OHSU

Publications

2014

Abnormalities in human pluripotent cells due to reprogramming mechanisms. Ma H, Morey R, O'Neil RC, He Y, Daughtry B, Schultz MD, Hariharan M, Nery JR, Castanon R, Sabatini K, Thiagarajan RD, Tachibana M, Kang E, Tippner-Hedges R, Ahmed1 R, Gutierrez  NM, Van Dyken1 C, Polat  A, Sugawara A, Sparman M, Gokhale S, Amato P, Wolf DP, Ecker JR, Laurent LC & Mitalipov S. Nature. 2014 Jul 10;511(7508):177-83. doi: 10.1038/nature13551. Epub 2014 Jul 2. PMID:25008523

Mitochondrial Replacement Therapies Can Circumvent mtDNA-Based Disease Transmission. Wolf DP and Mitalipov SM. Cell Metabolism, 2014 Jul 1;20(1):6-8. doi: 10.1016/j.cmet.2014.06.012 PMID:24988456

Limitations of preimplantation genetic diagnosis for mitochondrial DNA diseases. Mitalipov S, Amato P, Parry S, Falk MJ. Cell Rep. 2014 May 22;7(4):935-7. PMID:24856294

Nuclear reprogramming by interphase cytoplasm of two-cell mouse embryos. Kang E, Wu G, Ma H, Li Y, Tippner-Hedges R, Tachibana M, Sparman M, Wolf DP, Schöler HR, Mitalipov S. Nature. 2014 May 1;509(7498):101-4.  PMID:24670652

The challenges of mitochondrial replacement. Chinnery PF, Craven L, Mitalipov S, Stewart JB, Herbert M, Turnbull DM.PLoS Genet. 2014 Apr 24;10(4):e1004315. PMID: 24762741

Concise review: parthenote stem cells for regenerative medicine: genetic, epigenetic, and developmental features. Daughtry B, Mitalipov S.Stem Cells Transl Med. 2014 Mar;3(3):290-8. doi: 10.5966/sctm.2013-0127. PMID: 24443005

Three-parent in vitro fertilization: gene replacement for the prevention of inherited mitochondrial diseases. Amato P, Tachibana M, Sparman M, Mitalipov S.Fertil Steril. 2014 Jan;101(1):31-5. Review. PMID: 24382342

Clinical and ethical implications of mitochondrial gene transfer. Mitalipov S, Wolf DP.Trends Endocrinol Metab. 2014 Jan;25(1):5-7. PMID: 24373414

2013

Restoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy. Janovick JA, Stewart MD, Jacob D, Martin LD, Deng JM, Stewart CA, Wang Y, Cornea A, Chavali L, Lopez S, Mitalipov S, Kang E, Lee HS, Manna PR, Stocco DM, Behringer RR, Conn PM. Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21030-5. PMID: 24324164. PMCID: PMC3876212.

Cloning Primates. Simerly C, Tachibana M, Mitalipov S. and Schatten G. In: Principles of Cloning. Second Edition. Edited by José Cibelli, John Gurdon, Ian Wilmut, Rudolf Jaenisch, Robert Lanza, Michael D. West and Keith H.S. Campbell. Academic Press, Elsevier. 2013. ISBN: 978-0-12-386541-0

Primate and Human Somatic Cell Nuclear Transfer. Cervera RP, Mitalipov SM. In: Biology and Pathology of the Oocyte - Role in Fertility, Medicine and Nuclear Reprograming. 2nd Edition. Edited by Alan Trounson, Roger Gosden and Ursula Eichenlaub-Ritter. Cambridge University Press. 2013. ISBN: 9781107021907

Human embryonic stem cells derived by somatic cell nuclear transfer. Tachibana M, Amato P, Sparman M, Gutierrez NM, Tippner-Hedges R, Ma H, Kang E, Fulati A, Lee HS, Sritanaudomchai H, Masterson K, Larson J, Eaton D, Sadler-Fredd K, Battaglia D, Lee D, Wu D, Jensen J, Patton P, Gokhale S, Stouffer RL, Wolf D, Mitalipov S. Cell. 2013 Jun 6;153(6):1228-38. PMID: 23683578. PMCID: PMC3772789.

