OHSU

Laura Heiser

laura heiser

Email:
Phone: 503 494-9895
Fax: 503 494-6886

Current Appointment
Research Assistant Professor

Office
3181 SW Sam Jackson Park Road
Mail code: L103
Richard Jones Hall #4513
Portland, OR 97239

Education
B.A., University of California, Berkeley, 1998
Ph.D., University of Pittsburgh, 2004

Research Area
OHSU Center for Spatial Systems Biology

Research Interests


Selected Publications
Ordinario, E., Han, H.-J., Furuta, S., Heiser, L.M., Jakkula, L.R., Rodier, F., Spellman, P.T., Campisi, J., Gray, J.W., Bissell, M.J., Kohwi, Y., Kohwi-Shigematsu, T. (2012) ATM Suppresses SATB1-Induced Malignant Progression in Breast Epithelial Cells. PLoS ONE, 7 (12), art. no. e51786, .

Hill, S.M., Lu, Y., Molina, J., Heiser, L.M., Spellman, P.T., Speed, T.P., Gray, J.W., Mills, G.B., Mukherjee, S. (2012) Bayesian Inference of Signaling Network Topology in a Cancer Cell Line. Bioinformatics, 28 (21), pp. 2804-2810.

Collisson, E.A., Trejo, C.L., Silva, J.M., Gu, S., Korkola, J.E., Heiser, L.M., Charles, R.-P., Rabinovich, B.A., Hann, B., Dankort, D., Spellman, P.T., Phillips, W.A., Gray, J.W., McMahon, M.A. (2012) Central role for RAF→MEK→ERK signaling in the genesis of pancreatic ductal adenocarcinoma. Cancer Discovery, 2 (8), pp. 685-693.

Heiser, L.M., Sadanandam, A., Kuo, W.-L., Benz, S.C., Goldstein, T.C., Ng, S., Gibb, W.J., Wang, N.J., Ziyad, S., Tong, F., Bayani, N., Hu, Z., Billig, J.I., Dueregger, A., Lewis, S., Jakkula, L., Korkola, J.E., Durinck, S., Pepin, F., Guan, Y., Purdom, E., Neuvial, P., Bengtsson, H., Wood, K.W., Smith, P.G., Vassilev, L.T., Hennessy, B.T., Greshock, J., Bachman, K.E., Hardwicke, M.A., Park, J.W., Marton, L.J., Wolf, D.M., Collisson, E.A., Neve, R.M., Mills, G.B., Speed, T.P., Feiler, H.S., Richard, F.W., Haussler, D., Stuart, J.M., Gray, J.W., Spellman, P.T. (2012) Subtype and pathway specific responses to anticancer compounds in breast cancer. Proceedings of the National Academy of Sciences of the United States of America, 109 (8), pp. 2724-2729. PUBMED ID: 22003129

