J., Low, M. J., and Cunningham, C. L. (1998). Intravenous self-administration of ethanol in beta-endorphin-deficient mice. Alcoholism: Clinical and Experimental Research 22: 1093-1098. PubMed Link
Crawshaw, L. I., Wallace, H., and Crabbe, J. (1998). Ethanol, body temperature and thermoregulation. Clinical and Experimental Pharmacology and Physiology 25: 150-154. PubMed Link
Ryabinin, A. E. (1998). Role of hippocampus in alcohol-induced memory impairment: Implications from behavioral and immediate early gene studies. Psychopharmacology 139: 34-43. PubMed Link
Risinger, F. O. and Cunningham, C. L. (1998). Ethanol-induced conditioned taste aversion in BXD recombinant inbred mice. Alcoholism: Clinical and Experimental Research 22: 1234-1244. PubMed Link
Cunningham, C. L. (1998). Drug conditioning and drug-seking behavior. In: O'Donohue, W. (Eds.), Learning and Behavior Therapy, Allyn & Bacon, Boston, pp. 518-544.
Crabbe, J. C., Belknap, J. K., Metten, P., Grisel, J. E., and Buck, K. J. (1998). Quantitative trait loci: Mapping drug and alcohol-related genes. Advances in Pharmacology 42: 1033-1037. PubMed Link
Crabbe, J. C., Gallaher, E. J., Cross, S. J., and Belknap, J. K. (1998). Genetic determinants of sensitivity to diazepam in inbred mice. Behavioral Neuroscience 112: 668-677. PubMed Link
Hajnal, A., Mark, G. P., Keys, A. S., and Lenard, L. (1998). Involvement of dopamine and acetylcholine in the interaction between amygdala and nucleus accumbens: chronic microdialysis in rats. Neurobiology 6: 363-367. PubMed Link
Ryabinin, A. E. and Wang, Y-M. (1998). Repeated alcohol administration differentially affects c-Fos and FosB protein immunoreactivity in DBA/2J mice. Alcoholism: Clinical and Experimental Research 22: 1646-1654. PubMed Link
Buck, K. J. (1998). Recent progress toward the identification of genes related to risk for alcoholism. Mammalian Genome 9: 927-928. PubMed Link
Phillips, T. J., Belknap, J. K., Buck, K. J., and Cunningham, C. L. (1998). Genes on mouse chromosomes 2 and 9 determine variation in ethanol consumption. Mammalian Genome 9: 936-941. PubMed Link
Buck, K. J. and Hood, H. M. (1998). Genetic association of a GABA(A) receptor gamma2 subunit variant with severity of acute physiological dependence on alcohol. Mammalian Genome 9: 975-978. PubMed Link
Schafer, G. L., Crabbe, J. C., and Wiren, K. M. (1998). Identification of neuroendocrine-specific protein as an ethanol-regulated gene with mRNA differential display. Mammalian Genome 9: 979-982. PubMed Link
Metten, P., Phillips, T. J., Crabbe, J. C., Tarantino, L. M., McClearn, G. E., Plomin, R., Erwin, V. G., and Belknap, J. K. (1998). High genetic susceptibility to ethanol withdrawal predicts low ethanol consumption. Mammalian Genome 9: 983-990. PubMed Link
Phillips, T. J. (1998). Alcohol-related genetics in animals: Knockouts and antisense technology. Report of a Subcommittee of the National Advisory Council on Alcohol Abuse and Alcoholism on the Review of the Extramural Research Portfolio for Genetics, DHHS, PHS, NIH pp. 38-40.
Chester, J. A. and Cunningham, C. L. (1998). Modulation of corticosterone does not affect the acquisition or expression of ethanol-induced conditioned place preference in DBA/2J mice. Pharmacology, Biochemistry and Behavior 59: 67-75. PubMed Link
Crabbe, J. C. and Belknap, J. K. (1998). Ethical consequences of mapping QTLs for complex human traits. In: Paterson, A. H. (Eds.), Molecular Dissection of Complex Traits, CRC Press, Boca Raton FL, pp. 279-285.
