My main research interest involves studying the biological mechanisms that give rise to symptoms and physical frailty among adults with heart failure (“symptom biology”) that, in turn, affect outcomes such as quality of life and clinical events. In my prior research (F31NR015936), I demonstrated that physical frailty is highly prevalent in heart failure and reflects worse functional, hemodynamic, cognitive, and symptomatic parameters. My post-doctoral area of research (T32HL094294) focused on studying dysregulation of the sympathetic nervous system in heart failure, specifically centered on changes surrounding beta-adrenergic receptors (i.e. beta-adrenergic receptor kinase-1) and catecholamines, and how this relates to quality-of-life. A parallel research interest involves examining novel biomarkers (i.e. sST2) and undiscovered biomarkers using proteomics to identify patients with heart failure who will have better or worse patient-oriented and clinical outcomes. I am currently funded (K12HD043488) to study gender differences in physical frailty in heart failure, including gender differences in the mechanisms underlying physical frailty in heart failure and in the resultant outcomes. The goal of my research is to identify, and eventually target, specific markers in guiding the clinical management of heart failure patients as a means to improving overall quality of life. As a former critical care nurse at OHSU, I am also passionate about leveraging the knowledge and skillsets of nurses to research innovative questions and accelerate the translation of findings from bench-to-bedside-to-community.
Areas of interest
- Heart Failure
- B.S.N., Linfield College 2005
- Ph.D., Oregon Health & Science University 2016
- Post-Doctoral Fellowship, Habecker Lab, OHSU Knight Cardiovascular Institute (2016-2017)
Memberships and associations
- American Heart Association
- Heart Failure Society of America
- American Physiological Society
- The International Society for Heart & Lung Transplantation
Denfeld, Q.E., Mudd, J.O., Gelow, J.M., Chien, C., Hiatt, S.O., & Lee, C.S. (2015) Physical and psychological symptom biomechanics in moderate to advanced heart failure. J Cardiovasc Nurs, 30(4); 346-350.
Denfeld, Q.E., Winters-Stone, K., Mudd, J.O., Hiatt, S.O., Chien, C.V., & Lee, C.S. (2017) Frequency of and significance of physical frailty in patients with heart failure. Am J Cardiol 119(8); 1243-1249.
Denfeld, Q.E., Winters-Stone, K., Mudd, J.O., Gelow, J.M., Kurdi, S., & Lee, C.S. (2017) The prevalence of frailty in heart failure: A systematic review and meta-analysis. Int J Cardiol, 236; 283-289.
Denfeld, Q.E., Winters-Stone, K., Mudd, J.O., Hiatt, S.O., & Lee, C.S. (2018) Identifying a relationship between physical frailty and heart failure symptoms. J Cardiovasc Nurs, 33(1); E1-E7
Denfeld, Q.E., Habecker, B.A., & Woodward, W.R. (2018) Measurement of plasma norepinephrine and 3,4-dihydroxyphenylglycol: Method development for a translational research study. BMC Research Notes, 11(1), 248.
Complete list of published work in MyBibliography: https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/48818440/?sort=date&direction=ascending