NHP Resource Programs

special resources monkeys

 The purpose of the NHP Resource Programs is to ensure that the animal needs of the various research programs are met. The current NHP Resource programs are Aging, Obese, Infectious Disease, and Japanese Macaques.

The Aging NHP Resource (APR) provides animals necessary for research on the mechanisms of aging and age-related diseases, and is an important component of the Biology of Aging Program at the ONPRC and OHSU Healthy Aging Alliance. This unique, highly translational resource is supported by ONPRC and also the National Institute on Aging (NIA). The NIA recognized the need for a highly translatable model, similar to humans, to address the health concerns of the growing elderly population. Already the oldest baby-boomers have entered retirement, and accompanying the continued escalation in the number of post-retirees, will be a transition of individuals into greater levels of fragility and chronic, progressive illnesses. Hence, any therapies that can delay, diminish, and in some cases, cure maladies that are associated with advanced age, will be essential to mitigate health concerns in the elderly. For information on tissue or animal availability please send an e-mail to: kohamas@ohsu.edu

The Obese NHP Resource (ONR) is comprised of three colonies of macaques that become obese when fed a high-fat/high-calorie diet. The Japanese macaque model supports investigations on the effects of maternal diet and metabolic health on the development of metabolic systems in the offspring;the rhesus macaque model is employed for studies testing novel therapeutics and surgical interventions for obesity, insulin resistance, and cardiovascular disease;and the cynomolgous macaque model supports research models that investigate metabolic disease and type 2 diabetes mellitus. These models are being expanded in an effort to understand the mechanisms of progression of metabolic diseases like type 2 diabetes as well as to understand the full spectrum of complications that are associated with obesity. For information on tissue or animal availability please send an e-mail to: kievitp@ohsu.edu

The Infectious Disease NHP Resource (IDR) serves to facilitate a large and diverse portfolio of infectious disease research to develop vaccines and therapies as well as understand pathogenesis for viral, bacterial, and parasitic diseases. Ongoing studies involve a range of pathogens, including SIV/SHIV as models for HIV, hepatitis B, yellow fever virus, Zika virus, chikungunya virus, rhesus rhadinovirus, cytomegalovirus, Mycobacterium tuberculosis, Neisseria gonorrhea, and Plasmodium species (malaria). The IDR is capable of supporting nonhuman primate research with other pathogens that require ABSL2 and ABSL3-level biocontainment. The IDR supports all aspects of study planning, conduct of specialized technical, surgical, pathological and imaging procedures, optimization and development of new procedures or models to address experimental questions, and interpretation of data. For information on tissue or animal availability please send an e-mail to: smedley@ohsu.edu

The Japanese Macaque NHP Resource (JMR) oversees the unique Japanese macaque (JM) captive breeding colony, initially established in 1965 with a gift of 55 animals from the Japanese government. This colony has propagated for more than six decades without the addition of new founders, evolving into a one-of-a-kind NHP resource, and producing unique genetic disease models not available in other NHP species or even other JM colonies. Prominent among the models is Japanese macaque encephalomyelitis (JME), a disease that recapitulates both the etiological and pathophysiological processes that occur in multiple sclerosis (MS) and related demyelinating diseases. To our knowledge, this disease only occurs in the ONPRC JM colony, providing an unprecedented opportunity to study the mechanisms underlying the onset of inflammatory demyelinating disease like MS. The JMR is also home to a unique NHP model of retinal disease that closely parallel human dominant drusen syndromes such as Malattia Leventinese/Doyne honeycomb dystrophy. In addition, the JMR produces the only NHP model of neuronal ceroid lipofuscinosis, providing unprecedented opportunity to develop life-saving treatments for this devastating pediatric disease. The JMR oversees the careful management and characterization of these important models, while also insuring the long-term health and stability of the JM colony. For information on tissue or animal availability please send an e-mail to: fergusob@ohsu.edu