Charles D. Lopez, M.D., Ph.D.

Head Shot of Charles Lopez
click here
503 494-6594


My major research interest is investigating the basic cellular and molecular mechanisms of how tumors form and respond to treatment. By studying how these things work, I hope to find specific molecules that are targets for new cancer treatments. I see patients with gastrointestinal (digestive system) cancers and participate in clinical trials for a variety of gastrointestinal cancers.

Summary of Current Research

Additional Special Interests

Tumor biology

Selected Publications

"N terminus of ASPP2 binds to Ras and enhances Ras/Raf/MEK/ERK activation to promote oncogene-induced senescence," Proceedings of the National Academy of Sciences of the United States of America (Vol: 110, Issue: 1, Page 312-317) - 2013

"Putting the pieces together: Necrolytic migratory erythema and the glucagonoma syndrome," Journal of General Internal Medicine (Vol: 28, Issue: 11, Page 1525-1529) - 2013

"Safety and Outcomes Following Resection of Colorectal Liver Metastases in the Era of Current Perioperative Chemotherapy," Journal of Gastrointestinal Surgery (Vol: 17, Issue: 12, Page 2133-2142) - 2013

"Lapatinib and gemcitabine for metastatic pancreatic cancer: A phase II study," American Journal of Clinical Oncology: Cancer Clinical Trials (Vol: 34, Issue: 1, Page 50-52) - 2011

"Apoptosis-stimulating protein of p53 (ASPP2) heterozygous mice are tumor-prone and have attenuated cellular damage-response thresholds," Proceedings of the National Academy of Sciences of the United States of America (Vol: 106, Issue: 11, Page 4390-4395) - 2009


Back to faculty list

OHSU Knight Cancer Institute

Visit Our Site

For Healthcare Professionals


  Email Charles Lopez

503 494-6594

Memberships & Associations

American Society of Clinical Oncology Basic Mechanisms of Cancer Therapeutics Study Section , U.S. National Institutes of Health/National Cancer Institute