Owen McCarty

Mccarty New Headshot

Email:
Phone: 503 418-9307
Fax: 503 418-9311
Alt Phone: 503 418-9350

Current Appointments
Professor and Interim Chair, Department of Biomedical Engineering
Professor, Department of Cell & Development Biology

Office
Center for Health and Healing
Mail code: CH13B
3303 SW Bond Avenue, Rm #13033

Education
Ph.D., Chemical & Biomolecular Engineering, Johns Hopkins University, 2002
B.S., Chemical Engineering, State University of New York at Buffalo, 1997

Research Area(s)
Cardiovascular Research
Thrombosis and Hemostasis
Vascular Biology and Vascular Tissue Engineering

Biography
Dr. McCarty received his Ph.D in Chemical & Biomolecular Engineering from Johns Hopkins University with dissertation work focused on the role of platelets in cancer metastasis and thrombosis. As a Wellcome Trust Postdoctoral Fellow, he continued his research in the area of thrombosis, examining the signaling pathways governing platelet cytoskeletal reorganization, at the Department of Pharmacology, Oxford University and Centre for Cardiovascular Sciences, University of Birmingham, UK.

Research Interests
Dr. McCarty's research is focused on understanding the interplay between cell biology and fluid mechanics in the cardiovascular system. In particular, his research into the balance between hydrodynamic shear forces and chemical adhesive interactions has great relevance to underlying processes of cancer, cardiovascular disease, and inflammation.

Selected Publications

  1. McCarty OJ, Mousa SA, Bray PF, Konstantopoulos K. Immobilized platelets support human colon carcinoma cell tethering, rolling and firm adhesion under dynamic flow conditions. Blood 2000 Sep; 96(5): 1789-1797.

  2. Abulencia JP, Tien N, McCarty OJ, Plymire D, Mousa SA, Konstantopoulos K. Comparative antiplatelet efficacy of a novel nonpeptide GPIIb/IIIa antagonist (XV454) and abciximab (c7E3) in flow models of thrombosis. Arteriosclerosis Thrombosis & Vascular Biology. 2001 Jan; 21(1): 149-156.

  3. Burdick MM, McCarty OJ, Jadhav S, Konstantopoulos K. Cell-cell interactions in inflammation and cancer metastasis. IEEE Engineering in Medicine and Biology 2001 May; 20(3): 86-91.

  4. Mousa SA, Abulencia JP, McCarty OJ, Turner NA, Konstantopoulos K. Comparative efficacy between the GPIIb/IIIa antagonists, roxifiban and orbofiban, in inhibiting platelet function in flow models of thrombosis. Journal of Cardiovascular Pharmacology 2002 Apr; 39(4): 552-5560.

  5. McCarty OJ, Jadhav S, Burdick MM, Bell WR, Konstantopoulos K. Fluid shear regulates the kinetics and molecular mechanisms of activation-dependent platelet binding to colon carcinoma cells. Biophysical Journal 2002 Aug; 83(2): 836-48.

  6. McCarty OJ, Tien N, Bochner BS, Konstantopoulos K. Exogenous eosinophil activation converts PSGL-1-dependent binding to CD18-dependent stable adhesion to Platelets in shear flow. American Journal of Physiology: Cell Physiology 2003 May; 284(5): C1223-34.

  7. Hanley W†, McCarty OJ†, Jadhav S, Tseng Y, Wirtz D, Konstantopoulos K. Single-molecule characterization of P-selectin/ligand binding. Journal of Biological Chemistry 2003 Mar; 278(12): 10556-61. †equally contributing first authors.

  8. McCarty OJ, Abulencia JP, Mousa SA, Konstantopoulos K. Evaluation of platelet antagonists in in-vitro flow models of thrombosis. Methods of Molecular Medicine 2004 Aug; 93: 21-34.

  9. McCarty OJ, Zhao Y, Andrew N, Machesky LM, Staunton D, Frampton J, Watson SP. Evaluation of the role of platelet integrins in fibronectin-dependent spreading and adhesion. Journal of Thrombosis and Haemostasis 2004 Oct; 2(10): 1823-1833. (Paper of the year)

  10. Ahn KC, Jun A*, Pawar P, Jadhav S, Napier S, McCarty OJ, Konstantopoulos K. Preferential binding of Platelets to monocytes over neutrophils under flow. Biochemical and Biophysical Research Communications 2005 Apr; 329(1): 345-355.

  11. Watson SP, Auger JM, McCarty OJ, Pearce AC. GPVI and integrin αIIbβ3 signaling in Platelets. Journal of Thrombosis and Haemostasis 2005 Aug; 3(8): 1752-62.

