Pseudocolorized autoradiography of rhesus macaque hippocampus, showing in situ hybridization of mRNA encoding GluR1 (a subunit of the AMPA glutamate receptor).
Clinical visit with a Layton Center brain research participant
Diffusion tensor study of androgen deprivation effects in older men.  Cognition & Aging Lab, J.S. Janowsky Student doing volumetric analysis using the coronal slice of an MRI image
Program Director
Jeri Janowsky
Behavioral Neuroscience

Executive Committee
Daniel Dorsa
Physiology & Pharmacology
Jeffrey A. Kaye

Neurology
Jacob Raber
Behavioral Neuroscience
Henryk F. Urbanski
Oregon National Primate Research Center

Participating Faculty

Anesthesiology and Peri-Operative Medicine
Nabil Alkayed
Patricia Hurn
Stephanie J. Murphy
Richard J. Traytsman

Behavioral Neuroscience
K. Matthew Lattal
Charles K. Meshul
Suzanne Mitchell
Barry Oken

Biomedical Engineering
Misha Pavel

Neurological Sciences Institute
Paul Cordo
Alvin Eisner
Fay B. Horak
P. Hemachandra Reddy

Neurology
Patricia L. Kramer
Helmi L. Lutsep
Edward A. Neuwelt
John G. Nutt
Joseph F. Quinn

Oregon Hearing Research Center
Peter Gillespie
Alfred L. Nuttall

Oregon National Primate Research Center
Steven G. Kohama
Martha D. Neuringer
Larry S. Sherman
Mary B. Zelinski-Wooten

Physiology and Pharmacology
Steven W. Johnson

Psychiatry
Linda Ganzini
Alfred Lewy

Public Health & Preventive Medicine
Lynn M. Marshall

 


Neuroscience of Aging
Pre- and Post-Doc Training Program

(NIH #T32-AG023477)

Bringing lab and clinic face-to-face

As each discipline advances further into the far reaches of its own frontiers, it becomes challenging for bioscientists – particularly students – to maintain a perspective on how their research fits in with what's happening both in parallel fields and in clinical practice.

This pre- and post-doctoral training program aims to create scientists with a broad, “bench to bedside” understanding of the neuroscience of aging, including not only age-related neuropathologies but also the clinical manifestations and basic neuroscience of so-called “normal aging.” It provides instruction in molecular, cellular, systems, and behavioral approaches to research on age-related changes of the nervous system, as well as experience with the clinical manifestations of aging and age-related neurodegenerative diseases.

Participants will identify a primary mentor and research area to pursue while in the program. In addition, they will investigate the different aspects of neuroaging research through coursework, seminars, journal clubs, and cross-disciplinary laboratory and clinical research rotations with faculty from across the OHSU campus. Faculty areas of expertise include:

  • Aging and dementia
  • Cardiovascular risk and stroke
  • Cognition
  • Aging and movement disorders,
  • Sensory function in aging
  • Neuroendocrinology

Predoctoral students will participate primarily through the Neuroscience and Behavioral Neuroscience graduate programs.

For their individual projects, participants can take advantage of a broad range of OHSU's research resources, including the Advanced Imaging Research Center, the Oregon National Primate Research Center, and the General Clinical Research Center.

The perspectives gained through this program will allow trainees to continue as scientists of the neuroscience of aging with an understanding of how basic-science work contributes to clinical cures for aging and age-related disorders. Similarly, clinical research trainees will learn about how they can communicate with basic scientists on areas where mechanistic work can yield solutions for the clinical realm.

The program is open to PhD and MD/PhD students and post-doctoral trainees. Duration of appointments and stipends for the program typically last two years, pending annual evaluations.

Information

For more information or to apply for the Training in Neuroscience of Aging program, please contact:

Jeri Janowsky, Ph.D.
Department of Behavioral Neuroscience
Oregon Health & Science University
Mail Code CR131
3181 SW Sam Jackson Park Rd.
Portland, OR 97239-3098

ph 503.494.7872
fax 503.494.7499
janowskj@ohsu.edu

 


Last updated on November 1, 2005 by Cognition & Aging
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© 2001-2003, Oregon Health & Science University

ONPRC research with rhesus macaques includes MRI, MPRAGE, and proton density scans, histopathological preparations, immunofluorescence labeling of amyloid plaques, astrocytes and apolipoprotein) and gene expression in situ hybridization for a DNA repair enzyme, AP-endonuclease, in the temporal lobe and hippocampus.
Dr. Joe Quinn searches for plaques in research at the Layton Center for Aging & Alzheimers Disease.
Estradiol rapidly increases extracellular signal-regulated protein kinase (ERK) 2 phosphorylation in specific brain regions. Bryant DN, Bosch MA, Ronnekleiv OK, Dorsa DM. Neuroscience. 2005
Dr. Oken lab: Elders in studies of yoga and effects on age-related cognition