OHSU

Nuclear Magnetic Resonance Core

Analyze structures of small organic molecules via NMR

A facility that uses a state-of-the-art NMR spectrometer to verify or determine the structure of organic molecules.  Housed in the Department of Physiology and Pharmacology, it is designed to exploit the power of designed small molecules as probes of protein and cellular function and to provide the foundation for the development of prototypic therapeutic agents

NMR LAB

Some of its features include, but are not limited to, the following:

  • Multinuclear broadband observe (BBO) probe (5 mm sample diameter) with digital tuning covering the range from 15N to 31P, 1H decoupling, and an actively shielded Z-gradient coil.

  • Gradient Spectroscopy accessory for the Avance Series integrated into BSMS (Bruker Smart Magnet System), for generation of gradients up to 50 Gauss/cm.  

  • Variable temperature (VT) range from -100 to +180 °C.  

  • The types of 1D and 2D spectra that can be obtained are 1H, 13C, DEPT, 1D NOE difference, homonuclear decoupling, homonuclear COSY, DQF COSY, GRASP-DQD-COSY, XHCORR, HMQC, HMBC, NOESY, ROESY, TOCSY, COLOC, and several others.
  • Identify neurotransmitters, hormones, and most drugs
  • Follow reaction progress by analyzing products
  • Utilize our state-of-the-art Bruker Avance 400 MHz high performance NMR spectrometer
  • Run samples at prices below those charged by industry

To take advantage of this powerful diagnostic service, contact:

Tapasree Banerji

NMR Core Facility Manager

Department of Physiology and Pharmacology

OHSU Biomedical Research Building

Room 640A

503-494-9269

banerjit@ohsu.edu