William H. Fleming, M.D., Ph.D.

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Office:: 503 494-5058

Background

Dr. Fleming received both his medical degree and Ph.D. from the University of Manitoba, Winnipeg, in 1987. His specialty is bone marrow transplantation, and he is board certified in Internal Medicine and Medical Oncology. His research interests include stem-cell research, bone marrow transplantation, growth factors, and in utero transplantation. Dr. Fleming completed his residency and fellowship training at Stanford University.

Selected Publications

"Kinase pathway dependence in primary human leukemias determined by rapid inhibitor screening," Cancer Research (Vol: 73, Issue: 1, Page 285-296) - 2013

"Multiplex high-throughput gene mutation analysis in acute myeloid leukemia," Human Pathology (Vol: 43, Issue: 12, Page 2167-2176) - 2012

"A novel human cytomegalovirus locus modulates cell type-specific outcomes of infection," PLoS Pathogens (Vol: 7, Issue: 12, Page ) - 2011

"Fancd2^-/- mice have hematopoietic defects that can be partially corrected by resveratrol," Blood (Vol: 116, Issue: 24, Page 5140-5148) - 2010

"Granulocyte-colony stimulating factor reactivates human cytomegalovirus in a latently infected humanized mouse model," Cell Host and Microbe (Vol: 8, Issue: 3, Page 284-291) - 2010

"Endothelial cells mediate the regeneration of hematopoietic stem cells," Stem Cell Research (Vol: 4, Issue: 1, Page 17-24) - 2010

"BMP4 regulates the hematopoietic stem cell niche," Blood (Vol: 114, Issue: 20, Page 4393-4401) - 2009

"Apoptosis-stimulating protein of p53 (ASPP2) heterozygous mice are tumor-prone and have attenuated cellular damage-response thresholds," Proceedings of the National Academy of Sciences of the United States of America (Vol: 106, Issue: 11, Page 4390-4395) - 2009

"Hematopoietic stem cells contribute to lymphatic endothelium," PLoS ONE (Vol: 3, Issue: 11, Page ) - 2008

"Transvection mediated by the translocated cyclin D1 locus in mantle cell lymphoma," Journal of Experimental Medicine (Vol: 205, Issue: 8, Page 1843-1858) - 2008

"Myeloid lineage progenitors give rise to vascular endothelium," Proceedings of the National Academy of Sciences of the United States of America (Vol: 103, Issue: 35, Page 13156-13161) - 2006

"Bone marrow-derived cells fuse with normal and transformed intestinal stem cells," Proceedings of the National Academy of Sciences of the United States of America (Vol: 103, Issue: 16, Page 6321-6325) - 2006

"Mouse models of hematopoietic engraftment: Limitations of transgenic green fluorescent protein strains and a high-performance liquid chromatography approach to analysis of erythroid chimerism," Stem Cells (Vol: 24, Issue: 9, Page 2045-2051) - 2006

"In vivo genetic selection of renal proximal tubules," Molecular Therapy (Vol: 13, Issue: 1, Page 49-58) - 2006

"Endothelial cell-specific markers: Going . . . going . . . gone," Blood (Vol: 106, Issue: 3, Page 769-) - 2005

"Donor marker infidelity in transgenic hematopoietic stem cells," Stem Cells (Vol: 23, Issue: 5, Page 638-643) - 2005

"The hereditary hemochromatosis protein, HFE, lowers intracellular iron levels independently of transferrin receptor 1 in TRVb cells," Blood (Vol: 105, Issue: 6, Page 2564-2570) - 2005

"Transplanted human bone marrow contributes to vascular endothelium," Proceedings of the National Academy of Sciences of the United States of America (Vol: 101, Issue: 48, Page 16891-16896) - 2004

"PECAM-1 is expressed on hematopoietic stem cells throughout ontogeny and identifies a population of erythroid progenitors," Blood (Vol: 104, Issue: 4, Page 1010-1016) - 2004

"Myelomonocytic cells are sufficient for therapeutic cell fusion in liver," Nature Medicine (Vol: 10, Issue: 7, Page 744-748) - 2004

"Transplanted adult hematopoietic stems cells differentiate into functional endothelial cells," Blood (Vol: 103, Issue: 1, Page 13-19) - 2004

"Activation of the G-CSF and Flt-3 receptors protects hematopoietic stem cells from lethal irradiation," Experimental Hematology (Vol: 31, Issue: 11, Page 1119-1125) - 2003

"Converging roads: Evidence for an adult hemangioblast," Experimental Hematology (Vol: 31, Issue: 11, Page 987-993) - 2003

"Toxic megacolon: A life-threatening complication of high-dose therapy and autologous stem cell transplantation among patients with AL amyloidosis," Bone Marrow Transplantation (Vol: 30, Issue: 5, Page 279-285) - 2002

"Adult blood vessels restore host hematopoiesis following lethal irradiation," Experimental Hematology (Vol: 30, Issue: 8, Page 950-956) - 2002