Stem cell potency and the ability to contribute to chimeric organisms. Polejaeva I, Mitalipov S. Reproduction. 2013 Mar 7;145(3):R81-8. doi: 10.1530/REP-12-0396. Print 2013 Mar 1. Review. PMID: 23221011. PMCID: PMC3678546

2012

Spermatogonial stem cell transplantation into rhesus testes regenerates spermatogenesis producing functional sperm. Hermann BP, Sukhwani M, Winkler F, Pascarella JN, Peters KA, Sheng Y, Valli H, Rodriguez M, Ezzelarab M, Dargo G, Peterson K, Masterson K, Ramsey C, Ward T, Lienesch M, Volk A, Cooper DK, Thomson AW, Kiss JE, Penedo MC, Schatten GP, Mitalipov S, Orwig KE. Cell Stem Cell. 2012 Nov 2;11(5):715-26. PMID: 23122294

Towards germline gene therapy of inherited mitochondrial diseases. Tachibana M, Amato P, Sparman M, Woodward J, Sanchis DM, Ma H, Gutierrez NM, Tippner-Hedges R, Kang E, Lee HS, Ramsey C, Masterson K, Battaglia D, Lee D, Wu D, Jensen J, Patton P, Gokhale S, Stouffer R, Mitalipov S. Nature. 2012 Oct 24. [Epub ahead of print]. PMID: 23103867

X-chromosome inactivation in monkey embryos and pluripotent stem cells. Tachibana M, Ma H, Sparman ML, Lee HS, Ramsey CM, Woodword JS, Sritanaudomchai H, Masterson KR, Wolff EE, Jia Y, Mitalipov SM. Dev Biol. 2012 Nov 15;371(2):146-55. doi: 10.1016/j.ydbio.2012.08.009. Epub 2012 Aug 23.

Rapid mitochondrial DNA segregation in primate preimplantation embryos precedes somatic and germline bottleneck. Lee HS, Ma H, Juanes RC, Tachibana M, Sparman M, Woodward J, Ramsey C, Xu J, Kang EJ, Amato P, Mair G, Steinborn R, and Mitalipov S.  Cell Reports, 03 May 2012

Chromosome transfer in mature oocytes. Tachibana M, Sparman M, Mitalipov S. Fertil Steril. 2012 May;97(5):e16.

Generation of chimeric rhesus monkeys. Tachibana M, Sparman M, Ramsey C, Ma H, Lee HS, Penedo MC, Mitalipov S. Cell. 2012 Jan 20;148(1-2):285-95.

2011

Cloning of non-human primates: the road "less traveled by". Sparman ML, Tachibana M, and Mitalipov SM. Int. J. Dev. Biol. 2010; 54: 1671-1678

2010

Systems biology discoveries using non-human primate pluripotent stem and germ cells: novel gene and genomic imprinting interactions as well as unique expression patterns. Ben-Yehudah A, Easley CA 4th, Hermann BP, Castro C, Simerly C, Orwig KE, Mitalipov S, Schatten G. Stem Cell Res Ther. 2010 Aug 5;1(3):24.

Chromosome transfer in mature oocytes. Tachibana M, Sparman M, Mitalipov S. Nat Protoc. 2010;5(6):1138-47.

Discovery of a novel imprinted gene by transcriptional analysis of parthenogenetic embryonic stem cells. Sritanaudomchai H, Ma H, Clepper L, Gokhale S, Bogan R, Hennebold J, Wolf D, Mitalipov S. Hum Reprod. 2010 Aug;25(8):1927-41.

A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates. Blin G, Nury D, Stefanovic S, Neri T, Guillevic O, Brinon B, Bellamy V, Rücker-Martin C, Barbry P, Bel A, Bruneval P, Cowan C, Pouly J, Mitalipov S, Gouadon E, Binder P, Hagège A, Desnos M, Renaud JF, Menasché P, Pucéat M. J Clin Invest. 2010 Apr 1;120(4):1125-39

2009

DNA methylation programming and reprogramming in primate embryonic stem cells. Cohen NM, Dighe V, Landan G, Reynisdóttir S, Palsson A, Mitalipov S, Tanay A. Genome Res. 2009 Dec;19(12):2193-201.

CDX2 in the formation of the trophectoderm lineage in primate embryos. Sritanaudomchai H, Sparman M, Tachibana M, Clepper L, Woodward J, Gokhale S, Wolf D, Hennebold J, Hurlbut W, Grompe M, Mitalipov S. Dev Biol. 2009 Nov 1;335(1):179-87.

Mitochondrial gene replacement in primate offspring and embryonic stem cells. Tachibana M, Sparman M, Sritanaudomchai H, Ma H, Clepper L, Woodward J, Li Y, Ramsey C, Kolotushkina O, Mitalipov S. Nature. 2009 Sep 17;461(7262):367-72.

