OHSU

Xiangshu Xiao, Ph.D.

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Lab Phone: 
503 494-6249

Background

Our lab is focused on the development of novel cancer chemotherapeutic drugs targeting different biomolecular targets. To achieve these goals, we are utilizing the concepts and techniques in computer-assisted molecular modeling to design the molecules, organic chemistry to synthesize the molecules and biological assays to evaluate the molecules in cancer-relevant models. We recently discovered a small molecule inhibitor of CREB-mediated gene transcription by inhibiting the CREB-CBP interaction. This small molecule, naphthol AS-E, potently inhibits cancer cell proliferation and induce apoptosis in a variety of different cancer cells. Currently, we are investigating its mechanism of action and structure-activity relationships to design more potent derivatives as potential anticancer drugs. In addition, we are also interested in the development of novel nanotechnologies to deliver nucleic acids into the cells. This could potentially lead a new way for cancer gene therapy.


Selected Publications

"Novel type of prodrug activation through a long-range O,N-acyl transfer: A case of water-soluble CREB inhibitor," ACS Medicinal Chemistry Letters (Vol: 5, Issue: 10, Page 1104-1109) - 2014

"Synthesis of 14,15-EET From Arachidonic Acid Using Urea–Hydrogen Peroxide as the Oxidant," Synthetic Communications - 2014

"Discovery of a potent anti-tumor agent through regioselective mono-N-acylation of 7H-pyrrolo[3,2-f]quinazoline-1,3-diamine," MedChemComm (Vol: 4, Issue: 9, Page 1275-1282) - 2013

"Identification, synthesis and evaluation of substituted benzofurazans as inhibitors of CREB-mediated gene transcription," Bioorganic and Medicinal Chemistry Letters (Vol: 23, Issue: 19, Page 5371-5375) - 2013

"Soluble epoxide hydrolase dimerization is required for hydrolase activity," Journal of Biological Chemistry (Vol: 288, Issue: 11, Page 7697-7703) - 2013

 

OHSU Knight Cancer Institute

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Contact

  Email Xiangshu Xiao

503 494-8311

Memberships & Associations

American Chemical Society,
Sigma Xi Scientific Society