Shoukhrat Mitalipov, Ph.D.

Biography

Shoukhrat Mitalipov is an Assistant Scientist and a Co-Director of the Assisted Reproductive Technologies and Embryonic Stem Cell Core Laboratory at the Oregon National Primate Research Center, Oregon Health & Science University. He received his M.S. degree in Reproductive Biology from Timiriasev Academy, Moscow, Russia, and earned a Ph.D. in Developmental Genetics and Stem Cell Biology at the Research Center for Medical Genetics, Russian Academy of Medical Sciences. He moved to Utah State University in 1995 to conduct his postdoctoral research in stem cell and developmental biology. Dr. Mitalipov came to OHSU in 1998.

Research Overview

The main focus of Dr. Mitalipov's lab is genetic and epigenetic characteristics of human and monkey embryonic stem (ES) cells. ES cells are important as a unique research tool that allows investigating the mechanisms regulating early primate development and differentiation in vitro. Human ES cells also provide the far reaching foundation for the field of regenerative medicine and offer hope for the treatment of a wide range of clinical conditions that can be attributed to the loss or malfunction of specific cell types. However, translational research in clinically relevant nonhuman primate model is highly desirable to evaluate the safety, feasibility and efficacy of cell-based therapies. The basic research conducted in the lab provides new insights into the derivation, maintenance and directed differentiation of primate ES cells. Another area of interest for the Mitalipov lab is developing of ES cells that are ummunologically compatible to recipient animals using somatic cell nuclear transfer (SCNT). Generation of ES cells from parthenogenetic or androgenetic embryos is a different alternative solution to the immune rejection problem.

Selected References

Mitalipov S, Clepper L, Sritanaudomchai H, Fujimoto A, Wolf D. Methylation Status of Imprinting Centers for H19/IGF2 and SNURF/SNRPN in Primate Embryonic Stem Cells. Stem Cells. 2006 Dec 14; [Epub ahead of print]

Mitalipov S, Kuo HC, Byrne J, Clepper L, Meisner L, Johnson J, Zeier R, Wolf D. Isolation and characterization of novel rhesus monkey embryonic stem cell lines. Stem Cells. 2006 Oct;24(10):2177-86

Fujimoto A, Mitalipov SM, Kuo HC, Wolf DP. Aberrant genomic imprinting in rhesus monkey embryonic stem cells. Stem Cells. 2006 Mar;24(3):595-603.

Wolf DP, Thormahlen S, Ramsey C, Yeoman RR, Fanton J, Mitalipov S. Use of assisted reproductive technologies in the propagation of rhesus macaque offspring. Biol Reprod. 2004 Aug;71(2):486-93.