Xiangshu Xiao, Ph.D.
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- Lab Phone:
- 503 494-6249
Our lab is focused on the development of novel cancer chemotherapeutic drugs targeting different biomolecular targets. To achieve these goals, we are utilizing the concepts and techniques in computer-assisted molecular modeling to design the molecules, organic chemistry to synthesize the molecules and biological assays to evaluate the molecules in cancer-relevant models. We recently discovered a small molecule inhibitor of CREB-mediated gene transcription by inhibiting the CREB-CBP interaction. This small molecule, naphthol AS-E, potently inhibits cancer cell proliferation and induce apoptosis in a variety of different cancer cells. Currently, we are investigating its mechanism of action and structure-activity relationships to design more potent derivatives as potential anticancer drugs. In addition, we are also interested in the development of novel nanotechnologies to deliver nucleic acids into the cells. This could potentially lead a new way for cancer gene therapy.
"Erratum: Discovery of a potent anti-tumor agent through regioselective mono-N-acylation of 7H-pyrrolo[3,2-f]quinazoline-1,3-diamine (MedChemComm (2013) (4) DOI: 10.1039/C3MD00134B),"
"Novel type of prodrug activation through a long-range O,N-acyl transfer: A case of water-soluble CREB inhibitor,"
"Synthesis of 14,15-EET From Arachidonic Acid Using Ureaâ€“Hydrogen Peroxide as the Oxidant,"
"Discovery of a potent anti-tumor agent through regioselective mono-N-acylation of 7H-pyrrolo[3,2-f]quinazoline-1,3-diamine,"
"Identification, synthesis and evaluation of substituted benzofurazans as inhibitors of CREB-mediated gene transcription,"