2005-2006 Series



September 22, 2005

Gating and block of hERG channels

Michael Sanguinetti, Ph.D.
Department of Physiology, Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT
Hosts: John Adelman (Vollum Institute) and the OHSU Heart Research Center



October 6, 2005

Some properties of the mechanotransducer channels of auditory hair cells

Robert Fettiplace, Ph.D.
Department of Physiology, University of Wisconsin, Madison WI
Host: Peter Gillespie

October 13, 2005

From fish-hunting cone snail venoms and ion channels to drugs for pain

Baldomero Olivera, Ph.D.
Department of Biology, University of Utah
Host: Ed McCleskey

October 20, 2005

Genetic analysis of visual behavior

Herwig Baier, Ph.D.
Department of Physiology, University of California, San Francisco
Host: Wenbiao Chen

October 26, 2005

Synaptic Specializations in Auditory Hair Cells

Anthony J. Ricci, Ph.D.
Neuroscience Center, Louisiana State University, New Orleans
Hosts: Larry Trussell and Peter Gillespie
Sponsored jointly by the Oregon Hearing Research Center and The Vollum Institute.

October 27, 2005

Lipid signals in membrane transport

Donald Hilgemann, Ph.D.
Department of Physiology, University of Texas, Southwestern Medical Center, Dallas, TX
Host: Eric Gouaux

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November 3, 2005

Cholinergic and Dopamine Mechanisms Contributing to Nicotine Addiction

John Dani, Ph.D.
Department of Neuroscience, Baylor College of Medicine, Houston, TX
Host: John Williams

November 10, 2005

Conformational Dynamics of Beta2 Adrenoceptor Activation: The Effect of Ligand Structure on Receptor Structure

Brian Kobilka, M.D.
Molecular & Cellular Biology, Stanford University School of Medicine
Host: John Williams



December 1, 2005

Drosophila as a Model for Human Neurodegenerative Disease

Nancy M. Bonini, Ph.D.
HHMI, Department of Biology, University of Pennsylvania
Hosts: Vollum Institute and the OHSU Department of Neurology

December 8, 2005

Molecular Genetic Analysis of Neural Circuits Underlying Innate Behaviors in Flies and Mice

David J. Anderson, Ph.D.
HHMI, Biology, California Institute of Technology, Pasadena, CA
Host: Ed McCleskey

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January 20, 2006

Developmental Plasticity in Synaptic Transmission at the Mouse Calyx of Held Synapse

Lu-Yang Wang, Ph.D.
Senior Scientist, Hospital for Sick Children and University of Toronto
Host: Henrique von Gersdorff

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February 3, 2006

Activity-Dependent Modulation at an Auditory Synapse

Ian D. Forsythe, Ph.D.
Department of Cell Physiology and Pharmacology, University of Leicester, UK
Host: Larry Trussell

February 9, 2006

Logic and Mechanisms of Transcriptional Regulation

Kevin Struhl, Ph.D.
Biological Chemistry and Moleuclar Pharmacology, Harvard Medical School, Boston, MA
Host: Dick Goodman

February 15, 2006

Epigenetic Regulation of Neurogenesis

Fred Gage, Ph.D.
The Salk Institute for Biological Studies
Host: Gary Westbrook

February 16, 2006

Molecular Physiology and Pathology of the Hair Cell Ribbon Synapse

Tobias Moser, M.D.
Department of Otolaryngology & Center for Molecular Physiology of the Brain, University of Göettingen
Host: Teresa Nicolson

February 23, 2006

Dissecting the Multiple Mechanisms of Regulation of Synaptic NMDA Receptors

Robert Wenthold, Ph.D.
National Institute of Deafness and Other Communication Disorders, NIH
Host: Larry Trussell

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MARCH 2006

March 2, 2006

Long-term and Short-term Regulation of Potassium Channels in Auditory Neurons

Leonard Kaczmarek, Ph.D.
Department of Pharmacology and Molecular & Cellular Physiology, Yale University, New Haven, CT
Host: Henrique von Gersdorff

March 9, 2006

Olfaction: From Receptors to Perception

Leslie Vosshall, Ph.D.
Neurogenetics and Behavior, The Rockefeller University, New York
Host: Richard Walker

March 13, 2006

An Rb/E2F/DP Complex and Chromatin Remodeling Antagonize a Ras Pathway During C. elegans Vulva Development

Robert Horvitz, Ph.D.
HHMI, Biology, Massachusetts Institute of Technology, McGovern Institute for Brain Research
Host: Wenbiao Chen