Bell, D., Berchuck, A., Birrer, M., Chien, J., Cramer, D.W., Dao, F., Dhir, R., Disaia, P., Gabra, H., Glenn, P., Godwin, A.K., Gross, J., Hartmann, L., Huang, M., Huntsman, D.G., Iacocca, M., Imielinski, M., Kalloger, S., Karlan, B.Y., Levine, D.A., Mills, G.B., Morrison, C., Mutch, D., Olvera, N., Orsulic, S., Park, K., Petrelli, N., Rabeno, B., Rader, J.S., Sikic, B.I., Smith-Mccune, K., Sood, A.K., Bowtell, D., Penny, R., Testa, J.R., Chang, K., Dinh, H.H., Drummond, J.A., Fowler, G., Gunaratne, P., Hawes, A.C., Kovar, C.L., Lewis, L.R., Morgan, M.B., Newsham, I.F., Santibanez, J., Reid, J.G., Trevino, L.R., Wu, Y.-Q., Wang, M., Muzny, D.M., Wheeler, D.A., Gibbs, R.A., Getz, G., Lawrence, M.S., Cibulskis, K., Sivachenko, A.Y., Sougnez, C., Voet, D., Wilkinson, J., Bloom, T., Ardlie, K., Fennell, T., Baldwin, J., Gabriel, S., Lander, E.S., Ding, L., Fulton, R.S., Koboldt, D.C., McLellan, M.D., Wylie, T., Walker, J., O'Laughlin, M., Dooling, D.J., Fulton, L., Abbott, R., Dees, N.D., Zhang, Q., Kandoth, C., Wendl, M., Schierding, W., Shen, D., Harris, C.C., Schmidt, H., Kalicki, J., Delehaunty, K.D., Fronick, C.C., Demeter, R., Cook, L., Wallis, J.W., Lin, L., Magrini, V.J., Hodges, J.S., Eldred, J.M., Smith, S.M., Pohl, C.S., Vandin, F., Raphael, B.J., Weinstock, G.M., Mardis, E.R., Wilson, R.K., Meyerson, M., Winckler, W., Getz, G., Verhaak, R.G.W., Carter, S.L., Mermel, C.H., Saksena, G., Nguyen, H., Onofrio, R.C., Lawrence, M.S., Hubbard, D., Gupta, S., Crenshaw, A., Ramos, A.H., Ardlie, K., Chin, L., Protopopov, A., Zhang, J., Kim, T.M., Perna, I., Xiao, Y., Zhang, H., Ren, G., Sathiamoorthy, N., Park, R.W., Lee, E., Park, P.J., Kucherlapati, R., Absher, D.M., Waite, L., Sherlock, G., Brooks, J.D., Li, J.Z., Xu, J., Myers, R.M., Laird, P.W., Cope, L., Herman, J.G., Shen, H., Weisenberger, D.J., Noushmehr, H., Pan, F., Triche Jr, T., Berman, B.P., Van Den Berg, D.J., Buckley, J., Baylin, S.B., Spellman, P.T., Purdom, E., Neuvial, P., Bengtsson, H., Jakkula, L.R., Durinck, S., Han, J., Dorton, S., Marr, H., Choi, Y.G., Wang, V., Wang, N.J., Ngai, J., Conboy, J.G., Parvin, B., Feiler, H.S., Speed, T.P., Gray, J.W., Levine, D.A., Socci, N.D., Liang, Y., Taylor, B.S., Schultz, N., Borsu, L., Lash, A.E., Brennan, C., Viale, A., Sander, C., Ladanyi, M., Hoadley, K.A., Meng, S., Du, Y., Shi, Y., Li, L., Turman, Y.J., Zang, D., Helms, E.B., Balu, S., Zhou, X., Wu, J., Topal, M.D., Hayes, D.N., Perou, C.M., Getz, G., Voet, D., Saksena, G., Zhang, J., Zhang, H., Wu, C.J., Shukla, S., Cibulskis, K., Lawrence, M.S., Sivachenko, A., Jing, R., Park, R.W., Liu, Y., Park, P.J., Noble, M., Chin, L., Carter, H., Kim, D., Karchin, R., Spellman, P.T., Purdom, E., Neuvial, P., Bengtsson, H., Durinck, S., Han, J., Korkola, J.E., Heiser, L.M., Cho, R.J., Hu, Z., Parvin, B., Speed, T.P., Gray, J.W., Schultz, N., Cerami, E., Taylor, B.S., Olshen, A., Reva, B., Antipin, Y., Shen, R., Mankoo, P., Sheridan, R., Ciriello, G., Chang, W.K., Bernanke, J.A., Borsu, L., Levine, D.A., Ladanyi, M., Sander, C., Haussler, D., Benz, C.C., Stuart, J.M., Benz, S.C., Sanborn, J.Z., Vaske, C.J., Zhu, J., Szeto, C., Scott, G.K., Yau, C., Hoadley, K.A., Du, Y., Balu, S., Hayes, D.N., Perou, C.M., Wilkerson, M.D., Zhang, N., Akbani, R., Baggerly, K.A., Yung, W.K., Mills, G.B., Weinstein, J.N., Penny, R., Shelton, T., Grimm, D., Hatfield, M., Morris, S., Yena, P., Rhodes, P., Sherman, M., Paulauskis, J., Millis, S., Kahn, A., Greene, J.M., Sfeir, R., Jensen, M.A., Chen, J., Whitmore, J., Alonso, S., Jordan, J., Chu, A., Zhang, J., Barker, A., Compton, C., Eley, G., Ferguson, M., Fielding, P., Gerhard, D.S., Myles, R., Schaefer, C., Mills Shaw, K.R., Vaught, J., Vockley, J.B., Good, P.J., Guyer, M.S., Ozenberger, B., Peterson, J., Thomson, E. (2011) Integrated genomic analyses of ovarian carcinoma. Nature, 474 (7353), pp. 609-615.