OHSU

Students

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Jordan Devereaux - Reed College, BA in Biochemistry & Molecular Biology

I was born and raised in Seattle, Washington. My research career began in 2001, while I was in high school, with a short internship in Roland Strong's laboratory at the Fred Hutchinson Cancer Research Center where I investigated the structural biology of the MHC protein MicB. That later led to another opportunity with a local organization called BioLab where I worked in developing yeast assay systems for investigating BrcA mutations that can lead to breast cancer. I came to Portland in 2002 to attend Reed College where I majored in Biochemistry & Molecular Biology in 2006. As part of Reed College's graduation requirements, I produced a thesis investigating the enzyme kinetics of the purine nucleoside phosphorylase-hypoxanthine complex under Ronald McClard. After graduation I joined Francis Valiyaveetil's lab at OHSU studying structure-function relationships in model potassium ion channels. After several years as a research assistant, I joined the PMCB graduate program at OHSU in 2009. During my first year I joined Tom Scanlan's lab for my graduate research - developing new analogs of thyroid hormone. These compounds, unlike thyroid hormone, have selective properties that make them potentially useful for treating conditions ranging from impaired heart function to hyperthyroidism. After graduation, I plan on continuing to work in medicinal chemistry, either in industry or private research foundations to produce new drugs, preferably in the realm of malaria, HIV, TB and other infectious diseases.


Rebecca Lazelle

Rebecca Lazelle - Oregon State University, BS in Microbiology

Like most Portlanders I'm originally from the Midwest. However, a lucky coin toss led me to Oregon where I graduated from Oregon State with a BS in microbiology and a minor in chemistry. While in undergrad I worked as a research assistant in Valarian Dolga's plant pathology lab, which studies closteroviruses.  Afterwards I spent some time backpacking through SE Asia teaching English, working as an assistant winemaker and then as a quality control officer for an analytical chemistry company.
Somewhere along the line I had a change of heart with regards to career paths and headed back to school.  Intrigued by OHSU's unique blend of clinical and basic science research, I am currently enjoying my latest endeavor as a graduate student in David Ellison's lab. The focus of the Ellison lab is the sodium chloride cotransporter which is located in the kidney and plays a role in blood pressure regulation and electrolyte balance. My project stems from clinical observations that patients on the immunosuppressive drug tacrolimus present like patients with genetic disorders that lead to an increase in the activity of the sodium chloride cotransporter. I'm trying to unravel the molecular mechanism by which tacrolimus causes an increase in the activity of the sodium chloride cotransporter, and consequently hypertension and hyperkalemia. We hope that understanding this pathological pathway will improve future drug design as well as patient care.

Ultimately, I plan to utilize the skills I've developed at OHSU to pursue a career which involves teaching, community outreach and research. Whether that is in academia or industry it promises to be a good next chapter!


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Kayly Lembke - Scripps College, BA in Biochemistry

I was born an Army kid, my father being an officer in the U.S. Army. My family traveled all round the United States, moving from Alabama to Texas, Colorado to Hawaii, and Chicago to Oregon. My life in science began in high school, doing summer work as a Biological Aid with the USDA-ARS National Clonal Germplasm Repository in Corvallis, OR. I attended Scripps College, in Claremont, CA, and did undergraduate research on Prp43 and its role in rRNA metabolism. I received my Bachelors in 2010 and in 2011 entered the PMCB program at OHSU and the lab of Dr. David Morton. My project is currently centered on understanding how gene misregulation affects synaptic transmission in a Drosophila model of Amyotrophic Lateral Sclerosis. Currently, I am focused on successfully completing my qualifying exam. I am also a founding member of the Women in Science Organization here at OHSU, a contributor to the Student Speak blog, and am actively involved in student life.


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Rory Morgan - University of Oregon, MS in Chemistry

I was born and raised in Canby, OR, a small town just south of Portland.  Although I grew up on a cattle farm and was involved in all things agricultural throughout high school, I chose a different path when I attended Gonzaga University in Spokane, WA to pursue a degree in biochemistry.  I conducted undergraduate research on parasitic metabolism elucidation to aid in the development of antiparasitic therapeutics.  Upon graduation in 2007, I debated graduate school and an industrial position, but found a balance in the Master's Industrial Internship Program in Organic Synthesis at University of Oregon, where I completed a MS degree in chemistry and a nine-month internship at the pharmaceutical research company Bend Research, Inc. in Bend, OR.  My internship progressed into a permanent position as a Research Chemist, where I was employed from 2008-2012, researching a variety of projects centered around drug delivery technologies.  With the realization that I was more interested in the early stages of drug development, I enrolled in the PMCB graduate program at OHSU in 2012 to pursue chemical biology research.  With my chemistry background, I joined the lab of Dr. Michael Cohen to investigate the biological role of the post-translational modification known as ADP-ribosylation using rationally designed chemical probes and chemical genetic strategies.  Upon completion of my doctoral studies, I hope to find a postdoctoral position to aid in my transition back to industry to pursue drug discovery research.


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Diana Parrish – Reed College, BA in Biology

I grew up in San Diego, California and moved to Portland to pursue my undergraduate degree at Reed College. For my senior thesis I studied suppression of T cells in Dr. Laurens Ruben's lab, and I graduated in 2006 with a BA in biology. I worked as a lab technician at OHSU for 3 years before beginning my PhD program in 2009 and joining Dr. Beth Habecker's lab in 2010. The goal of my thesis research is to identify the proteins responsible for nerve degeneration in the heart after a heart attack, and how this degeneration contributes to abnormal heart rhythms. Following graduation, I plan to further my training as a postdoctoral fellow, and eventually hope to have my own lab.


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Katie Tallman - Western Washington University, BS in Biochemistry

I grew up in Tacoma, WA and attended Western Washington University for my undergraduate education.  While at WWU, I performed organic synthesis research with Dr. James Vyvyan.  I graduated with a BS in biochemistry in 2010 and joined OHSU's Program in Molecular and Cellular Biosciences the same year.  I began my thesis research with Dr. David Grandy, but joined Dr. Kimberly Beatty's group in 2013.  Our research employs a combination of chemistry and biology to target two main areas of tuberculosis research:  host/pathogen interactions and point-of-care diagnostic assay development.  My current work focuses on the development of enzyme-activated fluorophores for tuberculosis biomarker discovery.  Ultimately, I aim to remain in health-related research and currently find myself drawn to non-academic career paths.


Sarah Wicher

Sarah Wicher - University of Idaho, BS in Microbiology

I grew up in southeastern Idaho.  In 2008, I graduated from the University of Idaho with a Bachelor of Science degree in Microbiology. Prior to entering the OHSU Graduate Program in Molecular and Cellular Biosciences, I gained research experience working in Dr. Arrizabalaga's laboratory at the University of Idaho. In Spring 2012, I joined Dr. Allison Fryer's laboratory and am researching the systemic effects of ozone exposure on asthma. Specifically, I am interested in the role of eosinophils in airway hyperreactivity following ozone exposure. Ultimately, I would like to pursue a career in research at the university level.


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Daniel Yaeger - Willamette University, BA in Exercise Physiology

I graduated from Willamette University with a degree in exercise science in 2007.  After working in research labs in Portland, Detroit, and Baltimore, I entered the Program in Molecular & Cellular Biosciences at OHSU in 2009.  I joined the lab of Dr. Larry Trussell through the Department of Physiology and Pharmacology.  In Dr. Trussell's lab, my work focuses on neuromodulation and synaptic physiology of neurons in the auditory brainstem.  I have received the Vertex Scholars award to fund my studies.  After graduating, I plan on pursuing an academic position that balances research and teaching/mentoring.