  12. McCarty OJ, Larson M, Auger JM, Atkinson BT, Kalia N, Pearce AC, Ruf S, Henderson, Tybulewicz V, Machesky LM, Watson SP. Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow. Journal of Biological Chemistry 2005 Nov; 280(47): 39474-39484.
  13. Inoue O, Suzuki-Inoue K, McCarty OJ, Moroi M, Ruggeri ZM, Kunicki TJ, Ozaki Y, Watson SP. Laminin stimulates spreading of Platelets through integrin α6β1-dependent activation of GPVI. Blood 2006 Feb; 107(4): 1405-12.

  14. McCarty OJ, Calaminus SD, Berndt MC, Machesky LM, Watson SP. VWF mediates platelet spreading through GPIb and αIIbβ3 in the presence of botrocetin and ristocetin, respectively. Journal of Thrombosis and Haemostasis 2006 Jun; 4(6): 1367-78.

  15. Thornber K, McCarty OJ, Watson SP, Pears CJ. Distinct but critical roles for integrin αIIbβ3 in platelet spreading on fibrinogen, collagen-related peptide and thrombin. FEBS Journal 2006 Nov; 273(22): 5032-5043. (Cover)

  16. Pearce AC, McCarty OJ, Calaminus SDJ, Vigorito E, Turner M, Watson SP. Vav family proteins are required for optimal regulation of the PLCγ2 by integrin αIIbβ3. Biochemical Journal 2007; 401: 753-761.

  17. Hughan SC, Hughes CE, McCarty OJ, Schweighoffer E, Soultanova I, Ware J, Tybulewicz VL, Watson SP. GPVI-potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk. Arterioscler Thromb & Vasc Biol. 2007; 27:422-429.

  18. Dhanjal TS, Ross EA, Auger JM, McCarty OJ, Hughes CE, Senis YA, Buckley CD, Watson SP. Minimal regulation of platelet activity by PECAM-1. Platelets 2007 Feb; 18(1): 56-67.

  19. Calaminus SD†, McCarty OJ†, Auger JM, Insall RH, Watson SP, Machesky LM. A major role for Scar/WAVE-1 downstream of GPVI in platelets. Journal of Thrombosis and Haemostasis 2007 Mar; 5(3): 537-43. †equally contributing first authors

  20. White TC, Berny MA, Robinson DK, Yin H, DeGrado WF, Hanson SR, McCarty OJ. The leech product saratin is a potent inhibitor of platelet integrin α2β1 and von Willebrand factor binding to collagen. FEBS Journal 2007 Mar; 274(6): 1481-1492.

  21. Gruber A, Marzec U, Bush L, Di Cera E, Fernandez JA, Berny MA, Tucker EI, McCarty OJ, Griffin JH, Hanson SR. Relative antithrombotic and antihemostatic effects of protein C activator versus low molecular weight heparin in primates. Blood 2007 May; 109(9): 3733-40.

  22. Calaminus SDJ, Auger JM, McCarty OJ, Wakelam MJO, Machesky LM, Watson SP. MyosinIIa contractility is required for maintenance of platelet structure during spreading on collagen and contributes to thrombus stability. Journal of Thrombosis and Haemostasis 2007 Oct; 5(10): 2136-45. (Paper of the year)

  23. Berny MA, White TC, Tucker EI, Bush-Pelc LA, Di Cera E, Gruber A, McCarty OJ. The thrombin mutant W215A/E217A acts as a platelet GPIb antagonist. Arteriosclerosis Thrombosis & Vascular Biology. 2008 Feb;28(2):329-34. (Featured article with Editorial)

  24. Markway BD, McCarty OJ, Marzec UM, Courtman DW, Hanson SR, Hinds MT. Capture of flowing endothelial cells using surface-immobilized anti-kinase insert domain antibody. Tissue Engineering Part C 2008 Jun; 14(2):97-105. (In Focus article)

  25. White TC, Berny MA, Tucker EI, Urbanus RT, de Groot PG, Fernandez JA, Griffin JH, Gruber A, McCarty OJ. Protein C supports platelet binding and activation under flow: role of glycoprotein Ib and apolipoprotein E receptor 2'. Journal of Thrombosis and Haemostasis 2008 Jun; 6(6): 995-1002. (Cover)

  26. Calaminus SDJ, Thomas S, McCarty OJ, Machesky LM, Watson SP. Identification of a novel, actin-rich structure, the actin nodule, in the early stage of platelet spreading. Journal of Thrombosis and Haemostasis 2008 Nov; 6(11):1944-52.