Klein, R. F., Mitchell, S. R., Phillips, T. J., Belknap, J. K., and Orwoll, E. S. (1998). Quantitative trait loci affecting peak bone mineral density in mice. Journal of Bone and Mineral Research 13: 1648-1656. PubMed Link
Phillips, T. J., Huson, M. G., and McKinnon, C. S. (1998). Localization of genes mediating acute and sensitized locomotor responses to cocaine in BXD/Ty recombinant inbred mice. Journal of Neruoscience 18: 3023-3034. PubMed Link
Kelly, M. A., Rubinstein, M., Phillips, T. J., Lessov, C. N., Burkhart-Kasch, S., Zhang, G., Bunzow, J. R., Fang, Y., Gerhardt, G. A., Grandy, D. K., and Low, M. J. (1998). Locomotor activity in D2 dopamine receptor-deficient mice is determined by gene dosage, genetic background, and developmental adaptations. Journal of Neruoscience 18: 3470-3479. PubMed Link
1997[return to top of page]
Crawshaw, L. I., Wallace, H. L., Crabbe, J. C., Ramos, C., Duerr, J., and O'Connor, C. S. (1997). Ethanol disrupts and decreases the regulated body temperature differentially in C57BL/6J and DBA/2J mice. American Journal of Physiology 273: R696-R702. PubMed Link
Burrows, K. B. and Meshul, C. K. (1997). Methamphetamine alters presynaptic glutamate immunoreactivity in the caudate nucleus and motor cortex. Synapse 27: 133-144. PubMed Link
Cunningham, C. L., Okorn, D. M., and Howard, C. E. (1997). Interstimulus interval determines whether ethanol produces conditioned place preference or aversion in mice. Animal Learning and Behavior 25: 31-42.
Rubinstein, M., Phillips, T. J., Bunzow, J. R., Falzone, T. L., Dziewczapolski, G., Zhang, G., Fang, Y., Larson, J. L., McDougall, J. A., Chester, J. A., Saez, C., Pugsley, T. A., Gershanik, O., Low, M. J., and Grandy, D. K. (1997). Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine. Cell 90: 991-1001. PubMed Link
Crabbe, J. C. (1997). Where does alcohol act in the brain? Molecular Psychiatry 2: 17-20. PubMed Link
Phillips, T. J. (1997). Genetic studies with animal models. Contribution to Alcohol and Health, Ninth Special Report to the U.S.Congress from Secretary of Health and Human Services, DHHS, PHS, NIH, NIAAA pp. 40-43.
Grisel, J. E., Belknap, J. K., O'Toole, L. A., Helms, M. L., Wenger, C. D., and Crabbe, J. C. (1997). Quantitative trait loci affecting methamphetamine responses in BXD recombinant inbred mouse strains. Journal of Neuroscience 17: 745-754. PubMed Link
Buck, K. J., Metten, P., Belknap, J. K., and Crabbe, J. C. (1997). Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice. Journal of Neuroscience 17: 3946-3955. PubMed Link
Buckman, J. F. and Meshul, C. K. (1997). Immunocytochemical analysis of glutamate and GABA in selectively bred mice. Brain Research 760: 193-203. PubMed Link
Belknap, J. K., Dubay, C., Crabbe, J. C., and Buck, K. J. (1997). Mapping quantitative trait loci for behavioral traits in the mouse. In: Blum, K. and Noble, E. P. (Eds.), Handbook of Psychiatric Genetics, CRC Press, Boca Raton FL, pp. 435-453.
Phillips, T. J. (1997). Behavior genetics of drug sensitization. Critical Reviews in Neurobiology 11: 21-33.
Finn, D. A., Phillips, T. J., Okorn, D. M., Chester, J. A., and Cunningham, C. L. (1997). Rewarding effect of the neuroactive steroid 3 alpha-hydroxy-5 alpha-pregnan-20-one in mice. Pharmacology, Biochemistry and Behavior 56: 261-264. PubMed Link
Grahame, N. J. and Cunningham, C. L. (1997). Intravenous ethanol self-administration in C57BL/6J and DBA/2J mice. Alcoholism: Clinical and Experimental Research 21: 56-62. PubMed Link
Phillips, T. J., Wenger, C. D., and Dorow, J. D. (1997). Naltrexone effects on ethanol drinking acquisition and on established ethanol consumption in C57BL/6J mice. Alcoholism: Clinical and Experimental Research 21: 691-702. PubMed Link
Finn, D. A. and Crabbe, J. C. (1997). Exploring alcohol withdrawal syndrome. Alcohol Health and Research World 21: 149-156. PubMed Link
Belknap, J. K., Richards, S. P., O'Toole, L. A., Helms, M. L., and Phillips, T. J. (1997). Short-term selective breeding as a tool for QTL mapping: ethanol preference drinking in mice. Behavior Genetics 27: 55-66. PubMed Link