March 16, 2006

Optical Approaches to Understanding Synaptic Learning Rules

Samuel Wang, Ph.D.
Assistant Professor, Department of Molecular Biology, Princeton University
Host: John Adelman

March 21, 2006

Expression of a G-protein Coupled Receptor Predisposes Mice to Cutaneous Melanoma Development

Suzie Chen, Ph.D.
Susan Lehman Cullman Laboratory for Cancer Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey
Hosts: Vollum Institute and the Molecular Pathobiology of Skin Training Grant

March 23, 2006

p53 Displays Neuron Specific Apoptotic Actions: Characterizing the p53 Cell Death Proteome in Neurons

Richard Morrison, Ph.D.
Department of Neurological Surgery, University of Washington School of Medicine, Seattle
Host: Mike Forte

March 23, 2006

Junger Center Special Seminar: Toward Understanding Polyglutamine Neurodegeneration

Henry Paulson, M.D., Ph.D.
Huntington's Disease Center of Excellence, Department of Neurology, University of Iowa, Carver College of Medicine
Hosts: Gary Westbrook and the OHSU Department of Neurology

March 30, 2006

Optical Control of Ion Channels

Ehud Isacoff, Ph.D.
Department of Neurobiology, University of California, Berkeley
Host: Wolfhard Almers

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APRIL 2006

April 5, 2006

Arg-based ER localization signals in COPI-mediated retrieval and 14-3-3-dependent forward transport

Blanche Schwappach, Ph.D.
Center for Molecular Biology, Heidelberg
Hosts: John Adelman (Vollum) and Peter Mayinger (Division of Nephrology & Hypertension)

April 6, 2006

Fat Metabolism in Obesity

Samuel Klein, M.D.
Washington University School of Medicine, Danforth Professor of Medicine and Nutritional Science
Host: Roger Cone

April 10, 2006

Light-activated ion channels for remote control of neuronal activity

Richard H. Kramer, Ph.D.
Department of Molecular & Cell Biology, University of California, Berkeley
Hosts: John Adelman (Vollum) and David Dawson (Physiology & Pharmacology)

April 13, 2006

Mechanisms Regulating Ras Pathway Signaling

Deborah K. Morrison, Ph.D.
National Cancer Institute/Laboratory of Protein Dynamics and Signaling
Host: Phil Stork

April 16, 2006

Functional proteomic analysis of voltage- and Ca2+-activated (BKCa) K+ channels

Uwe Schulte, Ph.D.
CEO/CSO Logopharm GmbH
Host: John Adelman

April 20, 2006

Ras Signaling: From basic principles to human diseases

Dafna Bar-Sagi, Ph.D.
Molecular Genetics and Microbiology, SUNY Stony Brook
Host: John Scott

April 26, 2006

Functional proteomic analysis of voltage- and Ca2+-activated (BKCa) K+ channels

Uwe Schulte, Ph.D.
CEO/CSO Logopharm GmbH
Host: John Adleman

April 27, 2006

How are CNS synapses eliminated?

Ben A. Barres, M.D., Ph.D.
Professor, Neurobiology and Developmental Biology, Stanford University
Hosts: Gary Westbrook and the OHSU Department of Neurology

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MAY 2006

May 11, 2006

Change of Mind: Optical Control of Neuronal Circuits

Gero Miesenböck, M.D.
Department of Cell Biology, Yale University School of Medicine
Host: Henrique von Gersdorff

May 18, 2006

Activity-dependent plasticity in the visual cortex

Yang Dan, Ph.D.
Department of Molecular & Cell Biology, Professor of Neurobiology, University of California, Berkeley
Host: John Adleman

May 25, 2006

Dynamics of Recurrent Inhibitory Circuits in the Cortex

Massimo Scanziani, Ph.D.
University of California San Diego, Division of Biological Sciences, Neurobiology Section
Host: Henrique von Gersdorff

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JUNE 2006

June 1, 2006

Structural biology of glutamate receptor ion channels: They are not all the same.

Mark Mayer, Ph.D.
Laboratory of Cellular and Molecular Neurophysiology, NICHD, NIH
Host: Eric Gouaux



August 22, 2006

Junger Center Special Seminar: Neurotransmitter Release: Molecules, Plasticity and Disease

Thomas C. Sudhof, M.D.
Howard Hughes Medical Insitute, Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas
Hosts: Gary Westbrook and the OHSU Department of Neurology

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