  27. Lovely RS, Rein CM, White TC, Jouihan SA, Boshkov LK, Bakke AC, McCarty OJ, Farrell DH. γA/γ' fibrinogen inhibits thrombin-induced platelet aggregation. Thrombosis and Haemostasis 2008 Nov; 100(5):837-846.

  28. Yang XV, Banerjee Y, Fernandez JA, Deguchi H, Xu X, Mosnier LO, Urbanus RT, de Groot PG, White-Adams TC, McCarty OJ, Griffin JH. Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells. Proceedings of the National Academy of Science 2009 Jan; 106(1): 274-279.

  29. Miller MW, Basra S, Kulp DW, Billings PC, Choi S, Beavers MP, McCarty OJ, Zou Z, Kahn M, Bennett JS, DeGrado WF. Small molecule inhibitors of integrin α2β1 that prevent pathological thrombus formation via an allosteric mechanism. Proceedings of the National Academy of Science 2009 Jan; 106(3): 719-724.

  30. Tucker EI, Marzec UM, White TC, Hurst S, Rugonyi S, McCarty OJ, Gailani D, Gruber A, Hanson SR. Prevention of vascular graft occlusion and thrombus-associated thrombin generation by inhibition of factor XI. Blood 2009 Jan; 113(4): 936-944.

  31. Scholl B, Liu HY, Long BR, McCarty OJ, O'Hare T, Druker, BJ, Vu TQ. Single Particle quantum dot imaging achieves ultrasensitive detection capabilities for western immunoblot analysis. American Chemical Society Nano 2009 Jun 23;3(6):1318-28.

  32. White-Adams TC, Berny MA, Tucker EI, Gertz JM, Gailani D, Urbanus RT, de Groot PG, Gruber A, McCarty OJ. Identification of coagulation factor XI as a ligand for platelet apolipoprotein E receptor 2 (ApoER2). Arteriosclerosis Thrombosis & Vascular Biology. 2009 Oct; 29(10): 1602-7. (Featured article with Editorial)

  33. Vartanian KB, Kirkpatrick SJ, McCarty OJ, Vu TQ, Hanson SR, Hinds MT. Progenitor and carotid endothelial cells elongated on micropatterned surfaces exhibit distinct and shape-dependent extracellular matrix microenvironments. Journal of Biomedical Materials Research Part A 2009 Nov; 91A(2): 528-539.

  34. Eshel-Green T, Berny MA, Conley RB, McCarty OJ. Effect of sex difference on platelet adhesion, spreading and aggregate formation under flow. Thrombosis and Haemostasis 2009 Nov; 102(5): 958-65

  35. Vartanian KB, Berny MA, McCarty OJ, Hanson SR, Hinds MT. Cytoskeletal structure regulates endothelial cell immunogenicity independent of fluid shear stress. American Journal of Physiology: Cell Physiology 2010 Feb; 298(2):C333-41.

  36. Berny MA, Munnix ICA, Auger JM, Schols SEM, Cosemans JMEM, Panizzi P, Bock PE, Watson SP, McCarty OJ†, Heemskerk JWM†. Spatial distribution of factor Xa, thrombin, and fibrin(ogen) on thrombi at venous shear. PLoS ONE 2010 Apr; 5(4): e10415(1-8). †equally contributing senior authors.

  37. Berny MA, Patel IA, White-Adams TC, Simonson P, Gruber A, Rugonyi S, McCarty OJ. Rational design of an ex vivo model of thrombosis. Cellular and Molecular Bioengineering 2010 Jun; 3(2): 187-189.

  38. White-Adams TC, Berny MA, Patel IA, Tucker EI, Gailani D, Gruber A, McCarty OJ. Laminin promotes coagulation and thrombus formation in a FXII-dependent manner. Journal of Thrombosis and Haemostasis 2010 Jun; 8(6):1295-301.

  39. Tucker EI, Marzec UM, Berny MA, Hurst S, Bunting S, McCarty OJ, Gruber A, Hanson SR. Safety and antithrombotic efficacy of moderate platelet count reduction by thrombopoietin inhibition in primates. Science Translational Medicine 2010 Jun; 2(37): 37ra45.

  40. Sinha S, Miller L, Subramanian S, McCarty OJ, Proctor T, Meza-Romero R, Burrows GG, Vandenbark AA, Offner H. Binding of recombinant T cell receptor ligands (RTL) to APC prevents upregulation of CD11b and Ly6c and inhibits T cell activation and transfer of experimental autoimmune encephalomyelitis. Journal of Neuroimmunology 2010 Aug 25;225(1-2):52-61.

