OHSU

Ov D. Slayden

Disorders of the reproductive tract including tubal infertility, endometriosis and excessive uterine bleeding continue to levy a heavy burden on women's health. In order to identify new therapies for the treatment and prevention of these disorders we must advance our fundamental knowledge regarding basic physiology of the reproductive tract.               

 

The Slayden laboratory investigates factors that mediate the action of estrogens and progestins in the macaque reproductive tract. Techniques including immunocytochemistry, ligand binding, western blotting, RealTime RT-PCR and in situ hybridization are applied to understand the cyclic effects of ovarian hormones on the uterus, oviduct and cervix. Recent studies in Dr. Slayden's laboratory have focused extensively on the application of progesterone antagonists (antiprogestins) to regulate cellular function in the tract. Antiprogestins block progesterone action and can also specifically inhibit estrogen-stimulated uterine cell proliferation. Slayden and colleagues have shown that antiprogestins strikingly increase androgen receptor in the endometrium and that local androgens may play an important role in the antiproliferative effects of these important therapeutic compounds. In collaborative studies with Dr. Robert M. Brenner and Dr. Hilary Critchley at the Centre for Reproductive Biology at the University of Edinburgh, Dr. Slayden's group is also studying the use of antiprogestins to control uterine bleeding in women who use progestin releasing intrauterine devices.

 

Another area of interest for the Slayden lab is endometriosis, a disease in which endometrium-like lesions exist at sites outside the uterus. Like women, rhesus macaques develop endometriosis, and Dr. Slayden's laboratory is investigating the effects of estrogen and estrogen antagonists on ectopic endometrium in rhesus macaques. In recent studies conducted in collaboration with Dr. Laura Greenberg, M.D., and Jeffrey Jensen M.D., Slayden and colleagues have demonstrated that both macaque and human endometriosis can be engrafted into immunodeficient mice to provide a unique model for the evaluation of anti-endometriotic therapies on the human disease.

 

BIOGRAPHY               

Ov Daniel Slayden is an assistant scientist in the Division of Reproductive Sciences at ONPRC and has a joint appointment in the Department of Obstetrics and Gynecology in the School of Medicine, OHSU. He received his B.A. and M.A. degrees in Biology from Sonoma State University, and earned a Ph.D. in Biochemistry and Animal Science at Oregon State University. Dr. Slayden moved to the Center in 1991 after being awarded a Reproductive Biology Training Fellowship through the Department of Physiology at OHSU.               

 

KEY PUBLICATIONS                

Slayden OD. Induced endometriosis in nonhuman primates. Biol Reprod, 21;88:43, 2013. PMC3589233.

Dancet EA, Brännström M, Brasky K, Chai D, Chan AW, Conn PM, Else J, Falconer H, Fazleabas AT, Farah IO, Goddeeris BM, Golos TG, Hau J, Hearn JP, Kariuki TM,Kyama CM, Lebovic DI, Mwenda JM, Ndung'u J, Nyachieo A, Parker J, Slayden OD,Stouffer RL, Strauss JF, Taylor HS, Vanderpoel S, Westergaard JG, Zelinski M,D'Hooghe TM. The role of scientists and clinicians in raising public support for animal research in reproductive biology and medicine. Biol Reprod, 88:33, 1013. PMID:23255340.

Brenner RM, Slayden OD. Molecular and functional aspects of menstruation inthe macaque. Rev Endocr Metab Disord, 13:309-18, 2012. PMC3523117.

McComas C, Cohen J, Huselton C, Marella M, Melenski E, Mugford C, Slayden O,Winneker R, Wrobel J, Yudt MR, Fensome A. Novel progesterone receptor modulators:4-aryl-phenylsulfonamides. Bioorg Med Chem Lett, 22:7119-22, 2012 PMID: 23079530.

Varlamov O, White AE, Carroll JM, Bethea CL, Reddy A, Slayden O, O'Rourke RW, Roberts CT Jr. Androgen effects on adipose tissue architecture and function innonhuman primates. Endocrinology, 153:3100-10, 2012. PMC3380299.

Keator CS, Mah K, Slayden OD. Alterations in progesterone receptor membranecomponent 2 (PGRMC2) in the endometrium of macaques afflicted with advancedendometriosis. Mol Hum Reprod, 18:308-19, 2012.  PMC3358041.

Keator CS, Lindner JR, Belcik JT, Bishop CV, Slayden OD. Contrast-enhancedultrasound reveals real-time spatial changes in vascular perfusion during earlyimplantation in the macaque uterus. Fertil Steril, 95:1316-21., 12011. PMC3070443.

Brenner RM, Slayden OD, Nath A, Tsong YY, Sitruk-Ware R. Intrauterineadministration of CDB-2914 (Ulipristal) suppresses the endometrium of rhesusmacaques. Contraception, 81:336-42, 2010. PMC2841062

 

See a full listing of Dr. Slayden's publications