OHSU

Graduate Studies Faculty

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Caroline A. Enns, Ph.D.

Professor
Admin Unit: SOM-Cell & Developmental Biology Department
Phone: 503-494-5845
Lab Phone: 503-494-5846
Fax: 503-494-4253
Office: BSAC 5588
Mail Code: L215
Programs:
Cell & Developmental Biology
Neuroscience Graduate Program
Program in Molecular & Cellular Biosciences
Cancer Biology
Research Interests:
cell biology protein trafficking hereditary hemochromatosis cellular basis of human disease structure function of membrane proteins cancer » Click here for more about Dr. Enns's research » PubMed Listing
Preceptor Rotations
Academic Term Available Winter 2014 Yes Spring 2014 Yes
Faculty Mentorship
Dr. Enns is available as a mentor for 2014-2015.
Profile

The cell is a highly organized and dynamic structure. Most proteins are found exclusively in one compartment of the cell and are only transported to other locations as a result of intra- or extra-cellular signaling pathways. For the most part, proteins are synthesized in the cytoplasm and targeted either co- or post-translationally to their particular destination. Recently, an increasing number of human diseases have been attributed to mutations which result in themistargeting of essential proteins. The signals responsible for the targeting membrane proteins in the biosynthetic and endocytic pathways are of particular interest to my laboratory. In addition to studying the basic cell biology of protein trafficking within the cell, we have begun to examine the trafficking and function of the protein implicated in hemochromatosis, the most common hereditary disease of people of European ancestry. Malfunctioning of this protein results in the abnormal accumulation of iron in the body. Iron uptake into the body is highly regulated. Although it is essential for life, too much iron is toxic and results in heart failure, adult onset diabetes, arthritis, and cirrhosis of the liver. We are examining the intracellular trafficking of this protein and how it participates in the control of iron uptake and egress.

Education
Ph.D., University of Oregon, 1976
 
Current Position
Professor, Cell and Developmental Biology