  41. McCarty OJ, Conley RB, Shentu W, Tormoen GW, Zha D, Xie A, Qi Y, Zhao Y, Carr C, Belcik T, Keene DR, de Groot PG, Lindner JR. Molecular imaging of activated von Willebrand factor to detect high-risk atherosclerotic phenotype. JACC Cardiovascular Imaging 2010 Sep; 3; 947-955. (with Editorial)

  42. Cheng Q, Tucker EI, Pine MS, Sisler I, Matafonov A, Sun M, White-Adams TC, Smith SA, Hanson SR, McCarty OJ, Renne T, Gruber A, Gailani D. A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo. Blood 2010 Nov; 116(19): 3981-9.

  43. Itakura A, Aslan JE, Sinha S, White-Adams TC, Patel IA, Vandenbark AA, Burrows GG, Offner H, McCarty OJ. Characterization of human platelet binding of recombinant T-cell receptor ligand. Journal of Neuroinflammation 2010 Nov 8;7:75.

  44. Berny-Lang MA, Aslan JE, Tormoen GW, Patel IA, Bock PE, Gruber A, McCarty OJ. Promotion of experimental thrombus formation by the procoagulant activity of breast cancer cells. Physical Biology 2011 Feb 7; 8(1): 015014.

  45. Berny-Lang MA, Hurst S, Tucker EI, Pelc LA, Wang RK, Hurn PD, Di Cera E, McCarty OJ, Gruber A. Thrombin mutant W215A/E217A treatment improves neurological outcome and reduces cerebral infarct size in a mouse model of ischemic stroke. Stroke 2011 Jun; 42(6):1736-41.

  46. Aslan JE, Spencer AM, Loren CP, Pang J, Welch HC, Greenberg DL, McCarty OJ. Characterization of the Rac guanine nucleotide exchange factor P-Rex1 in Platelets. Journal of Molecular Signaling 2011 Sep; 6(1):11.

  47. Aslan JE, Tormoen GW, Loren CP, Pang J, McCarty OJ. S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation. Blood 2011 Sep; 118(11):3129-36. (Cover)

  48. Itakura A, Verbout NG, Phillips KG, Insall RH, Gailani D, Tucker EI, Gruber A, McCarty OJ. Activated factor XI stimulates neutrophil oxidative burst and inhibits chemotaxis. Journal of Leukocyte Biology 2011 Nov; 90 (5):923-927.

  49. Tormoen GW, Rugonyi S, Gruber A, McCarty OJ. Role of carrier number on the procoagulant activity of tissue factor in blood and plasma. Physical Biology 2011 Dec; 8(6): 066005.

  50. Subhash HM, Xie H, Smith JW, McCarty OJ. Optical detection of indocyanine green (ICG)-encapsulated biocompatible poly (lactic-co-glycolic) acid (PLGA) nanoparticles with photo-thermal optical coherence tomography. Optics Letters 2012 Mar;37(5):981-3. Featured article for Virtual Journal for Biomedical Optics 2012;7(5).

  51. Tucker EI, Verbout NG, Leung PY, Hurst S, McCarty OJ, Gailani D, Gruber A. Inhibition of factor XI activation attenuates inflammation and coagulopathy while improving the survival of mouse polymicrobial sepsis. Blood 2012 May;119(20):4762-8.

  52. Phillips KG, Velasco CR, Li J, Kolatkar A, Luttgen M, Bethel K, Duggan B, Kuhn P, McCarty OJ. Optical quantification of cellular mass, volume and density of circulating tumor cells identified in an ovarian cancer patient. Frontiers in Oncology 2012 Jul;2:72(1-8).

  53. Phillips KG, Kolatkar A, Rees KJ, Rigg R, Marrinucci D, Luttgen M, Bethel K, Kuhn P, McCarty OJ. Quantification of cellular volume and sub-cellular density fluctuations of circulating tumor cells from a breast cancer patient. Frontiers in Oncology 2012 Aug;2:96(1-10).

  54. Lee AM, Berny-Lang MA, Liao S, Kanso E, Kuhn P, McCarty OJ, Newton PK. A low-dimensional deformation model for cancer cells in flow. Physics of Fluids 2012 Aug;24(8):81903(1-14). (Most Read Article 2012)

  55. Tormoen GW, Cianchetti FA, Bock PE, McCarty OJ. Development of coagulation factor probes for the identification of procoagulant circulating tumor cells. Frontiers in Oncology 2012 Sep;2:110(1-12).