Epigenetic reprogramming by somatic cell nuclear transfer in primates. Sparman M, Dighe V, Sritanaudomchai H, Ma H, Ramsey C, Pedersen D, Clepper L, Nighot P, Wolf D, Hennebold J, Mitalipov S. Stem Cells. 2009 Jun;27(6):1255-64.

Developmental biology: Transgenic primate offspring. Schatten G, Mitalipov S. Nature. 2009 May 28;459(7246):515-6.

Totipotency, pluripotency and nuclear reprogramming. Mitalipov S, Wolf D. Adv Biochem Eng Biotechnol. 2009;114:185-99

2008

Pluripotent stem cells: maintenance of genetic and epigenetic stability and prospects of cell technologies.Gordeeva OF, Mitalipov SM. Ontogenez. 2008 Nov-Dec;39(6):405-19.

Methods in stem cell research. Mitalipov S, Wolf DP. Methods. 2008 Jun;45(2):99-100.

Gene targeting in adult rhesus macaque fibroblasts. Meehan DT, Zink MA, Mahlen M, Nelson M, Sanger WG, Mitalipov SM, Wolf DP, Ouellette MM, Norgren RB Jr. BMC Biotechnol. 2008 Mar 26;8:31

Heterozygous embryonic stem cell lines derived from nonhuman primate parthenotes. Dighe V, Clepper L, Pedersen D, Byrne J, Ferguson B, Gokhale S, Penedo MC, Wolf D, Mitalipov S. Stem Cells. 2008 Mar;26(3):756-66. 

Primate Models for the Assisted Reproductive Technologies and Embryonic Stem Cell Biology. In: Sourcebook of models for biomedical research. Wolf DP, Mitalipov SM, Byrne JA. Edited by P. Michael Conn. Springer-Verlag New York, LLC. January 2008. SBN-13:9781597452854. 397-404

2007

Producing primate embryonic stem cells by somatic cell nuclear transfer. Byrne JA, Pedersen DA, Clepper LL, Nelson M, Sanger WG, Gokhale S, Wolf DP, Mitalipov SM. Nature. 2007 Nov 22;450(7169):497-502.  

Reprogramming following somatic cell nuclear transfer in primates is dependent upon nuclear remodeling. Mitalipov SM, Zhou Q, Byrne JA, Ji WZ, Norgren RB, Wolf DP. Hum Reprod. 2007 Aug;22(8):2232-42.

Evaluation of the vervet (Clorocebus aethiops) as a model for the assisted reproductive technologies. Sparman ML, Ramsey CM, Thomas CM, Mitalipov SM, Fanton JW, Maginnis GM, Stouffer RL, Wolf DP. Am J Primatol. 2007 Aug;69(8):917-29.

Characterization and multilineage differentiation of embryonic stem cells derived from a buffalo parthenogenetic embryo. Sritanaudomchai H, Pavasuthipaisit K, Kitiyanant Y, Kupradinun P, Mitalipov S, Kusamran T. Mol Reprod Dev. 2007 Oct;74(10):1295-302.

Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells. Rajesh D, Chinnasamy N, Mitalipov SM, Wolf DP, Slukvin I, Thomson JA, Shaaban AF. Stem Cells. 2007 Feb;25(2):490-9. 

Methylation status of imprinting centers for H19/IGF2 and SNURF/SNRPN in primate embryonic stem cells. Mitalipov S, Clepper L, Sritanaudomchai H, Fujimoto A, Wolf D. Stem Cells. 2007 Mar;25(3):581-8. Epub 2006 Dec 1. 

Nuclear transfer in non-human primates. Mitalipov SM, Wolf DP. In: Nuclear transfer protocols: Cell reprogramming and transgenesis. Methods in Molecular Biology. Human Press. Edited by Verma PJ and Trounson AO. June 2006. ISBN: 1-58829-280-0

2006

Genomic imprinting in primate embryos and embryonic stem cells. Mitalipov SM. Reprod Fertil Dev. 2006;18(8):817-21.

Nuclear transfer in nonhuman primates. Mitalipov SM, Wolf DP. Methods Mol Biol. 2006;348:151-68.

Transcriptional profiling of rhesus monkey embryonic stem cells. Byrne JA, Mitalipov SM, Clepper L, Wolf DP. Biol Reprod. 2006 Dec;75(6):908-15. Epub 2006 Aug 30.

A comparative approach to somatic cell nuclear transfer in the rhesus monkey. Zhou Q, Yang SH, Ding CH, He XC, Xie YH, Hildebrandt TB, Mitalipov SM, Tang XH, Wolf DP, Ji WZ. Hum Reprod. 2006 Oct;21(10):2564-71. Epub 2006 Jun 22.

