Dennis Bourdette, M.D., F.A.A.N.

Lab Phone:: 503 494-7321
Office:: 503 494-7772; Lab Page: http://www.ohsu.edu/xd/research/centers-institutes/neurology/jungers-center/research/bourdette-lab.cfm

Background

Dr. Bourdette is Chair of the Department of Neurology, Roy and Eulalia Swank Family Research Professor, Executive Director of the OHSU Multiple Sclerosis Center and Co-Director of the VA MS Center of Excellence-West. He directs a team dedicated to curing and treating diseases such as multiple sclerosis, Alzheimer’s, Parkinson’s, Stroke, and ALS.

He is nationally recognized for his important discoveries in the field of multiple sclerosis and oversees an annual research budget of over $2 million. His team has attracted grants from the National Institutes of Health, Department of Veterans Affairs, National MS Society, Nancy Davis Foundation for Multiple Sclerosis, to name a few. He and his colleagues have received international attention for their development of a TCR peptide vaccine called Neurovax for the treatment of multiple sclerosis and a new therapy called VG1000 being developed with a local biotechnology company, Virogenomics. Dr. Bourdette received his medical degree at the University of California at Davis, joined OHSU in 1984 as a resident in the Department of Neurology.

Selected Publications

"People With Multiple Sclerosis Use Many Fall Prevention Strategies but Still Fall Frequently," Archives of Physical Medicine and Rehabilitation (Vol: , Issue: , Page ) - 2013

"Fingolimod and multiple sclerosis: Four cautionary tales," Neurology (Vol: 79, Issue: 19, Page 1942-1943) - 2012

"Treat patients with radiologically isolated syndrome when the MRI brain scan shows dissemination in time: No," Multiple Sclerosis (Vol: 18, Issue: 11, Page 1529-1530) - 2012

"New disease-modifying therapies and new challenges for MS," Current Neurology and Neuroscience Reports (Vol: 12, Issue: 5, Page 489-491) - 2012

"Ginkgo biloba does not improve cognitive function in MS A randomized placebo-controlled trial," Neurology (Vol: 79, Issue: 12, Page 1278-1284) - 2012

"Focal increases of axoplasmic Ca ²⁺, aggregation of sodium-calcium exchanger, N-type Ca ²⁺ channel, and actin define the sites of spheroids in axons undergoing oxidative stress," Journal of Neuroscience (Vol: 32, Issue: 35, Page 12028-12037) - 2012

""Undiagnosing" multiple sclerosis: The challenge of misdiagnosis in MS," Neurology (Vol: 78, Issue: 24, Page 1986-1991) - 2012

"Body-worn motion sensors detect balance and gait deficits in people with multiple sclerosis who have normal walking speed," Gait and Posture (Vol: 35, Issue: 4, Page 573-578) - 2012

"Crystal-storing histiocytosis: An unusual relapsing inflammatory CNS disorder," Multiple Sclerosis and Related Disorders (Vol: 1, Issue: 2, Page 95-99) - 2012

"Genetic inactivation of the p66 isoform of ShcA is neuroprotective in a murine model of multiple sclerosis," European Journal of Neuroscience (Vol: 35, Issue: 3-4, Page 562-571) - 2012

"Recombinant T-Cell Receptor Ligand (RTL) for treatment of multiple sclerosis: A double-blind, placebo-controlled, phase 1, dose-escalation study," Autoimmune Diseases (Vol: 1, Issue: 1, Page ) - 2012

"Anti-NMDA receptor encephalitis with paroxysmal sympathetic hyperactivity: an under-recognized association?," Clinical Autonomic Research (Vol: , Issue: , Page 1-3) - 2012

"Genetic inactivation of mitochondria-targeted redox enzyme p66shcA preserves neuronal viability and mitochondrial integrity in response to oxidative challenges," Frontiers in Physiology (Vol: 3 JUL, Issue: , Page 1-9) - 2012

"Magnetic resonance imaging correlates of dichotic listening performance in multiple sclerosis," Seminars in Hearing (Vol: 33, Issue: 3, Page 283-294) - 2012

"Electrophysiological measures of auditory processing in patients with multiple sclerosis," Seminars in Hearing (Vol: 33, Issue: 3, Page 274-282) - 2012

"Preliminary identification of central auditory processing screening tests for individuals with multiple sclerosis," Seminars in Hearing (Vol: 33, Issue: 3, Page 261-273) - 2012

"Oxidative stress inhibits axonal transport: Implications for neurodegenerative diseases," Molecular Neurodegeneration (Vol: 7, Issue: 1, Page ) - 2012

"American ginseng does not improve fatigue in multiple sclerosis: A single center randomized double-blind placebo-controlled crossover pilot study," Multiple Sclerosis (Vol: 17, Issue: 12, Page 1523-1526) - 2011

"Inflammatory neurological disease in patients treated with tumor necrosis factor alpha inhibitors," Multiple Sclerosis (Vol: 17, Issue: 12, Page 1472-1487) - 2011

"The radiologically isolated syndrome: Look (again) before you treat," Current Neurology and Neuroscience Reports (Vol: 11, Issue: 5, Page 498-506) - 2011

"Cognitive impairment and MS: Searching for effective therapies," Current Neurology and Neuroscience Reports (Vol: 11, Issue: 5, Page 451-454) - 2011

"Japanese macaque encephalomyelitis: A spontaneous multiple sclerosis-like disease in a nonhuman primate," Annals of Neurology (Vol: 70, Issue: 3, Page 362-373) - 2011

"Mitochondrial calcium and its regulation in neurodegeneration induced by oxidative stress," European Journal of Neuroscience (Vol: 34, Issue: 3, Page 437-447) - 2011

"Lipoic acid stimulates cAMP production via G protein-coupled receptor-dependent and -independent mechanisms," Journal of Nutritional Biochemistry (Vol: 22, Issue: 7, Page 681-690) - 2011

"Change in quality of life in patients with relapsing-remitting multiple sclerosis over 2 years in relation to other clinical parameters: Results from a trial of intramuscular interferon Î²-1a," Multiple Sclerosis (Vol: 17, Issue: 6, Page 734-742) - 2011