  56. Leung PY, Berny-Lang MA, Hurst S, Verbout NG, Gailani D, Tucker EI, McCarty OJ*, Gruber A*. Inhibition of factor XII-mediated activation of factor XI provides protection against experimental acute ischemic stroke in mice. Translational Stroke Research 2012 Sep;3(3):381-389. *equally contributing senior authors

  57. Lee AM, Tormoen GW, Kanso E, McCarty OJ, Newton PK. Modeling and simulation of procoagulant circulating tumor cells in flow. Frontiers in Oncology 2012 Sep;2:108(1-9).

  58. Winkler CW, Foster SC, Xing R, Matsumoto SG, Banine F, Berny-Lang MA, Itakura A, McCarty OJ, Sherman LS. Hyaluronan anchored to activated CD44 on CNS vascular endothelial cells promotes lymphocyte extravasation in experimental autoimmune encephalomyelitis. Journal of Biological Chemistry 2012 Sep;287(40):33237-51.

  59. Phillips KG, Jacques SL, McCarty OJ. Measurement of single cell dry mass, volume, and density using tomographic bright field imaging. Physical Review Letters 2012 Sep;109:118105(1-5). (Featured article, Cover)

  60. Baker SM, Phillips KG, McCarty OJ. Development of a label-free imaging technique for the quantification of thrombus formation. Cellular and Molecular Bioengineering 2012 Dec;5(4):488-492.

  61. Liu YN, Davidson BP, Yue W, Belcik T, Xie A, Inaba Y, McCarty OJ, Tormoen GW, Zhao Y, Ruggeri ZM, Kaufmann BA, Lindner JR. Molecular imaging of inflammation and platelet adhesion in advanced atherosclerosis effects of antioxidant therapy with NADPH oxidase inhibition. Circulation: Cardiovascular Imaging 2013 Jan 1;6(1):74-82.

  62. Baker-Groberg SM, Phillips KG, McCarty OJ. Quantification of volume, mass, and density of thrombus formation using brightfield and differential interference contrast microscopy. Journal of Biomedical Optics 2013 Jan;18(1):16014.

  63. Larson MK, Tormoen GW, Patel IA, Hjelmen CE, Ensz NM, McComas LS, McCarty OJ. Exogenous modification of platelet membranes with the omega-3 fatty acids EPA and DHA reduces platelet procoagulant activity and thrombus formation. American Journal of Physiology: Cell Physiology 2013 Feb;304(3):C273-9.

  64. Winkler CW, Foster SC, Itakura A, Matsumoto SG, Asari A, McCarty OJ, Sherman LS. Hyaluronan oligosaccharides perturb lymphocyte slow rolling on brain vascular endothelial cells: implications for inflammatory demyelinating disease. Matrix Biology 2013 Apr 24;32(3-4):160-8.

  65. Physical Sciences - Oncology Centers Network, Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, Damania D, Davies PC, Decuzzi P, Dickinson L, Estevez-Salmeron L, Estrella V, Ferrari M, Fischbach C, Foo J, Fraley SI, Frantz C, Fuhrmann A, Gascard P, Gatenby RA, Geng Y, Gerecht S, Gillies RJ, Godin B, Grady WM, Greenfield A, Hemphill C, Hempstead BL, Hielscher A, Hillis WD, Holland EC, Ibrahim-Hashim A, Jacks T, Johnson RH, Joo A, Katz JE, Kelbauskas L, Kesselman C, King MR, Konstantopoulos K, Kraning-Rush CM, Kuhn P, Kung K, Kwee B, Lakins JN, Lambert G, Liao D, Licht JD, Liphardt JT, Liu L, Lloyd MC, Lyubimova A, Mallick P, Marko J, McCarty OJ, Meldrum DR, Michor F, Mumenthaler SM, Nandakumar V, O'Halloran TV, Oh S, Pasqualini R, Paszek MJ, Philips KG, Poultney CS, Rana K, Reinhart-King CA, Ros R, Semenza GL, Senechal P, Shuler ML, Srinivasan S, Staunton JR, Stypula Y, Subramanian H, Tlsty TD, Tormoen GW, Tseng Y, van Oudenaarden A, Verbridge SS, Wan JC, Weaver VM, Widom J, Will C, Wirtz D, Wojtkowiak J, Wu PH. A physical sciences network characterization of nonmalignant and metastatic cells. Scientific Reports 2013 Apr 25;3:1449.