Isolation and characterization of novel rhesus monkey embryonic stem cell lines. Mitalipov S, Kuo HC, Byrne J, Clepper L, Meisner L, Johnson J, Zeier R, Wolf D. Stem Cells. 2006 Oct;24(10):2177-86.

Aberrant genomic imprinting in rhesus monkey embryonic stem cells. Fujimoto A, Mitalipov SM, Kuo HC, Wolf DP. Stem Cells. 2006 Mar;24(3):595-603.

Cell cycle features of primate embryonic stem cells. Fluckiger AC, Marcy G, Marchand M, Négre D, Cosset FL, Mitalipov S, Wolf D, Savatier P, Dehay C. Stem Cells. 2006 Mar;24(3):547-56.

Current progress with primate embryonic stem cells. Byrne JA, Mitalipov SM, Wolf DP. Curr Stem Cell Res Ther. 2006 May;1(2):127-38

2005

Low temperature storage of rhesus monkey spermatozoa and fertility evaluation by intracytoplasmic injection. Yeoman RR, Mitalipov S, Gerami-Naini B, Nusser KD, Wolf DP. Theriogenology. 2005 Jun;63(9):2356-71.

Development of a monkey model for the study of primate genomic imprinting. Fujimoto A, Mitalipov SM, Clepper LL, Wolf DP. Mol Hum Reprod. 2005 Jun;11(6):413-22

2004

Use of assisted reproductive technologies in the propagation of rhesus macaque offspring. Wolf DP, Thormahlen S, Ramsey C, Yeoman RR, Fanton J, Mitalipov S. Biol Reprod. 2004 Aug;71(2):486-93

2003

Oct-4 expression in pluripotent cells of the rhesus monkey. Mitalipov SM, Kuo HC, Hennebold JD, Wolf DP. Biol Reprod. 2003 Dec;69(6):1785-92. Epub 2003 Jul 30.

Differentiation of monkey embryonic stem cells into neural lineages. Kuo HC, Pau KY, Yeoman RR, Mitalipov SM, Okano H, Wolf DP. Biol Reprod. 2003 May;68(5):1727-35.

The mammalian blastocysts as an experimental model. Mitalipov SM, Kuo HC, Wolf DP. In: An atlas of human blastocysts. The Parthenon Publishing Group. New York, NY. Edited by Veeck LL and Zaninovic N. 2003. 231-250

2002

Monozygotic twinning in rhesus monkeys by manipulation of in vitro-derived embryos. Mitalipov SM, Yeoman RR, Kuo HC, Wolf DP. Biol Reprod. 2002 May;66(5):1449-55.

Rhesus monkey embryos produced by nuclear transfer from embryonic blastomeres or somatic cells. Mitalipov SM, Yeoman RR, Nusser KD, Wolf DP. Biol Reprod. 2002 May;66(5):1367-73.

Cloning mammals. Wolf DP, Mitalipov SM. In: Assisted Reproductive Technology. Accomplishments and New Horizons. Published by Cambridge University Press. Cambridge CB2 2RU. Edited by Christopher J. De Jonge and Christopher L.R. Barratt, 2002. 206-216

2001

Nuclear transfer technology in mammalian cloning. Wolf DP, Mitalipov S, Norgren RB Jr. Arch Med Res. 2001 Nov-Dec;32(6):609-13. Review.

Cryoloop vitrification yields superior survival of Rhesus monkey blastocysts. Yeoman RR, Gerami-Naini B, Mitalipov S, Nusser KD, Widmann-Browning AA, Wolf DP. Hum Reprod. 2001 Sep;16(9):1965-9.

Parthenogenetic activation of rhesus monkey oocytes and reconstructed embryos. Mitalipov SM, Nusser KD, Wolf DP. Biol Reprod. 2001 Jul;65(1):253-9.

Developmental competence of oocytes after ICSI in the rhesus monkey. Nusser KD, Mitalipov S, Widmann A, Gerami-Naini B, Yeoman RR, Wolf DP. Hum Reprod. 2001 Jan;16(1):130-137.

Application of ARTs and nuclear transfer in exotic or endangered species. White K L, Bunch T D, Mitalipov SM , Reed WA. In: Assisted fertilization and nuclear transfer in mammals. Series in Contemporary Endocrinology published by Humana Press. Edited by: D. Wolf and M. Zelinski-Wooten. 2001. 239-252

2000

Mammalian cloning: possibilities and threats. Mitalipov SM, Wolf DP. Ann Med. 2000 Oct;32(7):462-8