Graduate Studies Faculty
Miranda M. Lim, M.D., Ph.D.
Research Interests:sleep, EEG, traumatic brain injury, post-traumatic stress disorder, neurodegeneration, Alzheimer's, autism, social behavior, translational studies, Neurobiology of Disease » Click here for more about Dr. Lim's research » PubMed Listing
Preceptor RotationsAcademic Term Available Summer 2016 Maybe Fall 2016 Maybe Winter 2016 Maybe Spring 2016 Maybe Summer 2017 Maybe Fall 2017 Maybe Winter 2017 Maybe Spring 2017 Maybe
Faculty MentorshipDr. Lim might be available as a mentor for 2016-2017.
The research group of Dr. Miranda Lim is a part of the VA Portland Health Care System, with joint appointments at OHSU in the departments of Medicine, Neurology, Behavioral Neuroscience and the Oregon Institute of Occupational Health Sciences. Our research goals are to discover how sleep modulates processes in the developing brain and in neurodegenerative disease, and to directly translate basic sleep research findings in rodent models into the clinical practice of neurology and sleep medicine.
The Lim Laboratory is interested in the interface between sleep and common neurological disorders, such as traumatic brain injury (TBI), post-traumatic stress disorder (PTSD), autism, attention deficit hyperactivity disorder (ADHD), and Alzheimer’s disease. We implant EEG electrodes into rodents and record sleep for several days and nights while allowing them to behave freely. We then analyze the EEG for sleep, oscillations, and other quantitative markers in order to identify biomarkers that predict disease trajectories and response to treatment. We also manipulate sleep quality and sleep amounts to assess the function of sleep in the progression of these disorders. Our research moves seamlessly from animal models to clinical research in human subjects, and back to the bench again, with the ultimate goal of designing interventions to optimize sleep and enable better treatments in these vulnerable populations.