  66. Freeman ML, Burkum CE, Lanzer KG, Roberts AD, Pinkevych M, Itakura A, Kummer LW, Szaba FM, Davenport MP, McCarty OJ, Woodland DL, Smiley ST, Blackman MA. Gammeherpesvirus latency induces antibody-associated thrombocytopenia in mice. Journal of Autoimmunity 2013 May;42:71-9.

  67. Tormoen GW, Khader A, Gruber A, McCarty OJ. Physiological levels of blood coagulation factors IX and X control coagulation kinetics in an in vitro model of circulating tissue factor. Physical Biology 2013 Jun;10(3):036003.

  68. Aslan JE, Itakura A, Haley KM, Tormoen GW, Loren CP, Baker SM, Pang J, Chernoff J, McCarty OJ. p21-activated kinase (PAK) signaling coordinates GPVI-mediated platelet aggregation, lamellipodia formation and aggregate stability under shear. Arterioscler Thromb & Vasc Biol. 2013 Jul;33(7):1544-51.

  69. Puy C, Tucker EI, Wong ZC, Gailani D, Smith SA, Choi SH, Morrissey JH, Gruber A, McCarty OJ. Factor XII promotes blood coagulation independent of factor XI in the presence of long chain inorganic polyphosphates. Journal of Thrombosis and Haemostasis 2013 Jul;11(7):1341-52.

  70. Itakura A, McCarty OJ. Pivotal role for the mTOR pathway in the formation of neutrophil extracellular traps (NETs) via regulation of autophagy. American Journal of Physiology: Cell Physiology 2013 Aug;305(3):C348-54.

  71. Aslan JE, Baker SM, Haley KM, Loren CP, Itakura A, Pang J, Greenberg DL, David LL, Chernoff J, Manser E, McCarty OJ. The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation. American Journal of Physiology: Cell Physiology 2013 Sep;305(5):C519-28. (Featured article)

  72. Itakura A, Aslan JE, Kusanto BT, Phillips KG, Porter JE, Newton PK, Nan X, Insall RH, Chernoff J, McCarty OJ. p21-activated kinase (PAK) regulates cytoskeletal reorganization and directional migration in human neutrophils. PLoS ONE 2013 Sep;8(9):e73063.

  73. Tormoen GW, Recht O, Gruber A, Levine RL, McCarty OJ. Phosphatidylserine index as a marker of the procoagulant activity of acute myelogenous leukemia cells. Physical Biology 2013, Oct;10(5):056010.

  74. Baker-Groberg SM, Itakura A, Gruber A, McCarty OJ. Role of coagulation in the recruitment of colon adenocarcinoma cells to thrombus under shear. American Journal of Physiology: Cell Physiology 2013 Nov;305(9):C951-9.

  75. Aslan JE, Phillips KG, Healy LD, Itakura A, Pang J, McCarty OJ. Histone deacetylase 6 (HDAC6)-mediated deacetylation of α-tubulin coordinates cytoskeletal and signaling events during platelet activation. American Journal of Physiology: Cell Physiology 2013 Dec;305(12):C1230-39. (Featured article with Editorial)

  76. Damania D, Subramanian H, Backman V, Bubbers EJ, Wong MH, McCarty OJ, Phillips KG. Network signatures of nuclear and cytoplasmic density alterations in a model of pre- and post-metastatic colorectal cancer. Journal of Biomedical Optics 2014 Jan;19(1):016016

  77. Matafonov A, Leung PY, Gailani AE, Grach SL, Puy C, Cheng Q, Sun M, McCarty OJ, Tucker EI, Kataoka H, Renne T, Morrissey JH, Gruber A, Gailani D. Factor XII inhibition reduces thrombus formation in a primate thrombosis model. Blood 2014 Mar;123(11):1739-1746 (With Editorial)

  78. Totonchy JE, Clepper L, Phillips KG, McCarty OJ, Moses AV. CXCR7 expression disrupts endothelial cell homeostasis and causes ligand-dependent invasion. Cell Adhesion & Migration 2014 Mar;8(2): 165-176. (Highlighted as part of a Special Focus: Adhesion in Vascular Biology)

  79. Baker-Groberg SM, Cianchetti FA, Phillips KG, McCarty OJ. Development of a method to quantify platelet adhesion and aggregation under static conditions. Cellular and Molecular Bioengineering 2014, Jun;7(2):285-290.

  80. Loren CP, Aslan JE, Rigg RA, Nowak MS, Healy LD, Gruber A, Druker BJ, McCarty OJ. The BCR-ABL inhibitor ponatinib inhibits platelet immunoreceptor tyrosine-based activation motif (ITAM) signaling, platelet activation, and aggregation formation under shear. Thrombosis Research 2015 Jan;135(1):155-160.

