Welcome
The Vaccine and Gene Therapy Institute at Oregon Health & Science University has assembled a multidisciplinary team of scientists to respond to serious viral disease threats, including AIDS, chronic viral infection-associated diseases, newly emerging viral diseases and infectious diseases of the elderly. Our programs are intended to span the continuum between basic and clinical science, in which discoveries are rapidly advanced from the level of molecular and cellular biology through animal models and ultimately into clinical testing. Learn more
VGTI Seminar Series
Recent publications
J Infect Dis. Jan 20, 2026
Mitochondrial DNA Fragment Dynamics in Acute and Chronic Human Immunodeficiency Virus: Insights From Human and Nonhuman Primate Modesl
J Virol. Dec 31, 2025
Inhibition of type I interferon signaling in a conserved function of gamma-herpesvirus-encoded microRNAs
Cell Rep Med. Dec 16, 2025
Intracranial injection of genetically modified, mosquito non-transmissible Zika virus: Safety in primates and ramifications for brain tumor therapy
JAMA Netw Open. Dec 1, 2025
Presenteeism Among Health Care Personnel With COVID-19
Commun Biol. Nov 24, 2025
A rhesus macaque model of congenital cytomegalovirus infection reveals a spectrum of vertical transmission outcomes
Genome Biol. Nov 21, 2025
Long-read structural variant discovery and targeted short read genotyping enables population scale characterization of structural variation in rhesus macaques
Nat Rev Immunol. Nov 18, 2025
Guidelines for T cell Nomenclature
Proc Natl Acad Sci USA. October 28, 2025
A cytoplasmic motif in HLA-E that drives clathrin-mediated endocytosis and VCP-associated postendocytic trafficking
ACS Med Chem Lett. Oct 24, 2025
Restructuring Antiviral Quinazolinone Frameworks to Derive and Optimize Inhibitors of Chikungunya Virus
Pathog Immun. Oct 18, 2025
Meeting Summary for Keystone Symposia on HIV Cure: Antiretroviral Therapy (ART) – Free Control of HIV Infection in Durban, South Africa, 2025
J Med Chem. October 15, 2025
N-Alkyl sulfamates as a New Class of nsP2 Cysteine Protease Inhibitors with Broad-Spectrum Antialphaviral Activity
Immunity. October 14, 2025
Primate resident memory T cells activate humoral and stromal immunity
J Virol. October 8, 2025
Human cytomegalovirus UL78 is a nuclear-localized GPCR necessary for efficient reactivation from latent infection in CD34+ hematopoietic progenitor cells
Eur J Med Chem. September 27, 2025
In silico discovery and mechanistic profiling of STING agonist engaging the transmembrane domain
PLoS Pathog. September 26, 2025
Liver biopsies obtained throughout SIV infection reveal evolving interferon stimulated protein expression within distinct monocyte/macrophage subsets
Bioorg Med Chem. September 8, 2025
Novel tricycle expanded purine nucleosides with pan-viral activity
Nat Rev Immunol. September 3, 2025
Targeting MHC-E as a new strategy for vaccines and immunotherapeutics
Microbiol Spectr. August 27, 2025
Impact of obesity on the gut microbiome and inflammatory markers during SIV infection and antiretroviral therapy
J Lipid Res. August, 2025
Integrated lipidomic and proteomic profiling reveals metabolic network disruption by SARS-SoV-2 variants
Front Immunol. August 8, 2025
An immune-focused supplemental alignment pipeline captures information missed from dominant single-cell RNA-seq analyses, including allele-specific MHC-I regulation
Ways to Give
Donate to Vaccine and Gene Therapy Institute.
VGTI offers two options and account to consider when donating that serve differing purposes:
The VGTI Support Foundation Fund
Gifts to the VGTI Support Foundation Fund provides vital support that allows us find cures for life threatening infectious diseases. These funds help us to have necessary resources and create and conduct innovative infectious disease research studies, leading to the development of vaccines and cures.
The Jay Nelson Memorial Fund
Gifts to the Jay Nelson Memorial Fund supports providing education and learning opportunities for our current up and coming scientists with a focus on Herpesvirus.
Biographical Feature:
In memoriam Jay A. Nelson (1948–2024)
Your Gift Brings Hope, Please support our mission in memory of Jay Nelson. Your generosity will help support education and learning opportunities for our current up and coming scientists with a focus on Herpesvirus. Click to Donate
The VGTI Support Foundation Fund
Donate to VGTI
Your gifts help provide vital resources to conduct innovative research and more.
COVID-19 Efforts - Building a COVID Testing Lab