Photo of Eric Gouaux, Ph.D.

Eric Gouaux Ph.D.

  •      (503) 494-5535
    • Professor Vollum Institute
    • Senior Scientist Vollum Institute
    • Jennifer and Bernard Lacroute Term Chair in Neuroscience Research Vollum Institute
    • Neuroscience Graduate Program School of Medicine
    • Biochemistry and Molecular Biology Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Eric Gouaux completed his B.A. and Ph.D. degrees in Chemistry at Harvard University. He remained at Harvard for a year as a postdoctoral fellow before continuing his postdoctoral studies at MIT. In 1993, he was appointed assistant professor at the University of Chicago Department of Biochemistry and Molecular Biology. In 1996, Gouaux joined the Department of Biochemistry and Molecular Biology at Columbia University as an assistant professor. In 2000, he was appointed Investigator with the Howard Hughes Medical Institute and associate professor with Columbia, reaching full professor the following year. Gouaux came to OHSU in 2005 as a senior scientist at the Vollum Institute, continuing his position with Howard Hughes. In 2015, Gouaux was appointed the Jennifer and Bernard Lacroute Term Chair in Neuroscience Research.

The work in the Gouaux Lab is concentrated on developing molecular mechanisms for the function of receptors and transporters at chemical synapses by utilizing cryo-electron microscopy, x-ray crystallography, and electrophysiology.

Areas of interest

  • chemical synapses and synaptic transmission
  • glutamate receptors
  • neurotransmitter transporters
  • ligand-gated ion channels
  • cryo-electron microscopy (cryo-EM)
  • x-ray crystallography
  • membrane proteins

Education

  • A.B., Harvard University, Cambridge Massachusetts 1984
  • Ph.D., Harvard University, Cambridge Massachusetts 1989

Honors and awards

  • Searle Scholar (1994)
  • Alfred P. Sloan Research Fellow (1996)
  • NINDS Javits Investigator Award (2008)
  • NIMH MERIT Award (2009)
  • Discovery Award, Medical Research Foundation of Oregon (2009)
  • National Academy of Sciences, elected member (2010)
  • Physiological Society Annual Review Prize Lecture (2013)
  • Anatrace Membrane Protein Award, Biophysical Society (2016)

Publications

  • "Gating mechanisms of acid-sensing ion channels." Nature  In: , Vol. 555, No. 7696, 15.03.2018, p. 397-401.
  • "Structural basis for recognition of diverse antidepressants by the human serotonin transporter." Nature Structural and Molecular Biology  In: , Vol. 25, No. 2, 01.02.2018, p. 170-175.
  • "Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation." Science  In: , Vol. 355, No. 6331, eaal3729, 24.03.2017.
  • "Structure and symmetry inform gating principles of ionotropic glutamate receptors." Neuropharmacology  In: , Vol. 112, 01.01.2017, p. 11-15.
  • "Activation and Desensitization Mechanism of AMPA Receptor-TARP Complex by Cryo-EM." Cell  In: , 2017.
  • "Thermostabilization, expression, purification, and crystallization of the human serotonin transporter bound to S-citalopram." Journal of Visualized Experiments  In: , Vol. 2016, No. 117, e54792, 27.11.2016.
  • "X-ray structures define human P2X 3 receptor gating cycle and antagonist action." Nature  In: , Vol. 538, No. 7623, 14.09.2016, p. 66-71.
  • "Architecture of fully occupied GluA2 AMPA receptor-TARP complex elucidated by cryo-EM." Nature  In: , Vol. 536, No. 7614, 01.07.2016, p. 108-111.
  • "Mechanism of NMDA Receptor Inhibition and Activation." Cell  In: , Vol. 165, No. 3, 21.04.2016, p. 704-714.
  • "X-ray structures and mechanism of the human serotonin transporter." Nature  In: , Vol. 532, No. 7599, 21.04.2016, p. 334-339.
  • "Thermostabilization of the human serotonin transporter in an antidepressant-bound conformation." PLoS One  In: , Vol. 10, No. 12, e0145688, 01.12.2015.
  • "Glycine receptor mechanism elucidated by electron cryo-microscopy." Nature  In: , Vol. 526, No. 7572, 08.10.2015, p. 224-229.
  • "X-ray structures of Drosophila dopamine transporter in complex with nisoxetine and reboxetine." Nature Structural and Molecular Biology  In: , Vol. 22, No. 6, 03.06.2015, p. 506-508.
  • "Neurotransmitter and psychostimulant recognition by the dopamine transporter." Nature  In: , Vol. 521, No. 7552, 21.05.2015, p. 322-327.
  • "Screening and large-scale expression of membrane proteins in mammalian cells for structural studies." Nature Protocols  In: , Vol. 9, No. 11, 27.11.2014, p. 2574-2585.
  • "X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors." Nature  In: , Vol. 512, No. 7514, 21.08.2014, p. 333-337.
  • "Structure and dynamics of AMPA receptor GluA2 in resting, pre-open, and desensitized states." Cell  In: , Vol. 158, No. 4, 14.08.2014, p. 778-792.
  • "How LeuT shapes our understanding of the mechanisms of sodium-coupled neurotransmitter transporters." Journal of Physiology  In: , Vol. 592, No. 5, 01.03.2014, p. 863-869.
  • "X-ray structure of acid-sensing ion channel 1-snake toxin complex reveals open state of a Na+-selective channel." Cell  In: , Vol. 156, No. 4, 13.02.2014, p. 717-729.
  • "X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanism." Science  In: , Vol. 345, No. 6200, 2014, p. 1021-1026.
  • "NMDA receptor structures reveal subunit arrangement and pore architecture." Nature  In: , Vol. 511, No. 7508, 2014, p. 191-197.
  • "Novel Dicarboxylate Selectivity in an Insect Glutamate Transporter Homolog." PLoS One In: , Vol. 8, No. 8, e70947, 07.08.2013.
  • "Unanticipated parallels in architecture and mechanism between ATP-gated P2X receptors and acid sensing ion channels." Current Opinion in Structural Biology  In: , Vol. 23, No. 2, 04.2013, p. 277-284.
  • "Structural basis for action by diverse antidepressants on biogenic amine transporters." Nature  In: , Vol. 503, No. 7474, 2013, p. 141-145.
  • "X-ray structure of dopamine transporter elucidates antidepressant mechanism." Nature  In: , Vol. 503, No. 7474, 2013, p. 85-90.
  • "Structural plasticity and dynamic selectivity of acid-sensing ion channelspider toxin complexes." Nature  In: , Vol. 489, No. 7416, 20.09.2012, p. 400-405.
  • "Substrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologue." EMBO Reports  In: , Vol. 13, No. 9, 09.2012, p. 861-866.
  • "A fluorescence-detection size-exclusion chromatography-based thermostability assay for membrane protein precrystallization screening." Structure  In: , Vol. 20, No. 8, 08.08.2012, p. 1293-1299.
  • "Molecular mechanism of ATP binding and ion channel activation in P2X receptors." Nature  In: , Vol. 484, No. 7397, 10.05.2012, p. 207-212.
  • "Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context." Nature Structural and Molecular Biology  In: , Vol. 19, No. 2, 02.2012, p. 212-219.

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