  81. Verbout NG, Yu X, Healy LD, Phillips KG, Tucker EI, Gruber A, McCarty OJ, Offner H. Thrombin mutant W215A/E217A treatment improves neurological outcome and attenuates central nervous system damage in experimental autoimmune encephalomyelitis. Metab Brain Dis 2015 Feb;30(1):57-65.

  82. Phillips KG, Lee AM, Tormoen GW, Rigg RA, Kolatkar A, Luttgen M, Bethel K, Bazhenova L, Kuhn P, Newton PK, McCarty OJ. The thrombotic potential of circulating tumor microemboli: computational modeling of circulating tumor cell-induced coagulation. American Journal of Physiology: Cell Physiology 2015 Feb;308(3):C229-C236.

  83. Puy C, Tucker EI, Matafonov A, Cheng Q, Zientek KD, Gailani D, Gruber A, McCarty OJ. Activated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor. Blood 2015 Feb;125(9):1488-96.

  84. King MR, Phillips KG, Mitrugno A, Lee T, de Guillebon AM, Chandrasekaran S, McGuire MJ, Carr, RT, Baker-Grober SM, Rigg RA, Kolatkar A, Luttgen M, Bethel K, Kuhn P, Decuzzi P, McCarty OJ. A physical sciences network characterization of circulating tumor cell aggregate transport. American Journal of Physiology: Cell Physiology 2015 May 15;308(10):C792-C802. (Selected as the AJP: Cell Image of the Week)

  85. Kosoff RE, Aslan JE, Kostyak JC, Dulaimi E, Chow HY, Prudnikova TY, Radu M, Kunapuli SP, McCarty OJ, Chernoff J. Pak2 restrains endomitosis during megakaryopoiesis. Blood 2015 May;125(19):2995-3005.

  86. Baker-Groberg SM, Bornstein S, Zilberman-Rudenk J, Schmidt M, Tormoen GT, Kernan C, Thomas CR, Wong MH, Phillips KG, McCarty OJ. Effect of ionizing radiation on the physical biology of head and neck squamous cell carcinoma cells. Cellular and Molecular Bioengineering 2015 Sep;8(3): 517-525.

  87. Aslan JE, Rigg RA, Nowak MS, Loren CP, Baker-Grober SM, Pang J, David LL, McCarty OJ. Lysine acetylation supports platelet function. Journal of Thrombosis & Haemostasis 2015 Oct;13: 1908-17.

  88. Baker-Groberg SM, Phillips KG, Healy LD, Itakura A, Porter JE, Newton PK, Nan X, McCarty OJ. Critical behavior of subcellular density organization during neutrophil activation and migration. Cellular and Molecular Bioengineering 2015 Dec;8(4): 543-552. (Cover)

  89. Zilberman-Rudenko J, Itakura A, Wiesenekker CP, Vetter R, Maas C, Gailani D, Tucker EI, Gruber A, Gerdes C, McCarty OJ. Coagulation factor XI promotes distal platelet activation and single platelet consumption in the bloodstream under shear flow. Arterioscler Thromb & Vasc Biol 2016 Mar;36(5): 510-7.

  90. Rigg RA, Aslan JE, Healy LD, Wallisch M, Thierheimer MLD, Loren CP, Pang J, Hinds MT, Gruber A, McCarty OJ. Oral administration of Bruton's Tyrosine Kinase (Btk) inhibitors impairs GPVI-mediated platelet function. American Journal of Physiology: Cell Physiology 2016 Mar;310(5): C373-80.

  91. Mattheij NJA, Swieringa F, Mastenbroek TG, Berny-Lang MA, May F, Baaten CCFMJ, van der Meijden PEJ, Henskens YMC, Beckers EAM, Suylen DPL, Nolte MW, Hackeng TM, McCarty OJ, Heemskerk JWM, Cosemans JMEM. Coated platelets function in platelet-dependent fibrin formation via integrin αIIbβ3 and transglutaminase factor XIII. Haematologica 2016 Apr;101(4):427-36.

  92. Rigg RA, Healy LD, Nowak MS, Mallet J, Thierheimer MLD, Pang J, McCarty OJ*, Aslan JE*. Heat shock protein 70 (Hsp70) regulates platelet integrin activation, granule secretion and aggregation. American Journal of Physiology: Cell Physiology 2016 Apr;310(7): C568-C575. *equally contributing senior authors (Editor's Pick as Featured Article)

  93. Baker-Groberg SM, Lattimore S, Recht M, McCarty OJ, Haley KM. Assessment of neonatal platelet adhesion, activation, and aggregation. Journal of Thrombosis & Haemostasis 2016 Apr;14(4): 815-827.

