Larry David, the core's director, is a protein chemist with over 10 years of experience studying proteins using mass spectrometry. His research interests include studying age-related modifications in proteins by mass spectrometry, and in addition to directing the core is a principal investigator conducting NIH sponsored research.
Ashok Reddy, the core's associate director, is a bioanalytical chemist who assists the director of the OHSU Proteomics Shared Resource in managing proteomics projects across the entire university. He has 14 years of experience conducting cancer research including the world's largest cancer dose response study and 9 years of experience conducting proteomics/biomarker discovery studies in human body fluids, such as serum, saliva, cervico-vaginal fluid (cvf), amniotic fluid and urine. He has managed large cancer and proteomics projects from conception to discovery as demonstrated by the successful discovery of biomarkers of infection for Pre-term birth, Preeclampsia, and Neonatal sepsis. His work with protein biomarkers led to venture capital investment of $20 million for his former employer Proteogenix, Inc. His research interests are in disease biomarkers in body fluids and tumor markers in cancer tissues.
John came to PSR in 2006. He previously worked for the Proteomics Core Facility at the Institute for Systems Biology in Seattle Washington. His past research includes studies into the effects of particular mutations on the fuctioning of genes in drosophila. In Seattle John spent most of his time providing proteomics services for clients but also created MS/MS databases from a multitude of different instuments to aid in the development of peptide and protein identification software. Here at PSR John spends his time as handling many of the smaller projects; operating instruments, performing data analysis, and processing billings. John spends much of his free time at home with his wife and two young daughters.
Dr. Wu joined the PSR in Summer 2015 following completion of the post-doctoral fellowship with Drs. Richard Smith and Tao Liu at Pacific Northwest National Laboratory (PNNL). He received his Ph.D. under the direction of Dr. Rong Zeng at the Shanghai Chinese Academy of Sciences. His current interests are the development of high throughput methods to generate and evaluate targeted mass spectrometry assays for peptides using single reaction monitoring, optimizing data-collection for both TMT and targeted assays using the Orbitrap Fusion's instrument control software, and developing methodology for large scale phosphoproteomics analysis. His role in the PSR is to also act as a liaison to facilitate collaborations between OHSU and PNNL. His work in the PSR will facilitate collaborations between our two institutions and greatly increase the scope of future proteomics experiments due to direct access to the considerable instrumentation and computational resources at PNNL.
Jen is a bioanalytical chemist with 8 years of experience developing bioanalytical LC-MS/MS assays in the pharmaceutical industry. She has developed and validated numerous pre-clinical and clinical methods in biological matrices (plasma, blood, cerebral spinal fluid, etc.), and has experience with toxicokinetic and pharmacokinetic analyses. Jen works part-time in the PSR and focuses on developing targeted peptide assays. Jen spends her free time cycling, running, and spending time with her two young children.