OHSU

Jacob Raber, Ph.D.

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503 494-1431

Background

Our research focuses on effects of genetic factors, such as apoE, and environmental factors on brain structure and function in experimental mouse models of human neurological diseases. Based on what we learn in the mouse models, we try to develop tests and treatment strategies to improve brain function in humans suffering from these diseases. Routinely, we use a combination of behavioral, neuroendocrinological, pharmacological, neurochemical, immunohistochemical, cellular, and molecular approaches.

We developed humanized versions of the mouse object recognition and spatial navigation tests and assess whether they are sensitive to detect effects of sex and apoE4 on cognition in health and disease. These tests might be valuable in identifying biomarkers of cognitive function and susceptibility to cognitive impairments.


Summary of Current Research

Research Interests Include; aging, alzheimer's disease, androgen receptor, sex differences, histamine, apoE, methamphetamine, irradiation, neurogenesis, cognitive function, behavioral


Selected Publications

"Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner," Neurobiology of Disease (Vol: 64, Page 150-162) - 2014

"Sex differences in activation of the hypothalamic-pituitary-adrenal axis by methamphetamine," Journal of Neurochemistry - 2014

"ApoE isoform modulates effects of cranial 56Fe irradiation on spatial learning and memory in the water maze," Behavioural Brain Research (Vol: 237, Issue: 1, Page 207-214) - 2013

"Correcting deregulated Fxyd1 expression ameliorates a behavioral impairment in a mouse model of Rett syndrome," Brain Research (Vol: 1496, Page 104-114) - 2013

"Developmental methamphetamine exposure results in short- and long-term alterations in hypothalamic-pituitary-adrenal-axis-associated proteins," Developmental Neuroscience (Vol: 35, Issue: 4, Page 338-346) - 2013

 

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Contact

  Email Jacob Raber

503 494-1524