Crawley, J. N., Belknap, J. K., Collins, A., Crabbe, J. C., Frankel, W., Henderson, N., Hitzemann, R. J., Maxson, S. C., Miner, L. L., Silva, A. J., Wehner, J. M., Wynshaw-Boris, A., and Paylor, R. (1997). Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies. Psychopharmacology 132: 107-124. PubMed Link
Hajnal, A., Mark, G. P., Rada, P. V., Lenard, L., and Hoebel, B. G. (1997). Norepinephrine microinjections in the hypothalamic paraventricular nucleus increase extracellular dopamine and decrease acetylcholine in the nucleus accumbens: Relevance to feeding reinforcement. Journal of Neurochemistry 68: 667-674. PubMed Link
Boehm, S. L., II, Lundahl, K. R., Caldwell, J., and Gilliam, D. M. (1997). Ethanol teratogenesis in the C57BL/6J, DBA/2J and A/J inbred mouse strains. Alcohol 14: 389-395. PubMed Link
Finn, D. A., Roberts, A. J., Lotrich, F., and Gallaher, E. J. (1997). Genetic differences in behavioral sensitivity to a neuroactive steroid. Journal of Pharmacology and Experimental Therapeutics 280: 820-828. PubMed Link
Risinger, F. O. (1997). Fluoxetine's effects on ethanol's rewarding, aversive and stimulus properties. Life Sciences 61: PL235-PL242. PubMed Link
Phillips, T. J., Roberts, A. J., and Lessov, C. N. (1997). Behavioral sensitization to ethanol: Genetics and the effects of stress. Pharmacology, Biochemistry and Behavior 57: 487-493. PubMed Link
Keys, A. S. (1997). Structural CNS changes following cocaine: Implications for feedback regulation of mesolimbic circuitry. In: Nahas, G. G. and Burks, T. F. (Eds.), Drug Abuse in the Decade of the Brain, IOS Press, Amsterdam, pp. 223-232.
1996 [return to top of page]
Belknap, J. K., Mitchell, S. R., O'Toole, L. A., Helms, M. L., and Crabbe, J. C. (1996). Type I and type II error rates for quantitative trait loci (QTL) mapping studies using recombinant inbred mouse strains. Behavior Genetics 26: 149-160. PubMed Link
Broadbent, J., Linder, H. V., and Cunningham, C. L. (1996). Genetic differences in naloxone enhancement of ethanol-induced conditioned taste aversion. Psychopharmacology 126: 147-155. PubMed Link
Gallaher, E. J., Jones, G. E., Belknap, J. K., and Crabbe, J. C. (1996). Identification of genetic markers for initial sensitivity and rapid tolerance to ethanol-induced ataxia using quantitative trait locus analysis in BXD recombinant inbred mice. Journal of Pharmacology and Experimental Therapeutics 277: 604-612. PubMed Link
Phillips, T. J., Lessov, C. N., Harland, R. D., and Mitchell, S. R. (1996). Evaluation of potential genetic associations between ethanol tolerance and sensitization in BXD/Ty recombinant inbred mice. Journal of Pharmacology and Experimental Therapeutics 277: 613-623. PubMed Link
Crabbe, J. C., Phillips, T. J., Gallaher, E. J., Crawshaw, L. I., and Mitchell, S. R. (1996). Common genetic determinants of the ataxic and hypothermic effects of ethanol in BXD/Ty recombinant inbred mice: genetic correlations and quantitative trait loci. Journal of Pharmacology and Experimental Therapeutics 277: 624-632. PubMed Link
Crabbe, J. C. (1996). A genetic animal model of alcohol withdrawal. Alcoholism: Clinical and Experimental Research 20: 96A-100A. PubMed Link
Buck, K. J. (1996). New insight into the mechanisms of ethanol effects on GABAA receptor function and expression, and their relevance to behavior. Alcoholism: Clinical and Experimental Research 20: 198A-202A. PubMed Link
Risinger, F. O. and Oakes, R. A. (1996). Mianserin enhancement of ethanol-induced conditioned place preference. Behavioral Pharmacology 7: 294-298. PubMed Link
Shen, E. H., Dorow, J. D., Huson, M., and Phillips, T. J. (1996). Correlated responses to selection in FAST and SLOW mice: Effects of ethanol on ataxia, temperature, sedation, and withdrawal. Alcoholism: Clinical and Experimental Research 20: 688-696. PubMed Link
Lotrich, F. E. and Gallaher, E. J. (1996). Micropharmacokinetics: A system dynamics model of drug diffusion and uptake following localized injection into the brain. In: Anderson, J. G. and Katzper, M. (Eds.), Simulation in the Medical Sciences: Proceedings of the 1996 Western Multiconference, Society for Computer Simulation, San Diego CA, pp. 165-170.
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by Mark Rutledge-Gorman
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