William Giardino

Ph.D. Graduate (2013)

William J. Giardino, Ph.D.Undergraduate Education

B.S., Psychology, 2008, University of Washington

Training Dates at OHSU

2008 - 2013

Second Year Project Title

Mapping the neural substrates underlying dopamine D2 receptor-dependent sensitivity to methamphetamine (Mentor: Andrey E. Ryabinin)

Dissertation Title

The centrally projecting Edinger-Westphal nucleus: Midbrain neuropeptide control of excessive alcohol intake (Mentor: Andrey E. Ryabinin)

Awards or Grant Received

(2013-16) F32 AA022832 NIH/NIAAA: Optogenetic Studies of Hypocretin in Binge Drinking and Negative Hedonic Valence.

(2011-13) F31 AA021023 NIH/NIAAA: Edinger-Westphal Urocortin-1 Involvement in Binge Ethanol Intake and Reward

Current Position

Postdoctoral Fellow, Department of Psychiatry & Behavioral Sciences, Stanford University

Email Address


Research Interests

Behavior, stress, addiction, neuropharmacology, neuroanatomy, genetics

My Portland Experience

Portland is the ideal city for a graduate student, offering affordability, transportability, and enriching arts & culture. Nowhere have I encountered people that match Portlanders' sense of community encouragement. Portland is a truly unique and special place, and my experience at OHSU was inextricably linked to those attributes.  

My OHSU Experience

As a student at OHSU, I was consistently impressed with the quality of scientific mentorship, course instruction, and administrative support that I received. In the Department, faculty are exceptionally committed to the academic progress and professional development of students. I'm endlessly grateful to the community at OHSU for providing an ideal setting for my PhD training.

Previous Positions

(2008-13) Graduate Student, Department of Behavioral Neuroscience, Oregon Health & Science University

(2007-08) Undergraduate Research Assistant, Department of Pharmacology, University of Washington

(2005-07) Undergraduate Research Assistant, Department of Psychology, University of Washington

Postdoctoral Training

Department of Psychiatry & Behavioral Sciences, Stanford University


Giardino WJ, Rodriguez ED, Smith ML, Cote DM, Li J, Cocking DL, Ford MM, Galili D, Mitchell SH, Chen A, Ryabinin AE. Control of chronic excessive alcohol drinking by the urocortin-1 neuropeptide system of the Edinger-Westphal nucleus. Submitted, September 2016.

Eban-Rothschild A, Rothschild G, Giardino WJ, Jones JR, de Lecea L. VTA dopaminergic neurons regulate ethologically relevant sleep-wake behaviors. Nat Neurosci. 2016 Sep 5. 

Giardino WJ, de Lecea L. Resting easy with a sleep regulator. Elife. 2015 Dec 10;4:e12093. PMC4744186 

Giardino WJ, de Lecea L. Hypocretin neuromodulatory pathways integrating stress and reward. Current Opinion in Neurobiology. 2014 Jul 20;29C:103-108. PMC4267967 

Giardino WJ, Ryabinin AE. CRF1 receptor signaling regulates food and fluid intake in the drinking-in-the-dark model of binge alcohol consumption. Alcohol. Clin. Exp. Res. EPub 2013 Feb 7.  PMC3657581

Ryabinin AE, Tsoory MM, Kozicz T, Thiele T, Neufeld-Cohen A, Chen A, Lowery-Gionta E, Giardino WJ, Kaur S. Urocortins: CRF's siblings and their potential role in anxiety, depression, and alcohol drinking behavior.Alcohol. 2012 Jun;46(4):349-57. EPub 2012 Mar 21.   PMC3358480

Giardino WJ, Cote DM, Li J, Ryabinin AE. Characterization of genetic differences within the centrally- projecting Edinger-Westphal nucleus of C57BL/6J and DBA/2J mice by expression profiling. Frontiers in Neuroanatomy.2012;6(5). EPub 2012 Feb 14.   PMC3278674

Giardino WJ, Ryabinin AE. Corticotropin-releasing factor: innocent until proven guilty. Nature Rev. Neurosci.2012 Jan;13(1):70. EPub 2011 Dec 20.  PMC3365568

Giardino WJ, Cocking DL, Kaur S, Cunningham CL, Ryabinin AE. Urocortin-1 within the Centrally Projecting Edinger-Westphal Nucleus is Critical for Ethanol Preference. PLoS One. 2011;6(10):e26997. EPub Oct 28.  PMC3203949

Giardino WJ, Mark GP, Stenzel-Poore MP, Ryabinin AE. Dissociation of corticotropin-releasing factor receptor subtype involvement in sensitivity to locomotor effects of methamphetamine and cocaine.Psychopharmacology. 2012 Feb;219(4):1055-63. EPub 2011 Aug 11.   PMC3266955

Giardino WJ, Pastor R, Anacker AMJ, Spangler E, Cote DM, Li J, Stenzel-Poore M, Phillips TJ, Ryabinin AE. Dissection of corticotropin-releasing factor system involvement in locomotor sensitivity to methamphetamine.Genes Brain and Behav. 2011 Feb;10(1):78-89. EPub 2010 Sep 30.   PMC3025045

Land BB, Bruchas MR, Schattauer S, Giardino WJ, Aita M, Messinger D, Hnasko TS, Palmiter RD, Chavkin C. Activation of the kappa opioid receptor in the dorsal raphé nucleus mediates the aversive effects of stress and reinstates drug seeking. Proc. Natl. Acad. Sci. USA. 2009 Nov 10;106(45):19168-73. EPub 2009 Oct 28. PMC2776420.

Date last updated: September 21, 2016