  94. Bane CE, Boyd KL, Cheng Q, Sherwood ER, Tucker EI, Smiley ST, McCarty OJ, Gruber A, Gailani D. Factor XI deficiency alters the cytokine response and activation of contact proteases during polymicrobial sepsis in mice. PLoS ONE 2016 Apr 5;11(4):e0152968.

  95. Healy LD, Itakura A, Chu T, Robinson DK, Bylund A, Phillips KG, Gardiner EE, McCarty OJ. Colocalization of neutrophils, extracellular DNA and coagulation factors during NETosis: development and utility of an immunofluorescence-based microscopy platform. Journal of Immunological Methods 2016 Aug;435: 77-84.

  96. Deguchi H, Sinha RK, Torkamani A, Marchese P, Ruggeri ZM, Zilberman-Rudenko J, McCarty OJ, Cohen MJ, Griffin JH. Prothrombotic skeletal muscle myosin directly enhances prothrombin activation by binding factors Xa and Va. Blood 2016 Oct;128(14): 1870-78. (With Editorial)

  97. Puy C, Tucker EI, Ivanov IS, Gailani D, Smith SA, Morrissey JH, Gruber A, McCarty OJ. Platelet polyphosphate serves as a cofactor to accelerate the inactivation of TFPI by factor XI. PLoS One 2016 Oct 20;11(10): e0165172.

  98. Zilberman-Rudenko J, Itakura A, Maddala J, Baker-Groberg SM, Vetter R, Tucker EI, Gruber A, Gerdes C, McCarty OJ. Biorheology of platelet activation in the bloodstream distal to thrombus formation. Cellular and Molecular Bioengineering 2016 Dec;9(4):496-508.

  99. Zilberman-Rudenko J, Sylman JL, Lakshmanan HH, McCarty OJ*, Maddala J*. Dynamics of blood flow and thrombus formation in a multi-bypass microfluidic ladder network. Cellular and Molecular Bioengineering 2017 Feb;10(1):16-29. *equally contributing senior authors (with Editorial)

  100. Mitrugno A, Sylman JL, Ngo AT, Pang J, Sears RC, Williams CD, McCarty OJ. Aspirin therapy reduces the ability of platelets to promote colon and pancreatic cancer cell proliferation: implications for the oncoprotein c-MYC. American Journal of Physiology: Cell Physiology 2017 Feb 1;312(2):C176-C189. (Selected as the AJP: Cell Image of the Week; Featured in AJP News)

  101. Verhoef JJF, Barendrecht AD, Nickel KF, de Maat S, Keene E, Labberton L, McCarty OJ, Schiffelers R, Heijnen HF, Hendrickx AP, Schellekens H, Fens MH, Renne T, Maas C. Polyphosphate nanoparticles on the platelet surface trigger contact system activation. Blood 2017;129(12):1707-1717. (with Editorial; Cover)

    In Press:


  102. Sylman JL, Daalkhaijav U, Zhang Y, Gray E, Farhang P, Chu TT, Zilberman-Rudenko J, Puy C, Tucker EI, Smith SA, Morrissey JH, Walker TW, Nan X, Gruber A, McCarty OJ. Differential roles for the coagulation factors XI and XII in regulating the physical biology of fibrin. Annals of Biomedical Engineering 2016: in Press.

  103. Ivanov I, Sun M, Dickeson SK, Puy C, McCarty OJ, Gruber A, Matafonov A, Gailani D. Activation of factor XI and prekallikrein on nucleic acids: different roles for high molecular weight kininogen. Thrombosis & Haemostasis 2016: in Press.

  104. Ngo AT, Thierheimer ML, Pang J, Babur O, Rocheleau AD, Rigg RA, Mitrugno A, Huang T, Nan X, Burchard J, Demir E, McCarty OJ*, Aslan JE*. Assessment of roles for the Rho-specific guanine nucleotide dissociation inhibitor (RhoGDI) Ly-GDI in platelet function. American Journal of Physiology: Cell Physiology 2017: in Press. *equally contributing senior authors (Selected as the AJP: Cell Image of the Week)

  105. Mitrugno A, Rigg RA, Laschober NB, Ngo AT, Pang J, Williams CD, Aslan JE, McCarty OJ. Potentiation of TRAP-6-induced platelet dense granule release by blockade of P2Y12 signaling with MRS2395. Platelets 2017: in Press.