Photo of Quin Denfeld, PhD, RN

Quin Denfeld PhD, RN

  • (503) 494-7948

    Portland Campus

    • Assistant Professor School of Nursing

My main research interest involves studying the biological mechanisms that give rise to symptoms and physical frailty among adults with heart failure (“symptom biology”) that, in turn, affect outcomes such as quality of life and clinical events. In my prior research (F31NR015936), I demonstrated that physical frailty is highly prevalent in heart failure and reflects worse functional, hemodynamic, cognitive, and symptomatic parameters. My post-doctoral area of research (T32HL094294) focused on studying dysregulation of the sympathetic nervous system in heart failure, specifically centered on changes surrounding beta-adrenergic receptors (i.e. beta-adrenergic receptor kinase-1) and catecholamines, and how this relates to quality-of-life. A parallel research interest involves examining novel biomarkers (i.e. sST2) and undiscovered biomarkers using proteomics to identify patients with heart failure who will have better or worse patient-oriented and clinical outcomes. I am currently funded (K12HD043488) to study gender differences in physical frailty in heart failure, including gender differences in the mechanisms underlying physical frailty in heart failure and in the resultant outcomes. The goal of my research is to identify, and eventually target, specific markers in guiding the clinical management of heart failure patients as a means to improving overall quality of life.

Areas of interest

  • Heart Failure
  • Frailty
  • Symptoms
  • Biomarkers

Education

  • B.S.N., Linfield College 2005
  • Ph.D., Oregon Health & Science University 2016
  • Fellowship:

    • Post-Doctoral Fellowship, Habecker Lab, OHSU Knight Cardiovascular Institute (2016-2017)

Publications

  • Complete List of Published Work in MyBibliography: http://www.ncbi.nlm.nih.gov/myncbi/browse/collection/48818440/?sort=date&direction=ascending 

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